Selected Publications

Academic Article

Year Title Altmetric
2022 Old Rivals in a New TrackCirculation Research.  131:859-861. 2022
2022 18F-FMISO PET Imaging Identifies Hypoxia and Immunosuppressive Tumor Microenvironments and Guides Targeted Evofosfamide Therapy in Tumors Refractory to PD-1 and CTLA-4 InhibitionClinical Cancer Research.  28:327-337. 2022
2022 BAC Recombineering and Transgenesis to Study Cell Polarity and Polarized Tissue Morphogenesis in MiceMethods in Molecular Biology.  2438:197-216. 2022
2020 A conserved aromatic moiety in the ectodomain is a key determinant for structural integrity and protein trafficking of TNFR superfamily 2020
2019 Planar cell polarity signaling regulates polarized second heart field morphogenesis to promote both arterial and venous pole septation 2019
2018 Planar Cell Polarity Signaling in Mammalian Cardiac MorphogenesisPediatric Cardiology.  39:1052-1062. 2018
2017 Bimodal regulation of Dishevelled function by Vangl2 during morphogenesisHuman Molecular Genetics.  26:2053-2061. 2017
2016 Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in miceCardioscience.  112:532-542. 2016
2016 Spatial regulation of cell cohesion by Wnt5a during second heart field progenitor deploymentDevelopmental Biology.  412:18-31. 2016
2015 Loss of Wnt5a disrupts second heart field cell deployment and may contribute to OFT malformations in DiGeorge syndromeHuman Molecular Genetics.  24:1704-1716. 2015
2015 Mapping the dynamic expression of Wnt11 and the lineage contribution of Wnt11-expressing cells during early mouse developmentDevelopmental Biology.  398:177-192. 2015
2012 Disheveled mediated planar cell polarity signaling is required in the second heart field lineage for outflow tract morphogenesisDevelopmental Biology.  370:135-144. 2012
2012 Wnt signaling in mammalian development: Lessons from mouse geneticsCold Spring Harbor perspectives in biology.  4:6. 2012
2011 Disruption of PCP signaling causes limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type BHuman Molecular Genetics.  20:271-285. 2011
2010 Planar polarization of node cells determines the rotational axis of node ciliaNature Cell Biology.  12:170-176. 2010
2008 Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube developmentPLoS Genetics.  4. 2008
2008 Initiation of Wnt signaling: Control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions 2008
2006 Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation 2006
2005 Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathwayNature Genetics.  37:980-985. 2005
2004 The canonical Wnt pathway in early mammalian embryogenesis and stem cell maintenance/differentiationCurrent Opinion in Genetics and Development.  14:533-539. 2004
2002 Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure 2002
2002 Identification of a Wnt/Dvl/β-catenin → Pitx2 pathway mediating cell-type-specific proliferation during developmentCell.  111:673-685. 2002
2002 The mouse PcG gene eed is required for Hox gene repression and extraembryonic developmentMammalian Genome.  13:493-503. 2002
2002 Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1Neuron.  35:489-505. 2002
2001 Imprinted X inactivation maintained by a mouse Polycomb group geneNature Genetics.  28:371-375. 2001
2000 Genesis: Editorial 2000
2000 Mouse homolog of the Drosophila Pc-G gene esc exerts a dominant negative effect in Drosophila 2000


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2022 Preface.  Ed. 2438.  2022


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2007 The Wnt-signaling pathways in mammalian patterning and morphogenesis.  111-158. 2007

Research Overview

  • Cell polarity and signaling mechanisms in animal development and human diseases.
  • Education And Training

  • Doctor of Philosophy in Genetics, Case Western Reserve University 2001
  • Bachelor of Science or Mathematics in Cell Biology and Anatomy, 1992
  • Full Name

  • Jianbo Wang