• Keith McGregor is an Associate Professor and Director of Research in the Department of Clinical and Diagnostic Sciences. His work currently investigates aging-related declines in motor control and its implications to stroke rehabilitation. His current projects employ multimodal imaging and neurophysiological techniques (TMS, rTMS, tDCS, fMRI and DTI) to investigate brain function. Dr. McGregor's work has shown that aging is associated with decreased levels of cortical inhibition, which affects motor control including motor learning. A major facet of this aging related phenomenon, however, is that individual differences in physical activity level appear to mitigate changes in cortical communication. Dr. McGregor's research has shown that lifestyle interventions can lessen or even reverse aging-related declines in behavioral performance in motor and cognitive domains. These findings have great relevance to rehabilitation programs which may be augmented by the incorporation of increased levels of physical activity.

    Keith graduated from the University of Florida with a PhD in Behavioral and Cognitive Neuroscience in 2010. He is interested in motor control, cognition, stroke rehabilitation, and aging.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2023 Rostral anterior cingulate connectivity in older adults with subthreshold depressive symptoms: A preliminary studyAging Brain.  3:100059. 2023
    2022 Baseline Measures of Cortical Inhibition Predict Motor Performance Changes after Exercise InterventionsArchives of Physical Medicine and Rehabilitation.  103:e130. 2022
    2022 Changes in Functional GABA Levels in Motor Cortex in Older AdultsArchives of Physical Medicine and Rehabilitation.  103:e130. 2022
    2022 Associations between Duration of Homelessness and Cardiovascular Risk Factors: A Pilot StudyInternational Journal of Environmental Research and Public Health.  19. 2022
    2022 Effects of exercise on the sleep microarchitecture in the aging brain: A study on a sedentary sampleFrontiers in Systems Neuroscience.  16. 2022
    2022 The Relationship Between Resting Cerebral Blood Flow, Neurometabolites, Cardio-Respiratory Fitness and Aging-Related Cognitive DeclineFrontiers in Psychiatry.  13. 2022
    2022 Reduced Interference and Serial Dependency Effects for Naming in Older but Not Younger Adults after 1 Hz rTMS of Right Pars TriangularisNeurobiology of Language.  3:256-271. 2022
    2021 Not All Lesioned Tissue Is Equal: Identifying Pericavitational Areas in Chronic Stroke With Tissue Integrity Gradation via T2w T1w RatioFrontiers in Neuroscience.  15. 2021
    2021 Integrative learning for population of dynamic networks with covariatesNeuroImage.  236. 2021
    2021 Neural Correlates of Effects of Internally versus Externally Guided Partnered Rehabilitative Tango for People with Parkinson’s Disease 2021
    2021 Integrative learning for population of dynamic networks with covariatesNeuroImage.  236:118181-118181. 2021
    2021 Smaller spared subcortical nuclei are associated with worse post-stroke sensorimotor outcomes in 28 cohorts worldwideBrain Communications.  3. 2021
    2020 The effect of time since stroke, gender, age, and lesion size on thalamus volume in chronic stroke: a pilot studyScientific Reports.  10. 2020
    2020 Changes in Gamma-aminobutyric Acid Concentrations in Sensorimotor Cortical Regions Following a 12-week Exercise Intervention in Older AdultsArchives of Physical Medicine and Rehabilitation.  101:e38. 2020
    2020 Correlation Between Exercise-Induced Increases in VO2 Peak and Motor/Cognitive Ability in Sedentary Older AdultsArchives of Physical Medicine and Rehabilitation.  101:e37. 2020
    2020 Correcting Task fMRI Signals for Variability in Baseline CBF Improves BOLD-Behavior Relationships: A Feasibility Study in an Aging ModelFrontiers in Neuroscience.  14. 2020
    2020 Effects of Combined Aerobic Exercise and Cognitive Training on Verbal Fluency in Older Adults 2020
    2020 Effects of Combined Aerobic Exercise and Cognitive Training on Verbal Fluency in Older Adults.Gerontology and Geriatric Medicine.  6:2333721419896884. 2020
    2019 Differences in dietary recall and subjective physical functioning status in stroke survivors with self-reported cognitive impairmentTopics in Stroke Rehabilitation.  26:307-311. 2019
    2019 Proceedings #45: Effects of Active and Sham tDCS on Lexical Decision in Three Persons with AphasiaBrain Stimulation.  12:e116-e117. 2019
    2019 Internally guided lower limb movement recruits compensatory cerebellar activity in people with Parkinson's diseaseFrontiers in Neurology.  10. 2019
    2018 Effects of a 12-week aerobic spin intervention on resting state networks in previously sedentary older adultsFrontiers in Psychology.  9. 2018
    2018 Task-residual functional connectivity of language and attention networksBrain and Cognition.  122:52-58. 2018
    2018 Influences of 12-week physical activity interventions on TMS measures of cortical network inhibition and upper extremity motor performance in older adults-A feasibility studyFrontiers in Aging Neuroscience.  9. 2018
    2017 Gamma-aminobutyric Acid (GABA) and Executive Function in Healthy Older AdultsArchives of Physical Medicine and Rehabilitation.  98:e171. 2017
    2017 Advances in neurocognitive rehabilitation research from 1992 to 2017: The ascension of neural plasticityNeuropsychology.  31:900-920. 2017
    2017 Changes in Cortical Activation Patterns in Language Areas following an Aerobic Exercise Intervention in Older AdultsNeural Plasticity.  2017. 2017
    2016 Changes in Cortical Activation Patterns in Language Areas Following Aerobic Exercise in Older AdultsMedicine and Science in Sports and Exercise.  48:126. 2016
    2015 Reliability of negative BOLD in ipsilateral sensorimotor areas during unimanual task activity 2015
    2015 The relevance of aging-related changes in brain function to rehabilitation in aging-related diseaseFrontiers in Human Neuroscience.  9. 2015
    2015 Broca's area - Thalamic connectivityBrain and Language.  141:80-88. 2015
    2015 Context-dependent neural activation: Internally and externally guided rhythmic lower limb movement in individuals with and without neurodegenerative diseaseFrontiers in Neurology.  6. 2015
    2015 Self-reported physical activity and objective aerobic fitness: Differential associations with gray matter density in healthy agingFrontiers in Aging Neuroscience.  7. 2015
    2015 Spin exercise improves semantic fluency in previously sedentary older adultsJournal of Aging and Physical Activity.  23:90-94. 2015
    2014 A behavioral manipulation engages right frontal cortex during aphasia therapyNeurorehabilitation and Neural Repair.  28:545-553. 2014
    2013 Broca's area and its striatal and thalamic connections: A diffusion-MRI tractography studyFrontiers in Neuroanatomy2013
    2013 Delineation of motor and somatosensory thalamic subregions utilizing probabilistic diffusion tractography and electrophysiologyJournal of Magnetic Resonance Imaging.  37:600-609. 2013
    2013 Effects of aerobic fitness on aging-related changes of interhemispheric inhibition and motor performanceFrontiers in Aging Neuroscience.  5. 2013
    2013 Functional language networks in sedentary and physically active older adultsJournal of the International Neuropsychological Society.  19:625-634. 2013
    2012 Motor map reliability and aging: A TMS/fMRI studyExperimental Brain Research.  219:97-106. 2012
    2012 Impact of changed positive and negative task-related brain activity on word-retrieval in agingNeurobiology of Aging.  33:656-669. 2012
    2012 Aging, aerobic activity and interhemispheric communicationBrain Sciences.  2:634-648. 2012
    2011 Physical activity and neural correlates of aging: A combined TMS/fMRI studyBehavioural Brain Research.  222:158-168. 2011
    2011 MO‐F‐211‐01: Delineation of Functional Thalamic Subregions: A Comparison of Probabilistic Diffusion Tractography and ElectrophysiologyMedical Physics.  38:3729. 2011
    2010 Structural connectivity of Broca's area and medial frontal cortexNeuroImage.  52:1230-1237. 2010
    2010 Functional imaging and related techniques: An introduction for rehabilitation researchersJournal of Rehabilitation Research and Development.  47:7-33. 2010
    2010 An fMRI study of the differences in brain activity during active ankle dorsiflexion and plantarflexion 2010
    2009 Age-related changes in motor control during unimanual movements 2009
    2009 Regional changes in word-production laterality after a naming treatment designed to produce a rightward shift in frontal activityBrain and Language.  111:73-85. 2009
    2009 Selective detrending method for reducing task-correlated motion artifact during speech in event-related FMRIHuman Brain Mapping.  30:1105-1119. 2009
    2008 Discriminating brain activity from task-related artifacts in functional MRI: Fractal scaling analysis simulation and applicationNeuroImage.  40:197-212. 2008
    2007 Functional MRI of language in aphasia: A review of the literature and the methodological challengesNeuropsychology Review.  17:157-177. 2007
    2006 Neural substrates of syntactic mapping treatment: An fMRI study of two casesJournal of the International Neuropsychological Society.  12:132-146. 2006
    2004 Poster 10 neural substrates of word retrieval training for nouns in aphasia. Anna Bacon Moore, Keith McGregor, Megan Gaiefsky, Kaudinya Gopinath, Kung K. Peck, Ashley Wabnitz, Keith D. White, Leslie J. Gonzalez-Rothi, PhD, Anastasia M. Raymer, PhD, Richard Briggs, Bruce CrossonArchives of Physical Medicine and Rehabilitation.  85:e7. 2004


    Year Title Altmetric
    2018 Aging with Parkinson’s Disease.  161-174. 2018
    2014 Aging-Related Changes in Neural Substrates of Motor and Cognitive Systems.  282-298. 2014

    Research Overview

  • Aging; Physical activity; Brain health; Transcranial magnetic stimulation; Non-invasive brain stimulation; Cognitive changes in aging; Motor control; Stroke rehabilitation
  • Education And Training

  • Doctor of Philosophy in Neuroscience, University of Florida 2010
  • Master of Psychology in Cognitive Psychology and Psycholinguistics, University of Florida 2006
  • Bachelor's Degree in Psychology, College of the Holy Cross 1997
  • Full Name

  • Keith McGregor