Oncogene

The microRNA-3622 family at the 8p21 locus exerts oncogenic effects by regulating the p53-downstream gene network in prostate cancer progression.  41:3186-3196. 2022

Epigenetic regulation of EIF4A1 through DNA methylation and an oncogenic role of eIF4A1 through BRD2 signaling in prostate cancer.  41:2778-2785. 2022

Targeting oncometabolism to maximize immunotherapy in malignant brain tumors.  41:2663-2671. 2022

H3K9me3 represses G6PD expression to suppress the pentose phosphate pathway and ROS production to promote human mesothelioma growth.  41:2651-2662. 2022

CRISPR interference and activation of the microRNA-3662-HBP1 axis control progression of triple-negative breast cancer.  41:268-279. 2022

Comprehensive molecular profiling of UV-induced metastatic melanoma in Nme1/Nme2-deficient mice reveals novel markers of survival in human patients.  40:6329-6342. 2021

Correction: Comprehensive molecular profiling of UV-induced metastatic melanoma in Nme1/Nme2-deficient mice reveals novel markers of survival in human patients (Oncogene, (2021), 40, 45, (6329-6342), 10.1038/s41388-021-01998-w).  40:6394. 2021

Ornithine decarboxylase (ODC1) gene variant (rs2302615) is associated with gastric cancer independently of Helicobacter pylori CagA serostatus.  40:5963-5969. 2021

Nuclear Aurora-A kinase-induced hypoxia signaling drives early dissemination and metastasis in breast cancer: implications for detection of metastatic tumors.  40:5651-5664. 2021

Targeting HIF-activated collagen prolyl 4-hydroxylase expression disrupts collagen deposition and blocks primary and metastatic uveal melanoma growth.  40:5182-5191. 2021

PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1.  40:2448-2462. 2021

Mass-spectrometry-based proteomic correlates of grade and stage reveal pathways and kinases associated with aggressive human cancers.  40:2081-2095. 2021

Transcriptional regulators and alterations that drive melanoma initiation and progression.  39:7093-7105. 2020

A cell-penetrating MARCKS mimetic selectively triggers cytolytic death in glioblastoma.  39:6961-6974. 2020

WSTF acetylation by MOF promotes WSTF activities and oncogenic functions.  39:5056-5067. 2020

Therapeutically actionable PAK4 is amplified, overexpressed, and involved in bladder cancer progression.  39:4077-4091. 2020

Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells.  39:1619-1633. 2020

Correction: EZH2 targeting reduces medulloblastoma growth through epigenetic reactivation of the BAI1/p53 tumor suppressor pathway (Oncogene, (2020), 39, 5, (1041-1048), 10.1038/s41388-019-1036-7).  39:1165. 2020

EZH2 targeting reduces medulloblastoma growth through epigenetic reactivation of the BAI1/p53 tumor suppressor pathway.  39:1041-1048. 2020

Glycine decarboxylase is a transcriptional target of MYCN required for neuroblastoma cell proliferation and tumorigenicity.  38:7504-7520. 2019

Oncolytic herpes simplex virus immunotherapy for brain tumors: current pitfalls and emerging strategies to overcome therapeutic resistance.  38:6159-6171. 2019

MicroRNA-1205, encoded on chromosome 8q24, targets EGLN3 to induce cell growth and contributes to risk of castration-resistant prostate cancer.  38:4820-4834. 2019

Protein Kinase N1 control of androgen-responsive serum response factor action provides rationale for novel prostate cancer treatment strategy.  38:4496-4511. 2019

Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia.  38:2241-2262. 2019

JMJD6 regulates histone H2A.X phosphorylation and promotes autophagy in triple-negative breast cancer cells via a novel tyrosine kinase activity.  38:980-997. 2019

Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer.  37:4792-4808. 2018

Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumors.  37:1610-1623. 2018

Atf3 deficiency promotes genome instability and spontaneous tumorigenesis in mice.  37:18-27. 2018

Serine hydroxymethyl transferase 1 stimulates pro-oncogenic cytokine expression through sialic acid to promote ovarian cancer tumor growth and progression.  36:4014-4024. 2017

KLF6 depletion promotes NF-κB signaling in glioblastoma.  36:3562-3575. 2017

LKB1 inhibits HPV-associated cancer progression by targeting cellular metabolism.  36:1245-1255. 2017

Epithelial-mesenchymal transition of ovarian cancer cells is sustained by Rac1 through simultaneous activation of MEK1/2 and Src signaling pathways.  36:1546-1558. 2017

MicroRNA-101 regulated transcriptional modulator SUB1 plays a role in prostate cancer.  35:6330-6340. 2016

Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5 + CK8 + epithelial cells.  35:3555-3564. 2016

Overexpression of miR-214-3p in esophageal squamous cancer cells enhances sensitivity to cisplatin by targeting survivin directly and indirectly through CUG-BP1.  35:2087-2097. 2016

The BET bromodomain inhibitor JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models.  35:833-845. 2016

Loss of ATF3 promotes Akt activation and prostate cancer development in a Pten knockout mouse model.  34:4975-4984. 2015

Erratum: Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation (Oncogene (2015) 34 (3881) DOI:10.1038/onc.2015.204).  34:3881. 2015

Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase.  34:3429-3440. 2015

β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids.  34:2297-2308. 2015

ICAM-2 confers a non-metastatic phenotype in neuroblastoma cells by interaction with α-actinin.  34:1553-1562. 2015

Phosphodiesterase 10A: A novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity.  34:1499-1509. 2015

HSPB1 as a novel regulator of ferroptotic cancer cell death.  34:5617-5625. 2015

ASC deficiency suppresses proliferation and prevents medulloblastoma incidence..  34:394-402. 2015

PTEN functions as a melanoma tumor suppressor by promoting host immune response.  33:4632-4642. 2014

Loss of N-Myc interactor promotes epithelial-mesenchymal transition by activation of TGF-β/SMAD signaling.  33:2620-2628. 2014

Regulation of several androgen-induced genes through the repression of the miR-99a/let-7c/miR-125b-2 miRNA cluster in prostate cancer cells.  33:1448-1457. 2014

Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer.  33:1181-1189. 2014

Soluble E-cadherin: A critical oncogene modulating receptor tyrosine kinases, MAPK and PI3K/Akt/mTOR signaling.  33:225-235. 2014

Tip60 degradation by adenovirus relieves transcriptional repression of viral transcriptional activator EIA.  32:5017-5025. 2013

Interleukin enhancer-binding factor 3 promotes breast tumor progression by regulating sustained urokinase-type plasminogen activator expression.  32:3933-3943. 2013

Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation.  32:3616-3626. 2013

Stabilization of HIF-2α through redox regulation of mTORC2 activation and initiation of mRNA translation.  32:3147-3155. 2013

Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation.  32:2304-2314. 2013

PI3K regulation of the SKP-2/p27 axis through mTORC2.  32:2027-2036. 2013

TβRIII/β-arrestin2 regulates integrin α5β1 trafficking, function, and localization in epithelial cells.  32:1416-1427. 2013

The miR-99 family regulates the DNA damage response through its target SNF2H.  32:1164-1172. 2013

SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells.  32:589-598. 2013

MTBP suppresses cell migration and filopodia formation by inhibiting ACTN4.  32:462-470. 2013

A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40kDa vasculostatin from tumor suppressor BAI1.  31:5144-5152. 2012

Sulindac inhibits tumor cell invasion by suppressing NF-κB-mediated transcription of microRNAs.  31:4979-4986. 2012

Inhibition of Gli1 results in altered c-Jun activation, inhibition of cisplatin-induced upregulation of ERCC1, XPD and XRCC1, and inhibition of platinum-DNA adduct repair.  31:4718-4724. 2012

DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontin.  31:4472-4483. 2012

Cyclin E1 is a common target of BMI1 and MYCN and a prognostic marker for neuroblastoma progression.  31:3785-3795. 2012

Increased vascularity and spontaneous metastasis of breast cancer by hedgehog signaling mediated upregulation of cyr61.  31:3370-3380. 2012

Tissue transglutaminase links TGF-Β, epithelial to mesenchymal transition and a stem cell phenotype in ovarian cancer.  31:2521-2534. 2012

Overexpression of 14-3-3ζ in cancer cells activates PI3K via binding the p85 regulatory subunit..  31:897-906. 2012

A mouse model of heterogeneous, c-MYC-initiated prostate cancer with loss of Pten and p53.  31:322-332. 2012

The tumor suppressor gene rap1GAP is silenced by miR-101-mediated EZH2 overexpression in invasive squamous cell carcinoma.  30:4339-4349. 2011

MiR-155 promotes macroscopic tumor formation yet inhibits tumor dissemination from mammary fat pads to the lung by preventing EMT.  30:3440-3453. 2011

NF-κB addiction and its role in cancer: One size does not fit all.  30:1615-1630. 2011

Prognostic significance of BRMS1 expression in human melanoma and its role in tumor angiogenesis.  30:896-906. 2011

Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair.  29:6125-6137. 2010

The neuronal repellent SLIT2 is a target for repression by EZH2 in prostate cancer.  29:5370-5380. 2010

Increased cell migration and plasticity in Nrf2-deficient cancer cell lines.  29:3703-3714. 2010

The prolyl isomerase Pin1 regulates the NF-B signaling pathway and interleukin-8 expression in glioblastoma.  28:3735-3745. 2009

Ror2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinoma.  28:2513-2523. 2009

Repression of E-cadherin by the polycomb group protein EZH2 in cancer.  27:7274-7284. 2008

Retinoblastoma protein modulates gankyrin-MDM2 in regulation of p53 stability and chemosensitivity in cancer cells.  27:4034-4043. 2008

Targeted disruption of Aurora A causes abnormal mitotic spindle assembly, chromosome misalignment and embryonic lethality.  27:4122-4127. 2008

Mtbp haploinsufficiency in mice increases tumor metastasis.  27:1813-1820. 2008

Distinct FAK-Src activation events promote α5β1 and α4β1 integrin-stimulated neuroblastoma cell motility.  27:1439-1448. 2008

Regulation of normal cell cycle progression by flavin-containing oxidases.  27:20-31. 2008

Erratum: HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cells (Oncogene (2006) 25, (1721-1732) DOI: 10.1038/sj.onc.1209199).  26:7282. 2007

Inactivation of the ubiquitin conjugating enzyme UBE2Q2 causes a prophase arrest and enhanced apoptosis in response to microtubule inhibiting agents.  26:6509-6517. 2007

Gli1 acts through Snail and E-cadherin to promote nuclear signaling by β-catenin.  26:4489-4498. 2007

Targeting SPARC expression decreases glioma cellular survival and invasion associated with reduced activities of FAK and ILK kinases.  26:4084-4094. 2007

A novel antioxidant 3-O-Caffeoyl-1-methylquinic acid enhances ultraviolet A-mediated apoptosis in immortalized HaCaT keratinocytes via Sp1-dependent transcriptional activation of p21^WAF1/Cip1.  26:3559-3571. 2007

Role of epidermal growth factor receptor degradation in gemcitabine-mediated cytotoxicity.  26:3431-3439. 2007

Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy.  26:2563-2573. 2007

Green tea polyphenol EGCG suppresses cigarette smoke condensate-induced NF-κB activation in normal human bronchial epithelial cells.  26:673-682. 2007

Prolactin modulates phosphorylation, signaling and trafficking of epidermal growth factor receptor in human T47D breast cancer cells.  25:7565-7576. 2006

Proteomic identification of the wt-p53-regulated tumor cell secretome.  25:7650-7661. 2006

Intrinsic FAK activity and Y925 phosphorylation facilitate an angiogenic switch in tumors.  25:5969-5984. 2006

Intrinsic focal adhesion kinase activity controls orthotopic breast carcinoma metastasis via the regulation of urokinase plasminogen activator expression in a syngeneic tumor model.  25:4429-4440. 2006

Loss of the human polycomb group protein BMI1 promotes cancer-specific cell death.  25:4370-4375. 2006

HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cells.  25:1721-1732. 2006

Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation.  25:609-621. 2006

Unique aspects of mda-7/IL-24 antitumor bystander activity: Establishing a role for secretion of MDA-7/IL-24 protein by normal cells.  24:7552-7566. 2005

Activation of the neuregulin-1/ErbB signaling pathway promotes the proliferation of neoplastic Schwann cells in human malignant peripheral nerve sheath tumors.  24:5589-5605. 2005

Expression of DLK1 in hematopoietic cells results in inhibition of differentiation and proliferation.  24:4472-4476. 2005

Vasculostatin, a proteolytic fragment of brain angiogenesis inhibitor 1, is an antiangiogenic and antitumorigenic factor.  24:3632-3642. 2005

DNA replication and progression through S phase.  24:2827-2843. 2005

Induction of KLF4 in basal keratinocytes blocks the proliferation- differentiation switch and initiates squamous epithelial dysplasia.  24:1491-1500. 2005

Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice.  23:7644-7650. 2004

Deregulation of the Rho GTPase, Rac1, suppresses cyclin-dependent kinase inhibitor p21^CIP1 levels in androgen-independent human prostate cancer cells.  23:5513-5522. 2004

Lupeol modulates NF-κB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice.  23:5203-5214. 2004

Modulations of critical cell cycle regulatory events during chemoprevention of ultraviolet B-mediated responses by resveratrol in SKH-1 hairless mouse skin.  23:5151-5160. 2004

Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression.  23:4315-4329. 2004

Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor kappaB and induction of apoptosis.  23:2507-2522. 2004

Regulation of apoptosis proteins in cancer cells by ubiquitin.  23:2009-2015. 2004

A novel time-course cDNA microarray analysis method identifies genes associated with the development of cisplatin resistance.  23:744-752. 2004

The destruction box of human Geminin is critical for proliferation and tumor growth in human colon cancer cells.  23:58-70. 2004

Suppression of UVB-induced phosphorylation of mitogen-activated protein kinases and nuclear factor kappa B by green tea polyphenol in SKH-1 hairless mice.  22:9254-9264. 2003

Oncostatin-M induction of vascular endothelial growth factor expression in astroglioma cells.  22:8117-8124. 2003

Tumor suppressor p53 inhibits transcriptional activation of invasion gene thromboxane synthase mediated by the proto-oncogenic factor ets-1.  22:7716-7727. 2003

Ras oncogene directs expression of a differentially sialylated, functionally altered β1 integrin.  22:7137-7145. 2003

Characterization of p73 functional domains necessary for transactivation and growth suppression.  22:4333-4347. 2003

A novel hypoxia-inducible factor (HIF) activated oncolytic adenovirus for cancer therapy.  22:2065-2072. 2003

Synergistic induction of tumor cell apoptosis by death receptor antibody and chemotherapy agent through JNK/p38 and mitochondrial death pathway.  22:2034-2044. 2003

Inhibition of ultraviolet B-mediated activation of nuclear factor κB in normal human epidermal keratinocytes by green tea Constituent (-)-epigallocatechin-3-gallate.  22:1035-1044. 2003

Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma..  22:298-307. 2003

Association of CDH1 haplotypes with susceptibility to sporadic diffuse gastric cancer.  21:8192-8195. 2002

Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1.  21:4212-4219. 2002

Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells.  21:3727-3738. 2002

Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells..  21:3727-3738. 2002

The leukemia-associated transcription repressor AML1/MDS1/EVI1 requires CtBP to induce abnormal growth and differentiation of murine hematopoietic cells.  21:3232-3240. 2002

The leukemia-associated transcription repressor aml1/mds1/evi1 requires ctbp to induce abnormal growth and differentiation of murine hematopoietic cells.  21:3232-3240. 2002

Molecular cloning of eset, a novel histone h3-specific methyltransferase that interacts with erg transcription factor.  21:148-152. 2002

Mathematical modeling of noise and discovery of genetic expression classes in gliomas.  21:7164-7174. 2002

Pathological splice mutations outside the invariant AG/GT splice sites of BRCA1 exon 5 increase alternative transcript levels in the 5′ end of the BRCA1 gene.  21:4171-4175. 2002

The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis.  21:7195-7204. 2002

TGF-β1 up-regulates paxillin protein expression in malignant astrocytoma cells: Requirement for a fibronectin substrate.  20:7976-7986. 2001

HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLα and hMLH1-hEXO1 complexes.  20:3590-3595. 2001

Quantitative real-time PCR does not show selective targeting of p14^ARF but concomitant inactivation of both p16^INK4A and p14^ARF in 105 human primary gliomas.  20:1103-1109. 2001

Transcriptional regulation of the human osteopontin promoter: Functional analysis and DNA-protein interactions.  19:5801-5809. 2000

p53 gene mutation and ink4a-arf-deletion appear to be two mutually exclusive events in human glioblastoma.  19:3816-3822. 2000

The p44(S10) locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanoma.  19:1419-1427. 2000

Increased protein kinase Cδ in mammary tumor cells: Relationship to transformation and metastatic progression.  18:6748-6757. 1999

Mitochondrial DNA determines the cellular response to cancer therapeutic agents.  18:6641-6646. 1999

Basic fibroblast growth factor induces a transformed phenotype in normal human melanocytes.  18:6469-6476. 1999

Cells with TP53 mutations in low grade astrocytic tumors evolve clonally to malignancy and are an unfavorable prognostic factor.  18:5870-5878. 1999

Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFα expression in transgenic mice.  18:3593-3607. 1999

Regulation of interleukin-8 expression by reduced oxygen pressure in human glioblastoma.  18:1447-1456. 1999

Post-transcriptional induction of p21cip1 protein by human papillomavirus E7 inhibits unscheduled DNA synthesis reactivated in differentiated keratinocytes.  17:2027-2038. 1998

Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas.  16:3331-3335. 1998

Genetic instability leads to loss of both p53 alleles in a human glioblastoma.  16:321-326. 1998

New deletion in low-grade oligodendroglioma at the glioblastoma suppressor locus on chromosome 10q25-26.  15:997-1000. 1997

The role of p27(Kip1) in gamma interferon-mediated growth arrest of mammary epithelial cells and related defects in mammary carcinoma cells.  14:2111-2122. 1997

The tetratricopeptide repeat containing Tg737 gene is a liver neoplasia tumor suppressor gene.  15:1797-1803. 1997

Transition of human papillomavirus type 16 and 18 transfected human foreskin keratinocytes towards immortality: Activation of telomerase and allele losses at 3p, 10p, 11q and/or 18q.  13:1249-1257. 1996

Loss of transactivation and transrepression function, and not RPA binding, alters growth suppression by p53.  12:2661-2668. 1996

The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.  12:265-275. 1996

The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells.  10:1855-1864. 1995

Identification of β-actin sequences necessary for induction by phorbol esters and calcium ionophores.  9:1713-1722. 1994

Microcell-mediated transfer of chromosome 6 into metastatic human C8161 melanoma cells suppresses metastasis but does not inhibit tumorigenicity.  9. 1994

Microcell-mediated transfer of chromosome 6 into metastatic human C8161 melanoma cells suppresses metastasis but does not inhibit tumorigenicity.  9:255-262. 1994

Recombinant retroviruses encoding human papillomavirus type 18 E6 and E7 genes stimulate proliferation and delay differentiation of human keratinocytes early after infection.  7:619-626. 1992

Evidence for tau expression in cells of monocyte lineage and its in vitro phosphorylation by v-fms kinase.  6:1085-1087. 1991

In vitro and in vivo growth control of transformed lymphoid cells expressing plasma membrane galactosyltransferase.  4:1337-1344. 1989