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Junqin Chen
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E-mail
jchen16@uab.edu
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Junqin Chen
Instructor
Positions
Scientist (C)
,
Comprehensive Diabetes Center
,
School of Medicine
Instructor (P)
,
Medicine - Endocrinology, Diabetes, and Metabolism
,
Department of Medicine
Publications
Research
Background
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Publications
Selected Publications
Academic Article
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Year
Title
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2022
Exploratory study reveals far reaching systemic and cellular effects of verapamil treatment in subjects with type 1 diabetes
.
Nature Communications
. 13.
2022
2022
Alpha Cell Thioredoxin-interacting Protein Deletion Improves Diabetes-associated Hyperglycemia and Hyperglucagonemia
2022
2022
Deletion of Gdf15 Reduces ER Stress-induced Beta-cell Apoptosis and Diabetes
2022
2021
Human Glucagon Expression Is under the Control of miR-320a
2021
2021
Human Glucagon Expression Is under the Control of miR-320a.
.
Endocrinology
. 162.
2021
2020
Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action
.
Cell Metabolism
. 32:353-365.e8.
2020
2019
Serum mir-204 is an early biomarker of type 1 diabetes-associated pancreatic beta-cell loss
2019
2018
miR-204 controls glucagon-like peptide 1 receptor expression and agonist function
.
Diabetes
. 67:256-264.
2018
2016
Islet ChREBP-β is increased in diabetes and controls ChREBP-α and glucose-induced gene expression via a negative feedback loop
.
Molecular Metabolism
. 5:1208-1215.
2016
2016
MiR-204 targets PERK and regulates UPR signaling and β-cell apoptosis
2016
2016
TXNIP regulates myocardial fatty acid oxidation via miR-33a signaling
2016
2014
MicroRNA-200 is induced by thioredoxin-interacting protein and regulates Zeb1 protein signaling and beta cell
.
Journal of Biological Chemistry
. 289:36275-36283.
2014
2014
Thioredoxin-interacting protein promotes islet amyloid polypeptide expression through miR-124a and FoxA2
.
Journal of Biological Chemistry
. 289:11807-11815.
2014
2014
Thioredoxin-interacting protein stimulates its own expression via a positive feedback loop
2014
2013
Thioredoxin-interacting protein regulates insulin transcription through microRNA-204
.
Nature Medicine
. 19:1141-1146.
2013
2013
FOXO1 competes with carbohydrate response element-binding protein (ChREBP) and inhibits thioredoxin-interacting protein (TXNIP) transcription in pancreatic beta cells
.
Journal of Biological Chemistry
. 288:23194-23202.
2013
2012
Preventing β-cell loss and diabetes with calcium channel blockers
.
Diabetes
. 61:848-856.
2012
2010
Intracellular shuttling and mitochondrial function of thioredoxin- interacting protein
.
Journal of Biological Chemistry
. 285:3997-4005.
2010
2010
Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated β-cell death
.
Diabetes
. 59:440-447.
2010
2010
Sterol regulatory element-binding protein-1c knockdown protected INS-1E cells from lipotoxicity
2010
2009
Glucose-stimulated expression of Txnip is mediated by carbohydrate response element-binding protein, p300, and histone H4 acetylation in pancreatic beta cells
.
Journal of Biological Chemistry
. 284:16898-16905.
2009
2009
Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein
2009
2008
Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes
2008
2008
Thioredoxin-interacting protein A critical link between glucose toxicity and β-cell apoptosis
.
Diabetes
. 57:938-944.
2008
2006
Exenatide inhibits β-cell apoptosis by decreasing thioredoxin-interacting protein
.
Biochemical and Biophysical Research Communications
. 346:1067-1074.
2006
2006
Generation of a conditional null allele of jumonji
2006
2004
Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors
.
Molecular and Cellular Biology
. 24:10151-10160.
2004
2004
Albusin B, a bacteriocin from the ruminal bacterium Ruminococcus albus 7 that inhibits growth of Ruminococcus flavefaciens
.
Applied and Environmental Microbiology
. 70:3167-3170.
2004
2003
JUMONJI, a Critical Factor for Cardiac Development, Functions as a Transcriptional Repressor
.
Journal of Biological Chemistry
. 278:42247-42255.
2003
2001
Competition among three predominant ruminal cellulolytic bacteria in the absence or presence of non-cellulolytic bacteria
.
Microbiology
. 147:21-30.
2001
Research
Investigator On
Promote Beta-Cell Survival by Blocking TXNIP: Role of Calcium Channel Blocker
awarded by
Juvenile Diabetes Research Foundation International
TXNIP Regulation of Endogenous Beta Cell Mass
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
Background
Education And Training
Doctor of Philosophy in Microbiology/Bacteriology,
University of Wisconsin System : Madison
2002
Master of Science in Microbiology,
1990
Contact
Full Name
Junqin
Chen