Positions

Overview

  • CEO of Southern Research Institute (retired)

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Synthesis of 9-(6-Deoxy-α-L-Talofuranosyl)-6-Methylpurine and 9-(6-Deoxy-β-D-Allofuranosyl)-6-Methylpurine Nucleosides.  Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.].  81. 2020
    2016 6-Methylpurine derived sugar modified nucleosides: Synthesis and evaluation of their substrate activity with purine nucleoside phosphorylases.  Bioorganic Chemistry.  65:9-16. 2016
    2016 The synthesis and biological evaluation of alkyl and benzyl naphthyridinium analogs of eupolauridine as potential antimicrobial and cytotoxic agents.  Bioorganic and Medicinal Chemistry.  24. 2016
    2015 Thiarabine, 1-(4-Thio-β-D-arabinofuranosyl)cytosine. A deoxycytidine analog with excellent anticancer activity.  Current Medicinal Chemistry.  22:3881-3896. 2015
    2012 Synthesis and SAR of geminal substitutions at the C5′ carbosugar position of pyrimidine-derived HCV inhibitors.  Bioorganic and Medicinal Chemistry Letters.  22:6967-6973. 2012
    2012 Preclinical antitumor activity of thiarabine in human leukemia and lymphoma xenograft models 2012
    2012 Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors.  Bioorganic and Medicinal Chemistry Letters.  22:5652. 2012
    2012 Preclinical combination therapy of thiarabine plus various clinical anticancer agents 2012
    2012 Pyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.  Bioorganic and Medicinal Chemistry Letters.  22:5144-5149. 2012
    2012 5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.  Bioorganic and Medicinal Chemistry Letters.  22:3229-3234. 2012
    2012 Novel substituted pyrimidines as HCV replication (replicase) inhibitors.  Bioorganic and Medicinal Chemistry Letters.  22:1160-1164. 2012
    2012 High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv 2012
    2012 Isolation and characterization of a murine P388 leukemia line resistant to thiarabine 2012
    2012 Synthesis and evaluation of the substrate activity of C-6 substituted purine ribosides with E. coli purine nucleoside phosphorylase: Palladium mediated cross-coupling of organozinc halides with 6-chloropurine nucleosides [1].  European Journal of Medicinal Chemistry.  47:167-174. 2012
    2011 Isolation and characterization of a murine P388 leukemia line resistant to clofarabine 2011
    2011 Binding and inhibition of human spermidine synthase by decarboxylated S-adenosylhomocysteine.  Protein Science.  20:1836. 2011
    2011 Lack of in vivo cross-resistance with 4′-thio-ara-C against drug-resistant murine P388 and L1210 leukemias.  Cancer Chemotherapy and Pharmacology.  68:399-403. 2011
    2011 The Alabama drug discovery alliance: A collaborative partnership to facilitate academic drug discovery 2011
    2010 Alteration of the carbohydrate for deoxyguanosine analogs markedly changes DNA replication fidelity, cell cycle progression and cytotoxicity.  Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.  1-10. 2010
    2009 Inhibition of herpesvirus replication by 5-substituted 4′- thiopyrimidine nucleosides.  Antimicrobial Agents and Chemotherapy.  53:5251-5258. 2009
    2009 Antituberculosis activity of the molecular libraries screening center network library 2009
    2009 Regioselective metalation of 6-methylpurines: Synthesis of fluoromethyl purines and related nucleosides for suicide gene therapy of cancer 2009
    2009 Synthesis and anticancer evaluation of 4'-C-methyl-2'-fluoro arabino nucleosides 2009
    2009 New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C 8 substitution in structural analogues of S-adenosylmethionine.  Journal of Medicinal Chemistry.  52:1388-1407. 2009
    2009 Activities of certain 5-substituted 4′-thiopyrimidine nucleosides against orthopoxvirus infections.  Antimicrobial Agents and Chemotherapy.  53:572. 2009
    2009 Synthesis of certain 2′-Deoxy-3′,5′-di-O-benzyl-4′- thio-nucleosides using natural phosphate doped with trifluoromethanesulfonic acid as catalyst 2009
    2007 Programs to facilitate tuberculosis drug discovery: The tuberculosis antimicrobial acquisition and coordinating facility 2007
    2007 In silico chemical library screening and experimental validation of a novel 9-aminoacridine based lead-inhibitor of human S-adenosylmethionine decarboxylase.  Journal of Chemical Information and Modeling.  47:1897. 2007
    2006 Discovery and development of clofarabine: A nucleoside analogue for treating cancer.  Nature Reviews Drug Discovery.  5:855-863. 2006
    2006 Antiangiogenic activity of 4′-thio-β-D-arabinofuranosylcytosine 2006
    2006 Recent development of therapeutics for chronic HCV infection.  Antiviral Research.  71:351-362. 2006
    2006 Synthesis and biological evaluation of some 4′-C-(hydroxymethyl)- α- and -β-D-arabinofuranosyl pyrimidine and adenine nucleosides 2006
    2006 The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation 2006
    2005 Synthesis and biological activity of 4′-thio-L-xylofuranosyl purine nucleosides 2005
    2005 Antibiotic-mediated chemoprotection enhances adaptation of E. coli PNP for herpes simplex virus-based glioma therapy.  Human gene therapy. Clinical development.  16:339. 2005
    2005 Nucleosides as anticancer agents: from concept to the clinic..  Nucleic Acids Symposium Series.  15-16. 2005
    2004 Purine nucleoside antimetabolites in development for the treatnment of cancer 2004
    2003 Synthesis and Anti-cancer Activity of Some Novel 5-Azacytosine Nucleosides 2003
    2003 The novel nucleoside transport system exhibited by NB4 cells, csg, transports deoxyguanosine analogues, including ara-G.  Biochemical Pharmacology.  66:733-737. 2003
    2003 Preclinical antitumor activity of 4′-thio-β-D-arabinofuranosylcytosine (4′-thio-ara-C).  Cancer Chemotherapy and Pharmacology.  51:422-426. 2003
    2003 Antitumor activity of 2-fluoro-2′-deoxyadenosine against tumors that express Escherichia coli purine nucleoside phosphorylase 2003
    2003 Designer Gene Therapy Using an Escherichia coli Purine Nucleoside Phosphorylase/Prodrug System.  Cell chemical biology.  10:1173-1181. 2003
    2002 Enhancement of nucleoside cytotoxicity through nucleotide prodrugs.  Journal of Medicinal Chemistry.  45:4505-4512. 2002
    2001 The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.  Biochemistry.  40:9484-9494. 2001
    2001 Synthesis and antiproliferative activity of some 4′-C-hydroxymethyl α- and -β-D-arabino-pentofuranosyl pyrimidine nucleosides 2001
    2001 Synthesis and biological activity of 4′-C-hydroxymethyl-2′ fluoro-D-arabinofuranosylpurine nucleosides 2001
    2001 Synthesis and biological activity of 4′-thio-L-xylofuranosyl nucleosides 2001
    2000 Metabolism of 4'-thio-β-d-arabinofuranosylcytosine in CEM cells.  Biochemical Pharmacology.  60:1925-1932. 2000
    2000 A convenient synthesis of 2'-deoxy-2-fluoroadenosine; a potential prodrug for suicide gene therapy 2000
    2000 Convenient syntheses of 6-methylpurine and related nucleosides 2000
    2000 Preclinical antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-β-D- arabinofuranosyl)adenine (Cl-F-ara-A) 2000
    2000 Synthesis and structure activity relationships of 5-substituted-4′-thio-β-D-arabinofuranosylcytosines 2000
    1999 Synthesis and biological activity of 2'-fluoro- darabinofuranosylpyrazolo[3,4-d]pyrimidine nucleosides 1999
    1999 Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists.  Journal of Medicinal Chemistry.  42:1625-1638. 1999
    1999 Certain 3,9-dideazapurines as inhibitors of purine nucleoside phosphorylase 1999
    1999 Comparison of the mechanism of cytotoxicity of 2-chloro-9,(2-deoxy-2- fluoro-β-D-arabinofuranosyl)adenine, 2-chloro-9-(2-deoxy-2-fluoro-β-D- ribofuranosyl)adenine, and 2-chloro-9-(2-deoxy-2,2-difluoro-β-D- ribofuranosyl)adenine in CEM cells.  Molecular Pharmacology.  55:515-520. 1999
    1999 Gene therapy of cancer: Activation of nucleoside prodrugs with E. coli purine nucleoside phosphorylase 1999
    1999 Kinetics for the acid-catalyzed hydrolysis of purine and cytosine 2'- deoxy-4'-thionucleosides 1999
    1999 Synthesis and biological activity of 4'-thio-2'-deoxy purine nucleosides 1999
    1999 Synthesis and biological activity of 5-azacytosine nucleosides derived from 4-thio-2-deoxy-L-threopentofuranose and 4-thio-2-deoxy-D-erythro- pentofuranose 1999
    1998 Synthesis and biological activity of certain 4'-thio-D- arabinofuranosylpurine nucleosides.  Journal of Medicinal Chemistry.  41:3865-3871. 1998
    1998 Polyamine pools in HIV-infected cells 1998
    1998 Synthesis and antiviral evaluation of analogs of adenosine-N1-oxide and 1-(benzyloxy)adenosine 1998
    1997 In vivo gene therapy of cancer with E. coli purine nucleoside phosphorylase.  Human gene therapy. Clinical development.  1637-1644. 1997
    1995 Metabolism and metabolic actions of 4′-thiothymidine in L1210 cells.  Biochemical Pharmacology.  50:687-695. 1995
    1995 The synthesis and biological activity of certain 4’-thionucleosides 1995
    1995 Search for New Purine- and Ribose-Modified Adenosine Analogues as Selective Agonists and Antagonists at Adenosine Receptors.  Journal of Medicinal Chemistry.  38:1174-1188. 1995
    1995 Nucleosides & Nucleotides 1995
    1994 α-(1 → 2)-, α-(1 → 3)-, and α-(1 → 6)-Linked thioglycosidic disaccharides: syntheses and anti-HIV testing of thiokojibiose octaacetate, thionigerose, and thioisomaltose.  Carbohydrate Research.  262:245-255. 1994
    1994 Synthesis and biological activity of 4,-thionucleosides of 2-chloroadenine 1994
    1994 PNP inhibitors 1994
    1994 synthesis and biologic evaluation of 8-substituted derivatives of nebularine (9/3-d-ribofuranosylpurine) 1994
    1994 Additions and Corrections: Structure-Based Design of Inhibitors of Purine Nucleoside Phosphorylase. 3. 9-Arylmethyl Derivatives of 9-Deazaguanine Substituted on the Methylene Group ((J. Med. Chem. (1993) 36(24) (3771–3783) (10.1021/jm00076a004)).  Journal of Medicinal Chemistry.  37:1034. 1994
    1994 Structure-Based Design of Inhibitors of Purine Nucleoside Phosphorylase. 4. A Study of Phosphate Mimics.  Journal of Medicinal Chemistry.  37:1109-1114. 1994
    1994 Phosphonate Analogs of Carbocyclic Nucleotides.  Journal of Medicinal Chemistry.  37:739-744. 1994
    1994 Synthesis and biologic activity of purine 2'-deoxy-2’-fluoro-ni&>nucleosides 1994
    1994 Characterization of S-adenosylmethionine decarboxylase induced by human cytomegalovirus infection 1994
    1994 In vitro and in vivo antiviral (RNA) evaluation of orotidine 5'- monophosphate decarboxylase inhibitors and analogues including 6-azauridine- 5'-(ethyl methoxyalaninyl)phosphate (a 5'-monophosphate prodrug).  Antiviral Chemistry and Chemotherapy.  5:209-220. 1994
    1994 Seaborgium: Name not yet approved by ACS [7].  Science.  265:303. 1994
    1993 Phosphorylation of the enantiomers of the carbocyclic analog of 2'- deoxyguanosine in cells infected with herpes simplex virus type 1 and in uninfected cells. Lack of enantiomeric selectivity with the viral thymidine kinase.  Molecular Pharmacology.  44:1258-1266. 1993
    1993 Nucleosides & Nucleotides 1993
    1993 THE SYNTHESIS AND BIOLOGICAL ACTIVITY OF 1-(2-DEOXY-4-THIO-α-L-7HREO-PENTOFURANOSYL)THYMINE 1993
    1993 Nucleosides & Nucleotides 1993
    1993 Nucleosides & nucleotides 1993
    1993 Conformational studies of thymidine dimers containing sulfonate and sulfonamide linkages by NMR spectroscopy 1993
    1993 Nucleosides & nucleotides 1993
    1993 Application of X‐Ray Crystallographic Methods in the Design of Purine Nucleoside Phosphorylase Inhibitors.  Annals of the New York Academy of Sciences.  685:237-247. 1993
    1993 Nucleosides & Nucleotides 1993
    1993 Structure-Based Design of Inhibitors of Purine Nucleoside Phosphorylase. 1. 9-(Arylmethyl) Derivatives of 9-Deazaguanine.  Journal of Medicinal Chemistry.  36:55-69. 1993
    1993 Structure-Based Design of Inhibitors of Purine Nucleoside Phosphorylase. 2. 9-Alicyclic and 9-Heteroalicyclic Derivatives of 9-Deazaguanine.  Journal of Medicinal Chemistry.  36:1847-1854. 1993
    1993 Structure-Based Design of Inhibitors of Purine Nucleoside Phosphorylase. 3. 9-Arylmethyl Derivatives of 9-Deazaguanine Substituted on the Methylene Group.  Journal of Medicinal Chemistry.  36:3771-3783. 1993
    1993 Syntheses of 5′-Substituted Analogues of Carbocyclic 3-Deazaadenosine as Potential Antivirals.  Journal of Medicinal Chemistry.  36:2102. 1993
    1993 Synthesis and antiviral evaluation of some novel [1,2,4]triazolo[4,3‐β][1,2,4]triazole nucleoside analogs 1993
    1992 Nucleosides & Nucleotides 1992
    1992 Nucleosides & nucleotides 1992
    1992 Interference with HIV-1 reverse transcriptase-catalyzed DNA chain elongation by the 5′-triphosphate of the carbocyclic analog of 2′-deoxyguanosine.  Antiviral Research.  19:325-332. 1992
    1992 Acyclic analogues of pyrazofurin: syntheses and antiviral evaluation.  Carbohydrate Research.  216:441-452. 1992
    1992 5,5-Disubstituted Hydantoins: Syntheses and Anti-HIV Activity.  Journal of Medicinal Chemistry.  35:3567-3572. 1992
    1992 Irreversible inhibition of S-adenosylmethionine decarboxylase of trypanosoma bru cei bru cei by S-adenosylmethionine analogues.  Biochemical Pharmacology.  44:905-911. 1992
    1992 Nucleosides & nucleotides 1992
    1992 Nucleosides & Nucleotides 1992
    1992 Synthesis and Antiviral Evaluation of N-Carboxamidine-Substituted Analogs of 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamidine Hydrochloride.  Journal of Medicinal Chemistry.  35:3231-3238. 1992
    1992 Nucleosides & Nucleotides 1992
    1992 Nucleosides & Nucleotides 1992
    1992 Synthesis of Thymidine Dimers Containing Internucleoside Sulfonate and Sulfonamide Linkages.  Journal of Organic Chemistry.  57:2983. 1992
    1992 Nucleosides and nucleotides 1992
    1992 Purification of Human S-Adenosylmethionine Decarboxylase Expressed in Escherichia coli and Use of This Protein To Investigate the Mechanism of Inhibition by the Irreversible Inhibitors, 5ʹ-Deoxy-5ʹ-[(3-hydrazinopropyl)methylamino] adenosine and 5ʹ-{[(Z)-4-Amino-2-butenyl]methylamino}-5ʹ-deoxyadenosine.  Biochemistry.  31:6848-6855. 1992
    1992 Syntheses of phosphonate analogues of dideoxyadenosine (dda)-, dideoxycytidine (ddc)-, dideoxyinosine (ddi)-, and deoxythymidine (ddt)-51-Moriophosphates 1992
    1992 Synthesis and Anti-HIV Activity of 4′-Thio-2′,3′-dideoxynucleosides.  Journal of Medicinal Chemistry.  35:533-538. 1992
    1992 Erratum: Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors (Proc. Natl. Acad. Sci. USA (December 15, 1991) 88:24 (11540-11544)) 1992
    1992 Nucleosides & Nucleotides 1992
    1992 Synthesis and Biological Activity of 2′-Fluoro-2-halo Derivatives of 9-β-d-Arabinofuranosyladenine.  Journal of Medicinal Chemistry.  35:397-401. 1992
    1991 Nucleosides & nucleotides 1991
    1991 Nucleosides & Nucleotides 1991
    1991 Nucleosides & nucleotides 1991
    1991 Synthesis and Biological Activity of 2′-Deoxy-4′-thio Pyrimidine Nucleosides.  Journal of Medicinal Chemistry.  34:2361. 1991
    1991 Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase and human DNA polymerases α, β, and γ by the 5'-triphosphates of carbovir, 3'-azido-3'-deoxythymidine, 2',3'-dideoxyguanosine, and 3'-deoxythymidine. A novel RNA template for the evaluation of antiretroviral drugs.  Journal of Biological Chemistry.  266:1754-1762. 1991
    1991 Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors 1991
    1991 Progress toward the synthesis of nonionic oligonucleotide analogues with sulfonate and sulfonamide internucleotide linkages..  Nucleic Acids Symposium Series.  5. 1991
    1990 Metabolism of the Carbocyclic Nucleoside Analogue Carbovir, an Inhibitor of Human Immunodeficiency Virus, in Human Lymphoid Cells.  Biochemistry.  29:9839-9843. 1990
    1990 Nucleosides & nucleotides 1990
    1990 5-C-chain-extended adenosine derivatives related to sinefungin. synthesis and biological activity. 1990
    1990 Nucleosides & Nucleotides 1990
    1990 Nucleosides & Nucleotides 1990
    1990 Nucleosides & nucleotides 1990
    1989 8-Substituted Purine Ribosides: Synthesis And Biological Activity 1989
    1989 Effect of 1-amino-oxy-3-aminopropane on polyamine metabolism and growth of L1210 cells.  Biochemical Journal.  263:215-221. 1989
    1989 Nucleosides & Nucleotides 1989
    1989 Nucleosides & Nucleotides 1989
    1989 Nucleosides & nucleotides 1989
    1989 Nudeosides & Nucleotides 1989
    1989 Nudeosides & Nucleotides 1989
    1989 Phosphate modified analogues of 5'O-phosphorylated 2', 3'-dldeoxynucleosides: Synthesis and Anti-HIV activity 1989
    1989 Progress in the synthesis of a potential PNP transition state inhibitor 1989
    1989 Syn'Thesis And Antiviral Evaluation Of Adenosine-N1-Oxide And I-(Benzyloxy) Adenosines 1989
    1989 Synthesis of 5'-substituted analogues of carbocyclic 3-deazaadenosine as potential antivirals 1989
    1988 Nucleosides & Nucleotides 1988
    1988 Nucleosides & Nucleotides 1988
    1988 Nucleosides & Nucleotides 1988
    1988 Effect of Inhibitors of S-Adenosylmethionine Decarboxylase on Polyamine Content and Growth of L1210 Cells.  Biochemistry.  27:1408-1415. 1988
    1988 Synthesis and Biological Evaluations of Certain 2-Halo-2'-Substituted Derivatives of 9-β-D-Arabinofuranosyladenine.  Journal of Medicinal Chemistry.  31:405-410. 1988
    1988 Nucleosides & Nucleotides 1988
    1988 Effect of inhibitors of S-adenosylmethionine decarboxylase on the contents of ornithine decarboxylase and S-adenosylmethionine decarboxylase in L1210 cells.  Biochemical Journal.  254:45-50. 1988
    1988 Properties of L1210 Cells Resistant to α-Difluoro Methyl Or Nithine.  Cancer Research.  48:2678-2682. 1988
    1987 Nucleosides & Nucleotides 1987
    1987 Nucleosides & Nucleotides 1987
    1987 5′-Deoxy-5′-methylthioadenosine phosphorylase-IV. Biological activity of 2-fluoroadenine-substituted 5′-deoxy-5′ -methylthioadenosine analogs.  Biochemical Pharmacology.  36:1881-1893. 1987
    1987 Nucleosides & Nucleotides 1987
    1987 Resolution of Racemic Carbocyclic Analogues of Purine Nucleosides through the Action of Adenosine Deaminase. Antiviral Activity of the Carbocyclic 2′-Deoxyguanosine Enantiomers.  Journal of Medicinal Chemistry.  30:746-749. 1987
    1987 New substrate analogues as inhibitors of s-adenosylmethionine decarboxylase 1987
    1987 Nucleosides & Nucleotides 1987
    1986 Nucleosides & Nucleotides 1986
    1986 Differences in the metabolism and metabolic effects of carbocyclic adenosine analogs, neplanocin A and aristeromycin.  Molecular Pharmacology.  29:383-390. 1986
    1986 Nucleosides & Nucleotides 1986
    1986 Nucleosides & Nucleotides 1986
    1986 Nucleosides & Nucleotides 1986
    1986 9-(2-Deoxy-2-fluoro-3-D-arabinofuranosy1)guanine: A Metabolically Stable Cytotoxic Analogue of 2’-Deoxyguanosine.  Journal of Medicinal Chemistry.  29:2389-2392. 1986
    1986 Effects of Certain 5'-Substituted Adenosines on Polyarnine Synthesis: Selective Inhibitors of Spermine Synthase.  Biochemistry.  4091-4097. 1986
    1986 Synthesis and Biochemical Properties of 8-Amino-6-fluoro-9-β-D-ribofuranosyl-9H-purine.  Journal of Medicinal Chemistry.  29:2069-2074. 1986
    1985 Nudeosides & Nucleotides 1985
    1985 Acyclic Nucleosides Other Than Acyclovir as Potential Antiviral Agents 1985
    1985 Nudeosides & Nucleotides 1985
    1985 Metabolism and metabolic effects of halopurine nucleosides in tumor cells in culture 1985
    1985 Nucleosides & Nudeotides 1985
    1985 2-Fluoroformycin and 2-Aminoformycin. Synthesis and Biological Activity.  Journal of Medicinal Chemistry.  28:1740-1742. 1985
    1985 Inosine Analogs as Anti-Leishmanial Agents 1985
    1984 (±)-3-(4-Amino-lif-pyrrolo[2,3-d]pyrimidin-l-yl)-5-(hydroxymethyl)-(lα,2α,3β,5β)-1,2-cyclopentanediol, the Carbocyclic Analogue of Tubercidin.  Journal of Medicinal Chemistry.  27:534-536. 1984
    1984 Improved Synthesis And Antitumor Activity Of 2-Bromo-2'-Deoxyadenosine.  Journal of Medicinal Chemistry.  27:800-802. 1984
    1984 Nucleosides & Nucleotides 1984
    1984 Nucleosides & Nucleotides 1984
    1984 Nucleosides & Nucleotides 1984
    1984 Nucleosides & Nucleotides 1984
    1984 Nucleosides & Nucleotides 1984
    1983 Formation of 3-(2′-deoxyribofuranosyl) and 9-(2′-deoxyribofuranosyl) nucleosides of 8-substituted purines by nucleoside deoxyribosyltransferase.  Molecular cell biology research communications : MCBRC.  222:133-144. 1983
    1983 Nucleosides & Nucleotides 1983
    1983 Nucleosides & Nucleotides 1983
    1983 Nucleosides & Nucleotides 1983
    1983 Nucleosides & Nucleotides 1983
    1983 Nucleosides & Nucleotides 1983
    1983 Synthesis and Biological Evaluation of 2-Fluoro-8-azaadenosine and Related Compounds.  Journal of Medicinal Chemistry.  26:1483-1489. 1983
    1983 Synthesis of C-β-D-Ribofuranosyl Derivatives with a Highly Functionalized Two-Carbon Unit. Conversion to Certain Blocked Thiazole C-Nucleosides.  Journal of Organic Chemistry.  48:3141-3145. 1983
    1983 Synthesis of Chain-Extended and C-6’ Functionalized Precursors of the Nucleoside Antibiotic Sinefungin.  Journal of Organic Chemistry.  48. 1983
    1982 Nucleosides & Nucleotides 1982
    1982 Nucleosides & Nucleotides 1982
    1980 Synthesis of Methyl Peracetyl α-Hikosaminide, the Undecose Portion of the Nucleoside Antibiotic Hikizimycin.  Journal of Organic Chemistry.  45:4526-4528. 1980
    1979 Comparative Tumor-initiating Activity of Methylated Benzo(a)pyrene Derivatives in Mouse Skin 1.  Cancer Research.  40:1073-1076. 1979
    1979 Convenient Synthesis of 9-Methylbenzotalpyrene.  Journal of Organic Chemistry.  44:2941-2943. 1979
    1979 A convenient procedure for the formation of enol acetates under basic conditions 1979
    1979 Construction of Long-Chain Carbohydrates. Synthesis and Chemistry of a Galactose 6-Phosphorane.  Journal of Organic Chemistry.  44:1434. 1979
    1979 Synthesis of Certain β-D-Ribofuranosyl Thiazole C-Nucleosides from a Versatile Precursor.  Journal of Organic Chemistry.  44:4351-4358. 1979
    1978 Carbon-Carbon Bond Formation at C4' of a Nucleoside. Synthesis and Utilization of a Uridine 4',5'-Enamine.  Journal of the American Chemical Society.  100:2554-2555. 1978
    1978 Homo-C-nucleosides. The Synthesis of Certain 6-Substituted 4-Pyrimidinones1.  Journal of Organic Chemistry.  43:2925-2927. 1978
    1978 Total Synthesis of Erythromycins. 3. Stereoselective Routes to Intermediates Corresponding to C(1) to C(9) and C(10) to C(13) Fragments of Erythronolide B.  Journal of the American Chemical Society.  100:4618-4620. 1978
    1977 Generation and Reactivity of an Unstabilized Carbohydrate Phosphorane.  Journal of Organic Chemistry.  42:4084-4088. 1977
    1977 A Convenient Total Synthesis of (±)-(7E, 9E)-Trisporic Acid B Methyl Ester.  Journal of Organic Chemistry.  42. 1977
    1975 A convenient procedure for formation of certain uracil and thymine anhydronucleosides.  Carbohydrate Research.  42:379-381. 1975
    1974 [57] The Synthesis of 1,N6-Ethenoadenosine 3′,5′Monophosphate; A Fluorescent Analog of Cyclic AMP.  Methods in Enzymology.  38:428-430. 1974
    1973 Interactions of fluorescent analogs of adenine nucleotides with pyruvate kinase.  FEBS Letters.  29:215-218. 1973
    1972 Erratum: Synthetic spectroscopic models related to coenzymes and base pairs. An "abbreviated" nicotinamide adenine dinucleotide (Journal of the American Chemical Society (1972) 94 (1702)).  Journal of the American Chemical Society.  94:4400. 1972
    1972 Fluorescent Modification of Adenosine-Containing Coenzymes. Biological Activities and Spectroscopic Properties.  Biochemistry.  11:3499-3506. 1972
    1972 A spray reagent for adenine-containing residues: Detection by fluorescence 1972
    1972 Fluorescent adenosine and cytidine derivatives 1972
    1972 A Fluorescent modification of adenosine triphosphate with activity in enzyme systems: 1,N6-ethenoadenosine triphosphate.  Science.  175:646-647. 1972
    1972 A fluorescent analog of nicotinamide adenine dinucleotide. 1972
    1972 Fluorescent modification of adenosine 3′,5′-monophosphate: Spectroscopic properties and activity in enzyme systems.  Science.  177:279-280. 1972
    1971 Attachment of a fluorescent label to 4-thiouracil and 4-thiouridine 1971
    6-Methylpurine derived sugar modified nucleosides: Synthesis and in vivo antitumor activity in D54 tumor expressing M64V-Escherichia coli purine nucleoside phosphorylase.  European Journal of Medicinal Chemistry.  108:616-622.
    Chemical and enzymatic synthesis of 4′-thio-β-D- arabinofuranosylcytosine monophosphate and triphosphate
    Clofarabine Acts as Radiosensitizer In Vitro and In Vivo by Interfering With DNA Damage Response
    Comparison of the effect of Carbovir, AZT, and dideoxynucleoside triphosphates on the activity of human immunodeficiency virus reverse transcriptase and selected human polymerases
    Design and evaluation of 5′-modified nucleoside analogs as prodrugs for an E. coli purine nucleoside phosphorylase mutant
    Nucleosides & Nucleotides
    Nucleosides & Nucleotides
    Synthesis and biological activity of 2′-deoxy-4′-thio- pyrazolo[3,4-d]pyrimidine nucleosides
    Synthesis of some 2′-fluoro-2′-deoxy-3′-C-ethynyl and 3′-C-vinyl-β-D-lyxofuranosyl nucleosides
    bis(tBuSATE) phosphotriester prodrugs of 8-azaguanosine and 6-methylpurine riboside; bis(POM) phosphotriester prodrugs of 2′-deoxy-4′- thioadenosine and its corresponding 9α anomer

    Chapter

    Year Title Altmetric
    2008 Clofarabine: From Design to Approval.  631-646. 2008
    1984 Other Imidazoles with Fused Six-membered Rings.  607-668. 1984

    Research Overview

  • Keywords - Drug Discovery

    • Education And Training

  • Doctor of Philosophy, University of Michigan System : Ann Arbor 1972
  • Bachelor of Science or Mathematics, University of Illinois System : Chicago 1968

    • Full Name

  • John Secrist