Selected Publications

Academic Article

Year Title Altmetric
2014 Heat-shock response increases lung injury caused by pseudomonas aeruginosa via an Interleukin-10-dependent mechanism in miceAnesthesiology.  120:1450-1462. 2014
2013 IL-8 inhibits cAMP-stimulated alveolar epithelial fluid transport via a GRK2/PI3K-dependent mechanismThe FASEB Journal.  27:1095-1106. 2013
2013 Activation of the heat shock response attenuates the interleukin 1β-mediated inhibition of the amiloride-sensitive alveolar epithelial ion transportShock.  39:189-196. 2013
2012 Stroke-induced activation of the α7 nicotinic receptor increases Pseudomonas aeruginosa lung injuryThe FASEB Journal.  26:2919-2929. 2012
2011 Cytoprotective-selective activated protein C attenuates pseudomonas aeruginosa - Induced lung injury in miceAmerican Journal of Respiratory Cell and Molecular Biology.  45:632-641. 2011
2011 PAI-1 is an essential component of the pulmonary host response during Pseudomonas aeruginosa pneumonia in miceThorax.  66:788-796. 2011
2009 Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen speciesThe FASEB Journal.  23:3829-3842. 2009
2009 Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathwayFree Radical Biology and Medicine.  46:866-875. 2009
2009 Reactive species and pulmonary edemaExpert Review of Respiratory Medicine.  3:487-496. 2009
2007 Glutathione suppresses TGF-β-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoter 2007
2006 Fatty acid transduction of nitric oxide signaling: Nitrolinoleic acid potently activates endothelial heme oxygenase 1 expression 2006
2006 4-Hydroxynonenal induces rat γ-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signalingAmerican Journal of Respiratory Cell and Molecular Biology.  34:174-181. 2006
2006 The Adp-stimulated NADPH oxidase activates the ASK-1/MMK4/JNK pathway in alveolar macrophagesFree Radical Research.  40:865-874. 2006
2005 Fatty acid transduction of nitric oxide signaling: Multiple nitrated unsaturated fatty acid derivatives exist in human blood and urine and serve as endogenous peroxisome proliferator-activated receptor ligandsJournal of Biological Chemistry.  280:42464-42475. 2005
2005 HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cellsFree Radical Biology and Medicine.  39:355-364. 2005
2005 Mechanisms of glutamate cysteine ligase (GCL) induction by 4-hydroxynonenalFree Radical Biology and Medicine.  38:547-556. 2005
2004 Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stressArchives of Biochemistry and Biophysics.  423:116-125. 2004
2004 Analysis of Transcription Factor Remodeling in Phase II Gene Expression with CurcuminMethods in Enzymology.  378:302-318. 2004
2003 Cytoprotection against oxidative stress and the regulation of glutathione synthesis 2003
2003 Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression.The FASEB Journal.  17:473-475. 2003
2003 HNE - Signaling pathways leading to its eliminationMolecular Aspects of Medicine.  24:189-194. 2003
2002 4-Hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cellsFree Radical Biology and Medicine.  33:974-987. 2002
2002 A549 subclones demonstrate heterogeneity in toxicological sensitivity and antioxidant profile. 2002
2002 AP-1 activation through endogenous H2O2 generation by alveolar macrophagesFree Radical Biology and Medicine.  32:1304-1313. 2002
2002 A549 subclones demonstrate heterogeneity in toxicological sensitivity and antioxidant profile 2002
2002 Activation of the mitochondrial caspase cascade in the absence of protein synthesis does not require c-Jun N-terminal kinaseArchives of Biochemistry and Biophysics.  405:231-240. 2002
2002 Macrophage signaling and respiratory burstImmunologic Research.  26:95-105. 2002
1998 The role of cuznsod in the susceptibility to alloxan-induced diabetesThe FASEB Journal.  12. 1998
1996 The effect of dietary copper manipulation and pancreatic CuZn on the susceptibility to IDDMThe FASEB Journal.  10. 1996
1995 Chronic ethanol feeding increases the quantity of Gαs-protein in rat liver plasma membranesHepatology.  21:1154-1160. 1995


Year Title Altmetric
2016 Carcinogens, Environmental.  422-437. 2016
2016 Environmental Health: Overview.  487-498. 2016
2011 Glutathione.  3-20. 2011

Education And Training

  • Doctor of Philosophy Level Degree in Nutrition Sciences, 1998
  • Master's Level Degree in Biology / Biological Sciences, 1994
  • Bachelor's Level Degree in Biology / Biological Sciences, 1992
  • Full Name

  • Karen Iles