Free Radical Biology and Medicine

Mammalian peroxidasin (PXDN): From physiology to pathology.  182:100-107. 2022

Human and rodent red blood cells do not demonstrate xanthine oxidase activity or XO-catalyzed nitrite reduction to NO.  174:84-88. 2021

Cellular antioxidant mechanisms control immunoglobulin light chain-mediated proximal tubule injury.  171:80-90. 2021

Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy.  169:317-342. 2021

CYP11A1-derived vitamin D3 products protect against UVB-induced inflammation and promote keratinocytes differentiation.  155:87-98. 2020

Corrigendum to “Endogenous formation of novel nitro-nitrate species as intermediates of fatty acid nitration” [Free Radic. Biol. Med. 145(1) (2019) S22] (Free Radical Biology and Medicine (2019) 145(S1), (S0891584919317861) (10.1016/j.freeradbiomed.2020.01.180)).  152:867. 2020

Erythrocyte and plasma oxidative stress appears to be compensated in patients with sickle cell disease during a period of relative health, despite the presence of known oxidative agents.  141:408-415. 2019

Plasma xanthine oxidase activity is related to increased sodium and left ventricular hypertrophy in resistant hypertension.  134:343-349. 2019

Maternal perinatal calorie restriction temporally regulates the hepatic autophagy and redox status in male rat.  130:592-600. 2019

Increased TFAM binding to mtDNA damage hot spots is associated with mtDNA loss in aged rat heart.  124:447-453. 2018

Rust never sleeps: The continuing story of the Iron Bolt.  124:353-357. 2018

An overview of the emerging interface between cardiac metabolism, redox biology and the circadian clock.  119:75-84. 2018

Circadian regulation of renal function.  119:93-107. 2018

Introduction to special issue: Circadian regulation of metabolism, redox signaling and function in health and disease.  119:1-2. 2018

Nrf2 in keratinocytes modulates UVB-induced DNA damage and apoptosis in melanocytes through MAPK signaling.  108:918-928. 2017

Role of the oxidized form of XRCC1 in protection against extreme oxidative stress.  107:292-300. 2017

Hyper-activation of pp60^Src limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury.  102:217-228. 2017

TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity.  102:260-273. 2017

Ferriheme catalyzes nitric oxide reaction with glutathione to form S-nitrosoglutathione: A novel mechanism for formation of S-nitrosothiols.  101:296-304. 2016

464 Characterization of Microparticles and Exosomes from Red Blood Cells During Storage: Implications for Transfusion Toxicity.  100:s193. 2016

Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism.  100:94-107. 2016

Redox regulation of epidermal growth factor receptor signaling during the development of pulmonary hypertension..  95:96-111. 2016

Modification of platelet proteins by 4-hydroxynonenal: Potential Mechanisms for inhibition of aggregation and metabolism.  91:143-153. 2016

Nitrite and nitrate-dependent generation of anti-inflammatory fatty acid nitroalkenes.  89:333-341. 2015

315 Hydrogen Sulfide Alters M. Tuberculosis Bioenergetics and Promotes Tuberculosis Disease.  87:s141. 2015

Prion protein functions as a ferrireductase partner for ZIP14 and DMT1.  84:322-330. 2015

Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis.  86:47-56. 2015

Red blood cell washing, nitrite therapy, and antiheme therapies prevent stored red blood cell toxicity after trauma-hemorrhage.  85:207-218. 2015

Upregulation of autophagy decreases chlorine-induced mitochondrial injury and lung inflammation.  85:83-94. 2015

Epigenetic mechanisms regulate NADPH oxidase-4 expression in cellular senescence.  79:197-205. 2015

Thioredoxin rod-derived cone viability factor protects against photooxidative retinal damage.  81:22-29. 2015

168 Heme Scavenging Attenuates Bromine Induced Lung Injury.  76:s77. 2014

407 Exposure to Cigarette Smoke Causes DNA Damage and Contributes to Drug Resistance in Mycobacterium Tuberculosis.  76:s166-s167. 2014

A mitochondria-targeted mass spectrometry probe to detect glyoxals: Implications for diabetes.  67:437-450. 2014

Endothelin-1 stimulates catalase activity through the PKCδ-mediated phosphorylation of serine 167..  67:255-264. 2014

Nrf2 deficiency promotes apoptosis and impairs PAX7/MyoD expression in aging skeletal muscle cells.  71:402-414. 2014

Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeutics.  71:196-207. 2014

PSS124 Mechanistic Insights into the Role of Hydrogen Sulfide in Mycobacterial Disease and Persistence.  65:s62. 2013

PSS220 pp60Src Limits Nitric Oxide Signaling through Increases in Asymmetric Dimethylarginine.  65:s100. 2013

Erratum: Elevated levels of NO are localized to distal airways in asthma (Free Radical Biology and Medicine (2011) 50 (1679-1688)).  58:45. 2013

Dietary patterns are associated with plasma F2-isoprostanes in an observational cohort study of adults.  57:201-209. 2013

Bosentan inhibits oxidative and nitrosative stress and rescues occlusive pulmonary hypertension..  56:28-43. 2013

Antioxidant functions for the hemoglobin β93 cysteine residue in erythrocytes and in the vascular compartment in vivo.  55:119-129. 2013

Oxidative Stress Adaption with Acute, Chronic and Repeated Stress 2013

Temporal patterns of tyrosine nitration in embryo heart development.  55:101-108. 2013

Cellular metabolic and autophagic pathways: Traffic control by redox signaling.  63:207-221. 2013

Inhibition of autophagy and glycolysis by nitric oxide during hypoxia-reoxygenation impairs cellular bioenergetics and promotes cell death in primary neurons.  65:1215-1228. 2013

Mitochondrial genetics and obesity: Evolutionary adaptation and contemporary disease susceptibility.  65:1229-1237. 2013

Utilization of fluorescent probes for the quantification and identification of subcellular proteomes and biological processes regulated by lipid peroxidation products.  59:56-68. 2013

Vascular peroxidase 1 catalyzes the formation of hypohalous acids: Characterization of its substrate specificity and enzymatic properties.  53:1954-1959. 2012

Administration of nitrite after chlorine gas exposure prevents lung injury: Effect of administration modality.  53:1431-1439. 2012

Increased NADPH oxidase-derived superoxide is involved in the neuronal cell death induced by hypoxia-ischemia in neonatal hippocampal slice cultures..  53:1139-1151. 2012

Transforming growth factor β suppresses glutamate-cysteine ligase gene expression and induces oxidative stress in a lung fibrosis model.  53:554-563. 2012

Corrigendum to "Ozone exposure is a risk factor for Alzheimer's disease" [Free Radical Biology and Medicine (2011) 51 (S68)).  52:1334. 2012

Metabolic syndrome and mitochondrial dysfunction: Insights from preclinical studies with a mitochondrially targeted antioxidant.  52:838-840. 2012

A simple fluorescence labeling method for studies of protein oxidation, protein modification, and proteolysis..  52:239-246. 2012

Acute exercise stress activates Nrf2/ARE signaling and promotes antioxidant mechanisms in the myocardium..  52:366-376. 2012

Measuring reactive oxygen and nitrogen species with fluorescent probes: Challenges and limitations.  52:1-6. 2012

Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes.  52:198-207. 2012

Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress.  51:2007-2017. 2011

Novel insights into interactions between mitochondria and xanthine oxidase in acute cardiac volume overload.  51:1975-1984. 2011

Assessing bioenergetic function in response to oxidative stress by metabolic profiling.  51:1621-1635. 2011

Reactive Oxygen Species and the Macroalgal Wound Response.  51:s106-s107. 2011

Role of VPO1, a newly identified heme-containing peroxidase, in ox-LDL induced endothelial cell apoptosis.  51:1492-1500. 2011

HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress..  51:1355-1364. 2011

Oxidases and peroxidases in cardiovascular and lung disease: New concepts in reactive oxygen species signaling.  51:1271-1288. 2011

Vascular peroxidase-1 is rapidly secreted, circulates in plasma, and supports dityrosine cross-linking reactions.  51:1445-1453. 2011

Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy.  51:805-812. 2011

Generation and characterization of a novel kidney-specific manganese superoxide dismutase knockout mouse.  51:406-416. 2011

Elevated levels of NO are localized to distal airways in asthma.  50:1679-1688. 2011

Dipyridamole reverses peripheral ischemia and induces angiogenesis in the Db/Db diabetic mouse hind-limb model by decreasing oxidative stress.  50:262-269. 2011

Role of mitochondrial-derived oxidants in renal tubular cell cold-storage injury.  49:1273-1282. 2010

ICAM-1 cytoplasmic tail regulates endothelial glutathione synthesis through a NOX4/PI3-kinase-dependent pathway.  49:1119-1128. 2010

Dietary flavonoid quercetin stimulates vasorelaxation in aortic vessels.  49:339-347. 2010

Mitochondrial dysfunction may explain the cardiomyopathy of chronic iron overload.  49:401-407. 2010

Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species.  48:905-914. 2010

Effects of T-state and R-state stabilization on Deoxyhemoglobin-nitrite Reactions and Stimulation of Nitric Oxide (NO) Signaling.  49:s111. 2010

Nitration-mediated Activation of RhoA: Its Role in LPS-induced Endothelial Barrier Dysfunction.  49:s49. 2010

Oxidative stress and glutathione in TGF-β-mediated fibrogenesis.  48:1-15. 2010

Post–Cl2 Exposure Therapeutics Using Nitrite: Different Effects of IM vs. IP Administration.  49:s196. 2010

Role of Hemoglobin Beta93Cys as an Antioxidant in the Vascular Compartment: Implications for Vascular Homeostasis During Endotoxemia.  49:s150. 2010

The Effects of Red Blood Cell Storage Time on Nitric Oxide and Nitrite-dependent Signaling.  49:s30. 2010

The Role of Reactive Oxygen Species in Antiherbivore Defense along the Western Antarctic Peninsula.  49:s98. 2010

Fibroblasts from long-lived mutant mice show diminished ERK1/2 phosphorylation but exaggerated induction of immediate early genes.  47:1753-1761. 2009

Methods for the determination and quantification of the reactive thiol proteome.  47:675-683. 2009

Methods for imaging and detecting modification of proteins by reactive lipid species.  47:201-212. 2009

Ozone Induces Pulmonary Fibrosis via a TGF-beta Signaling Pathway.  47. 2009

Ethanol and tobacco smoke increase hepatic steatosis and hypoxia in the hypercholesterolemic apoE^-/- mouse: Implications for a "multihit" hypothesis of fatty liver disease.  46:928-938. 2009

Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway.  46:866-875. 2009

Supression of hemin-mediated oxidation of low-density lipoprotein and subsequent endothelial reactions by hydrogen sulfide (H2S).  46:616-623. 2009

Antioxidant Role of Hemoglobin Beta93 Cysteine in the Red Blood Cell and the Vascular Compartment.  47:S67-S68. 2009

Hypoxic Nitrite Reduction to Nitric Oxide Varies by Cell Type.  47:S33-S34. 2009

Mouse Strains with Differential Cardiovascular Disease Susceptibilities Have Significantly Different Measures of Mitochondrial Function and Damage.  47:S57-S58. 2009

Sodium Nitrite Administration Mitigates Lung Injury After Chlorine Gas Exposure in Rats.  47:S103-S103. 2009

Identification and characterization of VPO1, a new animal heme-containing peroxidase.  45:1682-1694. 2008

Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases.  44:1259-1272. 2008

Activation of Endothelial Nitric Oxide Synthase and Heme Oxygenase 1 Expression in Vasculature by Nitro-Fatty Acids.  45:S32-S32. 2008

Direct Measurement of Bioenergetic Stress in Cardiomyocytes Exposed to Hydrogen Peroxide and Protection by O-Glcnac.  45:S143-S143. 2008

Effect of alcohol and tobacco smoke on mtDNA damage and atherogenesis.  43:1279-1288. 2007

Action of reactive oxygen species on colonic mucus secretions.  43:800-808. 2007

Manganese porphyrin reduces renal injury and mitochondrial damage during ischemia/reperfusion.  42:1571-1578. 2007

Measurement of plasma nitrite by chemiluminescence without interference of S-, N-nitroso and nitrated species.  42:1146-1154. 2007

Regulation of endothelial glutathione by ICAM-1 governs VEGF-A-mediated eNOS activity and angiogenesis.  42:720-729. 2007

Deoxyhemoglobin possesses dual functions as NO scavenger and a nitrite dependent NO generator: Insights from oxygen controlled vessel bioassays.  43:S167-S167. 2007

ICAM-1 cytoplasmic tail regulates endothelial cell redox status through an NADPH oxidase pathway.  43:S78-S78. 2007

Nitrite transport in erythrocytes: Evidence for oxygen-dependent modulation of export.  43:S172-S173. 2007

Purinergic signaling and kinase activation for survival in pulmonary oxidative stress and disease.  41:29-40. 2006

γ-Glutamyl transpeptidase is induced by 4-hydroxynonenal via EpRE/Nrf2 signaling in rat epithelial type II cells.  40:1281-1292. 2006

Endothelial Akt activation by hyperoxia: Role in cell survival.  40:1108-1118. 2006

Moderate hypoxia induces xanthine oxidoreductase activity in arterial endothelial cells.  40:952-959. 2006

Upregulation of immunoproteasomes by nitric oxide: Potential antioxidative mechanism in endothelial cells.  40:1034-1044. 2006

A sensitive method for the quantitative measurement of protein thiol modification in response to oxidative stress.  40:459-468. 2006

Activation of a novel isoform of methionine adenosyl transferase 2A and increased S-adenosylmethionine turnover in lung epithelial cells exposed to hyperoxia.  40:348-358. 2006

Chlorination modulates anti-inflammatory effects of isoflavones via PPAR gamma: Insights into the structure-activity relationships.  41:S20-S20. 2006

Chronic administration of nitrite therapy protects blood flow in the murine hind limb ischemia induced angiogenesis model.  41:S51-S51. 2006

Is S-nitrosohemoglobin dependent valsodilatation under allosteric control? Insights from a hemoglobin beta C93A mouse model.  41:S50-S50. 2006

Nitrite uptake by erythrocytes: Insights into mechanism and regulation.  41:S55-S55. 2006

Sildenafil enhances ischemia-induced angiogenesis independent of nitric oxide.  41:S48-S48. 2006

The cytoplasmic tail of ICAM-1 regulates endothelial glutathione synthesis.  41:S72-S72. 2006

Evidence of cardiovascular protection by moderate alcohol: Role of nitric oxide.  39:540-548. 2005

HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cells.  39:355-364. 2005

Lung epithelial cells release ATP during ozone exposure: Signaling for cell survival.  39:213-226. 2005

Antioxidant up-regulation and increased nuclear DNA protection play key roles in adaptation to oxidative stress in epithelial cells.  38:1382-1391. 2005

Mitochondrial dysfunction in cardiovascular disease.  38:1278-1295. 2005

Nitric oxide-induced resistance to hydrogen peroxide stress is a glutamate cysteine ligase activity-dependent process.  38:1361-1371. 2005

Stimulation of HIF-1α, HIF-2α, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells.  38:1002-1013. 2005

Mechanisms of glutamate cysteine ligase (GCL) induction by 4-hydroxynonenal.  38:547-556. 2005

4-Hydroxynonenal increases γ-glutamyl transpeptidase gene expression through mitogen-activated protein kinase pathways.  38:463-471. 2005

Nitroxia: The pathological consequence of dysfunction in the nitric oxide-cytochrome c oxidase signaling pathway.  38:297-306. 2005

Mitochondrial proteomics in free radical research.  38:175-188. 2005

Dietary modulation of vascular N-glycosylation: Mechanistic implications for anti-inflammatory effects of polyphenols.  39:S31-S31. 2005

Mass spectrometric methods for the determination of flavonoids in biological samples.  37:1324-1350. 2004

Human glutamate cysteine ligase gene regulation through the electrophile response element.  37:1152-1159. 2004

The powerhouse takes control of the cell; The role of mitochondria in signal transduction.  37:753-754. 2004

Introduction to serial reviews on 4-hydroxy-2-nonenal as a signaling molecule.  37:594-596. 2004

Weight loss and race modulate nitric oxide metabolism in overweight women.  37:695-702. 2004

The biochemistry of nitric oxide, nitrite, and hemoglobin: Role in blood flow regulation.  36:707-717. 2004

The biochemistry of nitric oxide, nitrite, and hemoglobin: Role in blood flow regulation.  36:707-717. 2004

Physiologic, pathologic and therapeutic implications for hemoglobin interactions with nitric oxide.  36:399-401. 2004

Mechanistic re-examination of the reaction between nitrite and hemoglobin.  37:S82-S82. 2004

Nitrite activation of sGC in blood.  37:S84-S84. 2004

Proteomic analysis of skeletal muscle mitochondria reveal decreases in complex I and IV of the electron transport chain.  37:S27-S27. 2004

Neutrophil myeloperoxidase chlorinates and nitrates soy isoflavones and enhances their antioxidant properties.  35:1417-1430. 2003

Novel SIN-1 reactive intermediates modulate chloride secretion across murine airway cells.  35:662-675. 2003

The differential modification of mitochondrial proteins by nitroxyl and nitric oxide.  35:S97-S97. 2003

Inhibition of human surfactant protein A function by oxidation intermediates of nitrite.  33:1703-1713. 2002

Mitochondria, nitric oxide, and cardiovascular dysfunction.  33:1465-1474. 2002

Urate produced during hypoxia protects heart proteins from peroxynitrite-mediated protein nitration.  33:1243-1249. 2002

4-Hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells.  33:974-987. 2002

Spatial mapping of pulmonary and vascular nitrotyrosine reveals the pivotal role of myeloperoxidase as a catalyst for tyrosine nitration in inflammatory diseases.  33:1010-1019. 2002

Mitochondria: Regulators of signal transduction by reactive oxygen and nitrogen species.  33:755-764. 2002

Erratum: AP-1 activation through endogenous H2O2 generation by alveolar macrophages (Free Radical Biology and Medicine (2002) 32 (1304-1313) PII: S0891584902008407).  33:725. 2002

AP-1 activation through endogenous H2O2 generation by alveolar macrophages.  32:1304-1313. 2002

Mitochondrial function in response to cardiac ischemia-reperfusion after oral treatment with quercetin.  32:1220-1228. 2002

Hypothesis: The mitochondrial NO^· signaling pathway, and the transduction of nitrosative to oxidative cell signals: An alternative function for cytochrome c oxidase.  32:370-374. 2002

Associations of weight loss and race with plasma NO3-/NO2-and 3-nitrotyrosine.  33:S366-S366. 2002

Contribution of mitochondria to oxidative stress associated with alcoholic liver disease.  32:11-16. 2002

ICAM-1 modulates GCLC expression and GSH localization within endothelial cells.  33:S345-S345. 2002

Induction of glutamate-cysteine ligase by oxidized lipids is mediated through antioxidant responsive element (ARE).  33:S354-S355. 2002

Nitric oxide and cellular respiration at low oxygen tension: A study on bovine aortic endothelial cells..  33:S400-S400. 2002

Antioxidant mechanisms of isoflavones in lipid systems: Paradoxical effects of peroxyl radical scavenging.  31:1570-1581. 2001

Mitochondrial tyrosine nitration precedes chronic allograft nephropathy.  31:1603-1608. 2001

Formation of nanomolar concentrations of S-nitroso-albumin in human plasma by nitric oxide.  31:688-696. 2001

Photocytotoxicity of lipofuscin in human retinal pigment epithelial cells.  31:256-265. 2001

Anti-inflammatory effects of soy-isoflavones: Inhibition of leukocyte-endothelial interactions.  31:S35-S35. 2001

Biphasic effects of cyclopentenone prostaglandins on glutathione induction and apoptosis in endothelial cells: insights into the cell signaling pathways initiated by oxidized phospholipids.  31:S57-S57. 2001

Cytoprotection mediated by oxidized lipids in endothelial cells.  31:S88-S88. 2001

Effect of inhibition of mitochondrial protein synthesis on nitric oxide dependent apoptosis.  31:S106-S106. 2001

Glutathione nitroso-sulfoxide: a potential reaction product of glutathione and peroxynitrite.  31:S76-S76. 2001

Mitochondrial sensitivity to nitric oxide is dependent on respiratory state.  31:S73-S73. 2001

Non-heme iron enhances the induction of glutamate-cysteine ligase and heme oxygenase-1 by nitric oxide in human endothelial cells.  31:S70-S70. 2001

Regulation of endothelial cell redox status by ICAM-1: Identification of a novel pathway governing endothelial cell reactivity.  31:S47-S47. 2001

The Saccharomyces cerevisiae Sln1p-Ssk1p two-component system mediates response to oxidative stress and in an oxidant-specific fashion.  29:1043-1050. 2000

The origin of red cell fluorescence caused by hydrogen peroxide treatment.  29:659-663. 2000

Cell signaling by reactive nitrogen and oxygen species in atherosclerosis.  28:1780-1794. 2000

Biochemical aspects of the reaction of hemoglobin and NO: Implications for Hb-based blood substitutes.  28:1518-1525. 2000

Therapeutic applications of reactive oxygen and nitrogen species in human disease.  28:1449-1450. 2000

Peroxynitrite irreversibly decreases diastolic and systolic function in cardiac muscle.  27:1386-1392. 1999

Ethanol stimulates the production of reactive oxygen species at mitochondrial complexes I and III.  27:891-900. 1999

Effects of pyrrolidine dithiocarbamate on endothelial cells: Protection against oxidative stress.  26:1138-1145. 1999

Positive correlation between mammalian life span and cellular resistance to stress.  26:495-500. 1999

A critical appraisal of hydrogen peroxide and superoxide as signaling molecules using the JNK/SAPK map kinase pathway.  27:S64-S64. 1999

Is endothelium relaxing factor nitric oxide or an S-nitrosothiol? Insights from scavenging by hemoglobin.  27:S83-S83. 1999

Shear stress simulates cJUN N-terminal kinase (JNK) by activation of PI-3-kinase (PI3K), Akt and endothelial NO synthase (eNOS)..  27:S62-S62. 1999

Blue light-induced singlet oxygen generation by retinal lipofuscin in non-polar media.  24:1107-1112. 1998

Endothelial injury from a circulating mediator following rat liver ischemia.  24:427-434. 1998

A novel cellular mechanism for the antioxidant effects of the NF kappa B inhibitor pyrrolidine dithiocarbamate..  25:S15-S15. 1998

S-nitrosation of hemoglobin: Effects on O-2 delivery and antioxidant properties.  25:S17-S17. 1998

Nitric oxide regulation of superoxide-dependent lung injury: Oxidant- protective actions of endogenously produced and exogenously administered nitric oxide.  21:43-52. 1996

Oxidation of human low-density lipoprotein by soybean 15-lipoxygenase in combination with copper (II) or met-myoglobin.  20:525-532. 1996

Xanthine oxidase activity in the circulation of rats following hemorrhagic shock.  15:407-414. 1993

A sensitive fluorometric assay for measuring xanthine dehydrogenase and oxidase in tissues.  6:607-615. 1989

Oxidant inhibition of epithelial active sodium transport.  6:557-564. 1989