• My major research interest is the neurobiological regulation of reward-related memory systems in the brain and the role of these systems in drug addiction. My laboratory approaches this broad topic at diverse levels of analysis that integrate molecular, genetic, and epigenetic tools with techniques that probe the function of single neurons and entire neuronal circuits. My ultimate goal is to understand epigenetic regulation in normal and disease states, and to use tools that manipulate the epigenome to treat addiction-related diseases. My lab has broad experience with reward circuitry, transcriptional and epigenetic analyses, whole-genome sequencing, and CRISPR/Cas9 genome editing tools to understand the role of specific genes and epigenetic modifications at these genes in neuronal function and behavior.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Corrigendum to “Estrogen-related Receptor Alpha (ERRα) is Required for PGC-1α-dependent Gene Expression in the Mouse Brain” [Neuroscience 479 (2021) 70–90, (Neuroscience (2021) 479(70-90) (S0306452221005078), (10.1016/j.neuroscience.2021.10.007))Neuroscience.  493:119. 2022
    2022 An atlas of transcriptionally defined cell populations in the rat ventral tegmental areaCell Reports.  39. 2022
    2022 Single-cell transcriptional profiling in brain reward structuresNeuropsychopharmacology2022
    2021 Estrogen-related Receptor Alpha (ERRα) is Required for PGC-1α-dependent Gene Expression in the Mouse BrainNeuroscience.  479:70-90. 2021
    2021 Morphine, the microbiome, and fatty acids: short chains make a big link in opioid rewardNeuropsychopharmacology.  46:2039-2040. 2021
    2021 Delivering progranulin to neuronal lysosomes protects against excitotoxicityJournal of Biological Chemistry.  297. 2021
    2021 A cre-dependent crispr/dcas9 system for gene expression regulation in neuronseNeuro.  8. 2021
    2021 An atlas of transcriptionally defined cell populations in the rat ventral tegmental area 2021
    2021 Regulation of dopamine-dependent transcription and cocaine action by Gadd45bNeuropsychopharmacology.  46:709-720. 2021
    2021 From circuits to chromatin: The emerging role of epigenetics in mental healthThe Journal of Neuroscience.  41:873-882. 2021
    2020 A Cre-dependent CRISPR/dCas9 system for gene expression regulation in neurons 2020
    2020 Enhancer RNAs predict enhancer–gene regulatory links and are critical for enhancer function in neuronal systemsNucleic Acids Research.  48:9550-9570. 2020
    2020 Alzheimer’s disease risk gene BIN1 induces Tau-dependent network hyperexcitabilityeLife.  9:1-25. 2020
    2020 A dopamine-induced gene expression signature regulates neuronal function and cocaine responseScience Advances.  6. 2020
    2020 An improved CRISPR/dCas9 interference tool for neuronal gene suppression 2020
    2020 Regulation of dopamine-dependent transcription and cocaine action by Gadd45b 2020
    2020 Alzheimer’s disease risk gene BIN1 induces Tau-dependent network hyperexcitability 2020
    2020 Blue light-induced gene expression alterations in cultured neurons are the result of phototoxic interactions with neuronal culture mediaeNeuro.  7. 2020
    2019 Genetic and epigenetic editing in nervous systemDialogues in Clinical Neuroscience.  21:359-368. 2019
    2019 Multigenerational epigenetic inheritance: One step forward, two generations backNeurobiology of Disease.  132. 2019
    2019 Blue light-induced gene expression alterations in cultured neurons are the result of phototoxic interactions with neuronal culture media 2019
    2019 A Novel Dual Lentiviral CRISPR-based Transcriptional Activation System for Gene Expression Regulation in Neurons.Bio-protocol.  9:e3348. 2019
    2019 A neuron-optimized CRISPR/dCas9 activation system for robust and specific gene regulationeNeuro.  6. 2019
    2019 Genomic enhancers in brain health and diseaseGenes.  10. 2019
    2019 Pharmacologic inhibition of LIMK1 provides dendritic spine resilience against β-amyloidScience Signaling.  12. 2019
    2018 Cell-specific deletion of PGC-1α from medium spiny neurons causes transcriptional alterations and age-related motor impairmentThe Journal of Neuroscience.  38:3273-3286. 2018
    2018 Enhancer RNAs predict enhancer-gene regulatory links and are critical for enhancer function in neuronal systems 2018
    2018 Learning and Age-Related Changes in Genome-wide H2A.Z Binding in the Mouse HippocampusCell Reports.  22:1124-1131. 2018
    2017 Hippocampal transcriptomic profiles: Subfield vulnerability to age and cognitive impairmentFrontiers in Aging Neuroscience.  9. 2017
    2017 Applications of CRISPR/CAS9 in the mammalian central nervous systemYale Journal of Biology and Medicine.  90:567-581. 2017
    2017 Experience-dependent epigenomic reorganization in the hippocampusLearning and Memory.  24:278-288. 2017
    2017 Genetic predisposition to high anxiety- and depression-like behavior coincides with diminished DNA methylation in the adult rat amygdalaBehavioural Brain Research.  320:165-178. 2017
    2016 Neonatal maternal separation stress elicits lasting DNA methylation changes in the hippocampus of stress-reactive Wistar Kyoto ratsEuropean Journal of Neuroscience.  44:2829-2845. 2016
    2016 Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory FunctionCell Reports.  16:2666-2685. 2016
    2016 Extra-coding RNAs regulate neuronal DNA methylation dynamicsNature Communications.  7. 2016
    2016 Dopamine and opioid systems interact within the nucleus accumbens to maintain monogamous pair bondseLife.  5. 2016
    2015 DNA methylation regulates neuronal glutamatergic synaptic scalingScience Signaling.  8. 2015
    2015 DNA methylation slows effects of C9orf72 mutationsNeurology.  84:1616-1617. 2015
    2015 DNA methylation and its implications and accessibility for neuropsychiatric therapeuticsAnnual Review of Pharmacology and Toxicology.  55:591-611. 2015
    2014 Histone H2A.Z subunit exchange controls consolidation of recent and remote memoryNature.  515:582-586. 2014
    2014 New approaches to manipulating the epigenomeDialogues in Clinical Neuroscience.  16:345-357. 2014
    2013 DNA methylation regulates associative reward learningNature Neuroscience.  16:1445-1452. 2013
    2013 Development of behavioral preferences for the optimal choice following unexpected reward omission is mediated by a reduction of D2-like receptor tone in the nucleus accumbensEuropean Journal of Neuroscience.  38:2572-2588. 2013
    2012 Direct bisulfite sequencing for examination of DNA methylation with gene and nucleotide resolution from brain tissuesCurrent protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.].  1. 2012
    2012 Phasic nucleus accumbens dopamine encodes risk-based decision-making behaviorBiological Psychiatry.  71:199-205. 2012
    2012 Epigenetic treatments for cognitive impairmentsNeuropsychopharmacology.  37:247-260. 2012
    2011 Cognitive neuroepigenetics: A role for epigenetic mechanisms in learning and memoryNeurobiology of Learning and Memory.  96:2-12. 2011
    2011 Epigenetic Mechanisms in CognitionNeuron.  70:813-829. 2011
    2011 Cocaine cues drive opposing context-dependent shifts in reward processing and emotional stateBiological Psychiatry.  69:1067-1074. 2011
    2011 Epigenetic mechanisms in memory and synaptic functionEpigenomics.  3:157-181. 2011
    2011 Epigenetic modifications in neurons are essential for formation and storage of behavioral memoryNeuropsychopharmacology.  36:357-358. 2011
    2011 Nucleus accumbens neurons encode predicted and ongoing reward costs in ratsEuropean Journal of Neuroscience.  33:308-321. 2011
    2010 DNA methylation and memory formationNature Neuroscience.  13:1319-1323. 2010
    2010 The basolateral amygdala differentially regulates conditioned neural responses within the nucleus accumbens core and shellNeuroscience.  169:1186-1198. 2010
    2010 Phasic nucleus accumbens dopamine release encodes effort- and delay-related costsBiological Psychiatry.  68:306-309. 2010
    2010 Basolateral Amygdala Modulates Terminal Dopamine Release in the Nucleus Accumbens and Conditioned RespondingBiological Psychiatry.  67:737-744. 2010
    2009 Regional specificity in the real-time development of phasic dopamine transmission patterns during acquisition of a cue-cocaine association in ratsEuropean Journal of Neuroscience.  30:1889-1899. 2009
    2008 Preferential enhancement of dopamine transmission within the nucleus accumbens shell by cocaine is attributable to a direct increase in phasic dopamine release eventsThe Journal of Neuroscience.  28:8821-8831. 2008
    2008 Extracellular signal-related kinase activation during natural reward learning: A physiological role for phasic nucleus accumbens dopamine?The Journal of Neuroscience.  28:4295-4297. 2008
    2008 Methamphetamine Induces Chronic Corticostriatal Depression: Too Much of a Bad ThingNeuron.  58:6-7. 2008
    2007 Associative learning mediates dynamic shifts in dopamine signaling in the nucleus accumbensNature Neuroscience.  10:1020-1028. 2007
    2007 Spatial and visual discrimination reversals in adult and geriatric rats exposed during gestation to methylmercury and n - 3 polyunsaturated fatty acidsNeuroToxicology.  28:707-719. 2007
    2007 The nucleus accumbens and pavlovian reward learningThe Neuroscientist: reviews at the interface of basic and clinical neurosciences.  13:148-159. 2007
    2006 Nucleus accumbens neurons encode Pavlovian approach behaviors: Evidence from an autoshaping paradigmEuropean Journal of Neuroscience.  23:1341-1351. 2006
    2005 Neuromotor deficits and mercury concentrations in rats exposed to methyl mercury and fish oilNeurotoxicology and Teratology.  27:629-641. 2005


    Year Title Altmetric
    2017 DNA Modifications and Memory.  95-111. 2017
    2013 Epigenetic Mechanisms in Learning and Memory.  121-170. 2013

    Principal Investigator On

  • Amphetamine in Adolescence Disrupts Frontal Cortex Development  awarded by McGill University
  • Behavioral Epigenetics of Developmental Methylmercury Exposure  awarded by AUBURN UNIVERSITY ^
  • CRISPR/dCas9-targeted Manipulation of bdnf Transcription in Synaptic Plasticity and Contextual Learning  awarded by National Institute of Mental Health/NIH/DHHS
  • Enhancer RNA Regulation of Experience-dependent Neuroepigenetic Processes  awarded by National Institute of Mental Health/NIH/DHHS
  • Epigenetic Control of Brain Reward Systems  awarded by National Institute on Drug Abuse/NIH/DHHS
  • Epigenetic Regulation of Cocaine-Induced Neuroadaptions  awarded by National Institute on Drug Abuse/NIH/DHHS
  • Estradiol-mediated Gene Signatures in Hippocampal Memory  awarded by National Institute of Mental Health/NIH/DHHS
  • Gene-Specific Epigenetic Modifications in Cocaine-Induced Plasticity  awarded by National Institute on Drug Abuse/NIH/DHHS
  • Identification and Interrogation of Cocaine-Mediated Gene Signatures in Volitional Drug-Seeking Behavior  awarded by Brain and Behavior Research Foundation
  • Leveraging Single-cell Epigenomics for Targeted Manipulation of Drug-activated Ensembles  awarded by McKnight Foundation
  • Molecular Genetics of Associative Reward Learning  awarded by National Institute on Drug Abuse/NIH/DHHS
  • Reelin Signaling and Function in Cocaine Response  awarded by National Institute on Drug Abuse/NIH/DHHS
  • Role of Gadd45b in Cocaine-driven Epigenetic and Behavioral Dynamics  awarded by National Institute on Drug Abuse/NIH/DHHS
  • Striatal Modulation of Epigenetic DNA Demethylation in Reward Learning  awarded by National Institute on Drug Abuse/NIH/DHHS
  • Education And Training

  • University of Alabama at Birmingham, Birmingham Neurobiology, Postdoctoral Fellowship
  • Doctor of Philosophy in Psychology, University of North Carolina System : Chapel Hill 2009
  • Full Name

  • Jeremy Day