Positions

Selected Publications

Academic Article

Year Title Altmetric
2022 Exploratory study reveals far reaching systemic and cellular effects of verapamil treatment in subjects with type 1 diabetes.  Nature Communications.  13. 2022
2022 Alpha Cell Thioredoxin-interacting Protein Deletion Improves Diabetes-associated Hyperglycemia and Hyperglucagonemia 2022
2022 Deletion of Gdf15 Reduces ER Stress-induced Beta-cell Apoptosis and Diabetes 2022
2021 Human Glucagon Expression Is under the Control of miR-320a 2021
2021 Human Glucagon Expression Is under the Control of miR-320a..  Endocrinology.  162. 2021
2020 Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action.  Cell Metabolism.  32:353-365.e8. 2020
2019 Serum mir-204 is an early biomarker of type 1 diabetes-associated pancreatic beta-cell loss 2019
2018 miR-204 controls glucagon-like peptide 1 receptor expression and agonist function.  Diabetes.  67:256-264. 2018
2016 Islet ChREBP-β is increased in diabetes and controls ChREBP-α and glucose-induced gene expression via a negative feedback loop.  Molecular Metabolism.  5:1208-1215. 2016
2016 MiR-204 targets PERK and regulates UPR signaling and β-cell apoptosis 2016
2016 TXNIP regulates myocardial fatty acid oxidation via miR-33a signaling 2016
2014 MicroRNA-200 is induced by thioredoxin-interacting protein and regulates Zeb1 protein signaling and beta cell.  Journal of Biological Chemistry.  289:36275-36283. 2014
2014 Thioredoxin-interacting protein promotes islet amyloid polypeptide expression through miR-124a and FoxA2.  Journal of Biological Chemistry.  289:11807-11815. 2014
2014 Thioredoxin-interacting protein stimulates its own expression via a positive feedback loop 2014
2013 Thioredoxin-interacting protein regulates insulin transcription through microRNA-204.  Nature Medicine.  19:1141-1146. 2013
2013 FOXO1 competes with carbohydrate response element-binding protein (ChREBP) and inhibits thioredoxin-interacting protein (TXNIP) transcription in pancreatic beta cells.  Journal of Biological Chemistry.  288:23194-23202. 2013
2012 Preventing β-cell loss and diabetes with calcium channel blockers.  Diabetes.  61:848-856. 2012
2010 Intracellular shuttling and mitochondrial function of thioredoxin- interacting protein.  Journal of Biological Chemistry.  285:3997-4005. 2010
2010 Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated β-cell death.  Diabetes.  59:440-447. 2010
2010 Sterol regulatory element-binding protein-1c knockdown protected INS-1E cells from lipotoxicity 2010
2009 Glucose-stimulated expression of Txnip is mediated by carbohydrate response element-binding protein, p300, and histone H4 acetylation in pancreatic beta cells.  Journal of Biological Chemistry.  284:16898-16905. 2009
2009 Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein 2009
2008 Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes 2008
2008 Thioredoxin-interacting protein A critical link between glucose toxicity and β-cell apoptosis.  Diabetes.  57:938-944. 2008
2006 Exenatide inhibits β-cell apoptosis by decreasing thioredoxin-interacting protein.  Biochemical and Biophysical Research Communications.  346:1067-1074. 2006
2006 Generation of a conditional null allele of jumonji 2006
2004 Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors.  Molecular and Cellular Biology.  24:10151-10160. 2004
2004 Albusin B, a bacteriocin from the ruminal bacterium Ruminococcus albus 7 that inhibits growth of Ruminococcus flavefaciens.  Applied and Environmental Microbiology.  70:3167-3170. 2004
2003 JUMONJI, a Critical Factor for Cardiac Development, Functions as a Transcriptional Repressor.  Journal of Biological Chemistry.  278:42247-42255. 2003
2001 Competition among three predominant ruminal cellulolytic bacteria in the absence or presence of non-cellulolytic bacteria.  Microbiology.  147:21-30. 2001

Education And Training

  • Doctor of Philosophy in Microbiology/Bacteriology, University of Wisconsin System : Madison 2002
  • Master of Science in Microbiology, 1990

    • Full Name

  • Junqin Chen