Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 Frontal Cortical Monoamine Release, Attention, and Working Memory in a Perinatal Nicotine Exposure Mouse Model following Kappa Opioid Receptor Antagonism.  Cerebral Cortex.  31:483-496. 2021
2019 Diverse mechanisms lead to common dysfunction of striatal cholinergic interneurons in distinct genetic mouse models of Dystonia 2019
2019 Schizophrenia-like dopamine release abnormalities in a mouse model of NMDA receptor hypofunction.  Schizophrenia Bulletin.  45:138-147. 2019
2017 Strength of cholinergic tone dictates the polarity of dopamine D2 receptor modulation of striatal cholinergic interneuron excitability in DYT1 dystonia.  Experimental Neurology.  295:162-175. 2017
2017 Evaluation of AZD1446 as a therapeutic in DYT1 dystonia.  Frontiers in Systems Neuroscience.  11. 2017
2016 Dynamic DNA methylation regulates levodopa-induced Dyskinesia 2016
2015 Striatal cholinergic dysfunction as a unifying theme in the pathophysiology of dystonia.  Progress in Neurobiology.  127-128:91-107. 2015
2013 Effects of 5-HT1A receptor stimulation on striatal and cortical M1 pERK induction by l-DOPA and a D1 receptor agonist in a rat model of Parkinson's disease.  Brain Research.  1537:327-339. 2013
2013 Rotigotine polyoxazoline conjugate SER-214 provides robust and sustained antiparkinsonian benefit.  Movement Disorders.  28:1675-1682. 2013
2013 Removing the blinkers: Moving beyond striatal dopamine in Parkinson's disease.  Journal of Neurochemistry.  125:639-641. 2013
2013 Effects of 5-HT1A receptor stimulation on D1 receptor agonist-induced striatonigral activity and dyskinesia in hemiparkinsonian rats.  ACS Chemical Neuroscience.  4:747-760. 2013
2012 Serotonin transporter inhibition attenuates l-DOPA-induced dyskinesia without compromising l-DOPA efficacy in hemi-parkinsonian rats.  European Journal of Neuroscience.  36:2839-2848. 2012
2012 L-DOPA-induced dysregulation of extrastriatal dopamine and serotonin and affective symptoms in a bilateral rat model of Parkinson's disease.  Neuroscience.  218:243-256. 2012
2011 Role of the primary motor cortex in l-DOPA-induced dyskinesia and its modulation by 5-HT1A receptor stimulation.  Neuropharmacology.  61:753-760. 2011
2011 Behavioral and cellular modulation of L-DOPA-induced dyskinesia by β-adrenoceptor blockade in the 6-hydroxydopamine-lesioned rat.  Journal of Pharmacology and Experimental Therapeutics.  337:755-765. 2011
2011 Local modulation of striatal glutamate efflux by serotonin 1A receptor stimulation in dyskinetic, hemiparkinsonian rats.  Experimental Neurology.  229:288-299. 2011
2011 Tryptophan hydroxylase 2 aggregates through disulfide cross-linking upon oxidation: Possible link to serotonin deficits and non-motor symptoms in Parkinson's disease.  Journal of Neurochemistry.  116:426-437. 2011
2011 Potential mechanisms underlying anxiety and depression in Parkinson's disease: Consequences of l-DOPA treatment.  Neuroscience and Biobehavioral Reviews.  35:556-564. 2011
2010 Behavioral and neurochemical effects of chronic L-DOPA treatment on nonmotor sequelae in the hemiparkinsonian rat.  Behavioural Pharmacology.  21:627-637. 2010
2009 Serotonin 1B receptor stimulation reduces D1 receptor agonist-induced dyskinesia.  NeuroReport.  20:1265-1269. 2009
2009 The role of the dorsal raphe nucleus in the development, expression, and treatment of L-dopa-induced dyskinesia in hemiparkinsonian rats 2009
2009 Contribution of the striatum to the effects of 5-HT1A receptor stimulation in L-DOPA-treated hemiparkinsonian rats.  Journal of Neuroscience Research.  87:1645-1658. 2009
2008 Striatal 5-HT1A receptor stimulation reduces D1 receptor-induced dyskinesia and improves movement in the hemiparkinsonian rat.  Neuropharmacology.  55:1321-1328. 2008
2008 Exogenous corticosterone reduces l-DOPA-induced dyskinesia in the hemi-parkinsonian rat: Role for interleukin-1β.  Neuroscience.  156:30-41. 2008
2008 Effects of coincident 5-HT1A receptor stimulation and NMDA receptor antagonism on L-DOPA-induced dyskinesia and rotational behaviors in the hemi-parkinsonian rat.  Psychopharmacology.  199:99-108. 2008
2007 The partial 5-HT1A agonist buspirone reduces the expression and development of l-DOPA-induced dyskinesia in rats and improves l-DOPA efficacy 2007
2007 The differential effects of 5-HT1A receptor stimulation on dopamine receptor-mediated abnormal involuntary movements and rotations in the primed hemiparkinsonian rat.  Brain Research.  1158:135-143. 2007
2006 MDMA and fenfluramine reduce L-DOPA-induced dyskinesia via indirect 5-HT1A receptor stimulation.  European Journal of Neuroscience.  23:2669-2676. 2006

Education And Training

  • Doctor of Philosophy in Neuroscience, State University of New York System : Binghamton 2012
  • Master of Social or Behavioral Sciences in Psychology, State University of New York System : Binghamton 2008

    • Full Name

  • Karen Jaunarajs