Positions

Selected Publications

Academic Article

Year Title Altmetric
2022 Alpha Cell Thioredoxin-interacting Protein Deletion Improves Diabetes-associated Hyperglycemia and HyperglucagonemiaEndocrinology.  163. 2022
2022 Deletion of Gdf15 Reduces ER Stress-induced Beta-cell Apoptosis and DiabetesEndocrinology.  163. 2022
2021 Human Glucagon Expression Is under the Control of miR-320aEndocrinology.  162. 2021
2021 Human Glucagon Expression Is under the Control of miR-320a.Endocrinology.  162. 2021
2020 Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon ActionCell Metabolism.  32:353-365.e8. 2020
2019 Serum mir-204 is an early biomarker of type 1 diabetes-associated pancreatic beta-cell lossAmerican Journal of Physiology: Endocrinology and Metabolism.  317:E723-E730. 2019
2018 miR-204 controls glucagon-like peptide 1 receptor expression and agonist functionDiabetes.  67:256-264. 2018
2016 Islet ChREBP-β is increased in diabetes and controls ChREBP-α and glucose-induced gene expression via a negative feedback loopMolecular Metabolism.  5:1208-1215. 2016
2016 MiR-204 targets PERK and regulates UPR signaling and β-cell apoptosisMolecular Endocrinology.  30:917-924. 2016
2016 TXNIP regulates myocardial fatty acid oxidation via miR-33a signalingAmerican Journal of Physiology: Heart and Circulatory Physiology.  311:H64-H75. 2016
2014 MicroRNA-200 is induced by thioredoxin-interacting protein and regulates Zeb1 protein signaling and beta cellJournal of Biological Chemistry.  289:36275-36283. 2014
2014 Thioredoxin-interacting protein promotes islet amyloid polypeptide expression through miR-124a and FoxA2Journal of Biological Chemistry.  289:11807-11815. 2014
2014 Thioredoxin-interacting protein stimulates its own expression via a positive feedback loopMolecular Endocrinology.  28:674-680. 2014
2013 Thioredoxin-interacting protein regulates insulin transcription through microRNA-204Nature Medicine.  19:1141-1146. 2013
2013 FOXO1 competes with carbohydrate response element-binding protein (ChREBP) and inhibits thioredoxin-interacting protein (TXNIP) transcription in pancreatic beta cellsJournal of Biological Chemistry.  288:23194-23202. 2013
2012 Preventing β-cell loss and diabetes with calcium channel blockersDiabetes.  61:848-856. 2012
2010 Intracellular shuttling and mitochondrial function of thioredoxin- interacting proteinJournal of Biological Chemistry.  285:3997-4005. 2010
2010 Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated β-cell deathDiabetes.  59:440-447. 2010
2010 Sterol regulatory element-binding protein-1c knockdown protected INS-1E cells from lipotoxicityDiabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics.  12:35-46. 2010
2009 Glucose-stimulated expression of Txnip is mediated by carbohydrate response element-binding protein, p300, and histone H4 acetylation in pancreatic beta cellsJournal of Biological Chemistry.  284:16898-16905. 2009
2009 Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting proteinAmerican Journal of Physiology: Endocrinology and Metabolism.  296. 2009
2008 Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetesThe FASEB Journal.  22:3581-3594. 2008
2008 Thioredoxin-interacting protein A critical link between glucose toxicity and β-cell apoptosisDiabetes.  57:938-944. 2008
2006 Generation of a conditional null allele of jumonjiGenesis: The Journal of Genetics and Development.  44:407-411. 2006
2006 Exenatide inhibits β-cell apoptosis by decreasing thioredoxin-interacting proteinBiochemical and Biophysical Research Communications.  346:1067-1074. 2006
2004 Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factorsMolecular and Cellular Biology.  24:10151-10160. 2004
2004 Albusin B, a bacteriocin from the ruminal bacterium Ruminococcus albus 7 that inhibits growth of Ruminococcus flavefaciensApplied and Environmental Microbiology.  70:3167-3170. 2004
2003 JUMONJI, a Critical Factor for Cardiac Development, Functions as a Transcriptional RepressorJournal of Biological Chemistry.  278:42247-42255. 2003
2001 Competition among three predominant ruminal cellulolytic bacteria in the absence or presence of non-cellulolytic bacteriaMicrobiology.  147:21-30. 2001

Education And Training

  • Doctor of Philosophy in Microbiology/Bacteriology, University of Wisconsin System : Madison 2002
  • Master of Science in Microbiology, 1990
  • Full Name

  • Junqin Chen