Positions

Overview

  • Dr. Mountz is a Professor of Medicine and Director of the UAB Recombinant Inbred Strain Facility. Dr. Mountz is the Co-Director of the UAB Bone Center, the UAB Center for Aging, Basic Biology Component, and is a Physician at the Birmingham Veterans Administration Medical Center. Dr. Mountz is the recipient of the J. W. & Virginia Goodwin-Warren D. Blackburn, Jr. Research Chair in Rheumatology (2002) and recipient of the Max Cooper Award for Excellence in Research (2003). Dr. Mountz was designated one of 50 Arthritis Foundation ¡§Heroes¡¨for outstanding contributions for research in Rheumatology (2002). Dr. Mountz was Co-Chair of the National Institutes on Aging Task Force on Immunology and Aging and Co-Chair of the ¡§Leukocyte Trafficking in Inflammatory Disease¡¨ symposium at the 2004 annual meeting of the American Association of Immunologists. Dr. Mountz received a Ph.D. in High Energy Physics and graduated Summa Cum Laude before carrying out a post-doctoral fellowship in the area of biophysics studying bilayer lipid membranes. Dr. Mountz then received an MD from Ohio State University and carried out an internship of residency and a one-year fellowship in Internal Medicine in Rheumatology. Dr. Mountz was a research staff fellow at the National Institutes of Health for five years and also an Assistant Professor of Medicine at the Naval Bethesda Medical Center. During this time, Dr. Mountz was the first investigator to identify that Onco genes were elevated in autoimmune mice and humans. Dr. Mountz became an Assistant Professor of Medicine at The University of Alabama at Birmingham in 1987, where he produced the first transgenic mouse expressing Fas in T cells and ameliorated the lymphoproliferative autoimmune disease in /lpr (Fas mutant mice). Dr. Mountz then identified the Fas mutation in MRL-lpr/lpr mice as being an insertion of the Etn retrotransposon. Dr. Mountz also was the first investigator to study clono-deletion and energy induction in PCR transgenic mice on the lpr/lpr background. Dr. Mountz continues an active research program in lupus, arthritis, molecular nuclear imaging, immune response to virus and poxvirus and gene therapy, as well as T-cell senescence in aging in both mice and humans.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Autoreactive B cells in SLE, villains or innocent bystanders?Immunological Reviews.  292:120-138. 2019
    2018 Editorial: STATus of STAT3 in Psoriatic ArthritisArthritis and Rheumatology.  70:801-804. 2018
    2018 Unmasking Fucosylation: from Cell Adhesion to Immune System Regulation and DiseasesCell Chemical Biology.  25:499-512. 2018
    2018 Role of production of type I interferons by B cells in the mechanisms and pathogenesis of systemic lupus erythematosusDiscovery medicine.  25:21-29. 2018
    2014 Inhibition of fucosylation reshapes inflammatory macrophages and suppresses type II collagen-induced arthritisArthritis and Rheumatology.  66:2368-2379. 2014
    2014 Interleukin-21 promotes germinal center reaction by skewing the follicular regulatory T cell to follicular helper T cell balance in autoimmune BXD2 miceArthritis and Rheumatology.  66:2601-2612. 2014
    2013 Death receptor 5-targeted depletion of interleukin-23-producing macrophages, Th17, and Th1/17 associated with defective tyrosine phosphatase in mice and patients with rheumatoid arthritisArthritis and Rheumatism.  65:2594-2605. 2013
    2013 Extension of the germinal center stage of B cell development promotes autoantibodies in BXD2 miceArthritis and Rheumatism.  65:2703-2712. 2013
    2013 Inhibition of Rgs10 Expression Prevents Immune Cell Infiltration in Bacteria-induced Inflammatory Lesions and Osteoclast-mediated Bone DestructionBone Research.  1:267-281. 2013
    2012 Managing macrophages in rheumatoid arthritis by reform or removalCurrent Rheumatology Reports.  14:445-454. 2012
    2012 Systemic autoimmunity caused by fas deficiency in macrophages: A new perspective on the first identified autoimmunity geneArthritis and Rheumatism.  64:609-612. 2012
    2012 Treatment of arthritis by macrophage depletion and immunomodulation: testing an apoptosis-mediated therapy in a humanized death receptor mouse model.Arthritis and Rheumatism.  64:1098-1109. 2012
    2011 Longitudinal assessment of cognitive and psychosocial functioning after Hurricanes Katrina and Rita: Exploring disaster impact on middle-aged, older, and oldest-old adultsJournal of Applied Biobehavioral Research.  16:187-211. 2011
    2011 ReplyArthritis and Rheumatism.  63:3175-3177. 2011
    2011 Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 miceArthritis and Rheumatism.  63:2038-2048. 2011
    2011 Plant homologue constitutive photomorphogenesis 9 (COP9) signalosome subunit CSN5 regulates innate immune responses in macrophagesBlood.  117:4796-4804. 2011
    2011 Alloantigen specific deletion of primary human T cells by Fas ligand (CD95L)-transduced monocyte-derived killer-dendritic cellsImmunology.  133:115-122. 2011
    2011 Type i interferon-dependent CD86high marginal zone precursor b cells are potent T cell costimulators in miceArthritis and Rheumatism.  63:1054-1064. 2011
    2011 Cytokine regulation of B-cell migratory behavior favors formation of germinal centers in autoimmune disease.Discovery medicine.  11:76-85. 2011
    2011 mRNA editing, FAS, and systemic lupus erythematosus.Human Mutation.  32. 2011
    2010 Metabolic syndrome, hormones, and maintenance of T cells during agingCurrent Opinion in Immunology.  22:541-548. 2010
    2010 Visualizing CD4 T-cell migration into inflamed skin and its inhibition by CCR4/CCR10 blockades using in vivo imaging modelBritish Journal of Dermatology.  162:487-496. 2010
    2008 Cancer gene therapy using mesenchymal stem cells expressing interferon-β in a mouse prostate cancer lung metastasis model 2008
    2006 Principal component analysis of quantitative trait loci for immune response to adenovirus in miceHereditas.  143:189-197. 2006
    2006 Targeted and shielded adenovectors for cancer therapy 2006
    2006 Soluble human p55 and p75 tumor necrosis factor receptors reverse spontaneous arthritis in transgenic mice expressing transmembrane tumor necrosis factor αArthritis and Rheumatism.  54:2872-2885. 2006
    2006 In vivo analysis of adenovirus-specific cytotoxic T lymphocyte response in mice deficient in CD28, Fas ligand, and perforinHuman Gene Therapy.  17:669-682. 2006
    2006 Production of a novel class of polyreactive pathogenic autoantibodies in BXD2 mice causes glomerulonephritis and arthritisArthritis and Rheumatism.  54:343-355. 2006
    2006 Tumor necrosis factor ligand-receptor superfamily and arthritis.Current Directions in Autoimmunity.  9:37-54. 2006
    2005 Rheumatoid arthritis: safe and sound. 2005
    2005 Safe and sound 2005
    2005 Synovial fibroblasts promote osteoclast formation by RANKL in a novel model of spontaneous erosive arthritisArthritis and Rheumatism.  52:3257-3268. 2005
    2005 Primary adenovirus-specific cytotoxic T lymphocyte response occurs after viral clearance and liver enzyme elevation 2005
    2005 Impaired apoptosis and immune senescence - Cause or effect?Immunological Reviews.  205:130-146. 2005
    2005 Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblastsAmerican Journal of Pathology.  167:705-719. 2005
    2004 Nur77 family of nuclear hormone receptors 2004
    2004 Novel Tumor Necrosis Factor α-Regulated Genes in Rheumatoid ArthritisArthritis and Rheumatism.  50:420-431. 2004
    2004 Elimanation of activated but not resting primary human CD4+ and CD8+ T cells by Fas ligand (FasL/Cd95L)-expressing Killer-dendritic cellsImmunobiology.  208:463-475. 2004
    2004 Identification of multiple genetic loci that regulate adenovirus gene therapy 2004
    2003 Age-related thymic involution in C57BL/6J x DBA/2J recombinant-inbred mice maps to mouse chromosomes 9 and 10Genes and Immunity.  4:402-410. 2003
    2003 Impact of immune senescence on human agingImmunology and Allergy Clinics of North America.  23. 2003
    2003 Monkey see, monkey do 2003
    2003 Origin of late-onset autoimmune diseaseImmunology and Allergy Clinics of North America.  23:65-82. 2003
    2002 Immunobiology of tumor necrosis factor receptor superfamilyImmunologic Research.  26:323-336. 2002
    2002 Specific deletion of autoreactive T cells by adenovirus-transfected, Fas ligand-producing antigen-presenting cellsImmunologic Research.  26:235-246. 2002
    2002 BXD recombinant inbred mice represent a novel T cell-mediated immune response tumor modelInternational Journal of Cancer.  101:270-279. 2002
    2002 Local production of complement proteins in rheumatoid arthritis synoviumArthritis and Rheumatism.  46:934-945. 2002
    2002 Soluble Fas gene therapy protects against Fas-mediated apoptosis of hepatocytes but not the lethal effects of Fas-induced TNF-α production by Kupffer cellsCell Death and Differentiation.  9:626-635. 2002
    2001 Defective Fas Ligand-Mediated Apoptosis Predisposes to Development of a Chronic Erosive Arthritis Subsequent to Mycoplasma pulmonis InfectionArthritis and Rheumatism.  44:2146-2159. 2001
    2001 Defective Fas ligand-mediated apoptosis predisposes to development of a chronic erosive arthritis subsequent to Mycoplasma pulmonis infection.Arthritis and Rheumatism.  44:2146-2159. 2001
    2001 Regulation of tumor necrosis factor α-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase AktArthritis and Rheumatism.  44:1555-1567. 2001
    2001 Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt.Arthritis and Rheumatism.  44:1555-1567. 2001
    2001 Recombinant adenovirus expressing adeno-associated virus cap and rep proteins supports production of high-titer recombinant adeno-associated virus 2001
    2001 Treatment of chronic sialadenitis in a murine model of Sjögren's syndrome by local fasL gene transferArthritis and Rheumatism.  44:964-973. 2001
    2001 Treatment of chronic sialadenitis in a murine model of Sjögren's syndrome by local fasL gene transfer.Arthritis and Rheumatism.  44:964-973. 2001
    2001 Apoptosis and rheumatoid arthritis: past, present, and future directions.Current Rheumatology Reports.  3:70-78. 2001
    2001 Re: "collagen-induced arthritis in TNF receptor-1-deficient mice: TNF receptor-2 can modulate arthritis in the absence of TNF receptor 1"Clinical Immunology.  99:305-307. 2001
    2001 Regulation of apoptosis of synovial fibroblasts.Current Directions in Autoimmunity.  3:216-239. 2001
    2000 Adeno-associated virus production of soluble tumor necrosis factor receptor neutralizes tumor necrosis factor α and reduces arthritisHuman Gene Therapy.  11:2431-2442. 2000
    2000 Gene therapy that inhibits nuclear translocation of nuclear factor kappaB results in tumor necrosis factor alpha-induced apoptosis of human synovial fibroblasts.Arthritis and Rheumatism.  43:1094-1105. 2000
    2000 Gene therapy that inhibits nuclear translocation of nuclear factor κB results in tumor necrosis factor α-induced apoptosis of human synovial fibroblastsArthritis and Rheumatism.  43:1094-1105. 2000
    1999 Apoptosis and cell death in the endocrine system 1999
    1999 Specific targeting of activated endothelium in rat adjuvant arthritis with a 99mTc-radiolabeled E-selectin-binding peptide.Arthritis and Rheumatism.  42:641-649. 1999
    1999 Specific targeting of activated endothelium in rat adjuvant arthritis with a 99mTc-radiolabeled e-selectin-binding peptideArthritis and Rheumatism.  42:641-649. 1999
    1999 Regulation of Fas-mediated apoptosis in CD2-fas transgenic miceInternational Reviews of Immunology.  18:309-327. 1999
    1998 Murine cytomegalovirus induces a Sjogren's syndrome-like disease in C57B1/6-lpr/lpr miceArthritis and Rheumatism.  41:2175-2184. 1998
    1998 Murine cytomegalovirus induces a Sjögren's syndrome-like disease in C57Bl/6-lpr/lpr mice.Arthritis and Rheumatism.  41:2175-2184. 1998
    1998 Inhibition of tumor necrosis factor α decreases inflammation and prolongs adenovirus gene expression in lung and liverHuman Gene Therapy.  9:1875-1884. 1998
    1998 Calmodulin antagonists inhibit apoptosis of CD4+ T-cells from patients with AIDS 1998
    1998 Imaging and tissue biodistribution of 99mTc-labeled adenovirus knob (serotype 5) 1998
    1998 Reduction of arthritis and pneumonitis in motheaten mice by soluble tumor necrosis factor receptorArthritis and Rheumatism.  41:139-149. 1998
    1998 Reduction of arthritis and pneumonitis in motheaten mice by soluble tumor necrosis factor receptor.Arthritis and Rheumatism.  41:139-149. 1998
    1997 Cell death and longevity: Implications of Fas-mediated apoptosis in T-cell senescenceImmunological Reviews.  160:19-30. 1997
    1997 Clinical features associated with correction of T-cell senescence: Increased acute-phase response, amyloidosis and arthritisDevelopmental and Comparative Immunology.  21:509-523. 1997
    1997 Persistent expression of a soluble form of Fas/APO1 in continuously activated T cells from a patient with SLEClinical and Experimental Rheumatology.  15:19-23. 1997
    1996 Role of calmodulin in HIV-potentiated fas-mediated apoptosisAmerican Journal of Pathology.  149:903-910. 1996
    1996 The role of programmed cell death as an emerging new concept for the pathogenesis of autoimmune diseases.Clinical immunology and immunopathology.  80:S2-14. 1996
    1996 Autoimmune disease results from multiple interactive defects in apoptosis induction molecules and signaling pathways.Behring Institute Mitteilungen.  200-219. 1996
    1996 Use of sensitive assays to detect soluble Fas in patients with systemic lupus erythematosus: comment on the article by Knipping et al and the article by Goel et al.Arthritis and Rheumatism.  39:1611-1612. 1996
    1995 Defective expression of hematopoietic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas-mediated apoptosisImmunity.  2:353-362. 1995
    1995 Differential expression of human Fas mRNA species upon peripheral blood mononuclear cell activationBiochemical Journal.  310:957-963. 1995
    1995 Fibromyalgia in womenArthritis and Rheumatism.  38:926-938. 1995
    1994 Apoptosis defects analyzed in tcr transgenic and fas transgenic ipr miceInternational Reviews of Immunology.  11:321-342. 1994
    1994 Autoimmune disease. a problem of defective apoptosisArthritis and Rheumatism.  37:1415-1420. 1994
    1994 T Cell Influence on Superantigen‐Induced Arthritis in MRL‐lpr/lpr MiceArthritis and Rheumatism.  37:113-124. 1994
    1994 T cells of staphylococcal enterotoxin B‐tolerized autoimmune MRL‐lpr/lpr mice require co‐stimulation through the B7‐CD28/CTLA‐4 pathway for activation and can be reanergized in vivo by stimulation of the T cell receptor in the absence of this co‐stimulatory signalEuropean Journal of Immunology.  24:1019-1025. 1994
    1993 Murine models of autoimmune disease and Sjogren's syndromeCurrent Opinion in Rheumatology.  5:557-569. 1993
    1992 Murine models of autoimmune diseaseCurrent Opinion in Rheumatology.  4:621-629. 1992
    1992 Murine models of autoimmunity: T-cell and B-cell defectsCurrent Opinion in Rheumatology.  4:612-620. 1992
    1991 Murine models for systemic lupus erythematosus and Sjogren's syndromeCurrent Opinion in Rheumatology.  3:738-756. 1991
    1990 Animal models of systemic lupus erythematosus and Sjogren's syndromeCurrent Opinion in Rheumatology.  2:740-748. 1990
    1990 Production of trangenic mice and application to immunology and autoimmunityAmerican Journal of the Medical Sciences.  300:322-329. 1990
    1988 Characteristics and functions of CD4-, CD8- T cells in normal and autoimmune mice.Concepts in immunopathology.  6:89-118. 1988
    1988 Expression of the murine proto-oncogene bcl-2 is stage specific and cell-type specific.Current Topics in Microbiology and Immunology.  141:332-336. 1988
    1987 IL-2 Modulation of Murine T-Cell Oncogene Expression 1987
    1987 Subpopulations of CD4, CD8 thymocytesEuropean Journal of Immunology.  17:1387-1390. 1987
    1986 Studies of the Effects of Y Chromosome Factors on the Expression of Autoimmune DiseaseAnnals of the New York Academy of Sciences.  475:200-218. 1986
    1984 Recent advances in SLEClinical Immunology Newsletter.  5:33-37. 1984
    1984 Rheumatoid arthritis and small airways functionArthritis and Rheumatism.  27:728-736. 1984
    1984 Studies of immune defective RII AnN miceClinical immunology and immunopathology.  30:346-361. 1984
    1983 Neutrophil migration in response to chemotactic factors - Effects of generation conditions and chemotherapeutic agentsInflammation.  7:57-65. 1983
    1983 An autopsy study of the prevalence of monosodium urate and calcium pyrophosphate dihydrate crystal deposition in first metatarsophalangeal jointsArthritis and Rheumatism.  26:1522-1524. 1983
    1983 Bleomycin‐induced cutaneous toxicity in the rat: analysis of histopathology and ultrastructure compared with progressive systemic sclerosis (sclerodermaBritish Journal of Dermatology.  108:679-686. 1983
    1981 Ethambutol-Induced Toxic Epidermal NecrolysisArchives of Internal Medicine.  141:1677-1678. 1981
    1978 Bilayer lipid membranes (BLM): Study of antigen-antibody interactionsJournal of Bioenergetics and Biomembranes.  10:139-151. 1978
    1978 Photo‐galvano‐voltaic cell: A new approach to the use of solar energyInternational Journal of Energy Research.  2:197-200. 1978

    Chapter

    Year Title Altmetric
    2017 Regulation of negative selection in the thymus by cytokines: Novel Role of IL-23 to Regulate RORγt.  41-52. 2017
    2009 Gene therapy and immune senescence.  1629-1646. 2009

    Principal Investigator On

  • B Cell Intrinsic Interferon-beta Regulates Autoreactive B Cell Development  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • B-Cell Control Point Dysregulation in African Americans with SLE  awarded by LUPUS RESEARCH ALLIANCE
  • DR5 Glycosylation Mediates Apoptosis Resistance in RA Synovial Fibroblasts  awarded by Arthritis Foundation
  • Disruption of Autoreactive Germinal Centers as a Novel Therapy for Lupus  awarded by LUPUS RESEARCH ALLIANCE
  • Follicular Exclusion of Self Antigens Prevents Development of Autoantibodies  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • High Dimension Single Cell Omics in CFCC  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION
  • Induction of Apoptotic Cell Reactive B Cells by Type I IFN in BXD2 Mice  awarded by Lupus Foundation of America, Inc.
  • Laser and Filter Upgrade for the Flow Cytometers in CFCC at Shelby  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION
  • Next Generation Cell Sorting to Streamline Core Operation in CFCC  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION
  • Next Generation Flow Cytometer to Streamline Core Operation in CFCC  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION
  • Optimal Approach to Block M1 Macrophages/Th17 Inflammation in Arthritis  awarded by American College of Rheumatology
  • Private Grant  awarded by DAIICHI SANKYO COMPANY LTD
  • Rheumatic Diseases Core Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Rheumatic Diseases Core Center: Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Rheumatic Diseases Core Center: Core C - Analytic and Preparative Cytometry Facility  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Rheumatic Diseases Core Center: Pilot Project - P & F 6  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Rheumatic Diseases Research Core Centers (P30)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Rheumatic Diseases Research Core Centers - Core A: Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Rheumatic Diseases Research Core Centers - Core B: Comprehensive Flow Cytometry Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Suppression of Pathogenic Autoantibodies in Lupus by Inhibition of AID  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Training Program in Rheumatic and Musculoskeletal Diseases Research  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Investigator On

  • CbfB Mediates Articular Cartilage Regeneration and Repair in Aging  awarded by National Institute on Aging/NIH/DHHS
  • Cbfß Mediates Articular Cartilage Regeneration and Repair in Aging  awarded by National Institute on Aging/NIH/DHHS
  • Characterizing the Mechanism by which Endogenous Negative Regulators of Osteoclasts Control Bone Homeostasis under Physiological and Pathological Conditions in Mouse Models  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Characterizing the Negative Signaling in Dendritic Cells and Macrophages to Attenuate Inflammation and Bone Destruction in Rheumatoid Arthritis  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Cytokine Immunoregulatory Strategy to Target SLE Autoreactive B Cells  awarded by LUPUS RESEARCH ALLIANCE
  • Flow Cytometry Core Enhancement: ISS PC1 Photon Counting Spectrofluorimeter  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION
  • INvestigations In Gout, Hyperuricemia, and ComorbidiTies (INSIGHT) Center of Research Translation (CORT)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Improving Resolution and Throughput on the HRIF Institutional Core  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION
  • Inhibiting Periodontitis by Targeting Cathepsin K and Attenuating TLR Signaling  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS
  • Private Grant  awarded by DAIICHI SANKYO COMPANY LTD
  • REduCing Immunogenicity to PegloticasE (RECIPE)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Repopulation of Tolerogenic B Cells Post B Cell Depletion Therapy in Lupus  awarded by LUPUS RESEARCH ALLIANCE
  • Rheumatic Diseases Research Core Centers (P30)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • UAB Multidisciplinary Clinical Research Center (P60)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Education And Training

  • Doctor of Medicine, Ohio State University System : Columbus 1978
  • Doctor of Philosophy, Michigan State University 1974
  • Full Name

  • John Mountz