Molecular Pharmacology

Direct binding of the Corrector VX-809 to Human CFTR NBD1: Evidence of an Allosteric coupling between the Binding site and the NBD1:CL4 Interface ^s.  92:124-135. 2017

Arsenic attenuates gli signaling, increasing or decreasing its transcriptional program in a context-dependent manner.  89:226-232. 2016

The Nurr1 activator 1,1-bis(3′-indolyl)-1-(p-chlorophenyl) methane blocks inflammatory gene expression in BV-2 microglial cells by inhibiting nuclear factor κB.  87:1021-1034. 2015

ABCD2 alters peroxisome proliferator-activated receptor α signaling in vitro, but does not impair responses to fenofibrate therapy in a mouse model of diet-induced obesity.  86:505-513. 2014

Effects on gene expression in rat liver after administration of RXR Agonists: UAB30, 4-Methyl-UAB30, and Targretin (Bexarotene)s.  83:698-708. 2013

Calcium channel blockers act through nuclear factor Y to control transcription of key cardiac genes.  82:541-549. 2012

Carbonylation induces heterogeneity in cardiac ryanodine receptor function in diabetes mellitus.  82:383-399. 2012

Bharangin, a diterpenoid quinonemethide, abolishes constitutive and inducible nuclear factor-κB (NF-κB) activation by modifying p65 on cysteine 38 residue and reducing inhibitor of nuclear factor-κB α kinase activation, leading to suppression of NF-κB-regulated gene expression and sensitization of tumor cells to chemotherapeutic agents.  80:769-781. 2011

Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1.  80:889-899. 2011

A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.  79:279-289. 2011

Enhanced hypotensive, bradycardic, and hypnotic responses to α2-adrenergic agonists in spinophilin-null mice are accompanied by increased G protein coupling to the α2A-adrenergic receptor.  78:279-286. 2010

Molecular mechanisms of amphetamine actions in caenorhabditis elegans.  78:151-156. 2010

Polyethylene glycosylated curcumin conjugate inhibits pancreatic cancer cell growth through inactivation of Jab1.  76:81-90. 2009

Thiazolidinediones mimic glucose starvation in facilitating Sp1 degradation through the up-regulation of β-transducin repeat-containing protein.  76:47-57. 2009

A juxtamembrane mutation in the n terminus of the dopamine transporter induces preference for an inward-facing conformation.  75:514-524. 2009

Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux.  74:1101-1108. 2008

Identification of oxysterol 7α-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor α (RORα) (NR1F1) target gene and a functional cross-talk between RORα and liver X receptor (NR1H3).  73:891-899. 2008

Dopamine transporter activity mediates amphetamine-induced inhibition of Akt through a Ca²⁺/calmodulin-dependent kinase II-dependent mechanism.  71:835-842. 2007

Amphetamine induces a calcium/calmodulin-dependent protein kinase II-dependent reduction in norepinephrine transporter surface expression linked to changes in syntaxin 1a/transporter complexes.  71:230-239. 2007

Human RNase H1 discriminates between subtle variations in the structure of the heteroduplex substrate.  71:83-91. 2007

The positional influence of the helical geometry of the heteroduplex substrate on human RNase H1 catalysis.  71:73-82. 2007

Regulation of dopamine transporter trafficking by intracellular amphetamine.  70:542-548. 2006

Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons.  69:1125-1136. 2006

Akt is essential for insulin modulation of amphetamine-induced human dopamine transporter cell-surface redistribution.  68:102-109. 2005

The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action.  67:1874-1881. 2005

Intracellular Ca²⁺ regulates amphetamine-induced dopamine efflux and currents mediated by the human dopamine transporter.  66:137-143. 2004

Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: Synthesis, quantitative structure-activity relationship analysis, and biological activity.  65:1336-1343. 2004

Dopamine D1-Dependent Trafficking of Striatal N-Methyl-D-aspartate Glutamate Receptors Requires Fyn Protein Tyrosine Kinase but Not DARPP-32.  65:121-129. 2004

Saturation transfer difference nuclear magnetic resonance spectroscopy as a method for screening proteins for anesthetic binding.  66:929-935. 2004

Altered Striatal Function and Muscarinic Cholinergic Receptors in Acetylcholinesterase Knockout Mice.  64:1309-1316. 2003

Differential regulation of nonsteroidal anti-inflammatory drug-activated gene in normal human tracheobronchial epithelial and lung carcinoma cells by retinoids.  63:557-564. 2003

Differential roles of p21^Waf1 and p27^Kip1 in modulating chemosensitivity and their possible application in drug discovery studies.  60:900-906. 2001

Regulation of recombinant γ-aminobutyric acid (GABA)(A) and GABA(C) receptors by protein kinase C.  57:847-856. 2000

Alterations in subunit expression, composition, and phosphorylation of striatal N-methyl-D-aspartate glutamate receptors in a rat 6-hydroxydopamine model of Parkinson's disease.  57:342-352. 2000

Induction of the cytochrome P450 gene CYP26 during mucous cell differentiation of normal human tracheobronchial epithelial cells.  58:483-490. 2000

Post-transcriptional regulation of MyD118 and GADD45 in human lung carcinoma cells during 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid-induced apoptosis.  55:668-676. 1999

Comparison of the mechanism of cytotoxicity of 2-chloro-9,(2-deoxy-2- fluoro-β-D-arabinofuranosyl)adenine, 2-chloro-9-(2-deoxy-2-fluoro-β-D- ribofuranosyl)adenine, and 2-chloro-9-(2-deoxy-2,2-difluoro-β-D- ribofuranosyl)adenine in CEM cells.  55:515-520. 1999

Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity.  56:1105-1115. 1999

Regulation of α4β2 nicotinic receptor desensitization by calcium and protein kinase C.  55:432-443. 1999

Novel potent and selective inhibitors of inducible nitric oxide synthase.  47:831-834. 1995

Expression of α1-adrenergic receptor subtype mRNA in rat tissues and human SK-N-MC neuronal cells: Implications for α1-adrenergic receptor subtype classification.  46:221-226. 1994

Localization of mRNA for three distinct α1-adrenergic receptor subtypes in human tissues: Implications for human α-adrenergic physiology.  45:171-175. 1994

Pituitary cell line GH3 expresses two somatostatin receptor subtypes that inhibit adenylyl cyclase: Functional expression of rat somatostatin receptor subtypes 1 and 2 in human embryonic kidney 293 cells.  45:402-409. 1994

Phosphorylation of the enantiomers of the carbocyclic analog of 2'- deoxyguanosine in cells infected with herpes simplex virus type 1 and in uninfected cells. Lack of enantiomeric selectivity with the viral thymidine kinase.  44:1258-1266. 1993

Sequence analysis and expression of the cDNA for the phenol-sulfating form of human liver phenol sulfotransferase.  43:70-77. 1993

Induction of NADPH-dependent diaphorase and nitric oxide synthase activity in aortic smooth muscle and cultured macrophages.  41:1163-1168. 1992

Incorporation of the carbocyclic analog of 2'-deoxyguanosine into the DNA of herpes simplex virus and of HEp-2 cells infected with herpes simplex virus.  41:245-251. 1992

Hormone-induced biosynthesis of endothelium-derived relaxing factor/nitric oxide-like material in N1E-115 neuroblastoma cells requires calcium and calmodulin.  38:7-13. 1990

Interaction of 6-cyano-7-nitroquinoxaline-2,3-dione with the N-methyl-D-aspartate receptor-associated glycine binding site.  35:565-570. 1989

Effect of the N-glycosidic bond conformation and modifications in the pentose moiety on the binding of nucleoside ligands to uridine phosphorylase.  34:104-110. 1988

Differences in the metabolism and metabolic effects of carbocyclic adenosine analogs, neplanocin A and aristeromycin.  29:383-390. 1986

Rat renal glomeruli and tubules have specific insulin receptors of differing affinity.  16:1095-1100. 1979