Positions

Overview

  • The overall goal of my research program is to investigate environmental modulation of circadian clock function in mammalian systems and the contribution of clock disruption to pathological disease. One of the most exciting discoveries that has emerged in recent years is that the circadian molecular clock regulates excitability in neurons that are spontaneously active in the absence of synaptic input. Although the intrinsic 24-h rhythm in membrane properties of neurons of the suprachiasmatic nucleus (SCN) has been known for over 30 years, it is surprising that we know very little about how the brain’s circadian clock regulates circadian rhythmicity throughout the body as well as in other brain regions. We are interested in how nutrition (high caloric diets, meal timing) and disease (obesity, neurodegeneration) influence clock-driven changes in physiology and behavior in brain regions such as the SCN, hippocampus and substantia nigra. A second, related interest of the laboratory is translation what we have learned about circadian regulation in animal models to humans, specifically by determining the impact of environmental circadian misalignment (e.g., shift work) or addiction (e.g., smoking) on circadian rhythmicity of behavior and physiology.
  • Research Overview

  • Chronobiology, Sleep, Circadian Rhythms, Neuroscience, Electrophysiology, Neurodegenerative Diseases, Smoking, Shift Work
  • Investigator On

  • A Sleep and Media Intervention to Improve Adolescents Weight and Risk of Type 2 Diabetes  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Alcohol-Induced Mitochondrial Dysfunction and the Hepatocyte Clock  awarded by National Institute on Alcohol Abuse and Alcoholism/NIH/DHHS
  • Circadian Changes in Network Excitability and Alzheimer Disease Pathogenesis  awarded by National Institute on Aging/NIH/DHHS
  • Circadian Changes in Network Excitability and Alzheimer Disease Pathogenesis  awarded by National Institute on Aging/NIH/DHHS
  • Circadian and Sleep Mechanisms among Racial Groups for Nicotine Dependence, Craving, and Withdrawal  awarded by National Institute on Drug Abuse/NIH/DHHS
  • Consequences of Noradrenergic Degeneration in the Novel TgF344-AD Rat Model  awarded by National Institute on Aging/NIH/DHHS
  • Energetics, Disparities, & Lifespan: A Unified Hypothesis  awarded by National Institute on Aging/NIH/DHHS
  • Glucagon Mediated Potentiation of Insulin Sensitivity in Glucose Metabolism  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Hepatocyte Clock and Alcoholic Fatty Liver Injury  awarded by National Institute on Alcohol Abuse and Alcoholism/NIH/DHHS
  • In Vivo Experience with NRT to Increase Adherence and Smoking Abstinence  awarded by National Institute on Drug Abuse/NIH/DHHS
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure - AD Supplement: Salt-Dependent Hypertension and the Central Clock  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Short Chain Dehydrogenases in Retinol/Sterol Metabolism  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Timing of Sodium Intake and Nocturnal Sodium Excretion and Blood Pressure in Obese African Americans  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Transcriptional Regulation of Metabolism in Neurons  awarded by SOUTHERN RESEARCH INSTITUTE
  • Using Early Time-Restricted Feeding and Timed Light Therapy to Improve Glycemic Control in Adults with Type 2 Diabetes  awarded by DOD - Department of Defense
  • Teaching Overview

  • One of the most rewarding aspects of my job as a faculty member is training the next generation of scientists in my laboratory and in the classroom. Since starting my independent laboratory in 2009, I have mentored postdocs, graduate students, undergraduate students, and summer high school students. In addition, I have also been rewarded with the opportunity to mentor ~40 other graduate students by serving as the Neuroscience Theme Director of the Graduate Biomedical Sciences (GBS) program from 2016-2021. I have served on their thesis committees for many of these students. Throughout my career and training, I have realized the importance of obtaining extramural funding. As a predoctoral and postdoctoral fellow, I was granted individual F31 and F32 awards as well as a position on a postdoctoral T32 training grant. Finally, I completed my training with one of the first cycles of NIH K99/R00 awards. Together, these experiences have taught me the necessary building blocks for a successful training program. My graduate trainees have successfully received F31 applications. In the classroom, I have served as the course director for the Neuroscience Graduate Student Summer Seminar Series and currently direct the Introduction to Biostatistics and the Circadian Clocks Journal Club. In addition, I was invited to lead two workshops on for Trainee Day at the 2012 Society for Research in Biological Rhythms (SRBR) meeting. After this rewarding experience, I served as the Professional Development Day director for the 2014 and 2016 SRBR meetings. In 2014, I served as one of the invited instructors for the International Chronobiology Summer School, where I directed workshops on “Clock control of excitability” and “Statistical Analysis of Rhythmic Data.”
  • Teaching Activities

  • GBS737 - Neuro Student Summer Seminars (Summer Term 2021) 2021
  • GBS747J - JC- Circadian Rhythms & Sleep (Spring Term 2021) 2021
  • GBS737 - Neuro Student Summer Seminars (Summer Term 2020) 2020
  • GBS747J - JC- Circadian Clocks (Spring Term 2020) 2020
  • GRD770 - Intro to Biostats (Fall Term 2019) 2019
  • GBS737 - Neuro Student Summer Seminars (Summer Term 2019) 2019
  • GBS747J - JC- Circadian Clocks (Spring Term 2019) 2019
  • GRD703 - Special Topics (Fall Term 2018) 2018
  • GBS737 - Neuro Student Summer Seminars (Summer Term 2018) 2018
  • GBS747J - Circadian Clocks JC (Spring Term 2018) 2018
  • GBSC722 - Special Topics (Spring Term 2018) 2018
  • GBSC722 - Special Topics (Spring Term 2018) 2018
  • GBSC722 - Special Topics (Fall Term 2017) 2017
  • GBSC722 - Special Topics (Fall Term 2017) 2017
  • GBS737 - Neuro Student Summer Seminars (Summer Term 2017) 2017
  • GBSC722 - Special Topics (Summer Term 2017) 2017
  • GBS747J - Circadian Clocks JC (Spring Term 2017) 2017
  • GBSC722 - Special Topics (Spring Term 2017) 2017
  • GBSC722 - Special Topics (Spring Term 2017) 2017
  • GBS747J - Circadian Clocks JC (Spring Term 2016) 2016
  • GBS737 - Neuro Student Summer Seminars (Summer Term 2015) 2015
  • GBS747J - Circadian Clocks JC (Spring Term 2015) 2015
  • GBS737 - Student Summer Seminars (Summer Term 2014) 2014
  • GBS747J - Circadian Clocks JC (Spring Term 2014) 2014
  • GBS737 - Student Summer Seminars (Summer Term 2013) 2013
  • GBS747 - Special Topics (Spring Term 2013) 2013
  • GBS737 - Student Summer Seminars (Summer Term 2012) 2012
  • GBS737 - Student Summer Seminars (Summer Term 2011) 2011
  • Education And Training

  • Vanderbilt University Biological Sciences, Postdoctoral Fellowship
  • Doctor of Philosophy in Neuroscience, Georgia State University 2004
  • Master of Social or Behavioral Sciences in Psychology, Georgia State University 2001
  • Bachelor of Arts in Psychology, King College 1996
  • Full Name

  • Karen Gamble