Selected Publications

Academic Article

Year Title Altmetric
2022 Calcium selective channel TRPV6: Structure, function, and implications in health and diseaseGene.  817. 2022
2022 Molecular insights into the structural and dynamical changes of calcium channel TRPV6 induced by its interaction with phosphatidylinositol 4,5-bisphosphateJournal of Biomolecular Structure and Dynamics2022
2021 Auto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasionCommunications Biology.  4. 2021
2020 Autoinhibition of TRPV6 Channel and Regulation by PIP2iScience.  23. 2020
2019 Modeling the structural and dynamical changes of the epithelial calcium channel TRPV5 caused by the A563T variation based on the structure of TRPV6Journal of Biomolecular Structure and Dynamics.  37:3506-3512. 2019
2019 Unveiling the Distinct Mechanisms by which Disease-Causing Mutations in the Kelch Domain of KLHL3 Disrupt the Interaction with the Acidic Motif of WNK4 through Molecular Dynamics SimulationBiochemistry2019
2017 The L530R variation associated with recurrent kidney stones impairs the structure and function of TRPV5Biochemical and Biophysical Research Communications.  492:362-367. 2017
2017 Phosphorylation of KLHL3 at serine 433 impairs its interaction with the acidic motif of WNK4: a molecular dynamics studyProtein Science.  26:163-173. 2017
2016 Molecular Modeling of the Structural and Dynamical Changes in Calcium Channel TRPV5 Induced by the African-Specific A563T VariationBiochemistry.  55:1254-1264. 2016
2014 Trpv5: A ca2+ channel for the fine-tuning of ca2+reabsorptionHandbook of experimental pharmacology.  222:321-357. 2014
2013 Disease-causing mutations in KLHL3 impair its effect on WNK4 degradationFEBS Letters.  587:1717-1722. 2013
2013 Disease-causing R1185C mutation of WNK4 disrupts a regulatory mechanism involving calmodulin binding and SGK1 phosphorylation sites 2013
2012 Gene transfer of active Akt1 by an infectivity-enhanced adenovirus impacts β-cell survival and proliferation differentially in vitro and in vivoIslets.  4:366-378. 2012
2012 Suppression of intestinal calcium entry channel TRPV6 by OCRL, a lipid phosphatase associated with Lowe syndrome and Dent disease 2012
2012 Regeneration of pancreatic non-β endocrine cells in adult mice following a single diabetes-inducing dose of streptozotocinPLoS One.  7. 2012
2012 Disease-causing mutations in the acidic motif of WNK4 impair the sensitivity of WNK4 kinase to calcium ionsBiochemical and Biophysical Research Communications.  419:293-298. 2012
2012 Gene Transer of Constitutively Active AKL by an Infectivity-Enhanced Adenoviral Vector Improves Beta Cell Survival and Proliferation.Islets.  4:366-378. 2012
2011 Concerted actions of NHERF2 and WNK4 in regulating TRPV5Biochemical and Biophysical Research Communications.  404:979-984. 2011
2010 Down-regulation of intestinal apical calcium entry channel TRPV6 by ubiquitin E3 ligase Nedd4-2Journal of Biological Chemistry.  285:36586-36596. 2010
2010 Trpv6 mediates intestinal calcium absorption during calcium restriction and contributes to bone homeostasisBone.  47:301-308. 2010
2010 8-pCPT-cGMP stimulates αβγ-ENaC activity in oocytes as an external ligand requiring specific nucleotide moieties 2010
2009 Expression and regulation of epithelial Na+ channels by nucleotides in pleural mesothelial cellsAmerican Journal of Respiratory Cell and Molecular Biology.  40:543-554. 2009
2009 SARS-CoV proteins decrease levels and activity of human ENaC via activation of distinct PKC isoforms 2009
2009 The A563T variation of the renal epithelial calcium channel TRPV5 among African Americans enhances calcium influx 2009
2008 WNK4 regulates the secretory pathway via which TRPV5 is targeted to the plasma membraneBiochemical and Biophysical Research Communications.  375:225-229. 2008
2008 Calcium channel TRPV6 is involved in murine maternal-fetal calcium transportJournal of Bone and Mineral Research.  23:1249-1256. 2008
2008 Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k 2008
2008 WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway 2008
2007 Membrane tension modulates the effects of apical cholesterol on the renal epithelial sodium channel 2007
2007 Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel geneJournal of Bone and Mineral Research.  22:274-285. 2007
2007 WNK4 enhances TRPV5-mediated calcium transport: Potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4 2007
2007 WNK4-mediated regulation of renal ion transport proteins 2007
2006 Cellular mechanisms of WNK4-mediated regulation of ion transport proteins in the distal tubuleKidney International.  69:2116-2118. 2006
2006 1,25-Dihydroxyvitamin D and 25-hydroxyvitamin D - Mediated regulation of TRPV6 (a putative epithelial calcium channel) mRNA expression in Caco-2 cells 2006
2005 Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brainBiochemical and Biophysical Research Communications.  337:892-900. 2005
2005 Regulation of epithelial calcium channels by protein kinases 2005
2004 CaT1 knock-down strategies fail to affect CRAC channels in mucosal-type mast cells 2004
2004 The ABCs of solute carriers: Physiological, pathological and therapeutic implications of human membrane transport proteins 2004
2003 Epithelial Ca2+ entry channels: Transcellular Ca2+ transport and beyond 2003
2003 Calcium transporter 1 and epithelial calcium channel messenger ribonucleic acid are differentially regulated by 1,25 dihydroxyvitamin D3 in the intestine and kidney of mice 2003
2003 Apical entry channels in calcium-transporting epitheliaPhysiology.  18:158-163. 2003
2003 The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormoneJournal of Clinical Investigation.  111:1021-1028. 2003
2002 Calcium-selective ion channel, CaT1, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignanciesLaboratory Investigation.  82:1755-1764. 2002
2002 A family of calcium-permeable channels in the kidney: Distinct roles in renal calcium handlingCurrent Opinion in Nephrology and Hypertension.  11:555-561. 2002
2002 A mRNA molecule encoding truncated excitatory amino acid carrier 1 (EAAC1) protein (EAAC2) is transcribed from an independent promoter but not an alternative splicing eventCell Research.  12:257-262. 2002
2001 Single-channel activities of the human epithelial Ca2+ transport proteins CaT1 and CaT2 2001
2001 Inhibition of the glutamate transporter EAAC1 expressed in Xenopus oocytes by phorbol estersBrain Research.  914:196-203. 2001
2001 Structural conservation of the genes encoding CaT1, CaT2, and related cation channelsGenomics.  76:99-109. 2001
2001 CaT1 manifests the pore properties of the calcium-release-activated calcium channelNature.  410:705-709. 2001
2001 CaT1 expression correlates with tumor grade in prostate cancerBiochemical and Biophysical Research Communications.  282:729-734. 2001
2001 Inhibition of CaT1 channel activity by a noncompetitive IP3 antagonistBiochemical and Biophysical Research Communications.  280:145-150. 2001
2001 Polycystin-2 is a novel cation channel implicated in defective intracellular Ca2+ homeostasis in polycystic kidney diseaseBiochemical and Biophysical Research Communications.  282:341-350. 2001
2001 Transport function of the naturally occurring pathogenic polycystin-2 mutant, R742XBiochemical and Biophysical Research Communications.  282:1251-1256. 2001
2000 Human calcium transport protein cat1Biochemical and Biophysical Research Communications.  278:326-332. 2000
2000 A rat kidney-specific calcium transporter in the distal nephronJournal of Biological Chemistry.  275:28186-28194. 2000
2000 Cloning and analyzing of members of excitatory amino acid transporter family from neonatal mouse brainJournal of Molecular Cell Biology.  33:53-62. 2000
1999 Yeast SMF1 mediates H+-coupled iron uptake with concomitant uncoupled cation currentsJournal of Biological Chemistry.  274:35089-35094. 1999
1999 Polycystin-L is a calcium-regulated cation channel permeable to calcium ionsNature.  401:383-386. 1999
1999 Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorptionJournal of Biological Chemistry.  274:22739-22746. 1999
1999 Studies of substrate binding region of mEAAC1 and mASCT1 by constructing chimerasChinese Science Bulletin.  44:524-528. 1999
1998 Mutations of amino acid residues that alter the chloride conductance of the human neuronal glutamate transporter EAAC1 1998
1994 Expression of heterogenous arsenic resistance genes in the obligately autotrophic biomining bacterium Thiobacillus ferrooxidansApplied and Environmental Microbiology.  60:2653-2656. 1994
1994 Plasmid and transposon transfer to Thiobacillus ferrooxidansJournal of Bacteriology.  176:2892-2897. 1994
1994 Solid Medium For the Genetic Manipulation of Thiobacillus FerrooxidansThe Journal of General and Applied Microbiology.  40:243-253. 1994


Year Title Altmetric
2017 TRPV5 and TRPV6 calcium-selective channels.  241-274. 2017
2011 TRPV5 and TRPV6 in transcellular Ca 2+ transport: Regulation, gene duplication, and polymorphisms in African populations.  239-275. 2011

Education And Training

  • Doctor of Philosophy in Cell Biology and Anatomy, 1998
  • Master of Sciences or Mathematics in Microbiology, 1993
  • Bachelor of Science or Mathematics in Biochemistry, 1990
  • Full Name

  • Ji-Bin Peng