Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary HyperoxaluriaACS Medicinal Chemistry Letters.  12:1116-1123. 2021
2021 Effect of alanine supplementation on oxalate synthesisBBA: Molecular Basis of Disease.  1867. 2021
2020 The effects of the inactivation of Hydroxyproline dehydrogenase on urinary oxalate and glycolate excretion in mouse models of primary hyperoxaluriaBBA: Molecular Basis of Disease.  1866. 2020
2019 Reduction in urinary oxalate excretion in mouse models of Primary Hyperoxaluria by RNA interference inhibition of liver lactate dehydrogenase activityBBA: Molecular Basis of Disease.  1865:2203-2209. 2019
2019 Dietary oxalate and kidney stone formationAmerican Journal of Physiology: Renal Physiology.  316:F409-F413. 2019
2016 Probiotic properties of Oxalobacter formigenes: an in vitro examinationArchives of Microbiology.  198:1019-1026. 2016
2016 Effects of alanine: Glyoxylate aminotransferase variants and pyridoxine sensitivity on oxalate metabolism in a cell-based cytotoxicity assayBBA: Molecular Basis of Disease.  1862:1055-1062. 2016
2016 Metabolism of 13C5-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenaseBBA: Molecular Basis of Disease.  1862:233-239. 2016
2016 Response of germfree mice to colonization by Oxalobacter formigenes and altered Schaedler floraApplied and Environmental Microbiology.  82:6952-6960. 2016
2015 Hydroxyproline metabolism in a mouse model of Primary Hyperoxaluria Type 3BBA: Molecular Basis of Disease.  1852:2700-2705. 2015
2015 Oxalobacter formigenes colonization and oxalate dynamics in a mouse modelApplied and Environmental Microbiology.  81:5048-5054. 2015
2012 4-Hydroxy-2-oxoglutarate aldolase inactivity in primary hyperoxaluria type 3 and glyoxylate reductase inhibitionBBA: Molecular Basis of Disease.  1822:1544-1552. 2012
2012 Glyoxal formation and its role in endogenous oxalate synthesisAdvances in Urology2012
2012 Metabolism of [ 13C 5]hydroxyproline in vitro and in vivo: Implications for primary hyperoxaluriaAmerican Journal of Physiology: Gastrointestinal and Liver Physiology.  302. 2012
2012 Glycolate and 2-phosphoglycolate content of tissues measured by ion chromatography coupled to mass spectrometryAnalytical Biochemistry.  421:121-124. 2012
2012 Hydroxyproline metabolism in mouse models of primary hyperoxaluriaAmerican Journal of Physiology: Renal Physiology.  302. 2012
2005 Mitochondrial hydroxyproline metabolism: Implications for primary hyperoxaluriaAmerican Journal of Nephrology.  25:171-175. 2005

Chapter

Year Title Altmetric
2015 Role of Oxalobacter formigenes colonization in calcium oxalate kidney stone disease.  77-84. 2015

Investigator On

  • 4-Hydroxy-2-Oxoglutarate Metabolism in PH3  awarded by Oxalosis and Hyperoxaluria Foundation
  • Effect of Weight Loss on Urinary Oxalate Excretion in Obese Calcium Oxalate Kidney Stone Formers  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Endogenous Oxalate Synthesis  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Glycolate Metabolism and Kidney Oxalate  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Glyoxal: A Novel Source of Endogenous Oxalate Synthesis and Its Clinical Contribution to Kidney Stones  awarded by UROLOGY CARE FOUNDATION
  • Hydroxyproline Catabolism and Hyperoxaluria  awarded by WAKE FOREST UNIVERSITY
  • Hydroxyproline Dehydrogenase as a Target for Lowering Urinary Oxalate Excretion  awarded by WAKE FOREST UNIVERSITY
  • Influence of Obesity on Endogenous Oxalate Synthesis  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Influence of Obesity on Endogenous Oxalate Synthesis - Project  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Influence of Obesity on Oxalate Metabolism and Handling in Calcium Oxalate Stone Formers-Project-Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Inhibition of Oxalate Synthesis by RNA Interference Rare Kidney Stone Consortium  awarded by MAYO CLINIC
  • Kidney Undergraduate Research Experience (KURE)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Mitochondrial Metabolism in Primary Hyperoxaluria  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Obesity and Endogenous Oxalate Synthesis  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Oxalate Formation from Ascorbic Acid  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • PRedoctoral Interdisciplinary Training in Renal Physiology and MEdIcIne (PRIME)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Phenotypic Changes Associated with PH3  awarded by WAKE FOREST UNIVERSITY
  • Private Grant  awarded by BRIDGE BIO PHARMA
  • Private Grant  awarded by ARBOR BIOTECHNOLOGIES
  • The Influence of Obesity on Oxalate Metabolism and Handling in Calcium Oxalate Stone Formers  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Education And Training

  • Doctor of Philosophy in Physiology, Newcastle University 2001
  • Full Name

  • John Knight