Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 Widespread Doublecortin Expression in the Cerebral Cortex of the Octodon degusFrontiers in Neuroanatomy.  15. 2021
2020 Subchronic administration of auranofin reduced amyloid-β plaque pathology in a transgenic APPNL-G-F/NL-G-F mouse modelBrain Research.  1746. 2020
2018 Inhibition of amyloid Aβ aggregation by high pressures or specific d-enantiomeric peptidesChemical Communications.  54:3294-3297. 2018
2017 Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampusBMC Neuroscience.  18. 2017
2016 Dietary composition affects the development of cognitive deficits in WT and Tg AD model miceExperimental Gerontology.  86:39-49. 2016
2016 Observational research rigour alone does not justify causal inferenceEuropean Journal of Clinical Investigation.  46:985-993. 2016
2016 Blood-brain barrier penetration of an Aβ-targeted, arginine-rich, D-enantiomeric peptide 2016
2016 Allelic series of Huntington's disease knock-in mice reveals expression discorrelatesHuman Molecular Genetics.  25:1619-1636. 2016
2014 FK506-binding protein 1b/12.6: A key to aging-related hippocampal Ca2+ dysregulation? 2014
2014 Axonal tract tracing for delineating interacting brain regions: Implications for Alzheimer's disease-associated memoryFuture Neurology.  9:89-98. 2014
2013 Glucocorticoid-dependent hippocampal transcriptome in male rats: Pathway-specific alterations with agingEndocrinology.  154:2807-2820. 2013
2011 Insufficient DNA methylation affects healthy aging and promotes age-related health problemsClinical Epigenetics.  2:349-360. 2011
2009 In vitro and in vivo staining characteristics of small, fluorescent, Aβ42-binding D-enantiomeric peptides in transgenic AD mouse models 2009
2009 Pulmonary Angiogenesis in a Rat Model of Hepatopulmonary SyndromeGastroenterology.  136:1070-1080. 2009
2008 Reduction of Alzheimer's disease amyloid plaque load in transgenic mice by D3, a D-enantiomeric peptide identified by mirror image phage display 2008
2005 Transgenic AD model mice, effects of potential anti-AD treatments on inflammation and pathologyBrain Research Reviews.  48:370-378. 2005
2004 Retrosplenial cortex lesions of area Rgb (but not of area Rga) impair spatial learning and memory in the ratBehavioural Brain Research.  154:483-491. 2004
2003 Age-related decline in spatial learning and memory: Attenuation by captoprilClinical and experimental hypertension.  25:455-474. 2003
2002 The role of the laterodorsal nucleus of the thalamus in spatial learning and memory in the ratBehavioural Brain Research.  136:329-337. 2002
2002 Old rats remember old tricks; memories of the water maze persist for 12 monthsBehavioural Brain Research.  136:247-255. 2002
2002 Role of the anterodorsal and anteroventral nuclei of the thalamus in spatial memory in the ratBehavioural Brain Research.  132:19-28. 2002
2002 Transgenic mice expressing the human presenilin 1 gene demonstrate enhanced hippocampal reorganization following entorhinal cortex lesionsBrain Research Bulletin.  57:587-594. 2002
2002 Species differences in the projections from the entorhinal cortex to the hippocampusBrain Research Bulletin.  57:553-556. 2002
1999 Efferent connections of the anteromedial nucleus of the thalamus of the ratBrain Research Reviews.  30:1-26. 1999
1999 Distribution of neurons in the anterior hypothalamic nucleus activated by blood pressure changes in the ratBrain Research Bulletin.  49:163-172. 1999

Chapter

Year Title Altmetric
2014 The limbic system plays a significant role in epilepsy.  1-20. 2014
2014 Ongoing studies of deimination in neurodegenerative diseases using the F95 antibody.  257-280. 2014
2010 Aging and non-sirtuin histone modifications.  41-50. 2010
2008 Disorders of the limbic system.  397-399. 2008
2008 The limbic system.  379-396. 2008
2007 Transient occlusion of the middle cerebral artery in rats leads to permanent amyloid deposist in the thalamus..  99-111. 2007

Research Overview

  • Aging and Alzheimer’s disease.
    My expertise is in aging and Alzheimer’s disease-related degeneration and regeneration in the brain. The goal of my research is to elucidate the role of white matter pathology in the development of age-related cognitive deficits. Currently, our studies have shown two significant pathological changes in white matter with aging: malfunctioning of oligodendrocytes and demyelination of axons. These changes will lead to a “functional” disconnection in the brain leading to cognitive disturbances. My second research interest is the role of vascular pathology in Alzheimer’s disease, specifically hypertension and the relation between white matter infarcts and AD pathology. Our studies have shown that small ischemic infarcts both increase Aß deposition and decrease cognition. These studies include the use of therapeutic agents (i.e., amyloid β binding peptides) that may be promising in the alleviation or delay of agerelated neural and cognitive changes.

    Further, we have begun investigating the role of obesity, and/or caloric restriction and hunger (by using synthetic ghrelin agonist) in the development of cognitive deficits in aging and AD. We have demonstrated that hunger has similar positive effects on aging and AD as caloric restriction has, i.e., ghrelin agonist treated animals has less age and disease related inflammation in the brain.
  • Teaching Overview

  • I am very interested and motivated to continue to teach human gross anatomy. Through my education, training and lengthy research experience, my greatest strengths lie within the areas of human physiology, and neurobiology. During my graduate studies in Finland, I held special interests in area of neurodegenerative diseases and neurology and taught a neuroscience course to the undergraduate students. During my postdoctoral fellowship, I greatly expanded my knowledge in vascular biology and hypertension. I believe that my strong background and training in physiology, neuroscience and neurology enables me to better explain to the students the functional and clinical significance of gross anatomy.
  • Education And Training

  • Doctor of Philosophy in Neuroscience, 2002
  • Full Name

  • Inga Kadisha