Positions

Selected Publications

Academic Article

Year Title Altmetric
2022 Old Rivals in a New Track.  Circulation Research.  131:859-861. 2022
2022 18F-FMISO PET Imaging Identifies Hypoxia and Immunosuppressive Tumor Microenvironments and Guides Targeted Evofosfamide Therapy in Tumors Refractory to PD-1 and CTLA-4 Inhibition.  Clinical Cancer Research.  28:327-337. 2022
2022 BAC Recombineering and Transgenesis to Study Cell Polarity and Polarized Tissue Morphogenesis in Mice.  Methods in Molecular Biology.  2438:197-216. 2022
2020 A conserved aromatic moiety in the ectodomain is a key determinant for structural integrity and protein trafficking of TNFR superfamily 2020
2019 Planar cell polarity signaling regulates polarized second heart field morphogenesis to promote both arterial and venous pole septation 2019
2018 Planar Cell Polarity Signaling in Mammalian Cardiac Morphogenesis.  Pediatric Cardiology.  39:1052-1062. 2018
2017 Bimodal regulation of Dishevelled function by Vangl2 during morphogenesis.  Human Molecular Genetics.  26:2053-2061. 2017
2016 Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice.  Cardioscience.  112:532-542. 2016
2016 Spatial regulation of cell cohesion by Wnt5a during second heart field progenitor deployment.  Developmental Biology.  412:18-31. 2016
2015 Loss of Wnt5a disrupts second heart field cell deployment and may contribute to OFT malformations in DiGeorge syndrome.  Human Molecular Genetics.  24:1704-1716. 2015
2015 Mapping the dynamic expression of Wnt11 and the lineage contribution of Wnt11-expressing cells during early mouse development.  Developmental Biology.  398:177-192. 2015
2012 Disheveled mediated planar cell polarity signaling is required in the second heart field lineage for outflow tract morphogenesis.  Developmental Biology.  370:135-144. 2012
2012 Wnt signaling in mammalian development: Lessons from mouse genetics.  Cold Spring Harbor perspectives in biology.  4:6. 2012
2011 Disruption of PCP signaling causes limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type B.  Human Molecular Genetics.  20:271-285. 2011
2010 Planar polarization of node cells determines the rotational axis of node cilia.  Nature Cell Biology.  12:170-176. 2010
2008 Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development.  PLoS Genetics.  4. 2008
2008 Initiation of Wnt signaling: Control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions 2008
2006 Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation 2006
2005 Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway.  Nature Genetics.  37:980-985. 2005
2004 The canonical Wnt pathway in early mammalian embryogenesis and stem cell maintenance/differentiation.  Current Opinion in Genetics and Development.  14:533-539. 2004
2002 Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure 2002
2002 Identification of a Wnt/Dvl/β-catenin → Pitx2 pathway mediating cell-type-specific proliferation during development.  Cell.  111:673-685. 2002
2002 The mouse PcG gene eed is required for Hox gene repression and extraembryonic development.  Mammalian Genome.  13:493-503. 2002
2002 Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1.  Neuron.  35:489-505. 2002
2001 Imprinted X inactivation maintained by a mouse Polycomb group gene.  Nature Genetics.  28:371-375. 2001
2000 Genesis: Editorial 2000
2000 Mouse homolog of the Drosophila Pc-G gene esc exerts a dominant negative effect in Drosophila 2000

Book

Year Title Altmetric
2022 Preface.  Ed. 2438.  2022

Chapter

Year Title Altmetric
2007 The Wnt-signaling pathways in mammalian patterning and morphogenesis.  111-158. 2007

Research Overview

  • Cell polarity and signaling mechanisms in animal development and human diseases.

    • Principal Investigator On

    Investigator On

    Education And Training

  • Doctor of Philosophy in Genetics, Case Western Reserve University 2001
  • Bachelor of Science or Mathematics in Cell Biology and Anatomy, 1992

    • Awards And Honors

    Full Name

  • Jianbo Wang