Positions

Overview

  • The overall research plans of our laboratory are aimed at discovering fundamental cellular and molecular mechanisms involved in the development of T and B lymphocytes. Particular attention is focused on the factors involved in the establishment of a diverse B cell repertoire and the identification of novel B cell subsets and B cell progenitors in mice and humans.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 GPR183 is Dispensable for B1 cell Accumulation and Function, but Affects B2 cell Abundance, in the Omentum and Peritoneal CavityCells.  11. 2022
    2021 Intrathymic differentiation of natural antibody-producing plasma cells in human neonatesNature Communications.  12. 2021
    2020 Neonatal Exposure to Commensal-Bacteria-Derived Antigens Directs Polysaccharide-Specific B-1 B Cell Repertoire DevelopmentImmunity.  53:172-186.e6. 2020
    2020 Glycan Reactive Natural Antibodies and Viral ImmunityViral Immunology.  33:266-276. 2020
    2018 Chemical Synthesis and Application of Biotinylated Oligo-α-(1 → 3)- d -Glucosides to Study the Antibody and Cytokine Response against the Cell Wall α-(1 → 3)- d -Glucan of Aspergillus fumigatusJournal of Organic Chemistry.  83:12965-12976. 2018
    2018 Terminal deoxynucleotidyl transferase is not required for antibody response to polysaccharide vaccines against Streptococcus pneumoniae and Salmonella enterica serovar TyphiInfection and Immunity.  86. 2018
    2018 IL-7 enables antibody responses to bacterial polysaccharides by promoting B cell receptor diversityJournal of Immunology.  201:1229-1240. 2018
    2018 Myeloid-derived suppressor cells impair B cell responses in lung cancer through IL-7 and STAT5Journal of Immunology.  201:278-295. 2018
    2017 Accelerated systemic autoimmunity in the absence of somatic hypermutation in 564Igi: A mouse model of systemic lupus with knocked-in heavy and light chain genesFrontiers in Immunology.  8. 2017
    2017 Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfacesJCI Insight.  2. 2017
    2017 CD36 and platelet-activating factor receptor promote house dust mite allergy developmentJournal of Immunology.  199:1184-1195. 2017
    2017 Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10Nature Immunology.  18:313-320. 2017
    2016 Immunological outcomes of antibody binding to glycans shared between microorganisms and mammalsJournal of Immunology.  197:4201-4209. 2016
    2016 Pulmonary α-1,3-glucan-specific iga-secreting b cells suppress the development of cockroach allergyJournal of Immunology.  197:3175-3187. 2016
    2016 Manipulation of the glycan-specific natural antibody repertoire for immunotherapyImmunological Reviews.  270:32-50. 2016
    2015 Neonatal exposure to pneumococcal phosphorylcholine modulates the development of house dust mite allergy during adult lifeJournal of Immunology.  194:5838-5850. 2015
    2015 Antibodies generated against streptococci protect in a mouse model of disseminated aspergillosisJournal of Immunology.  194:4387-4396. 2015
    2015 Natural antibody repertoires: Development and functional role in inhibiting allergic airway diseaseAnnual Review of Immunology.  33:475-504. 2015
    2015 Unique ligand-binding property of the human IgM Fc receptorJournal of Immunology.  194:1975-1982. 2015
    2015 Neonatal Exposure to Microbial Phosphorylcholine Dampens the Development of HDM Allergy Later in LifeJournal of Allergy and Clinical Immunology.  135:ab229. 2015
    2015 B cell autophagy mediates TLR7-dependent autoimmunity and inflammationAutophagy.  11:1010-1024. 2015
    2014 Microbicidal power of alpha radiation in sterilizing germinating Bacillus anthracis sporesAntimicrobial Agents and Chemotherapy.  58:1813-1815. 2014
    2014 Dosage of X-linked Toll-like receptor 8 determines gender differences in the development of systemic lupus erythematosusEuropean Journal of Immunology.  44:1503-1516. 2014
    2013 Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival 2013
    2013 The link between antibodies to oxldl and natural protection against pneumococci depends on dh gene conservationJournal of Experimental Medicine.  210:875-890. 2013
    2013 The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammationJournal of Investigative Dermatology.  133:2714-2721. 2013
    2012 Altered Ig levels and antibody responses in mice deficient for the Fc receptor for IgM (FcμR) 2012
    2012 Antibodies generated against conserved antigens expressed by bacteria and allergen-bearing fungi suppress airway diseaseJournal of Immunology.  189:2246-2256. 2012
    2012 Long-term maintenance of polysaccharide-specific antibodies by IgM-secreting cellsJournal of Immunology.  188:57-67. 2012
    2011 Cathelin-related antimicrobial peptide differentially regulates T- and B-cell functionEuropean Journal of Immunology.  41:3006-3016. 2011
    2011 Limiting CDR-H3 diversity abrogates the antibody response to the bacterial polysaccharide α 1→3 dextranJournal of Immunology.  187:879-886. 2011
    2011 Marginal zone B cells regulate antigen capture by marginal zone macrophagesJournal of Immunology.  186:2172-2181. 2011
    2010 Terminal deoxynucleotidyl transferase is required for an optimal response to the polysaccharide α-1,3 dextranJournal of Immunology.  184:851-858. 2010
    2010 ExsB, an unusually highly phosphorylated protein required for the stable attachment of the exosporium of Bacillus anthracisMolecular Microbiology.  76:1527-1538. 2010
    2009 Generation of B cell memory to the bacterial polysaccharide α-1,3 dextranJournal of Immunology.  183:6359-6368. 2009
    2009 PI3 Kinase Signals BCR-Dependent Mature B Cell SurvivalCell.  139:573-586. 2009
    2009 CD14-Mac-1 interactions in Bacillus anthracis spore internalization by macrophages 2009
    2008 Cathelicidin administration protects mice from Bacillus anthracis spore challengeJournal of Immunology.  181:4989-5000. 2008
    2008 PIR-B-deficient mice are susceptible to Salmonella infectionJournal of Immunology.  181:4229-4239. 2008
    2008 Cathelicidins protect mice from Bacillus anthracis spore challenge through their lytic and immunomodulatory abilities 2008
    2008 DNA Microarray Gene Expression Profile of Marginal Zone versus Follicular B cells and Idiotype Positive Marginal Zone B cells Before and After Activation 2008
    2008 The role of Terminal deoxynucleotidyl Transferase (TdT) in the T‐cell‐independent antibody response to α 1–3 Dextran 2008
    2008 VHJ558 transgenic mice: A model to study the development of polysaccharide specific B cells and the antibody response to gram‐negative bacteria 2008
    2008 B cell subpopulations and secondary lymphoid organ architectureSeminars in Immunology.  20:1-3. 2008
    2008 The integrin Mac-1 (CR3) mediates internalization and directs Bacillus anthracis spores into professional phagocytes 2008
    2008 CD36 is differentially expressed on B cell subsets during development and in responses to antigenJournal of Immunology.  180:230-237. 2008
    2008 DNA microarray gene expression profile of marginal zone versus follicular B cells and idiotype positive marginal zone B cells before and after immunization with Streptococcus pneumoniaeJournal of Immunology.  180:6663-6674. 2008
    2007 PIR-B-Deficient Mice Are Susceptible to Salmonella Infection.Blood.  110:2420-2420. 2007
    2007 Lupus susceptibility genes may breach tolerance to DNA by impairing receptor editing of nuclear antigen-reactive B cellsJournal of Immunology.  179:1340-1352. 2007
    2007 Non-uniform assembly of the Bacillus anthracis exosporium and a bottle cap model for spore germination and outgrowthMolecular Microbiology.  64:359-367. 2007
    2007 Susceptibility of PIR-B deficient mice to Salmonella infection (101.1)Journal of Immunology.  178:s200-s200. 2007
    2006 Fc receptor homolog 3 is a novel immunoregulatory marker of marginal zone and B1 B cellsJournal of Immunology.  177:6815-6823. 2006
    2006 The ExsY protein is required for complete formation of the exosporium of Bacillus anthracisJournal of Bacteriology.  188:7440-7448. 2006
    2006 Toll-like Receptor 7-Dependent Loss of B Cell Tolerance in Pathogenic Autoantibody Knockin MiceImmunity.  25:429-440. 2006
    2006 Erratum: Monoclonal antibodies for Bacillus anthracis spore detection and functional analyses of spore germination and outgrowth (Journal of Immunology (2006) 176 (6076-6084))Journal of Immunology.  177:2024. 2006
    2006 Monoclonal antibodies for Bacillus anthracis spore detection and functional analyses of spore germination and outgrowth.Journal of Immunology.  177:2024-2024. 2006
    2006 Monoclonal antibodies for Bacillus anthracis spore detection and functional analyses of spore germination and outgrowthJournal of Immunology.  176:6076-6084. 2006
    2006 Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen 2006
    2005 Characterization of the exosporium basal layer protein BxpB of Bacillus anthracisJournal of Bacteriology.  187:5868-5876. 2005
    2005 Marginal zone B cells in lymphocyte activation and regulationCurrent Opinion in Immunology.  17:244-250. 2005
    2005 Innate-like B cells 2005
    2005 Isoforms of terminal deoxynucleotidyltransferase: Developmental aspects and functionAdvances in Immunology.  86:113-136. 2005
    2005 Marginal zone B cell physiology and disease.Current directions in autoimmunity.  8:91-123. 2005
    2004 Distinct and opposite activities of human terminal deoxynucleotidyltransferase splice variantsJournal of Immunology.  173:4009-4019. 2004
    2004 B cell positive selection: Road map to the primary repertoire?Journal of Immunology.  173:15-19. 2004
    2004 Marginal Zone, but Not Follicular B Cells, Are Potent Activators of Naive CD4 T CellsJournal of Immunology.  172:803-811. 2004
    2004 Development and selection of marginal zone B cellsImmunological Reviews.  197:192-205. 2004
    2003 Peptide Ligands that Bind Selectively to Spores of Bacillus subtilis and Closely Related SpeciesApplied and Environmental Microbiology.  69:6841-6847. 2003
    2003 Delayed lupus onset in (NZB × NZW)F1 mice expressing a human C-reactive protein transgeneArthritis and Rheumatism.  48:1602-1611. 2003
    2003 Identification of the immunodominant protein and other proteins of the Bacillus anthracis exosporiumJournal of Bacteriology.  185:1903-1910. 2003
    2002 Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responsesImmunity.  17:341-352. 2002
    2002 Activated α4 integrins are preferentially expressed on immature thymocytes and activated T cellsJournal of Immunology Research.  9:73-84. 2002
    2002 CD9 is a unique marker for marginal zone B cells, B1 cells, and plasma cells in miceJournal of Immunology.  168:5605-5611. 2002
    2002 Distinct and opposite diversifying activities of terminal transferase splice variantsNature Immunology.  3:457-462. 2002
    2002 Marginal-zone B cellsNature Reviews Immunology.  2:323-335. 2002
    2001 Bacillus Spore Inactivation Methods Affect Detection AssaysApplied and Environmental Microbiology.  67:3665-3670. 2001
    2001 B1 cells: Similarities and differences with other B cell subsetsCurrent Opinion in Immunology.  13:195-201. 2001
    2001 Ku80 is required for addition of N nucleotides to V(D)J recombination junctions by terminal deoxynucleotidyl transferaseNucleic Acids Research.  29:1638-1646. 2001
    2001 Antigen receptor proximal signaling in splenic B-2 cell subsetsJournal of Immunology.  166:3122-3129. 2001
    2001 Autoreactivity by design: Innate B and T lymphocytesNature Reviews Immunology.  1:177-186. 2001
    2001 Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigensImmunity.  14:617-629. 2001
    2001 The long isoform of terminal deoxynucleotidyl transferase enters the nucleus and, rather than catalyzing nontemplated nucleotide addition, modulates the catalytic activity of the short isoformJournal of Experimental Medicine.  193:89-99. 2001
    2000 B-cell subsets and the mature preimmune repertoire. Marginal zone and B1 B cells as part of a ″natural immune memory″Immunological Reviews.  175:70-79. 2000
    2000 Terminal deoxynucleotidyl transferase and repertoire developmentImmunological Reviews.  175:150-157. 2000
    2000 Immune recognition of OxLDL in atherosclerosisJournal of Clinical Investigation.  105:1683-1685. 2000
    2000 Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btkImmunity.  12:39-49. 2000
    2000 Selection in the mature B cell repertoireCurrent Topics in Microbiology and Immunology.  252:97-105. 2000
    2000 The arthus reaction in rodents: Species-specific requirement of complementJournal of Immunology.  164:463-468. 2000
    1999 Partial IgA-deficiency with increased Th2-type cytokines in TGF-β1 knockout miceJournal of Immunology.  163:1951-1957. 1999
    1999 IgM(high)CD21(high) lymphocytes enriched in the splenic marginal zone generate effector cells more rapidly than the bulk of follicular B cellsJournal of Immunology.  162:7198-7207. 1999
    1999 A developmental bias in reading frame usage by human fetal thymic TCRBDJ transcripts is not present in genomic TCRBDJ rearrangementsJournal of Immunology Research.  7:9-15. 1999
    1999 Ab 93 antigen: Mouse FcγRII and FcγRIIIHybridoma.  18:211. 1999
    1999 CD21(high) IgM(High) splenic B cells enriched in the marginal zone: Distinct phenotypes and functionsCurrent Topics in Microbiology and Immunology.  246:45-52. 1999
    1999 Increased junctional diversity in fetal B cells results in a loss of protective anti-phosphorylcholine antibodies in adult miceImmunity.  10:607-617. 1999
    1999 Independently ligating CD38 and FcγRIIB relays a dominant negative signal to B cellsHybridoma.  18:113-119. 1999
    1998 T and B cell development in BP-1/6C3/aminopeptidase A-deficient miceJournal of Immunology.  160:4681-4687. 1998
    1998 Generation of the germline peripheral B cell repertoire: VH81X-λ B cells are unable to complete all developmental programsJournal of Immunology.  160:3748-3758. 1998
    1998 In vivo generation and function of CD21high IGMHIGH (MZ) B cells is BTK dependent and T independent 1998
    1998 Ontogeny of the autoreactive and anti-Streptococcus sanguis antibody repertoire in human infants 1998
    1998 Repertoire changes and loss of B lineage cells in TDT transgenic mice 1998
    1998 Splenic CD21high IGMhigh (MZ) B cells can quickly generate into plasma cells after in-vivo T-independent antigen stimulation 1998
    1997 AC133, a Novel Marker for Human Hematopoietic Stem and Progenitor CellsBlood.  90:5002-5012. 1997
    1997 AC133, a novel marker for human hematopoietic stem and progenitor cells.Blood.  90:5002-5012. 1997
    1997 Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responsesEuropean Journal of Immunology.  27:2366-2374. 1997
    1997 Fetal B cell developmentImmunology Letters.  56:98. 1997
    1997 Development of V(H)81X transgene-bearing B cells in fetus and adult: Sites for expansion and deletion in conventional and CD5/B1 cellsInternational Immunology.  9:493-505. 1997
    1997 Isolation and purification of CD14-negative mucosal macrophages from normal human small intestineImmunotechnology : an international journal of immunological engineering.  202:1-11. 1997
    1997 Evidence for selection of a population of multi-reactive B cells into the splenic marginal zoneInternational Immunology.  9:27-41. 1997
    1997 Mouse CD38 Is Down-Regulated on Germinal Center B Cells and Mature Plasma CellsJournal of Immunology.  158:1108-1115. 1997
    1997 B cell development in miceInternational Reviews of Immunology.  15:207-241. 1997
    1996 A novel murine integrin β subunit associates with α4 and is involved in lymphocyte trafficking 1996
    1996 Loss of fetal and neonatal B cells in TDT transgenic mice 1996
    1996 Lymphoid precursors in the human fetal mesentery 1996
    1996 Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif.International Immunology.  8:1195-1203. 1996
    1996 Generation and function of natural self-reactive B lymphocytesSeminars in Immunology.  8:19-27. 1996
    1995 Sequence analysis and antigen binding characteristics of Ig SCID Ig+; miceInternational Immunology.  7:807-819. 1995
    1995 Development of the Mouse B‐Cell RepertoireAnnals of the New York Academy of Sciences.  764:207-221. 1995
    1995 Do CD5 B cells respond to oral antigens?Advances in Experimental Medicine and Biology.  371:1439-1444. 1995
    1995 T cell activation through Thy-1 is associated with the expression of a surface protein(p100) on a subset of CD4 cellsInternational Immunology.  7:607-616. 1995
    1994 Immunofluorescence analysis of B-1 cell ontogeny in the mouseInternational Immunology.  6:355-361. 1994
    1994 CD5 transgenic miceCurrent Topics in Microbiology and Immunology.  194:209-217. 1994
    1994 Effects of Igm Allotype Suppression on Serum Igm Levels, B-L and B-2 Cells, and Antibody Responses Ir Allotype Heterozygous Fi MiceJournal of Immunology Research.  4:27-41. 1994
    1994 Formation of Autoantibodies, Including Anti-Cytokine Antibodies, Is a Hallmark of the Immune Response of Early B CellsJournal of Interferon and Cytokine Research.  14:151-152. 1994
    1994 Lymphopoiesis todayTrends in Immunology.  15:255-257. 1994
    1994 Synergistic induction of thermotolerance in murine natural killer cells by interferon α and mild heat shockRadiation Research.  139:364-369. 1994
    1993 Normal B lymphocyte differentiation.Best Practice and Research: Clinical Haematology.  6:785-806. 1993
    1993 3 Normal B lymphocyte differentiationBest Practice and Research: Clinical Haematology.  6:785-806. 1993
    1993 CD5+ B-cell networksCurrent Opinion in Immunology.  5:223-226. 1993
    1993 Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide: V. In vivo expression of individual antibody clones is dependent on Ig C(H) haplotypes and the categories of antigenJournal of Immunology.  151:4352-4361. 1993
    1992 Characterization, specificity, and lgV gene usage of anti-lymphocyte monoclonal antibodies from perinatal miceInternational Immunology.  4:1073-1084. 1992
    1992 The expression of the mouse VpreB/λ5 locus in transformed cell lines and tumors of the B lineage differentiation pathwayInternational Immunology.  4:831-840. 1992
    1992 Continuous anti-interleukin 10 antibody administration depletes mice of ly-1 b cells but not conventional b cellsJournal of Experimental Medicine.  175:1213-1220. 1992
    1992 The human fetal omentum: A site of B cell generationJournal of Experimental Medicine.  175:397-404. 1992
    1992 Development and function of the early b cell repertoireInternational Reviews of Immunology.  8:247-257. 1992
    1992 Early B-cell repertoiresCurrent Topics in Microbiology and Immunology.  182:81-84. 1992
    1992 Effect of a VH81X‐Expressing IgM Antibody on Early B‐Cell DevelopmentAnnals of the New York Academy of Sciences.  651:160-161. 1992
    1992 Identification of a surface protein (p100) associated with two glycosyl‐phosphatidylinositol‐linked molecules (Thy‐1 and ThB) by natural anti‐lymphocyte autoantibodiesEuropean Journal of Immunology.  22:2373-2380. 1992
    1992 Idiotypic Regulation of Development of the B‐Cell RepertoireAnnals of the New York Academy of Sciences.  651:336-345. 1992
    1992 Perinatally Derived Antiidiotypic Antibodies from the Antipolyfructosan Immune Response: Molecular Analysis of Idiotype RegulationAnnals of the New York Academy of Sciences.  651:316-318. 1992
    1992 The Fetal Omentum in Mice and Humans: A Site Enriched for Precursors of CD5 B Cells Early in DevelopmentAnnals of the New York Academy of Sciences.  651:10-20. 1992
    1991 An embryonic source of Ly1 but not conventional B cellsInternational Immunology.  3:543-550. 1991
    1991 Antigen-Independent Selection of T15 Idiotype During B-Cell Ontogeny in MiceJournal of Immunology Research.  1:203-212. 1991
    1991 Functional Relationship between T15 and J558 Idiotypes in Balb/C MiceJournal of Immunology Research.  1:213-224. 1991
    1991 Thymus-dependent network responses to a monoclonal cross-reactive antiidiotypic antibodyJournal of Immunology.  147:1849-1855. 1991
    1990 Association of transport-defective light chains with immunoglobulin heavy chain binding proteinMolecular Immunology.  27:623-630. 1990
    1990 Thymus-dependent antiidiotype and anti-antiidiotype responses to a dinitrophenyl-specific monoclonal antibodyJournal of Immunology.  145:202-208. 1990
    1989 Early rearrangements of genes encoding murine immunoglobulin kappa chains, unlike genes encoding heavy chains, use variable gene segments dispersed throughout the locus. 1989
    1989 Idiotypes and B cell developmentChemical immunology and allergy.  48:1-13. 1989
    1989 Immune status of a μ, χ transgenic mouse line. Deficient response to bacterially related antigensEuropean Journal of Immunology.  19:459-468. 1989
    1989 Pauciclonal B cell involvement in production of immunoglobulin in scid Ig+ mice.Current Topics in Microbiology and Immunology.  152:137-147. 1989
    1989 Reconstitution of lymphocyte subsets in scid mice by transplantation of fetal primordia.Current Topics in Microbiology and Immunology.  152:161-168. 1989
    1989 The role of idiotypic interactions and B-cell subsets in development of the B-cell repertoire 1989
    1988 A role for human heavy chain binding protein in the developmental regulation of immunoglobin transportMolecular Immunology.  25:585-595. 1988
    1988 Activation of a functional idiotype network response by monoclonal antibody specific for a virus (M-MuLV)-induced tumor antigenJournal of Immunology.  140:3266-3272. 1988
    1988 Regulatory influences of neonatal multispecific antibodies on the developing b cell repertoireInternational Reviews of Immunology.  3:117-131. 1988
    1987 Monoclonal anti-Id antibodies react with varying proportions of human B lineage cellsJournal of Immunology.  138:4150-4158. 1987
    1987 Monoclonal IgM antibodies that inhibit primary Moloney murine sarcoma growth 1987
    1987 A Possible Cause of Myasthenia Gravis: Idiotypic Networks Involving Bacterial AntigensAnnals of the New York Academy of Sciences.  505:461-471. 1987
    1987 Analysis with antiidiotype antibody of a patient with chronic lymphocytic leukemia and a large cell lymphoma (Richter's syndrome)Blood.  70:45-50. 1987
    1987 Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding protein 1987
    1987 Idiotypes and autoimmunity.Novartis Foundation symposium.  129:109-122. 1987
    1987 Probing functional sites on complement protein B with monoclonal antibodies: Evidence for C3b-binding sites on BaJournal of Immunology.  138:1143-1149. 1987
    1987 The role of immunoglobulin heavy chain binding protein. in immunoglobulin transportTrends in Immunology.  8:111-114. 1987
    1987 The role of immunoglobulin heavy chain binding protein. in immunoglobulin transportTrends in Immunology.  8:111-114. 1987
    1986 Mouse monoclonal antibodies against bromelain-treated mouse erythrocytes: Reactivity with erythrocytes of various species of animals and idiotypesCellular Immunology.  102:241-250. 1986
    1986 Idiotypic network connectivity and a possible cause of myasthenia gravisJournal of Experimental Medicine.  164:1310-1318. 1986
    1986 Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiencyCell.  46:963-972. 1986
    1986 In Vitro Effect of Monoclonal Anti-ldiotype Antibodies (Anti-M104E) on MOPC 104E Myeloma CellsCancer Research.  46:1250-1254. 1986
    1986 Analysis of the hepatobiliary transport of IgA with monoclonal anti-idiotype and anti-allotype antibodiesMolecular Immunology.  23:339-346. 1986
    1986 Clonotypic analysis of the fetal B cell repertoire: Evidence for an early and predominant expression of idiotypes associated with the V(H) 36-60 familyThe Journal of molecular and cellular immunology : JMCI.  2:283-292. 1986
    1986 Functional characterization of monoclonal auto‐antiidiotype antibodies isolated from the early B cell repertoire of BALB/c miceEuropean Journal of Immunology.  16:1151-1158. 1986
    1986 Functional idiotype networks during B-cell ontogenyResearch in immunology.  137:77-82. 1986
    1986 Idiotype‐Directed Interactions during Ontogeny Play a Major Role in the Establishment of the Adult B Cell RepertoireImmunological Reviews.  94:39-50. 1986
    1986 In vivo suppression of perinatal multispecific B cells results in a distortion of the adult B cell repertoireEuropean Journal of Immunology.  16:1159-1165. 1986
    1986 Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas 1986
    1985 Induction of germ-line anti-α1-3 dextran antibody responses in mice by members of the enterobacteriaceae familyJournal of Immunology.  135:3468-3472. 1985
    1985 Analysis of V region diversity and specificities of neonatal B cells 1985
    1985 Analysis of the hepatobiliary transport of polymeric IgA with monoclonal anti-allotypic antibodies 1985
    1985 Antiidiotypic antibodiesMethods in Enzymology.  VOL. 116:174-189. 1985
    1985 Developmentally controlled expression of immunoglobulin VH genesScience.  227:1597-1601. 1985
    1985 Differential effects of monoclonal anti-idiotype antibodies on MOPC 104E myeloma 1985
    1985 Isolation and characterization of hybridomas with auto-anti-idiotype activity from newborn Balb/c mice 1985
    1985 The association of immunoglobulin heavy chain binding protein with unassembled immunoglobulin heavy chains occurs within the rough endoplasmic reticulum 1985
    1984 A biological consequence of variation in the site of D-JH gene rearrangementNature.  311:376-379. 1984
    1984 Ontogeny of B cell precursors responding to α1->3 dextran in BALB/c miceJournal of Immunology.  133:2323-2326. 1984
    1984 Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell linesNature.  311:727-733. 1984
    1984 Monoclonal antibodies against protease-sensitive pneumococcal antigens can protect mice from fatal infection with Streptococcus PneumoniaeJournal of Experimental Medicine.  160:386-397. 1984
    1984 Quantitation of complement factor D in human serum by a solid-phase radioimmunoassayImmunotechnology : an international journal of immunological engineering.  67:303-309. 1984
    1984 Isotype specificity of helper T cell clones peyer’s patch Th cells preferentially collaborate with mature IgA B cells for IgA responsesJournal of Experimental Medicine.  159:798-811. 1984
    1984 A role for immunoglobulin heavy chain binding protein in the intracellular transport or processing of immunoglobulin in heavy chains 1984
    1984 Analysis of the reactivity of four anti-mouse IgM allotype antibodies with μ+ B lineage cells at various stages of differentiationJournal of Immunology.  133:2098-2103. 1984
    1984 Cellular expression of idiotopes defined by monoclonal antibodiesEuropean Journal of Immunology.  14:623-628. 1984
    1984 Identification and characterization of an apparent germline set of auto-anti-idiotypic regulatory B lymphocytesJournal of Immunology.  132:44-121. 1984
    1984 Ontogeny of 1->3 dextran positive B cell precursors in mice 1984
    1984 Programmed expression of immunoglobulin V(H) genes during murine development 1984
    1984 The use of monoclonal antibodies as probes of the three-dimensional structure of human complement factor DJournal of Immunology.  132:809-815. 1984
    1983 Fine idiotype analysis of b cell precursors in the t-dependent and t-independent responses to αl→3 dextran in balb/c miceJournal of Experimental Medicine.  158:2081-2094. 1983
    1983 Localization of the phosphocholine-binding sites on C-reactive protein by immunoelectron microscopyJournal of Immunology.  131:2411-2415. 1983
    1983 Naturally occurring anti-idiotypic antibodies in myasthenia gravis patientsNature.  301:611-614. 1983
    1983 Nonrandom Escape of Tumor Cells from Immune Lysis Due to Intraclonal Fluctuations in Antigen ExpressionCancer Research.  43:4050-4056. 1983
    1983 An enzyme-linked immunoabsorbent assay for measuring antibodies against muscle acetylcholine receptorImmunotechnology : an international journal of immunological engineering.  57:111-119. 1983
    1983 Analysis of Idiotypic Heterogeneity in the Anti‐α1–3 Dextran and Anti‐Phosphorylcholine Responses Using Monoclonal Anti‐Idiotype AntibodiesAnnals of the New York Academy of Sciences.  418:151-169. 1983
    1983 Analysis of the anti-α1→3 dextran response with monoclonal anti-idiotype antibodiesJournal of Immunology.  131:1375-1379. 1983
    1983 Ten percent of normal B cells and plasma cells share A V(H) determinants) (J606-GAC) with a distinct subset of murine V(H)III plasmacytomasJournal of Immunology.  130:2423-2428. 1983
    1982 CRP-associated determinant expressed by human monocytes 1982
    1982 Structural and biological properties of a monoclonal auto-anti-(anti- idiotype) antibodyNature.  299:447-449. 1982
    1982 Studies on the clonal origin of human B cell leukemia using monoclonal anti-idiotype antibodiesJournal of Immunology.  129:904-910. 1982
    1982 Immunoglobulin VH determinants defined by monoclonal antibodiesJournal of Experimental Medicine.  156:1010-1024. 1982
    1982 Immunoglobulin isotype expression of normal pre-B cells as determined by immunofluorescenceJournal of Clinical Immunology.  2:264-269. 1982
    1982 Murine peyer’s patch T cell clones: Characterization of antigen-specific helper T cells for immunoglobulin a responsesJournal of Experimental Medicine.  156:1115-1130. 1982
    1982 A monoclonal antibody (MMA) thet identifies a differentiation antigen on human myelomonocytic cellsClinical Immunology.  23:172-188. 1982
    1982 Anti-DNA autoantibodies in (NZB x NZW)F1 mice are clonally heterogeneous, but the majority share a common idiotypeJournal of Immunology.  128:668-674. 1982
    1982 CRP-associated determinant expressed by human monocytes 1982
    1982 Demonstration of calcium-induced conformational change(s) in C-reactive protein by using monoclonal antibodiesMolecular Immunology.  19:1159-1165. 1982
    1982 Enhancement of in Vitro Immune Responses of Murine Peyer's Patch Cultures by Concanavalin A, Muramyl Dipeptide and LipopolysaccharideScandinavian Journal of Immunology.  15:329-339. 1982
    1982 Estimate of the light chain repertoire size of fetal and adult BALB/cJ and CBA/J miceJournal of Immunology.  129:673-677. 1982
    1982 Human blood monocytes and platelets share a cell surface componentBlood.  60:767-771. 1982
    1981 Light chain isotypes selectively associate with heavy chain idiotypes in T-dependent and T-independent dextran-specific precursorsNature.  292:629-631. 1981
    1981 Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 Streptococcus pneumoniaeJournal of Experimental Medicine.  153:694-705. 1981
    1981 Structural analysis of the μ-chains synthesized by fetal liver hybridomasJournal of Immunology.  126:1346-1350. 1981
    1981 Anti-immunoglobulin antibodies. II. Expression of individual and cross-reactive idiotypes on syngeneic and homologous anti-idiotype antibodiesJournal of Immunology.  127:491-495. 1981
    1981 Cross-reactivity between C-reactive protein and idiotypic determinants on a phosphocholine-binding murine myeloma proteinJournal of Experimental Medicine.  153:1604-1614. 1981
    1981 INTERACTION OF HUMAN ANTIBODY AND MURINE MONOCLONAL ANTIBODY WITH MUSCLE ACETYLCHOLINE RECEPTORAnnals of the New York Academy of Sciences.  377:143-157. 1981
    1981 Monoclonal vs. heterogeneous anti‐H‐8 antibodies in the analysis of the anti‐phosphorylcholine response in BALB/c miceEuropean Journal of Immunology.  11:877-883. 1981
    1981 Organization and expression of immunoglobulin genes in fetal liver hybridomas 1981
    1980 Differentiation of human B cells expressing the IgA subclasses as demonstrated by monoclonal hybridoma antibodiesJournal of Immunology.  125:2311-2316. 1980
    1980 Effects of Anti‐Ig Antibodies on the Development and Differentiation of B CellsImmunological Reviews.  52:29-53. 1980
    1980 Immunoglobulin gene rearrangement in immature B cellsScience.  209:1366-1369. 1980
    1980 Studies on phosphorylcholine-specific T cell idiotypes and idiotype-specific immunityMolecular Immunology.  17:823-831. 1980
    1979 A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell linesJournal of Immunology.  123:1548-1550. 1979
    1979 Evidence that murine pre-B cells synthesise mu; heavy chains but no light chains [11]Nature.  280:838-841. 1979
    1978 B cell differentiation induced by lipopolysaccharide. V. Suppression of plasma cell maturation by anti-μ: mode of action and characteristics of suppressed cellsJournal of Immunology.  120:158-166. 1978
    1978 Pre-B cells: Bone marrow persistence in anti-μ-suppressed mice, conversion to B lymphocytes, and recovery after destruction by cyclophosphamideJournal of Immunology.  120:1526-1531. 1978
    1978 Sequential expression of immunoglobulin on developing mouse B lymphocytes: a systematic survey that suggests a model for the generation of immunoglobulin isotype diversityJournal of Immunology.  120:2041-2049. 1978
    1978 Generation of clonal and isotype diversity.Advances in Experimental Medicine and Biology.  107:9-17. 1978
    1978 Immunoglobulin isotype expression.Contemporary topics in immunobiology.  8:245-265. 1978
    1977 Ontogeny of Ia and IgD on IgM-bearing B lymphocytes in mice*Journal of Experimental Medicine.  146:297-301. 1977
    1976 B cell differentiation induced by lipopolysaccharide. IV. Development of immunoglobulin class restriction in precursors of IgG synthesizing cellsJournal of Immunology.  117. 1976
    1976 B lymphocyte differentiation induced by lipopolysaccharide. III. Suppression of B cell maturation by anti mouse immunoglobulin antibodiesJournal of Immunology.  116:1664-1668. 1976
    1976 Generation of immunoglobulin class diversity in B cells: a discussion with emphasis on IgD developmentResearch in immunology.  127 C:573-581. 1976
    1976 Relationship between β2 microglobulin and cell surface alloantigens of the mouseJournal of Immunology.  117:1532-1537. 1976
    1976 Studies of generation of B cell diversity in mouse, man, and chicken Origins of Lymphocyte Diversity 1976
    1975 B lymphocyte differentiation induced by lipopolysaccharide. I. Generation of cells synthesizing four major immunoglobulin classesJournal of Immunology.  115:671-676. 1975
    1975 B lymphocyte differentiation induced by lipopolysaccharide. II. Response of fetal lymphocytesJournal of Immunology.  115:677-681. 1975
    1975 Ontogeny of B lymphocytes in mice: induction of polyclonal immunoglobulin synthesis by lipopolysaccharide 1975
    1974 T and B lymphocytesJournal Of Oral Pathology and Medicine.  3:151-166. 1974

    Chapter

    Year Title Altmetric
    2018 Expression of idiotypes and anti-idiotypes during development: Frequencies and functional significance in the acquisition of the adult B-cell repertoire.  75-89. 2018
    2015 Chapter 7 Development and Function of B Cell Subsets.  99-119. 2015
    2015 Development and Function of B Cell Subsets.  99-119. 2015
    2004 Chapter 10 Development and Function of B Cell Subsets.  155-160. 2004
    2004 Development and Function of B Cell Subsets.  155-160. 2004
    1998 Hybridomas, B Cell.  1148-1151. 1998
    1989 Idiotypes and B Cell Development.  1-13. 1989
    1989 Idiotypes and B Cell Development.  1-13. 1989
    1986 Idiotype-Directed Interactions during B Cell Ontogeny.  368-375. 1986
    1984 Chapter 11 Selective Alteration of the Humoral Response to α1-3 Dextran and Phosphorylcholine by Early Administration of Monoclonal Antiidiotype Antibody.  187-202. 1984
    1984 Chapter 18 Idiotypes in Myasthenia Gravis.  347-364. 1984
    1982 MONOCLONAL IgM ANTIBODIES THAT INDUCE T CELL-MEDIATED CYTOTOXICITY OF MURINE SARCOMA CELLS.  538. 1982
    1980 Immunoglobulin Diversity.  437-466. 1980
    1978 Immunoglobulin Isotype Expression.  245-265. 1978
    Regulation of Idiotypic Profiles: Expected Dominance and Paradoxical Loss of T15 Expression.  215-224.

    Research Overview

  • Based on long-term studies in mouse models our long-range goals are to now study the ontogenetic development of human B cell repertoires to organisms of clear relevance to human health.
  • Principal Investigator On

  • Analysis of Human and Mouse Antibodies to Beta Cell Antigens Bearing N-Acetyl Glucosamine Post-Translation Modifications and their Potential to Prevent Human Type 1 Diabetes  awarded by Juvenile Diabetes Research Foundation International
  • Antibodies to Beta Cell GlcNAc - Modified Autoantigens Blocks T1D in NOD Mice  awarded by Juvenile Diabetes Research Foundation International
  • Antibody Induction by Group B Streptococcal Vaccines for Protection against Fungal Infections  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Characterization of B-Lymphocytes in the Cutaneous Immune System  awarded by ALABAMA LYME DISEASE ASSOCIATION
  • Commensal-Dependent Maturation of the Natural IgM Repertoire  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Effects of Neonatal Microbial Exposure on Anti-Polysaccharide B Cell Development  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Effects of Neonatal Microbial Exposure on Anti-polysaccharide B Cell Development  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Immunobiology of Bacillus Anthracis Spore-Host Interactions  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Modulation of Allergic Asthma by B Cells and Antibodies  awarded by Sandler Program for Asthma Research
  • Modulation of Autoimmune Diabetes by N-acetyl-D-glucosamine Specific B Cells  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Natural Antibody Idiotopes as Biomarkers for Progression in The At-risk Setting for Type 1 Diabetes  awarded by Juvenile Diabetes Research Foundation International
  • Protective Effects of Anti-BclA Antibodies in Bacillus Anthracis Infection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Regulation of B Cell Clonal Diversity  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Regulation of B Cell Clonal Diversity and Its Role in Disease  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Regulation of B Cell Clonal Diversity and Its Role in Disease  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Role of Aryl Hydrocarbon Receptor in B Cell Development and Function  awarded by American Heart Association (Southeast Affiliate)
  • The Influence of Anti-N-Acetyl-D-Glucosamine B Cells on Type One Diabetes in Mice  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • The Role of IL-10 Secreting MZ B Cells in Response to a Bacterial Challenge  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Tissue and Organ Specific Human B Cell Immunity - Project 1: Development and Maintenance of Human Glycan and Phospholipid Antibody Repertoires  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Teaching Overview

  • Lectures in Fundamental Immunology.
  • Education And Training

  • Doctor of Philosophy in Microbiological Sciences and Immunology, University of Melbourne 1973
  • Bachelor's Degree in Dental Clinical Sciences, The University of Adelaide 1969
  • Full Name

  • John Kearney