Selected Publications

Academic Article

Year Title Altmetric
2022 Dehydrogenase reductase 9 (SDR9C4) and related homologs recognize a broad spectrum of lipid mediator oxylipins as substratesJournal of Biological Chemistry.  298. 2022
2021 Characterization of subunit interactions in the hetero-oligomeric retinoid oxidoreductase complexBiochemical Journal.  478:3597-3611. 2021
2021 Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetesJournal of Biological Chemistry.  296. 2021
2020 Generation of retinaldehyde for retinoic acid biosynthesisBiomolecules.  10. 2020
2019 Mice lacking the epidermal retinol dehydrogenases SDR16C5 and SDR16C6 display accelerated hair growth and enlarged meibomian glandsJournal of Biological Chemistry.  294:17060-17074. 2019
2019 Tissue-specific kinase expression and activity regulate flux through the pyruvate dehydrogenase complexJournal of Biological Chemistry.  294:838-851. 2019
2008 Allosteric coupling in pyruvate dehydrogenase kinase 2Biochemistry.  47:8358-8366. 2008
2008 Structural and functional insights into the molecular mechanisms responsible for the regulation of pyruvate dehydrogenase kinase 2Journal of Biological Chemistry.  283:15789-15798. 2008
2007 Corrigendum to "Identification of a novel PP2C-type mitochondrial phosphatase" [Biochem. Biophys. Res. Commun. 356 (2007) 38-44] (DOI:10.1016/j.bbrc.2007.02.108)Biochemical and Biophysical Research Communications.  361:1061. 2007
2007 Recognition of the inner lipoyl-bearing domain of dihydrolipoyl transacetylase and of the blood glucose-lowering compound AZD7545 by pyruvate dehydrogenase kinase 2Biochemistry.  46:8592-8602. 2007
2007 Amino acid residues responsible for the recognition of dichloroacetate by pyruvate dehydrogenase kinase 2FEBS Letters.  581:2988-2992. 2007
2007 Identification of a novel PP2C-type mitochondrial phosphataseBiochemical and Biophysical Research Communications.  356:38-44. 2007
2006 Gender and post-ischemic recovery of hypertrophied rat heartsBMC Cardiovascular Disorders.  6. 2006
2005 The carboxy-terminal tail of pyruvate dehydrogenase kinase 2 is required for the kinase activityBiochemistry.  44:13573-13582. 2005
2005 Role of protein-protein interactions in the regulation of pyruvate dehydrogenase kinase activityBiochemical Journal.  387:147-153. 2005
2004 Regular exercise is associated with a protective metabolic phenotype in the rat heartAmerican Journal of Physiology: Heart and Circulatory Physiology.  287. 2004
2004 Probing a putative active site of the catalytic subunit of pyruvate dehydrogenase phosphatase 1 (PDP1c) by site-directed mutagenesisBBA: Proteins and Proteomics.  1700:43-51. 2004
2003 Characterization of the isozymes of pyruvate dehydrogenase phosphatase: Implications for the regulation of pyruvate dehydrogenase activityBBA: Proteins and Proteomics.  1652:126-135. 2003
2003 Starvation and diabetes reduce the amount of pyruvate dehydrogenase phosphatase in rat heart and kidneyDiabetes.  52:1371-1376. 2003
2003 Formation of functional heterodimers by isozymes 1 and 2 of pyruvate dehydrogenase kinaseBBA: Proteins and Proteomics.  1645:183-192. 2003
2002 Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complexBiochemical Journal.  366:129-136. 2002
2002 Pyruvate dehydrogenase and the regulation of glucose oxidation in hypertrophied rat heartsCardiovascular Research.  53:841-851. 2002
2001 Structure of pyruvate dehydrogenase kinase: Novel folding pattern for a serine protein kinaseJournal of Biological Chemistry.  276:37443-37450. 2001
2001 Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sitesBiochemical Journal.  358:69-77. 2001
2001 An Essential Role of Glu-243 and His-239 in the Phosphotransfer Reaction Catalyzed by Pyruvate Dehydrogenase KinaseJournal of Biological Chemistry.  276:17994-17999. 2001
2000 Starvation increases the amount of pyruvate dehydrogenase kinase in several mammalian tissuesArchives of Biochemistry and Biophysics.  381:1-7. 2000
2000 Experimental hyperthyroidism causes inactivation of the branched-chain α-ketoacid dehydrogenase complex in rat liverArchives of Biochemistry and Biophysics.  375:55-61. 2000
2000 Branched-chain α-keto acid dehydrogenase kinaseMethods in Enzymology.  324:162-178. 2000
2000 Determination of branched-chain α-keto acid dehydrogenase activity state and branched-chain α-keto acid dehydrogenase kinase activity and protein in mammalian tissuesMethods in Enzymology.  324:48-62. 2000
2000 Mammalian methylmalonate-semialdehyde dehydrogenaseMethods in Enzymology.  324:207-218. 2000
2000 Production of recombinant E1 component of branched-chain α-keto acid dehydrogenase complexMethods in Enzymology.  324:200-207. 2000
1999 Evidence that pyruvate dehydrogenase kinase belongs to the ATPase/kinase superfamilyBiochemical Journal.  344:47-53. 1999
1999 Mechanism responsible for inactivation of skeletal muscle pyruvate dehydrogenase complex in starvation and diabetesDiabetes.  48:1593-1599. 1999
1998 Evidence for the existence of two isozymes of pyruvate dehydrogenase phosphatase in mammalsThe FASEB Journal.  12. 1998
1998 Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulationJournal of Biological Chemistry.  273:17680-17688. 1998
1998 Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complexBiochemical Journal.  329:191-196. 1998
1998 Insulin downregulates pyruvate dehydrogenase kinase (PDK) mRNA: Potential mechanism contributing to increased lipid oxidation in insulin- resistant subjectsMolecular Genetics and Metabolism.  65:181-186. 1998
1998 Pyruvate dehydrogenase E1α isoform in rat testis: cDNA cloning, characterization, and biochemical comparison of the recombinant testis and liver enzymesComparative Biochemistry and Physiology - B: Comparative Biochemistry.  120:205-216. 1998
1998 Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heartBiochemical Journal.  329:197-201. 1998
1997 Regulation of mammalian pyruvate dehydrogenase kinaseFEBS Letters.  419:197-200. 1997
1997 Gender difference in regulation of the branched-chain a-keto acid dehydrogenase complex (bckdc) and its kinaseThe FASEB Journal.  11. 1997
1997 Gender difference in regulation of branched-chain amino acid catabolismBiochemical Journal.  327:449-453. 1997
1997 Studies on the regulation of the mitochondrial α-ketoacid dehydrogenase complexes and their kinasesAdvances in Enzyme Regulation.  37:271-293. 1997
1997 Dihydrolipoamide dehydrogenase-binding protein of the human pyruvate dehydrogenase complex. DNA-derived amino acid sequence, expression, and reconstitution of the pyruvate dehydrogenase complexJournal of Biological Chemistry.  272:19746-19751. 1997
1997 cDNA sequence and catalytic properties of a chick embryo alcohol dehydrogenase that oxidizes retinol and 3β,5α-hydroxysteroidsJournal of Biological Chemistry.  272:7494-7500. 1997
1997 9 Mitochondrial α-ketoacid dehydrogenase kinases: A new family of protein kinasesAdvances in second messenger and phosphoprotein research.  31:105-111. 1997
1996 Characterization of isoenzyme 3 of pyruvate dehydrogenase kinase (PDK3)The FASEB Journal.  10. 1996
1996 Evidence that isoenzymes i and 2 of pyruvate dehydrogenase kinase (PDK) can form heterodimers in vitroThe FASEB Journal.  10. 1996
1996 Naturally occurring mutant (H263l) of pyruvate dehydrogenase complex EL subunit: implications in thiamine binding and phosphorylationThe FASEB Journal.  10. 1996
1996 Site-directed mutagenesis within the catalytic domain of pyruvate dehydrogenase kinase (PDK)The FASEB Journal.  10. 1996
1996 Cloning and characterization of PDK4 on 7q21.3 encoding a fourth pyruvate dehydrogenase kinase isoenzyme in humanJournal of Biological Chemistry.  271:22376-22382. 1996
1996 Erratum: Diversity of the pyruvate dehydrogenase kinase gene family in humans (Journal of Biological Chemistry (1995) 270 (28989-28994))Journal of Biological Chemistry.  271:1250. 1996
1995 Roles of amino acid residues surrounding phosphorylation site 1 of branched-chain α-ketoacid dehydrogenase (BCKDH) in catalysis and phosphorylation site recognition by BCKDH kinaseJournal of Biological Chemistry.  270:31071-31076. 1995
1995 Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase: Active-site amino acid sequence explains substrate specificity compared with liver isozymesJournal of Biological Chemistry.  270:3625-3630. 1995
1995 Regulation by physical training of enzyme activity and gene expression of branched-chain 2-oxo acid dehydrogenase complex in rat skeletal muscleBBA: General Subjects.  1243:277-281. 1995
1995 A new family of protein kinases- The mitochondrial protein kinasesAdvances in Enzyme Regulation.  35. 1995
1995 Dietary control and tissue specific expression of branched-chain α-ketoacid dehydrogenase KinaseArchives of Biochemistry and Biophysics.  316:148-154. 1995
1995 Diversity of the pyruvate dehydrogenase kinase gene family in humansJournal of Biological Chemistry.  270:28989-28994. 1995
1995 Nutritional regulation of the protein kinases responsible for the phosphorylation of the α-ketoacid dehydrogenase complexesThe Journal of Nutrition.  125. 1995
1994 Molecular cloning of the p45 subunit of pyruvate dehydrogenase kinaseJournal of Biological Chemistry.  269:29720-29724. 1994
1994 Site-directed mutagenesis of phosphorylation sites of the branched chain α-ketoacid dehydrogenase complexJournal of Biological Chemistry.  269:18583-18587. 1994
1994 Coordinated expression of valine catabolic enzymes during adipogenesis: Analysis of activity, mRNA, protein levels, and metabolic consequencesArchives of Biochemistry and Biophysics.  315:317-322. 1994
1994 Effect of dietary protein on the liver content and subunit composition of the branched-chain α-ketoacid dehydrogenase complexArchives of Biochemistry and Biophysics.  308:446-453. 1994
1994 Regulation of branched-chain amino acid catabolismThe Journal of Nutrition.  124. 1994
1993 Evolutionary relationships of branched chain and non-specific alcohol and aldehyde dehydrogenasesAdvances in Experimental Medicine and Biology.  328:523-532. 1993
1993 Molecular cloning of the branched-chain α-keto acid dehydrogenase kinase and the CoA-dependent methylmalonate semialdehyde dehydrogenaseAdvances in Enzyme Regulation.  33:255-258. 1993
1993 Primary structure of pyruvate dehydrogenase kinase establishes a new family of eukaryotic protein kinasesJournal of Biological Chemistry.  268:26602-26606. 1993
1992 Coenzyme A- and NADH-dependent esterase activity of methylmalonate semialdehyde dehydrogenaseBBA: Proteins and Proteomics.  1119:69-73. 1992
1992 Branched-chain α-ketoacid dehydrogenase kinase. Molecular cloning, expression, and sequence similarity with histidine protein kinasesJournal of Biological Chemistry.  267:13127-13130. 1992
1992 CoA-dependent methylmalonate-semialdehyde dehydrogenase, a unique member of the aldehyde dehydrogenase superfamily. cDNA cloning, evolutionary relationships, and tissue distributionJournal of Biological Chemistry.  267:19724-19729. 1992
1992 Purification, characterization, regulation and molecular cloning of mitochondrial protein kinasesAdvances in Enzyme Regulation.  32:267-284. 1992
1991 Purification and comparative study of the kinases specific for branched chain α-ketoacid dehydrogenase and pyruvate dehydrogenaseProtein Expression and Purification.  2:278-286. 1991
1991 The effect of ligand binding on the proteolytic pattern of methylmalonate semialdehyde dehydrogenaseArchives of Biochemistry and Biophysics.  290:21-26. 1991
1990 Purification and partial characterization of branched-chain α-ketoacid dehydrogenase kinase from rat liver and rat heartArchives of Biochemistry and Biophysics.  283:293-299. 1990

Education And Training

  • Doctor of Philosophy in Biochemistry, Moscow State University named after M.V. Lomonosov 1986
  • Full Name

  • Kirill Popov