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Karina Yoon Ph.D.
Associate Professor
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E-mail
kyoon@uab.edu
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Co-investigator Network
Karina Yoon Ph.D.
Associate Professor
Positions
Scientist (C)
,
O'Neal Comprehensive Cancer Center
,
School of Medicine
Scientist
,
Cancer Cell Biology
,
O'Neal Comprehensive Cancer Center
Scientist (C)
,
Center for Clinical and Translational Science (CCTS)
,
General Clinical Research Center
Associate Scientist (C)
,
Comprehensive Neuroscience Center
,
General Clinical Research Center
Scientist (C)
,
Center for Women's Reproductive Health
,
General Clinical Research Center
Associate Professor (P)
,
Pharmacology and Toxicology
,
Academic Joint Departments
Publications
Research
Teaching
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
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2022
The BET Inhibitor JQ1 Potentiates the Anticlonogenic Effect of Radiation in Pancreatic Cancer Cells
.
Frontiers in Oncology
. 12.
2022
2022
Pre-Clinical Study Evaluating Novel Protein Phosphatase 2A Activators as Therapeutics for Neuroblastoma
.
Cancers
. 14.
2022
2022
Targeting High-Risk Neuroblastoma Patient-Derived Xenografts with Oncolytic Virotherapy
.
Cancers
. 14.
2022
2021
PIM kinases mediate resistance to cisplatin chemotherapy in hepatoblastoma
.
Scientific Reports
. 11.
2021
2021
The bet inhibitor JQ1 augments the antitumor efficacy of gemcitabine in preclinical models of pancreatic cancer
.
Cancers
. 13.
2021
2021
Downregulation of PDGFRß Signaling Overcomes Crizotinib Resistance in a TYRO3 and ALK Mutated Neuroendocrine-Like Tumor
.
Translational Oncology
. 14.
2021
2021
Novel second-generation rexinoid induces growth arrest and reduces cancer cell stemness in human neuroblastoma patient-derived xenografts
.
Journal of Pediatric Surgery
. 56:1165-1173.
2021
2021
PIM447 inhibits oncogenesis and potentiates cisplatin effects in hepatoblastoma
.
Journal of Pediatric Surgery
. 56:1157-1164.
2021
2021
EZH2 inhibition decreases neuroblastoma proliferation and in vivo tumor growth
.
PLoS One
. 16.
2021
2021
9-cis-UAB30, a novel rexinoid agonist, decreases tumorigenicity and cancer cell stemness of human neuroblastoma patient-derived xenografts
.
Translational Oncology
. 14.
2021
2020
Developing effective combination therapy for pancreatic cancer: An overview
.
Pharmacological Research
. 155.
2020
2020
Patient-derived xenograft models of pancreatic cancer: Overview and comparison with other types of models
.
Cancers
. 12.
2020
2020
Development of gemcitabine-resistant patient-derived xenograft models of pancreatic ductal adenocarcinoma
2020
2020
The combination of BET and PARP inhibitors is synergistic in models of cholangiocarcinoma
.
Cancer Letters
. 468:48-58.
2020
2019
Focal Adhesion Kinase Inhibition Contributes to Tumor Cell Survival and Motility in Neuroblastoma Patient-Derived Xenografts
.
Scientific Reports
. 9.
2019
2019
Corruption of neuroblastoma patient derived xenografts with human T cell lymphoma
.
Journal of Pediatric Surgery
. 54:2117-2119.
2019
2019
The BET inhibitor JQ1 attenuates double-strand break repair and sensitizes models of pancreatic ductal adenocarcinoma to PARP inhibitors
.
EBioMedicine
. 44:419-430.
2019
2019
The presence of PIM3 increases hepatoblastoma tumorigenesis and tumor initiating cell phenotype and is associated with decreased patient survival
.
Journal of Pediatric Surgery
. 54:1206-1213.
2019
2019
Targeting PIM Kinases Affects Maintenance of CD133 Tumor Cell Population in Hepatoblastoma
.
Translational Oncology
. 12:200-208.
2019
2019
The effects of focal adhesion kinase and platelet-derived growth factor receptor beta inhibition in a patient-derived xenograft model of primary and metastatic Wilms tumor
.
Oncotarget
. 10:5534-5548.
2019
2018
FTY720 enhances the anti-tumor activity of carboplatin and tamoxifen in a patient-derived xenograft model of ovarian cancer
.
Cancer Letters
. 436:75-86.
2018
2018
Targeting PIM kinase as a therapeutic strategy in human hepatoblastoma
.
Oncotarget
. 9:22665-22679.
2018
2018
Pediatric anaplastic embryonal rhabdomyosarcoma: Targeted therapy guided by genetic analysis and a patient-derived xenograft study
.
Frontiers in Oncology
. 7.
2018
2018
JQ1 induces DNA damage and apoptosis, and inhibits tumor growth in a patient-derived xenograft model of cholangiocarcinoma
.
Molecular Cancer Therapeutics
. 17:107-118.
2018
2018
Sphingolipid metabolism and drug resistance in ovarian cancer
2018
2017
Whole exome sequencing identified sixty-five coding mutations in four neuroblastoma tumors
.
Scientific Reports
. 7.
2017
2016
The tumor-associated glycosyltransferase ST6Gal-I regulates stem cell transcription factors and confers a cancer stem cell phenotype
.
Cancer Research
. 76:3978-3988.
2016
2016
The BET bromodomain inhibitor JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models
.
Oncogene
. 35:833-845.
2016
2016
Dysregulated human Tyrosyl-DNA phosphodiesterase I acts as cellular toxin
.
Oncotarget
. 7:86660-86674.
2016
2015
ICAM-2 confers a non-metastatic phenotype in neuroblastoma cells by interaction with α-actinin
.
Oncogene
. 34:1553-1562.
2015
2015
The role of ICAM-2 in neuroblastoma
.
Oncoscience
. 2:915-916.
2015
2013
Development and Histopathological Characterization of Tumorgraft Models of Pancreatic Ductal Adenocarcinoma
.
PLoS One
. 8.
2013
2013
N-glycosylation of ICAM-2 is required for ICAM-2-mediated complete suppression of metastatic potential of SK-N-AS neuroblastoma cells
.
BMC Cancer
. 13.
2013
2009
Cell adhesion molecules as targets for therapy of neuroblastoma
.
Cancer Biology and Therapy
. 8:306-311.
2009
2008
ICAM-2 expression mediates a membrane-actin link, confers a nonmetastatic phenotype and reflects favorable tumor stage or histology in neuroblastoma
.
PLoS One
. 3.
2008
2007
Targeting methylguanine-DNA methyltransferase in the treatment of neuroblastoma
.
Clinical Cancer Research
. 13:5418-5425.
2007
2007
Tumor-targeted enzyme/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma
.
Cancer Research
. 67:22-25.
2007
2006
Development of a tumor-selective approach to treat metastatic cancer
.
PLoS One
. 1.
2006
2006
Development of an etoposide prodrug for dual prodrug-enzyme antitumor therapy
.
Molecular Cancer Therapeutics
. 5:1577-1584.
2006
2006
Translocations of 17q21∼qter in neuroblastoma cell lines infrequently include the topoisomerase IIα gene
.
Cancer Genetics
. 167:92-94.
2006
2005
Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11
.
Chemico-Biological Interactions
. 157-158:247-252.
2005
2005
Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety
.
Journal of Medicinal Chemistry
. 48:5543-5550.
2005
2005
The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action
.
Molecular Pharmacology
. 67:1874-1881.
2005
2005
Identification and characterization of novel benzil (diphenylethane-1,2- dione) analogues as inhibitors of mammalian carboxylesterases
.
Journal of Medicinal Chemistry
. 48:2906-2915.
2005
2005
Development of prodrugs for enzyme-mediated, tumor-selective therapy
.
Anti-Cancer Agents in Medicinal Chemistry
. 5:107-113.
2005
2004
Characterization of inhibitors of specific carboxylesterases: Development of carboxylesterase inhibitors for translational application
.
Molecular Cancer Therapeutics
. 3:903-909.
2004
2004
Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: Synthesis, quantitative structure-activity relationship analysis, and biological activity
.
Molecular Pharmacology
. 65:1336-1343.
2004
2003
Activation of a camptothecin prodrug by specific carboxylesterases as predicted by quantitative structure-activity relationship and molecular docking studies
.
Molecular Cancer Therapeutics
. 2:1171-1181.
2003
2003
Synthesis and evaluation of esters and carbamates to identify critical functional groups for esterase-specific metabolism
.
Bioorganic and Medicinal Chemistry
. 11:3237-3244.
2003
2003
Acetyl-L-carnitine cytoprotection against 1-methyl-4-phenylpyridinium toxicity in neuroblastoma cells.
.
Biochemical Pharmacology
. 66:297-306.
2003
1998
New steroidal antiinflammatory agents: prednisolone derivatives with an isoxazoline fusion at the 16- and 17-carbons and an alkyl carboxylate at the 16 alpha-position.
.
Drugs under experimental and clinical research
. 24:57-66.
1998
1998
The thymolytic effect of cocaine and monoaminergic drugs in the mouse.
.
Life Sciences
. 62:905-912.
1998
1995
Steroidal anti-inflammatory antedrugs: synthesis and pharmacological evaluation of 16 alpha-alkoxycarbonyl-17-deoxyprednisolone derivatives.
.
Steroids
. 60:445-451.
1995
Research
Principal Investigator On
Developing Novel Combination Therapies for Pancreatic Cancer
awarded by
National Cancer Institute/NIH/DHHS
Developing Therapy for the Treatment of Cholangiocarcinoma
awarded by
National Cancer Institute/NIH/DHHS
Investigator On
Glycan Control of Stem Cell-Associated Pathways in Pancreatic Cancer
awarded by
National Cancer Institute/NIH/DHHS
Role of PIM Kinase in Maintaining Hepatoblastoma Tumor Initiating Cell Population
awarded by
KAUL PEDIATRIC RESEARCH INSTITUTE
Teaching
Teaching Activities
GBS703 - Res Analysis & Presentation (Fall Term 2016)
GBS753 - Intro to Pharmacology & Toxico (Spring Term 2022)
GBS753 - Intro to Pharmacology & Toxico (Spring Term 2023)
GBS753 - Pharm & Molec Med (Spring Term 2015)
GBS753 - Pharm & Molec Med (Spring Term 2016)
GBS753 - Pharm & Molec Med (Spring Term 2017)
GBS753 - Pharm & Molec Med (Spring Term 2018)
GBS753 - Pharm Tox & Molec Med (Spring Term 2020)
GBS753 - Pharm Tox & Molec Med (Spring Term 2021)
GBS753 - Pharmacology & Molec Med (Spring Term 2019)
GBS775 - Cancer Treatment (Fall Term 2011)
GBS775 - Cancer Treatment (Spring Term 2014)
GBS775 - Cancer Treatment (Spring Term 2016)
GBS775 - Cancer Treatment (Spring Term 2018)
GBS775 - Cancer Treatment (Spring Term 2020)
GBS775 - Cancer Treatment (Spring Term 2022)
GBSC720 - Journal Club 2 (Fall Term 2018)
GBSC720 - Journal Club 2 (Fall Term 2019)
GBSC720 - Journal Club 2 (Fall Term 2020)
GBSC720 - Journal Club 2 (Fall Term 2021)
GBSC720 - Journal Club 2 (Fall Term 2022)
GBSC720 - Journal Club 2 (Spring Term 2019)
GBSC720 - Journal Club 2 (Spring Term 2020)
GBSC720 - Journal Club 2 (Spring Term 2021)
GBSC720 - Journal Club 2 (Spring Term 2022)
GBSC720 - Journal Club 2 (Spring Term 2023)
MBS613 - Systems Pharmacology II (Summer Term 2019)
MBS613 - Systems Pharmacology II (Summer Term 2020)
MBS613 - Systems Pharmacology II (Summer Term 2022)
PHR613 - Systems Pharmacology II (Summer Term 2021)
Background
Education And Training
Doctor of Philosophy in Pharmacology,
Florida Agricultural & Mechanical University
2001
Contact
Full Name
Karina
Yoon