Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 Widespread Doublecortin Expression in the Cerebral Cortex of the Octodon degusFrontiers in Neuroanatomy.  15. 2021
2020 Subchronic administration of auranofin reduced amyloid-β plaque pathology in a transgenic APPNL-G-F/NL-G-F mouse modelBrain Research.  1746. 2020
2018 FK506-binding protein 12.6/1b, a negative regulator of [Ca 2+ ], rescues memory and restores genomic regulation in the hippocampus of aging ratsThe Journal of Neuroscience.  38:1030-1041. 2018
2018 Inhibition of amyloid Aβ aggregation by high pressures or specific d-enantiomeric peptidesChemical Communications.  54:3294-3297. 2018
2017 Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampusBMC Neuroscience.  18. 2017
2017 The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathologyScientific Reports.  7. 2017
2017 Optimization of d -Peptides for Aβ Monomer Binding Specificity Enhances Their Potential to Eliminate Toxic Aβ OligomersACS Chemical Neuroscience.  8:1889-1900. 2017
2017 Vitamin A and retinoic acid combination attenuates neonatal hyperoxia-induced neurobehavioral impairment in adult miceNeurobiology of Learning and Memory.  141:209-216. 2017
2016 Dietary composition affects the development of cognitive deficits in WT and Tg AD model miceExperimental Gerontology.  86:39-49. 2016
2016 Observational research rigour alone does not justify causal inferenceEuropean Journal of Clinical Investigation.  46:985-993. 2016
2016 Blood-brain barrier penetration of an Aβ-targeted, arginine-rich, D-enantiomeric peptideBBA: Biomembranes.  1858:2717-2724. 2016
2016 Memory-enhancing and brain protein expression-stimulating effects of novel calcium antagonist in Alzheimer's disease transgenic female micePharmacological Research.  113:781-787. 2016
2016 Increase of Positive Net Charge and Conformational Rigidity Enhances the Efficacy of d -Enantiomeric Peptides Designed to Eliminate Cytotoxic Aβ SpeciesACS Chemical Neuroscience.  7:1088-1096. 2016
2016 Allelic series of Huntington's disease knock-in mice reveals expression discorrelatesHuman Molecular Genetics.  25:1619-1636. 2016
2015 QIAD assay for quantitating a compounds efficacy in elimination of toxic Aβ oligomersScientific Reports.  5. 2015
2015 Reversal of aging-related neuronal Ca2+ dysregulation and cognitive impairment by delivery of a transgene encoding FK506-binding protein 12.6/1b to the hippocampusThe Journal of Neuroscience.  35:10878-10887. 2015
2015 Ghrelin agonist does not foster insulin resistance but improves cognition in an Alzheimer's disease mouse modelScientific Reports.  5. 2015
2015 A novel 1,4-dihydropyridine derivative improves spatial learning and memory and modifies brain protein expression in wild type and transgenic APPSweDI MicePLoS One.  10. 2015
2014 FK506-binding protein 1b/12.6: A key to aging-related hippocampal Ca2+ dysregulation? 2014
2014 Mildronate improves cognition and reduces amyloid-β pathology in transgenic Alzheimer's disease miceJournal of Neuroscience Research.  92:338-346. 2014
2014 Axonal tract tracing for delineating interacting brain regions: Implications for Alzheimer's disease-associated memoryFuture Neurology.  9:89-98. 2014
2013 Effect of high-fat diet on metabolic indices, cognition, and neuronal physiology in aging F344 ratsNeurobiology of Aging.  34:1977-1987. 2013
2013 Glucocorticoid-dependent hippocampal transcriptome in male rats: Pathway-specific alterations with agingEndocrinology.  154:2807-2820. 2013
2013 Hunger in the Absence of Caloric Restriction Improves Cognition and Attenuates Alzheimer's Disease Pathology in a Mouse ModelPLoS One.  8. 2013
2013 Neurodevelopmental impairment following neonatal hyperoxia in the mouseNeurobiology of Disease.  50:69-75. 2013
2013 In vivo and in vitro effects of an apolipoprotein E mimetic peptide on amyloid-β pathologyJournal of Alzheimer's Disease.  36:335-347. 2013
2013 Treatment with D3 removes amyloid deposits, reduces inflammation, and improves cognition in aged AβPP/PS1 double transgenic miceJournal of Alzheimer's Disease.  34:609-620. 2013
2012 Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of alzheimer's diseaseJournal of Alzheimer's Disease.  30:943-961. 2012
2012 Treatment with Aβ42 binding d-amino acid peptides reduce amyloid deposition and inflammation in APP/PS1 double transgenic miceAdvances in protein chemistry and structural biology.  88:133-152. 2012
2011 Age-related brain pathology in Octodon degu: Blood vessel, white matter and Alzheimer-like pathologyNeurobiology of Aging.  32:1651-1661. 2011
2011 Insufficient DNA methylation affects healthy aging and promotes age-related health problemsClinical Epigenetics.  2:349-360. 2011
2011 Disrupting function of FK506-binding protein 1b/12.6 induces the Ca 2+-dysregulation aging phenotype in hippocampal neuronsThe Journal of Neuroscience.  31:1693-1703. 2011
2011 Transgenic AD model mice, effects of potential anti-AD treatments on inflammation, and pathologyJournal of Alzheimer's Disease.  24:301-313. 2011
2010 Oral treatment with the d-enantiomeric peptide D3 improves the pathology and behavior of alzheimer's disease transgenic miceACS Chemical Neuroscience.  1:639-648. 2010
2009 Oral apolipoprotein A-I mimetic peptide improves cognitive function and reduces amyloid burden in a mouse model of Alzheimer's diseaseNeurobiology of Disease.  34:525-534. 2009
2009 DNA methylation impacts on learning and memory in agingNeurobiology of Aging.  30:549-560. 2009
2009 In vitro and in vivo staining characteristics of small, fluorescent, Aβ42-binding D-enantiomeric peptides in transgenic AD mouse modelsChemMedChem: chemistry enabling drug discovery.  4:276-282. 2009
2009 Hippocampal and cognitive aging across the lifespan: A bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairmentThe Journal of Neuroscience.  29:1805-1816. 2009
2009 Lesion-induced hippocampal plasticity in transgenic alzheimer's disease mouse models: Influences of age, genotype, and estrogenJournal of Alzheimer's Disease.  18:429-445. 2009
2009 Pulmonary Angiogenesis in a Rat Model of Hepatopulmonary SyndromeGastroenterology.  136:1070-1080. 2009
2008 Reduction of Alzheimer's disease amyloid plaque load in transgenic mice by D3, a D-enantiomeric peptide identified by mirror image phage displayChemMedChem: chemistry enabling drug discovery.  3:1848-1852. 2008
2008 Subfield and layer-specific depletion in calbindin-D28K, calretinin and parvalbumin immunoreactivity in the dentate gyrus of amyloid precursor protein/presenilin 1 transgenic miceNeuroscience.  155:182-191. 2008
2007 Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged ratsThe Journal of Neuroscience.  27:3098-3110. 2007
2006 Deposition of mouse amyloid β in human APP/PS1 double and single AD model transgenic miceNeurobiology of Disease.  23:653-662. 2006
2005 Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's modelsThe Journal of Neuroscience.  25:4649-4658. 2005
2005 Harnessing the power of gene microarrays for the study of brain aging and Alzheimer's disease: Statistical reliability and functional correlationAgeing Research Reviews.  4:481-512. 2005
2005 Transgenic AD model mice, effects of potential anti-AD treatments on inflammation and pathologyBrain Research Reviews.  48:370-378. 2005
2004 Retrosplenial cortex lesions of area Rgb (but not of area Rga) impair spatial learning and memory in the ratBehavioural Brain Research.  154:483-491. 2004
2004 Erratum: Gender differences in the amount and deposition of amyloidβ in APPswe and PS1 double transgenic mice (Neurobiology of Disease (2003) 14 (318-327) DOI: 10.1016/j.nbd.2003.08.009)Neurobiology of Disease.  16:290. 2004
2003 Age-related decline in spatial learning and memory: Attenuation by captoprilClinical and Experimental Hypertension.  25:455-474. 2003
2003 Diffuse amyloid deposition, but not plaque number, is reduced in amyloid precursor protein/presenilin 1 double-transgenic mice by pathway lesionsNeuroscience.  119:1185-1197. 2003
2003 The entorhinal cortex of the mouse: Organization of the projection to the hippocampal formationThe Hippocampus.  13:133-149. 2003
2003 Differences in lesion-induced hippocampal plasticity between mice and ratsNeuroscience.  116:499-509. 2003
2003 Gender differences in the amount and deposition of amyloidβ in APPswe and PS1 double transgenic miceNeurobiology of Disease.  14:318-327. 2003
2002 The role of the laterodorsal nucleus of the thalamus in spatial learning and memory in the ratBehavioural Brain Research.  136:329-337. 2002
2002 Old rats remember old tricks; memories of the water maze persist for 12 monthsBehavioural Brain Research.  136:247-255. 2002
2002 Low Levels of Estrogen Significantly Diminish Axonal Sprouting after Entorhinal Cortex Lesions in the MouseThe Journal of Neuroscience.  22:4095-4102. 2002
2002 Role of the anterodorsal and anteroventral nuclei of the thalamus in spatial memory in the ratBehavioural Brain Research.  132:19-28. 2002
2002 Transgenic mice expressing the human presenilin 1 gene demonstrate enhanced hippocampal reorganization following entorhinal cortex lesionsBrain Research Bulletin.  57:587-594. 2002
2002 Species differences in the projections from the entorhinal cortex to the hippocampusBrain Research Bulletin.  57:553-556. 2002
2001 Chronic, severe hypertension does not impair spatial learning and memory in Sprague-Dawley ratsLearning and Memory.  8:104-111. 2001
2000 Age-related decline in water maze learning and memory in rats: Strain differencesNeurobiology of Aging.  21:671-681. 2000
1999 Efferent connections of the anteromedial nucleus of the thalamus of the ratBrain Research Reviews.  30:1-26. 1999
1999 Distribution of neurons in the anterior hypothalamic nucleus activated by blood pressure changes in the ratBrain Research Bulletin.  49:163-172. 1999

Chapter

Year Title Altmetric
2014 The limbic system plays a significant role in epilepsy.  1-20. 2014
2014 Ongoing studies of deimination in neurodegenerative diseases using the F95 antibody.  257-280. 2014
2010 Aging and non-sirtuin histone modifications.  41-50. 2010
2008 Disorders of the limbic system.  397-399. 2008
2008 The limbic system.  379-396. 2008
2007 Transient occlusion of the middle cerebral artery in rats leads to permanent amyloid deposist in the thalamus..  99-111. 2007

Research Overview

  • Aging and Alzheimer’s disease.
    My expertise is in aging and Alzheimer’s disease-related degeneration and regeneration in the brain. The goal of my research is to elucidate the role of white matter pathology in the development of age-related cognitive deficits. Currently, our studies have shown two significant pathological changes in white matter with aging: malfunctioning of oligodendrocytes and demyelination of axons. These changes will lead to a “functional” disconnection in the brain leading to cognitive disturbances. My second research interest is the role of vascular pathology in Alzheimer’s disease, specifically hypertension and the relation between white matter infarcts and AD pathology. Our studies have shown that small ischemic infarcts both increase Aß deposition and decrease cognition. These studies include the use of therapeutic agents (i.e., amyloid β binding peptides) that may be promising in the alleviation or delay of agerelated neural and cognitive changes.

    Further, we have begun investigating the role of obesity, and/or caloric restriction and hunger (by using synthetic ghrelin agonist) in the development of cognitive deficits in aging and AD. We have demonstrated that hunger has similar positive effects on aging and AD as caloric restriction has, i.e., ghrelin agonist treated animals has less age and disease related inflammation in the brain.
  • Teaching Overview

  • I am very interested and motivated to continue to teach human gross anatomy. Through my education, training and lengthy research experience, my greatest strengths lie within the areas of human physiology, and neurobiology. During my graduate studies in Finland, I held special interests in area of neurodegenerative diseases and neurology and taught a neuroscience course to the undergraduate students. During my postdoctoral fellowship, I greatly expanded my knowledge in vascular biology and hypertension. I believe that my strong background and training in physiology, neuroscience and neurology enables me to better explain to the students the functional and clinical significance of gross anatomy.
  • Education And Training

  • Doctor of Philosophy in Neuroscience, 2002
  • Full Name

  • Inga Kadisha