Positions

Overview

  • Irshad H. Chaudry was born on May 2, 1945. He received a B.S. as well as M.S. with honors from Sind University, and a Ph.D. from Monash University, Australia. After his postdoctoral training at Toronto University, Canada, he was an appointed as an Instructor and subsequently as an Assistant Professor at the Jewish Hospital and Washington University School of Medicine. He then moved to Yale University as an Associate Professor and subsequently became a Professor. He moved to Michigan State University in 1986 as Professor and Director of Research and in 1996 became the Director of the Center for Surgical Research at Brown University. In 2000, he became the Director of the Center for Surgical Research at the University of Alabama at Birmingham. His has over 600 publications to his credit and is a recipient of the NIH MERIT award.

    Current research interests include determining the mechanisms responsible for cellular and subcellular alterations following soft tissue trauma, bone fracture, hemorrhage and sepsis. Additionally, the use of novel, readily available, FDA approved inexpensive therapeutic agents to attenuate such alterations in patients following trauma is planned. Other areas include evaluation of: (1) gender dimorphism and the mechanisms responsible for producing cardiovascular and hepatocellular dysfunction and immunological alterations following trauma-hemorrhage; (2) trauma-induced changes in the hypothalamus-pituitary-adrenal axis; (3) apoptosis of immune cells; and (4) wound healing. Specific research interests include determining the mechanism of regulation of estradiol levels by hypothalamic/pituitary factors, adrenals and steroidogenic enzyme activity and how differences in estradiol levels or the estradiol: androgen ratio due to the estrus cycle, ovariectomy, and age affect immune responses after trauma. Studies of T lymphocytes, macrophages and Kupffer cell functions using molecular biological techniques are being conducted to determine why low estradiol fails to maintain immune functions in aged females after trauma. The use of estradiol, Raloxifene, prolactin, metoclopramide, or flutamide to restore immune/cardiovascular functions following trauma should yield novel information and provide an innovative approach for improving the host responses and reducing mortality from sepsis following trauma in postmenopausal and in surgically ovariectomized patients with low estrogen activity. Additional interests encompass the mechanisms by which androgen depletion/androgen antagonists improve cardiac performance and other organ functions after trauma. These studies also examine whether androgen depletion/androgen antagonists affect the adrenals and modify the response of the heart, liver and vascular smooth muscle to catecholamines. The hemodynamic parameters and organ functions being measured include blood flow, circulating blood volume, cardiac output, left ventricular performance, vascular reactivity, liver, gut, adrenal and pulmonary functions. The integration of cardiac function with other organ functions and detailed mechanistic studies at the cellular and subcellular levels using physiological, pharmacological and molecular biology techniques to identify targets for novel treatment modalities using sex steroid antagonists/agonists or hormones should provide new information for the improved treatment of trauma victims with major blood loss and for decreasing the susceptibility to sepsis following trauma.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression.  Military Medical Research.  9. 2022
    2022 Molecular Mechanisms of Ischaemia-Reperfusion Injury and Regeneration in the Liver-Shock and Surgery-Associated Changes.  International Journal of Molecular Sciences.  23. 2022
    2022 An estrogen (17α-ethinyl estradiol-3-sulfate) reduces mortality in a swine model of multiple injuries and hemorrhagic shock.  Journal of Trauma and Acute Care Surgery.  92:57-64. 2022
    2021 17α-Ethinyl estradiol-3-sulfate increases survival and hemodynamic functioning in a large animal model of combined traumatic brain injury and hemorrhagic shock: a randomized control trial 2021
    2021 Retraction: Mechanisms of hemorrhage-induced hepatic insulin resistance: Role of tumor necrosis factor-α (Endocrinology (2004) 145:11 (5168-5176) DOI: 10.1210/en.2004-0524) 2021
    2021 Erratum: Hemorrhage induces the rapid development of hepatic insulin resistance (Am J Physiol Gastrointest Liver Physiol (2003) 284 (G107–G115) DOI: 10.1152/ajpgi.00217.2002) 2021
    2021 Ethinyl estradiol sulfate acts without fluid resuscitation through estrogen receptors to rapidly protect the cardiovascular system from severe hemorrhage.  Journal of Trauma and Acute Care Surgery.  90:353-359. 2021
    2020 Colchicine, aspirin, and montelukast-A case of successful combined pharmacotherapy for adult multisystem inflammatory syndrome in COVID-19.  Journal of Global Infectious Diseases.  12:221-224. 2020
    2019 A systematic review of large animal models of combined traumatic brain injury and hemorrhagic shock.  Neuroscience and Biobehavioral Reviews.  104:160-177. 2019
    2018 Gender differences in trauma, shock and sepsis.  Military Medical Research.  5. 2018
    2018 Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis (Infection, (2018), 46, 5, (687-691), 10.1007/s15010-018-1183-8) 2018
    2018 Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis 2018
    2017 Treatment of traumatic brain injury with 17α-ethinylestradiol-3-sulfate in a rat model.  Journal of Neurosurgery.  127:23-31. 2017
    2015 Potential therapeutic targets for sepsis in women.  Expert Opinion on Therapeutic Targets.  19:1531-1543. 2015
    2015 Salutary Effects of Estrogen Sulfate for Traumatic Brain Injury.  Journal of Neurotrauma.  32:1210-1216. 2015
    2015 Morbidity and survival probability in burn patients in modern burn care.  Critical Care Medicine.  43:808-815. 2015
    2015 17a-ethynylestradiol-3-sulfate treatment of severe blood loss in rats.  Journal of Surgical Research.  193:355-360. 2015
    2015 Inflammatory response to traumatic injury: Clinical and animal researches in inflammation.  Mediators of Inflammation.  2015. 2015
    2014 Efficacy of 17α-ethynylestradiol-3-sulfate for severe hemorrhage in minipigs in the absence of fluid resuscitation.  Journal of Trauma and Acute Care Surgery.  76:1409-1416. 2014
    2014 Gender-specific effects on immune response and cardiac function after trauma hemorrhage and sepsis.  Chirurgische Gastroenterologie.  30:91-96. 2014
    2014 Resveratrol restores sirtuin 1 (SIRT1) activity and pyruvate dehydrogenase kinase 1 (PDK1) expression after hemorrhagic injury in a rat model.  Molecular Medicine.  20:10-16. 2014
    2014 Sex- and diagnosis-dependent differences in mortality and admission cytokine levels among patients admitted for intensive care.  Critical Care Medicine.  42:1110-1120. 2014
    2013 17β-estradiol confers protection after traumatic brain injury in the rat and involves activation of G protein-coupled estrogen receptor 1.  Journal of Neurotrauma.  30:1531-1541. 2013
    2013 Role of Akt/HO-1 pathway in estrogen-mediated attenuation of trauma-hemorrhage-induced lung injury.  Journal of Surgical Research.  182:319-325. 2013
    2012 The effects of estrogen on various organs: Therapeutic approach for sepsis, trauma, and reperfusion injury. Part 1: Central nervous system, lung, and heart.  Journal of Anesthesia.  26:883-891. 2012
    2012 The effects of estrogen on various organs: Therapeutic approach for sepsis, trauma, and reperfusion injury. Part 2: Liver, intestine, spleen, and kidney.  Journal of Anesthesia.  26:892-899. 2012
    2012 Does gender influence outcomes in critically ill patients? 2012
    2012 Resveratrol improves cardiac contractility following trauma-hemorrhage by modulating Sirt1.  Molecular Medicine.  18:209-214. 2012
    2011 Influence of aging and hemorrhage injury on Sirt1 expression: Possible role of myc-Sirt1 regulation in mitochondrial function 2011
    2011 Aging influences cardiac mitochondrial gene expression and cardiovascular function following hemorrhage injury.  Molecular Medicine.  17:542-549. 2011
    2011 Role of PPARγ in the salutary effects of 17β-estradiol on kupffer cell cytokine production following trauma-hemorrhage.  Journal of Cellular Physiology.  226:205-211. 2011
    2011 The mitoscriptome in aging and disease.  Aging and Disease.  2:174-180. 2011
    2010 Erratum: The role of MAPK in Kupffer cell toll-like receptor (TLR) 2-, TLR4-, and TLR9-mediated signaling following trauma-hemorrhage.  Journal of Cellular Physiology.  225:915-915. 2010
    2010 Erratum: The PI3K/Akt pathway mediates the nongenomic cardioprotective effects of estrogen following trauma-hemorrhage (Annals of Surgery (2007) 245:6 (971-7)).  Annals of Surgery.  252:894. 2010
    2010 Single photon emission computed tomography demonstrated efficacy of 17β-estradiol therapy in male rats after trauma-hemorrhage and extended hypotension.  Journal of Trauma and Acute Care Surgery.  69:1266-1273. 2010
    2010 Salutary effects of 17β-estradiol on Peyer's patch T cell functions following trauma-hemorrhage.  Cytokine.  51:166-172. 2010
    2010 Corrigendum to "Anti-rat soluble IL-6 receptor antibody down-regulates cardiac IL-6 and improves cardiac function following trauma-hemorrhage" [J. Mol. Cell. Cardiol. 42 (2007) 620-630] (DOI:10.1016/j.yjmcc.2006.12.004).  Journal of Molecular and Cellular Cardiology.  48:429-430. 2010
    2010 Corrigendum to "Mechanism of IL-6-mediated cardiac dysfunction following trauma-hemorrhage" [J. Mol. Cell. Cardiol. 40 (2006) 570-579] (DOI:10.1016/j.yjmcc.2006.01.008).  Journal of Molecular and Cellular Cardiology.  48:428. 2010
    2010 Lidocaine enhances apoptosis and suppresses mitochondrial functions of human neutrophil in vitro.  Journal of Trauma and Acute Care Surgery.  68:401-408. 2010
    2010 Effect of estrogen on mitochondrial function and intracellular stress markers in rat liver and kidney following trauma-hemorrhagic shock and prolonged hypotension.  Molecular Medicine.  16:254-261. 2010
    2009 Gut dysfunction following alcohol exposure and trauma.  Journal of Organ Dysfunction.  5:171-181. 2009
    2009 Trauma-hemorrhage and hypoxia differentially influence kupffer cell phagocytic capacity: Role of hypoxia-inducible-factor-1α and phosphoinositide 3-kinase/akt activation.  Annals of Surgery.  250:995-1001. 2009
    2009 Anosmin-1 involved in neuronal cell migration is hypoxia inducible and cancer regulated.  Cell Cycle.  8:3770-3776. 2009
    2009 Cellular mechanisms of injury after major trauma 2009
    2009 ERK and not p38 pathway is required for IL-12 restoration of T cell IL-2 and IFN-γ in a rodent model of alcohol intoxication and burn injury.  Journal of Immunology.  183:3955-3962. 2009
    2009 The potential role of T-cells and their interaction with antigen-presenting cells in mediating immunosuppression following trauma-hemorrhage.  Innate Immunity.  15:233-241. 2009
    2009 Inflammation and the host response to injury, a large-scale collaborative project: Patient-oriented research core standard operating procedures for clinical care IX. Definitions for complications of clinical care of critically injured patients.  Journal of Trauma and Acute Care Surgery.  67:384-388. 2009
    2009 Neutrophil chemokines and their role in IL-18-mediated increase in neutrophil O-2 production and intestinal edema following alcohol intoxication and burn injury 2009
    2009 Mechanism of hepatoprotection in proestrus female rats following trauma-hemorrhage: Heme oxygenase-1-derived normalization of hepatic inflammatory responses.  Journal of Leukocyte Biology.  85:1015-1026. 2009
    2009 Mechanism of the salutary effects of estrogen on Kupffer cell phagocytic capacity following trauma-hemorrhage: Pivotal role of Akt activation.  Journal of Immunology.  182:4406-4414. 2009
    2009 Therapy of hemorrhagic shock : New strategies based on experimental results.  Notfall and Rettungsmedizin.  12:193-200. 2009
    2009 Glucosamine improves cardiac function following trauma-hemorrhage by increased protein O-GlcNAcylation and attenuation of NF-κB signaling 2009
    2009 Effect of interleukin-15 on depressed splenic dendritic cell functions following trauma-hemorrhage 2009
    2009 Large-scale multiplexed quantitative discovery proteomics enabled by the use of an M 18O-labeled universal reference sample.  Journal of Proteome Research.  8:290-299. 2009
    2009 Mechanism of salutary effects of estrogen on cardiac function following trauma-hemorrhage: Akt-dependent HO-1 up-regulation.  Critical Care Medicine.  37:2338-2344. 2009
    2009 Suppression of activation and costimulatory signaling in splenic CD4 + T cells after trauma-hemorrhage reduces t-cell function: A mechanism of post-traumatic immune suppression.  American Journal of Pathology.  175:1504-1514. 2009
    2008 Estrogen and multiple organ dysfunction syndrome in critical illness: From bench to bedside.  Journal of Organ Dysfunction.  4:230-238. 2008
    2008 Activation of endoplasmic reticulum stress response following trauma-hemorrhage 2008
    2008 Estradiol's salutary effects on keratinocytes following trauma-hemorrhage are mediated by estrogen receptor (ER)-α and ER-β.  Molecular Medicine.  14:689-696. 2008
    2008 Estrogen prevents intestinal inflammation after trauma-hemorrhage via downregulation of angiotensin II and angiotensin II subtype I receptor 2008
    2008 Estrogen: A novel therapeutic adjunct for the treatment of trauma-hemorrhage-induced immunological alterations (Molecular Medicine (2008) 14, 3-4, (213-221)).  Molecular Medicine.  14:752. 2008
    2008 Role of estrogen receptor subtypes in estrogen-induced organ-specific vasorelaxation after trauma-hemorrhage 2008
    2008 Selective inhibition of iNOS attenuates trauma-hemorrhage/resuscitation- induced hepatic injury.  Journal of Applied Physiology.  105:1076-1082. 2008
    2008 The role of MIP-1α in the development of systemic inflammatory response and organ injury following trauma hemorrhage.  Journal of Immunology.  181:2806-2812. 2008
    2008 Estrogen ameliorates trauma-hemorrhage-induced lung injury via endothelial nitric oxide synthase-dependent activation of protein kinase G.  Annals of Surgery.  248:294-302. 2008
    2008 Flutamide protects against trauma-hemorrhage-induced liver injury via attenuation of the inflammatory response, oxidative stress, and apopotosis.  Journal of Applied Physiology.  105:595-602. 2008
    2008 Bench-to-bedside review: Latest results in hemorrhagic shock 2008
    2008 Alcohol, burn injury, and the intestine. 2008
    2008 The role of estrogen receptor subtypes on hepatic neutrophil accumulation following trauma-hemorrhage: Direct modulation of CINC-1 production by Kupffer cells.  Cytokine.  43:88-92. 2008
    2008 Tissue-specific expression of estrogen receptors and their role in the regulation of neutrophil infiltration in various organs following trauma-hemorrhage (Journal of Leukocyte Biology (2006) 79,5,(963-970) DOI: 10.1189/jlb.1005596).  Journal of Leukocyte Biology.  84:329. 2008
    2008 p38 MAPK-dependent eNOS upregulation is critical for 17β-estradiol- mediated cardioprotection following trauma-hemorrhage 2008
    2008 Inhibition of protein tyrosine phosphatases prevents mesenteric lymph node T-cell suppression following alcohol intoxication and burn injury.  Journal of Burn Care and Research.  29:519-530. 2008
    2008 Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients 2008
    2008 Mitogen activated protein kinase (MAPK) mediates non-genomic pathway of estrogen on T cell cytokine production following trauma-hemorrhage.  Cytokine.  42:32-38. 2008
    2008 Estrogen-mediated activation of non-genomic pathway improves macrophages cytokine production following trauma-hemorrhage.  Journal of Cellular Physiology.  214:662-672. 2008
    2008 Estrogen: A novel therapeutic adjunct for the treatment of trauma-hemorrhage-induced immunological alterations.  Molecular Medicine.  14:213-221. 2008
    2008 Trauma-hemorrhage inhibits splenic dendritic cell proinflammatory cytokine production via a mitogen-activated protein kinase process 2008
    2008 Comparison of longitudinal leukocyte gene expression after burn injury or trauma-hemorrhage in mice.  Physiological Genomics.  32:299-310. 2008
    2008 17β-Estradiol's salutary effects on splenic dendritic cell functions following trauma-hemorrhage are mediated via estrogen receptor-α.  Molecular Immunology.  45:376-385. 2008
    2008 Heme oxygenase-1 protects against neutrophil-mediated intestinal damage by down-regulation of neutrophil p47phox and p67phox activity and O2- production in a two-hit model of alcohol intoxication and burn injury.  Journal of Immunology.  180:6933-6940. 2008
    2008 Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage: p38 MAPK-dependent upregulation of HO-1 2008
    2008 Sex steroids/receptor antagonist: Their use as adjuncts after trauma-hemorrhage for improving immune/cardiovascular responses and for decreasing mortality from subsequent sepsis.  Anesthesia and Analgesia.  107:159-166. 2008
    2007 Trauma and immune response-Effect of gender differences 2007
    2007 Mechanism of salutary effects of finasteride on post-traumatic immune/inflammatory response: Upregulation of estradiol synthesis.  Annals of Surgery.  246:836-843. 2007
    2007 Mechanism of estrogen-mediated attenuation of hepatic injury following trauma-hemorrhage: Akt-dependent HO-1 up-regulation.  Journal of Leukocyte Biology.  82:1019-1026. 2007
    2007 V. Guidelines for sedation and analgesia during mechanical ventilation general overview.  Journal of Trauma and Acute Care Surgery.  63:945-950. 2007
    2007 Estrogen receptor-α predominantly mediates the salutary effects of 17β-estradiol on splenic macrophages following trauma-hemorrhage 2007
    2007 Mechanism of the nongenomic effects of estrogen on intestinal myeloperoxidase activity following trauma-hemorrhage: Up-regulation of the PI-3K/Akt pathway.  Journal of Leukocyte Biology.  82:774-780. 2007
    2007 Metabolic modulators following trauma sepsis: Sex hormones.  Critical Care Medicine.  35. 2007
    2007 Surgical trauma-induced adrenal insufficiency is associated with postoperative inflammatory responses 2007
    2007 17β-Estradiol normalizes Toll receptor 4, mitogen activated protein kinases and inflammatory response in epidermal keratinocytes following trauma-hemorrhage.  Molecular Immunology.  44:3317-3323. 2007
    2007 Role of p38 mitogen-activated protein kinase pathway in estrogen-mediated cardioprotection following trauma-hemorrhage 2007
    2007 Salutary effects of 17β-estradiol on T-cell signaling and cytokine production after trauma-hemorrhage are mediated primarily via estrogen receptor-α 2007
    2007 The PI3K/Akt pathway mediates the nongenomic cardioprotective effects of estrogen following trauma-hemorrhage.  Annals of Surgery.  245:971-977. 2007
    2007 The role of estrogen receptor subtypes in ameliorating hepatic injury following trauma-hemorrhage.  Journal of Hepatology.  46:1047-1054. 2007
    2007 Acute alcohol intoxication increases interleukin-18-mediated neutrophil infiltration and lung inflammation following burn injury in rats 2007
    2007 Downregulation of TLR4-dependent ATP production is critical for estrogen-mediated immunoprotection in Kupffer cells following trauma-hemorrhage.  Journal of Cellular Physiology.  211:364-370. 2007
    2007 Downregulation of migration inhibitory factor is critical for estrogen-mediated attenuation of lung tissue damage following trauma-hemorrhage 2007
    2007 Erratum: Mitochondria play an important role in 17β-estradiol attenuation of H2O2-induced rat endothelial cell apoptosis (American Journal of Physiology Endocrinology and Metabolism (2007) 292 (E585-E593)) 2007
    2007 TLR4 regulates Kupffer cell chemokine production, systemic inflammation and lung neutrophil infiltration following trauma-hemorrhage.  Molecular Immunology.  44:2625-2630. 2007
    2007 17β-Estradiol downregulates Kupffer cell TLR4-dependent p38 MAPK pathway and normalizes inflammatory cytokine production following trauma-hemorrhage.  Molecular Immunology.  44:2165-2172. 2007
    2007 Androstenediol inhibits the trauma-hemorrhage-induced increase in caspase-3 by downregulating the inducible nitric oxide synthase pathway.  Journal of Applied Physiology.  102:933-941. 2007
    2007 Monocyte chemoattractant protein-1 influences trauma-hemorrhage-induced distal organ damage via regulation of keratinocyte-derived chemokine production 2007
    2007 The role of MAPK in Kupffer cell Toll-like receptor (TLR) 2-, TLR4-, and TLR9-mediated signaling following trauma-hemorrhage.  Journal of Cellular Physiology.  210:667-675. 2007
    2007 17β-Estradiol inhibits keratinocyte-derived chemokine production following trauma-hemorrhage 2007
    2007 Does estrogen contribute to the hepatic regeneration following portal branch ligation in rats? 2007
    2007 Flutamide attenuates pro-inflammatory cytokine production and hepatic injury following trauma-hemorrhage via estrogen receptor-related pathway.  Annals of Surgery.  245:297-304. 2007
    2007 Mitochondria play an important role in 17β-estradiol attenuation of H2O2-induced rat endothelial cell apoptosis 2007
    2007 17β-Estradiol modulates vasoconstriction induced by endothelin-1 following trauma-hemorrhage 2007
    2007 Anti-rat soluble IL-6 receptor antibody down-regulates cardiac IL-6 and improves cardiac function following trauma-hemorrhage.  Journal of Molecular and Cellular Cardiology.  42:620-630. 2007
    2007 G protein-coupled receptor 30-dependent protein kinase A pathway is critical in nongenomic effects of estrogen in attenuating liver injury after trauma-hemorrhage.  American Journal of Pathology.  170:1210-1218. 2007
    2007 Impact of sex and age on bone marrow immune responses in a murine model of trauma-hemorrhage.  Journal of Applied Physiology.  102:113-121. 2007
    2007 Liver cytokine production and ICAM-1 expression following bone fracture, tissue trauma, and hemorrhage in middle-aged mice 2007
    2007 Tissue compartment-specific role of estrogen receptor subtypes in immune cell cytokine production following trauma-hemorrhage.  Journal of Applied Physiology.  102:163-168. 2007
    2007 Young and middle-age associated differences in cytokeratin expression after bone fracture, tissue trauma, and hemorrhage 2007
    2006 Estrus cycle: Influence on cardiac function following trauma-hemorrhage 2006
    2006 Erratum: Trauma-hemorrhage induces depressed splenic dendritic cell functions in mice (Journal of Immunology (2006) 177 (4514-4520)).  Journal of Immunology.  177:8877. 2006
    2006 A role for corticosterone in impaired intestinal immunity and barrier function in a rodent model of acute alcohol intoxication and burn injury.  Journal of Neuroimmune Pharmacology.  1:428-434. 2006
    2006 Lidocaine depresses splenocyte immune functions following trauma-hemorrhage in mice 2006
    2006 Effects of 17β-estradiol and flutamide on splenic macrophages and splenocytes after trauma-hemorrhage.  Cytokine.  36:107-114. 2006
    2006 Effects of 17β-estradiol and flutamide on inflammatory response and distant organ damage following trauma-hemorrhage in metestrus females.  Journal of Leukocyte Biology.  80:759-765. 2006
    2006 High dynamic range characterization of the trauma patient plasma proteome.  Molecular and Cellular Proteomics.  5:1899-1913. 2006
    2006 Trauma-hemorrhage induces depressed splenic dendritic cell functions in mice.  Journal of Immunology.  177:4514-4520. 2006
    2006 Maintenance of lung myeloperoxidase activity in proestrus females after trauma-hemorrhage: Upregulation of heme oxygenase-1 2006
    2006 Src family kinases regulate p38 MAPK-mediated IL-6 production in Kupffer cells following hypoxia 2006
    2006 Upregulation of mitochondrial respiratory complex IV by estrogen receptor-β is critical for inhibiting mitochondrial apoptotic signaling and restoring cardiac functions following trauma-hemorrhage.  Journal of Molecular and Cellular Cardiology.  41:511-521. 2006
    2006 Castration prevents suppression of MHC class II (Ia) expression on macrophages after trauma-hemorrhage.  Journal of Applied Physiology.  101:448-453. 2006
    2006 A novel role for IL-18 in corticosterone-mediated intestinal damage in a two-hit rodent model of alcohol intoxication and injury.  Journal of Leukocyte Biology.  80:367-375. 2006
    2006 Nitric oxide contributes to the development of a post-injury Th2 T-cell phenotype and immune dysfunction.  Journal of Cellular Physiology.  208:418-427. 2006
    2006 Androstenediol administration after trauma-hemorrhage attenuates inflammatory response, reduces organ damage, and improves survival following sepsis 2006
    2006 A role of PPAR-γ in androstenediol-mediated salutary effects on cardiac function following trauma-hemorrhage.  Annals of Surgery.  244:131-138. 2006
    2006 Inflammation and the Host Response to Injury: An overview of the multicenter study of the genomic and proteomic response to burn injury.  Journal of Burn Care and Research.  27:448-451. 2006
    2006 Sex differences in mortality after burn injury: Results of analysis of the National Burn Repository of the American Burn Association.  Journal of Burn Care and Research.  27:452-456. 2006
    2006 Are the protective effects of 17β-estradiol on splenic macrophages and splenocytes after trauma-hemorrhage mediated via estrogen-receptor (ER)-α or ER-β?.  Journal of Leukocyte Biology.  79:1173-1180. 2006
    2006 Inhibition of cardiac PGC-1α expression abolishes ERβ agonist-mediated cardioprotection following trauma-hemorrhage 2006
    2006 Better understanding of organ dysfunction requires proteomic involvement.  Journal of Proteome Research.  5:1060-1062. 2006
    2006 Salutary effects of estrogen receptor-β agonist on lung injury after trauma-hemorrhage 2006
    2006 Androstenediol ameliorates alterations in immune cells cytokine production capacity in a two-hit model of trauma-hemorrhage and sepsis.  Cytokine.  34:76-84. 2006
    2006 MyD88 and Src are differentially regulated in Kupffer cells of males and proestrus females following hypoxia.  Molecular Medicine.  12:65-73. 2006
    2006 A role of PP1/PP2A in mesenteric lymph node T cell suppression in a two-hit rodent model of alcohol intoxication and injury.  Journal of Leukocyte Biology.  79:453-462. 2006
    2006 Estradiol improves cardiac and hepatic function after trauma-hemorrhage: Role of enhanced heat shock protein expression 2006
    2006 Influence of gender and age on T-cell responses in a murine model of trauma-hemorrhage: Differences between circulating and tissue-fixed cells.  Journal of Applied Physiology.  100:826-833. 2006
    2006 Commonality and differences in leukocyte gene expression patterns among three models of inflammation and injury.  Physiological Genomics.  24:298-309. 2006
    2006 Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: Up-regulation of estrogen receptor-β-dependent HO-1.  Journal of Leukocyte Biology.  79:277-284. 2006
    2006 Alcohol intoxication and post-burn complications.  Frontiers in Bioscience-Landmark.  11:998-1005. 2006
    2006 Flutamide restores cardiac function after trauma-hemorrhage via an estrogen-dependent pathway through upregulation of PGC-1 2006
    2006 Gender and sex hormones influence the response to trauma and sepsis - Potential therapeutic approaches.  Clinics.  61:479-488. 2006
    2006 Gender and susceptibility to sepsis following trauma 2006
    2006 Kupffer cells and their mediators: The culprits in producing distant organ damage after trauma-hemorrhage.  American Journal of Pathology.  169:784-794. 2006
    2006 Mechanism of IL-6-mediated cardiac dysfunction following trauma-hemorrhage.  Journal of Molecular and Cellular Cardiology.  40:570-579. 2006
    2006 Mechanism of cardioprotection following trauma-hemorrhagic shock by a selective estrogen receptor-β agonist: Up-regulation of cardiac heat shock factor-1 and heat shock proteins.  Journal of Molecular and Cellular Cardiology.  40:185-194. 2006
    2006 T cells of the γδ T-cell receptor lineage play an important role in the postburn wound healing process.  Journal of Burn Care and Research.  27:18-25. 2006
    2006 Tissue-specific expression of estrogen receptors and their role in the regulation of neutrophil infiltration in various organs following trauma-hemorrhage.  Journal of Leukocyte Biology.  79:963-970. 2006
    2005 Erratum: A network-based analysis of systemic inflammation in humans (Nature (2005) 437 (1032-1037) DOI: 10.1038/nature03985).  Nature.  438:696. 2005
    2005 PGC-1 upregulation via estrogen receptors: A common mechanism of salutary effects of estrogen and flutamide on heart function after trauma-hemorrhage 2005
    2005 Opiate analgesics contribute to the development of post-injury immunosuppression.  Journal of Surgical Research.  129:161-168. 2005
    2005 Current understanding of gender dimorphism in hepatic pathophysiology.  Journal of Surgical Research.  128:147-156. 2005
    2005 The association between sex and mortality among burn patients as modified by age.  Journal of Burn Care and Research.  26:416-421. 2005
    2005 Role of thromboxane in producing hepatic injury during hepatic stress.  JAMA Surgery.  140:801-807. 2005
    2005 Corticosterone suppresses mesenteric lymph node T cells by inhibiting p38/ERK pathway and promotes bacterial translocation after alcohol and burn injury 2005
    2005 L-arginine improves wound healing after trauma-hemorrhage by increasing collagen synthesis.  Journal of Trauma and Acute Care Surgery.  59:162-168. 2005
    2005 Mechanism of salutary effects of estradiol on organ function after trauma-hemorrhage: Upregulation of heme oxygenase 2005
    2005 Surgical trauma and immunosuppression: Pathophysiology and potential immunomodulatory approaches 2005
    2005 Mouse genetic background influences severity of immune responses following trauma-hemorrhage.  Cytokine.  30:168-176. 2005
    2005 Gender differences in small intestinal perfusion following trauma hemorrhage: The role of endothelin-1 2005
    2005 Inhibition of IL-18 reduces myeloperoxidase activity and prevents edema in intestine following alcohol and burn injury.  Journal of Leukocyte Biology.  77:719-728. 2005
    2005 Transgenic prolactin-/- mice: Effect of trauma-hemorrhage on splenocyte functions 2005
    2005 Alcohol ingestion before burn injury decreases splanchnic blood flow and oxygen delivery 2005
    2005 Mechanism of salutary effects of androstenediol on hepatic function after trauma-hemorrhage: Role of endothelial and inducible nitric oxide synthase 2005
    2005 Dehydroepiandrosterone restores depressed peripheral blood mononuclear cell function following major abdominal surgery via the estrogen receptors.  Critical Care Medicine.  33:1779-1786. 2005
    2005 Quantitative proteome analysis of human plasma following in vivo lypopolysaccharide administration using 16O/18O labeling and the accurate mass and time tag approach.  Molecular and Cellular Proteomics.  4:700-709. 2005
    2004 Insights into the role of interleukin-6 in the induction of hepatic injury after trauma-hemorrhagic shock.  Journal of Applied Physiology.  97:2184-2189. 2004
    2004 Splenectomy differentially influences immune responses in various tissue compartments of the body.  Cytokine.  28:101-108. 2004
    2004 Mechanism of cardiac depression after trauma-hemorrhage: Increased cardiomyocyte IL-6 and effect of sex steroids on IL-6 regulation and cardiac function 2004
    2004 MAP kinases differentially regulate the expression of macrophage hyperactivity after thermal injury.  Journal of Cellular Physiology.  201:35-44. 2004
    2004 Cellular Alterations Following Shock and Trauma and Their Modulation.  Journal- Japanese Association for Acute Medicine.  15:324-325. 2004
    2004 Estradiol's effect on portal response to endothelin-1 after trauma-hemorrhage.  Journal of Surgical Research.  121:25-30. 2004
    2004 The role of γδ T cells in the regulation of neutrophil-mediated tissue damage after thermal injury.  Journal of Leukocyte Biology.  76:545-552. 2004
    2004 Salutary effects of androstenediol on cardiac function and splanchnic perfusion after trauma-hemorrhage 2004
    2004 The effect of inhibition of a major cell signaling pathway following trauma hemorrhage on hepatic injury and interleukin 6 levels.  JAMA Surgery.  139:896-901. 2004
    2004 Differences in the expression of LPS-receptors are not responsible for the sex-specific immune response after trauma and hemorrhagic shock.  Cellular Immunology.  230:17-22. 2004
    2004 Are the immune responses different in middle-aged and young mice following bone fracture, tissue trauma and hemorrhage?.  Cytokine.  26:223-230. 2004
    2004 Alpha1-acid-glycoprotein protects against trauma-hemorrhagic shock.  Journal of Surgical Research.  119:21-28. 2004
    2004 Role of IL-10 in regulating proinflammatory cytokine release by Kupffer cells following trauma-hemorrhage 2004
    2004 The role of interleukin-10 in the regulation of the systemic inflammatory response following trauma-hemorrhage 2004
    2004 Gender differences in small intestinal endothelial function: inhibitory role of androgens. 2004
    2004 Sex steroid-mediated regulation of macrophage/monocyte function in a two-hit model of trauma-hemorrhage and sepsis.  Cytokine.  25:110-118. 2004
    2004 Physiological Levels of 5α-Dihydrotestosterone Depress Wound Immune Function and Impair Wound Healing Following Trauma-Hemorrhage.  JAMA Surgery.  139:157-163. 2004
    2004 Gender differences in small intestinal endothelial function: Inhibitory role of androgens 2004
    2004 Mechanisms of hemorrhage-induced hepatic insulin resistance: Role of tumor necrosis factor-α 2004
    2004 Metabolic disturbances in shock, and the role of ATP-MgCl2 and sex steroids.  Medical Principles and Practice.  13:2-9. 2004
    2003 Brain Death Significantly Reduces Isolated Pancreatic Islet Yields and Functionality In Vitro and In Vivo after Transplantation in Rats.  Diabetes.  52:2935-2942. 2003
    2003 Role of thromboxane in producing portal hypertension following trauma-hemorrhage. 2003
    2003 Sex Differences in Hepatic Heme Oxygenase Expression and Activity Following Trauma and Hemorrhagic Shock.  JAMA Surgery.  138:1375-1382. 2003
    2003 Inhibition of Fas/Fas ligand signaling improves septic survival: Differential effects on macrophage apoptotic and functional capacity.  Journal of Leukocyte Biology.  74:344-351. 2003
    2003 Cellular, molecular and sexual dimorphic response to trauma-hemorrhage.  International Congress Series.  1255:25-38. 2003
    2003 Immunomodulatory effects of dehydroepiandrosterone in proestrus female mice after trauma-hemorrhage.  Journal of Applied Physiology.  95:529-535. 2003
    2003 Administration of progesterone after trauma and hemorrhagic shock prevents hepatocellular injury.  JAMA Surgery.  138:727-734. 2003
    2003 Androgen-mediated modulation of macrophage function after trauma-hemorrhage: Central role of 5α-dihydrotestosterone.  Journal of Applied Physiology.  95:104-112. 2003
    2003 Mechanism for normal splenic T lymphocyte functions in proestrus females after trauma: Enhanced local synthesis of 17β-estradiol 2003
    2003 Mechanism for normal splenic T lymphocyte functions in proestrus females after trauma: enhanced local synthesis of 17beta-estradiol. 2003
    2003 Sex-specific p38 MAP kinase activation following trauma-hemorrhage: Involvement of testosterone and estradiol 2003
    2003 Differential alterations in intestinal permeability after trauma-hemorrhage.  Journal of Surgical Research.  112:198-204. 2003
    2003 Gender dimorphic tissue perfusion response after acute hemorrhage and resuscitation: Role of vascular endothelial cell function 2003
    2003 Gender dimorphic tissue perfusion response after acute hemorrhage and resuscitation: role of vascular endothelial cell function. 2003
    2003 Progesterone administration after trauma and hemorrhagic shock improves cardiovascular responses.  Critical Care Medicine.  31:1786-1793. 2003
    2003 Endocrine targets in experimental shock..  Journal of Trauma and Acute Care Surgery.  54. 2003
    2003 Effect of estradiol administration on splanchnic perfusion after trauma-hemorrhage and sepsis.  Current Opinion in Critical Care.  9:137-142. 2003
    2003 Mechanism of the salutary effects of 17β-estradiol following trauma-hemorrhage: Direct downregulation of Kupffer cell proinflammatory cytokine production.  Cytokine.  21:91-97. 2003
    2003 Adrenomedullin and adrenomedullin binding protein-1: Their role in the septic response.  Journal of Surgical Research.  109:175-181. 2003
    2003 Hemorrhage induces the rapid development of hepatic insulin resistance 2003
    2003 Hemorrhage induces the rapid development of hepatic insulin resistance. 2003
    2003 Immunoprotection in proestrus females following trauma-hemorrhage: The pivotal role of estrogen receptors.  Cellular Immunology.  222:27-34. 2003
    2003 Role of thromboxane in producing portal hypertension following trauma-hemorrhage 2003
    2003 The association between gender and mortality among trauma patients as modified by age.  Journal of Trauma and Acute Care Surgery.  54:464-471. 2003
    2003 Upregulation of hepatic prolactin receptor gene expression by 17β-estradiol following trauma-hemorrhage.  Journal of Applied Physiology.  95:2530-2536. 2003
    2002 Novel approach to prevent the transition from the hyperdynamic phase to the hypodynamic phase of sepsis: Role of adrenomedullin and adrenomedullin binding protein-1.  Annals of Surgery.  236:625-633. 2002
    2002 Alveolar macrophage activation after trauma-hemorrhage and sepsis is dependent on NF-kappaB and MAPK/ERK mechanisms. 2002
    2002 Flutamide induces relaxation in large and small blood vessels.  JAMA Surgery.  137:1180-1186. 2002
    2002 Decreased 5alpha-dihydrotestosterone catabolism suppresses T lymphocyte functions in males after trauma-hemorrhage. 2002
    2002 Estrogen pretreatment protects males against hypoxia-induced immune depression. 2002
    2002 Saturation of adrenomedullin receptors plays an important role in reducing pulmonary clearance of adrenomedullin during the late stage of sepsis 2002
    2002 L-arginine: A unique amino acid for improving depressed wound immune function following hemorrhage.  European Surgical Research.  34:53-60. 2002
    2002 Cyclooxygenase 2-mediated suppression of macrophage interleukin-12 production after thermal injury. 2002
    2002 Female sex hormones regulate macrophage function after trauma-hemorrhage and prevent increased death rate from subsequent sepsis.  Annals of Surgery.  235:105-112. 2002
    2002 A universal distribution for component failure times.  Measurement Techniques.  45:710-713. 2002
    2002 Administration of human inter-α-inhibitors maintains hemodynamic stability and improves survival during sepsis.  Critical Care Medicine.  30:617-622. 2002
    2002 Adrenomedullin binding protein-1 modulates vascular responsiveness to adrenomedullin in late sepsis 2002
    2002 Alveolar macrophage activation after trauma-hemorrhage and sepsis is dependent on NF-κB and MAPK/ERK mechanisms 2002
    2002 Cyclooxygenase 2-mediated suppression of macrophage interleukin-12 production after thermal injury 2002
    2002 Decreased 5α-dihydrotestosterone catabolism suppresses T lymphocyte functions in males after trauma-hemorrhage 2002
    2002 Differential expression and tissue compartmentalization of the inflammatory response following thermal injury.  Cytokine.  17:266-274. 2002
    2002 Estradiol administration improves splanchnic perfusion following trauma-hemorrhage and sepsis.  JAMA Surgery.  137:74-79. 2002
    2002 Estrogen pretreatment protects males against hypoxia-induced immune depression 2002
    2002 Gender dimorphism in immune responses following trauma and hemorrhage.  Immunologic Research.  26:63-76. 2002
    2002 Gender dimorphism in immune responses following trauma and hemorrhage..  Immunologic Research.  26:63-76. 2002
    2002 Preservation of splenic immune functions by female sex hormones after trauma-hemorrhage.  Critical Care Medicine.  30:888-893. 2002
    2002 Relationships between burn size, immunosuppression, and macrophage hyperactivity in a murine model of thermal injury.  Cellular Immunology.  220:63-69. 2002
    2002 Scientific priorities and strategic planning for resuscitation research and life saving therapy following traumatic injury: Report of the PULSE Trauma Work Group.  Academic Emergency Medicine.  9:621-626. 2002
    2002 Soluble Fas gene therapy protects against Fas-mediated apoptosis of hepatocytes but not the lethal effects of Fas-induced TNF-α production by Kupffer cells.  Cell Death and Differentiation.  9:626-635. 2002
    2002 The cellular basis of post-burn immunosuppression: macrophages and mediators..  International Journal of Molecular Medicine.  10:239-243. 2002
    2002 Trauma-haemorrhage-induced alterations in thymic prolactin receptor expression: Implications in immune dysfunction.  Cytokine.  18:127-132. 2002
    2001 Resistance of macrophages to the suppressive effect of interleukin-10 following thermal injury. 2001
    2001 The role of lipopolysaccharide in stimulating adrenomedullin production during polymicrobial sepsis 2001
    2001 Divergent Immune Responses in Male and Female Mice after Trauma-Hemorrhage: Dimorphic Alterations in T Lymphocyte Steroidogenic Enzyme Activities..  Endocrinology.  142:3519-3529. 2001
    2001 The role of Kupffer cell α2-adrenoceptors in norepinephrine-induced TNF-α production 2001
    2001 Gender differences in the inflammatory response and survival following haemorrhage and subsequent sepsis.  Cytokine.  14:162-169. 2001
    2001 IL-10 mediation of activation-induced Th1 cell apoptosis and lymphoid dysfunction in polymicrobial sepsis.  Cytokine.  14:37-48. 2001
    2001 17β-Estradiol normalizes immune responses in ovariectomized females after trauma-hemorrhage 2001
    2001 Adrenal insufficiency during the late stage of polymicrobial sepsis.  Critical Care Medicine.  29:618-622. 2001
    2001 Attenuation of vascular endothelial dysfunction by testosterone receptor blockade after trauma and hemorrhagic shock.  JAMA Surgery.  136:1158-1163. 2001
    2001 Dehydroepiandrosterone restores hepatocellular function and prevents liver damage in estrogen-deficient females following trauma and hemorrhage.  Journal of Surgical Research.  97:196-201. 2001
    2001 Divergent immune responses in male and female mice after trauma-hemorrhage: Dimorphic alterations in T lymphocyte steroidogenic enzyme activities 2001
    2001 Glycine attenuates hepatocellular depression during early sepsis and reduces sepsis-induced mortality.  Critical Care Medicine.  29:1201-1206. 2001
    2001 Increased apoptosis in lamina propria B cells during polymicrobial sepsis is FasL but not endotoxin mediated 2001
    2001 MAPK p38 antagonism as a novel method of inhibiting lymphoid immune suppression in polymicrobial sepsis 2001
    2001 Norepinephrine-induced hepatocellular dysfunction in early sepsis is mediated by activation of α2-adrenoceptors 2001
    2001 Resistance of macrophages to the suppressive effect of interleukin-10 following thermal injury 2001
    2001 Testosterone and estrogen differently effect Th1 and Th2 cytokine release following trauma-haemorrhage.  Cytokine.  16:22-30. 2001
    2001 The role of adrenomedullin in producing differential hemodynamic responses during sepsis.  Journal of Surgical Research.  95:207-218. 2001
    2001 The small intestine is an important source of adrenomedullin release during polymicrobial sepsis 2001
    2001 The small intestine plays an important role in upregulating CGRP during sepsis 2001
    2000 Sustained elevation of norepinephrine depresses hepatocellular function 2000
    2000 Estradiol administration after trauma-hemorrhage improves cardiovascular and hepatocellular functions in male animals.  Annals of Surgery.  232:673-679. 2000
    2000 The dissociation between upregulated endothelins and hemodynamic responses during polymicrobial sepsis 2000
    2000 Mechanism of the beneficial effects of pentoxifylline during sepsis: Maintenance of adrenomedullin responsiveness and downregulation of proinflammatory cytokines.  Journal of Surgical Research.  91:70-76. 2000
    2000 Inhibition of tyrosine kinase signaling after trauma-hemorrhage: A novel approach for improving organ function and decreasing susceptibility to subsequent sepsis.  Annals of Surgery.  231:399-407. 2000
    2000 Alterations in tissue oxygen consumption and extraction after trauma and hemorrhagic shock.  Critical Care Medicine.  28:2837-2842. 2000
    2000 Critical role of oxygen radicals in the initiation of hepatic depression after trauma hemorrhage.  Journal of Trauma and Acute Care Surgery.  49:879-885. 2000
    2000 Does early infusion of red blood cells after trauma and hemorrhage improve organ functions?.  Critical Care Medicine.  28:3498-3504. 2000
    2000 Effect of naloxone on immune responses after hemorrhagic shock.  Critical Care Medicine.  28:184-189. 2000
    2000 Gut-derived norepinephrine plays a critical role in producing hepatocellular dysfunction during early sepsis 2000
    2000 Immune depression in polymicrobial sepsis: The role of necrotic (injured) tissue and endotoxin.  Critical Care Medicine.  28:2949-2955. 2000
    2000 Immune dysfunction following trauma-haemorrhage: Influence of gender and age.  Cytokine.  12:69-77. 2000
    2000 Insight into the mechanism by which metoclopramide improves immune functions after trauma-hemorrhage 2000
    2000 Insights into the role of γδ T lymphocytes in the immunopathogenic response to thermal injury.  Journal of Leukocyte Biology.  67:644-650. 2000
    2000 Is prostacyclin responsible for producing the hyperdynamic response during early sepsis?.  Critical Care Medicine.  28:1534-1539. 2000
    2000 L-Arginine attenuates trauma-hemorrhage-induced liver injury.  Critical Care Medicine.  28:3242-3248. 2000
    2000 Mechanism of hepatocellular dysfunction during sepsis: the role of gut-derived norepinephrine (review)..  International Journal of Molecular Medicine.  5:457-465. 2000
    2000 Metoclopramide: A novel adjunct for improving cardiac and hepatocellular functions after trauma-hemorrhage 2000
    2000 Plasma α-glutathione S-transferase: A sensitive indicator of hepatocellular damage during polymicrobial sepsis.  JAMA Surgery.  135:198-203. 2000
    2000 Preinduction of heat shock proteins protects cardiac and hepatic functions following trauma and hemorrhage 2000
    2000 Restoration of body temperature to normothermia during resuscitation following trauma-hemorrhage improves the depressed cardiovascular and hepatocellular functions.  JAMA Surgery.  135:175-181. 2000
    2000 Reversal of sexual dimorphism in splenic T lymphocyte responses after trauma-hemorrhage with aging 2000
    2000 Severe hypoxemia in the absence of blood loss causes a gender dimorphic immune response 2000
    2000 Testosterone receptor blockade after trauma and hemorrhage attenuates depressed adrenal function 2000
    2000 The female reproductive cycle is an important variable in the response to trauma-hemorrhage 2000
    2000 The important role of the gut in initiating the hyperdynamic response during early sepsis.  Journal of Surgical Research.  89:31-37. 2000
    1999 Role of protein kinase C in cyclic AMP-mediated suppression of T-lymphocyte activation following burn injury 1999
    1999 Is gut the major source of proinflammatory cytokine release during polymicrobial sepsis? 1999
    1999 Salutary effects of ATP-MgCl2 on the depressed endothelium-dependent relaxation during hyperdynamic sepsis.  Critical Care Medicine.  27:959-964. 1999
    1999 Increased inducible apoptosis in CD4+ T lymphocytes during polymicrobial sepsis is mediated by Fas ligand and not endotoxin.  Immunology.  97:45-55. 1999
    1999 Kupffer cells are responsible for producing inflammatory cytokines and hepatocellular dysfunction during early sepsis.  Journal of Surgical Research.  83:151-157. 1999
    1999 Pulmonary clearance of adrenomedullin is reduced during the late stage of sepsis 1999
    1999 Adrenomedullin is upregulated in the heart and aorta during the early and late stages of sepsis 1999
    1999 Proteasome participates in the alteration of signal transduction in T and B lymphocytes following trauma-hemorrhage 1999
    1999 Dehydroepiandrosterone restores immune function following trauma-haemorrhage by a direct effect on T lymphocytes.  Cytokine.  11:443-450. 1999
    1999 Differential alterations in systemic and regional oxygen delivery and consumption during the early and late stages of sepsis.  Journal of Trauma and Acute Care Surgery.  47:706-712. 1999
    1999 Hypoxemia in the absence of blood loss upregulates iNOS expression and activity in macrophages.  American Journal of Physiology.  276. 1999
    1999 Immunological consequences of trauma and shock.  Annals of the Academy of Medicine, Singapore.  28:120-132. 1999
    1999 L-arginine restores splenocyte functions after trauma and hemorrhage potentially by improving splenic blood flow.  American Journal of Physiology.  276. 1999
    1999 Organ dysfunction following hemorrhage and sepsis: mechanisms and therapeutic approaches (Review)..  International Journal of Molecular Medicine.  4:575-583. 1999
    1999 Pentoxifylline prevents the transition from the hyperdynamic to hypodynamic response during sepsis.  American Journal of Physiology.  277. 1999
    1999 Reduction in vascular responsiveness to adrenomedullin during sepsis.  Journal of Surgical Research.  85:59-65. 1999
    1999 Sex steroids regulate pro- and anti-inflammatory cytokine release by macrophages after trauma-hemorrhage.  American Journal of Physiology.  277. 1999
    1998 Dehydroepiandrosterone: An inexpensive steroid hormone that decreases the mortality due to sepsis following trauma-induced hemorrhage.  JAMA Surgery.  133:1281-1288. 1998
    1998 The pivotal role of adrenomedullin in producing hyperdynamic circulation during the early stage of sepsis.  JAMA Surgery.  133:1298-1304. 1998
    1998 Upregulation of Kupffer cell β-adrenoceptors and cAMP levels during the late stage of sepsis 1998
    1998 Testosterone: The crucial hormone responsible for depressing myocardial function in males after trauma-hemorrhage.  Annals of Surgery.  227:790-799. 1998
    1998 The organs responsible for increased nitric oxide production after trauma-hemorrhage and resuscitation.  JAMA Surgery.  133:399-405. 1998
    1998 Sepsis induces increased apoptosis in lamina propria mononuclear cells which is associated with altered cytokene gene expression 1998
    1998 Increased mucosal B-lymphocyte apoptosis during polymicrobial sepsis is a Fas ligand but not an endotoxin-mediated process.  Blood.  91:1362-1372. 1998
    1998 Left ventricular thrombus.  Circulation.  97:412. 1998
    1998 Is gut the 'motor' for producing hepatocellular dysfunction after trauma and hemorrhagic shock?.  Journal of Surgical Research.  74:141-148. 1998
    1998 Pentoxifylline increases gut ketogenesis following trauma and hemorrhagic shock.  Critical Care Medicine.  26:101-107. 1998
    1998 Chronic resuscitation after trauma-hemorrhage and acute fluid replacement improves hepatocellular function and cardiac output.  Annals of Surgery.  227:112-119. 1998
    1998 Does neutrophil-mediated oxidative stress play any significant role in producing hepatocellular dysfunction during early sepsis?.  Journal of Surgical Research.  80:75-79. 1998
    1998 Hepatocellular dysfunction after severe hypotension in the absence of blood loss is associated with the increased IL-6 and PGE2.  Journal of Surgical Research.  80:136-142. 1998
    1998 Increased gut permeability after hemorrhage is associated with upregulation of local and systemic IL-6.  Journal of Surgical Research.  79:39-46. 1998
    1998 Is Fas ligand or endotoxin responsible for mucosal lymphocyte apoptosis in sepsis?.  JAMA Surgery.  133:1213-1220. 1998
    1998 Sepsis induces increased apoptosis in lamina propria mononuclear cells which is associated with altered cytokine gene expression.  Journal of Surgical Research.  77:63-70. 1998
    1998 Severe depression of host immune functions following closed-bone fracture, soft-tissue trauma, and hemorrhagic shock.  Critical Care Medicine.  26:1372-1378. 1998
    1998 Testosterone: The culprit for producing splenocyte immune depression after trauma hemorrhage.  American Journal of Physiology.  274. 1998
    1998 Thermal injury alters macrophage responses to prostaglandin E2: Contribution to the enhancement of inducible nitric oxide synthase activity.  Journal of Leukocyte Biology.  64:740-746. 1998
    1997 Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males.  American Journal of Physiology.  273. 1997
    1997 Administration of ATP-MgCl2 following hemorrhage and resuscitation increases hepatic phosphoenolpyruvate carboxykinase and decreases pyruvate kinase activities 1997
    1997 Severe hypoxemia in the absence of blood loss depresses hepatocellular function and up-regulates IL-6 and PGE2 1997
    1997 Inducible macrophage apoptosis following sepsis is mediated by cysteine protease activation and nitric oxide release.  Journal of Surgical Research.  70:113-118. 1997
    1997 Endothelial nitric oxide synthase is downregulated during hyperdynamic sepsis 1997
    1997 Liver endothelial cell function is depressed only during hypodynamic sepsis.  Journal of Surgical Research.  68:38-43. 1997
    1997 Trauma-hemorrhage induces increased thymic apoptosis while decreasing IL-3 release and increasing GM-CSF.  Journal of Surgical Research.  68:24-30. 1997
    1997 Effects of prolactin and metoclopramide on macrophage cytokine gene expression in late sepsis.  Cytokine.  9:437-446. 1997
    1997 Females in proestrus state maintain splenic immune functions and tolerate sepsis better than males.  Critical Care Medicine.  25:106-110. 1997
    1997 Male sex steroids are responsible for depressing macrophage immune function after trauma-hemorrhage.  American Journal of Physiology.  273. 1997
    1997 Mechanism of intestinal mucosal immune dysfunction following trauma- hemorrhage: Increased apoptosis associated with elevated Fas expression in Peyer's patches.  Journal of Surgical Research.  70:55-60. 1997
    1997 Salutary effects of ATP-MgCl2 on altered hepatocyte signal transduction after hemorrhagic shock.  American Journal of Physiology.  272. 1997
    1997 Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males 1997
    1997 The role of neutrophils in producing hepatocellular dysfunction during the hyperdynamic stage of sepsis in rats.  Journal of Surgical Research.  73:117-122. 1997
    1996 Prolactin Administration Following Hemorrhagic Shock Improves Macrophage Cytokine Release Capacity and Decreases Mortality from Subsequent Sepsis.  Journal of Immunology.  157:5748-5754. 1996
    1996 Depressed osteoblast activity after trauma-hemorrhage 1996
    1996 Mechanism of hepatocellular dysfunction following trauma and hemorrhagic shock: Key role of hypoxemia 1996
    1996 Metoclopramide improves splenocyte immune function and restores plasma corticosteroid levels after hemorrhagic shock 1996
    1996 Prolactin improves depressed macrophage indugible cytokine gene expression in peritoneal macrophages (PMφ), splenic macrophages (SMφ) and kupffer cells (KC) following sepsis 1996
    1996 Trauma-hemorrhage induces increased thymic apoptosis while decreasing il-3 release 1996
    1996 Increased melatonin levels after hemorrhagic shock in male and female C3H/HeN mice.  Cellular and Molecular Life Sciences.  52:587-590. 1996
    1996 Platelet activating factor and its role in trauma, shock, and sepsis.  New horizons (Baltimore, Md.).  4:265-275. 1996
    1996 Differential induction of apoptosis in lymphoid tissues during sepsis: Variation in onset, frequency, and the nature of the mediators.  Blood.  87:4261-4275. 1996
    1996 Depressed osteoblast activity and increased osteocyte necrosis after closed bone fracture and hemorrhagic shock.  Journal of Trauma and Acute Care Surgery.  41:628-634. 1996
    1996 Effects of nonanticoagulant heparin on cardiovascular and hepatocellular function after hemorrhagic shock.  American Journal of Physiology.  270. 1996
    1996 Enhanced immune responses in females, as opposed to decreased responses in males following haemorrhagic shock and resuscitation.  Cytokine.  8:853-863. 1996
    1996 Immune function is more compromised after closed bone fracture and hemorrhagic shock than hemorrhage alone.  JAMA Surgery.  131:995-1000. 1996
    1996 Inhibition of the Biologic Activity of Tumor Necrosis Factor Maintains Vascular Endothelial Cell Function during Hyperdynamic Sepsis.  Journal of Trauma and Acute Care Surgery.  40:694-700. 1996
    1996 Is Sepsis-Induced Apoptosis Associated with Macrophage Dysfunction?.  Journal of Trauma and Acute Care Surgery.  40:568-573. 1996
    1996 Mechanism of hepatocellular dysfunction during hyperdynamic sepsis.  American Journal of Physiology.  270. 1996
    1996 Melatonin administration following hemorrhagic shock decreases mortality from subsequent septic challenge.  Journal of Surgical Research.  65:109-114. 1996
    1996 Pentoxifylline restores the depressed cardiac performance after trauma- hemorrhage and resuscitation.  Journal of Surgical Research.  66:51-56. 1996
    1996 Prolactin inhibits the increased cytokine gene expression in Kupffer cells following haemorrhage.  Cytokine.  8:134-140. 1996
    1996 Relationship of pelvic radiation to intestinal blood flow.  Journal of Surgical Research.  60:239-244. 1996
    1995 ATP-MgCl2 restores depressed endothelial cell function after hemorrhagic shock and resuscitation.  American Journal of Physiology.  268. 1995
    1995 Cytokine gene expression in splenic macrophages and kupffer cells following haemorrhage.  Cytokine.  7:8-14. 1995
    1995 Dietary n-3 polyunsaturated fatty acid modulation of immune cell function before or after trauma.  Nutrition.  11:1-11. 1995
    1995 Does Endotoxin Play a Major Role in Inducing the Depression of Macrophage Function During Polymicrobial Sepsis?.  JAMA Surgery.  130:1178-1185. 1995
    1995 Downregulation of hepatic β-adrenergic receptors after trauma and hemorrhagic shock.  American Journal of Physiology.  268. 1995
    1995 Effect of surgical trauma on splenocyte and peritoneal macrophage immune function.  Journal of Trauma and Acute Care Surgery.  39:645-650. 1995
    1995 Effects of hydroxyethyl starch after trauma-hemorrhagic shock: Restoration of macrophage integrity and prevention of increased circulating interleukin- 6 levels.  Critical Care Medicine.  23:806-814. 1995
    1995 Endothelium-dependent relaxation is depressed at the macro- and microcirculatory levels during sepsis.  American Journal of Physiology.  269. 1995
    1995 Hemorrhage affects the ability of murine peritoneal macrophages to alkanize intracellular ph in acidic environments.  Journal of Surgical Research.  58:682-686. 1995
    1995 Hypoxemia in the absence of blood loss or significant hypotension causes inflammatory cytokine release.  American Journal of Physiology.  269. 1995
    1995 Impaired gut lipid absorptive capacity after trauma-hemorrhage and resuscitation.  American Journal of Physiology.  269. 1995
    1995 Intraperitoneal sodium carboxymethylcellulose administration prevents reformation of peritoneal adhesions following surgical lysis.  Journal of Surgical Research.  59:97-102. 1995
    1995 PAF-antagonist administration after hemorrhage-resuscitation prevents splenocyte immunodepression.  Journal of Surgical Research.  59:366-370. 1995
    1994 Methods to prevent colonic injury in pelvic radiation.  Diseases of the Colon and Rectum.  37:1090-1094. 1994
    1994 ATP-MgCl2 administration normalizes macrophage cAMP and gamma-adrenergic receptors after hemorrhage and resuscitation.  American Journal of Physiology.  267. 1994
    1994 Downregulation of hepatocyte P2-purinoceptor binding capacity after trauma-hemorrhage/resuscitation.  American Journal of Physiology.  266. 1994
    1994 ATP-MgCl2 administration normalizes macrophage cAMP and β-adrenergic receptors after hemorrhage and resuscitation 1994
    1994 ATP-MgCl2 treatment after trauma-hemorrhage/resuscitation increases hepatocyte P2-purinoceptor binding capacity.  American Journal of Physiology.  266. 1994
    1994 ATP-MgCl2treatment after trauma-hemorrhage/resuscitation increases hepatocyte P2-purinoceptor binding capacity 1994
    1994 Administration of tumor necrosis factor-α in vivo depresses endothelium- dependent relaxation.  American Journal of Physiology.  266. 1994
    1994 Biological significance of elevated TNF levels: In vivo administration of monoclonal antibody against TNF following haemorrhage shock increases the capacity of macrophages to release TNF while restoring immuno-responsiveness.  Cytokine.  6:624-632. 1994
    1994 Dextran 70 administration after trauma-hemorrhagic shock does not impair cellular immune functions.  Journal of Critical Care.  9:244-254. 1994
    1994 Does laser-Doppler flowmetry provide a quantitative measure of hepatic perfusion.  American Journal of Physiology.  266. 1994
    1994 Downregulation of hepatocyte P2-purinoceptor binding capacity after trauma-hemorrhage/resuscitation 1994
    1994 Effects of trauma, duration of hypotension, and resuscitation regimen on cellular immunity after hemorrhagic shock.  Critical Care Medicine.  22:1076-1083. 1994
    1994 Energetics of lymphocyte “Burnout” in late sepsis: Adjuvant treatment with ATP-MgCl2 improves energetics and decreases lethality.  Journal of Surgical Research.  56:537-542. 1994
    1994 Measurement of circulating blood volume in vivo after trauma-hemorrhage and hemodilution.  American Journal of Physiology.  266. 1994
    1994 Measurement of circulating blood volume in vivo after trauma-hemorrhage and hemodilution.  American Journal of Physiology.  266. 1994
    1994 Mechanism of Enhanced Susceptibility to Sepsis Following Hemorrhage: Interleukin-10 Suppression of T-Cell Response Is Mediated by Eicosanoid-Induced Interleukin-4 Release.  JAMA Surgery.  129:1172-1178. 1994
    1994 Nitric Oxide: To Block or Enhance Its Production During Sepsis?.  JAMA Surgery.  129:1137-1143. 1994
    1994 Pentoxifylline attenuates oxygen-induced lung injury.  Journal of Surgical Research.  56:543-548. 1994
    1994 Peritoneal macrophages show increased cytokine gene expression following haemorrhagic shock.  Immunology.  83:378-383. 1994
    1994 Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2/IFN-γ release while increasing IL-4/IL-10 production.  Journal of Surgical Research.  56:579-585. 1994
    1994 Severe depression of gut absorptive capacity in patients following trauma or sepsis.  Journal of Trauma and Acute Care Surgery.  36:803-809. 1994
    1994 Vascular smooth muscle contractile function is impaired during early and late stages of sepsis.  Journal of Surgical Research.  56:556-561. 1994
    1993 Tauromustine is more effective than conventional chemotherapy in the treatment of colonic tumors.  Diseases of the Colon and Rectum.  36:394-399. 1993
    1993 A model of pulmonary atelectasis in rats: Activation of alveolar macrophage and cytokine release.  American Journal of Physiology.  264. 1993
    1993 ATP-MgCl2 restores gut absorptive capacity early after trauma- hemorrhagic shock.  American Journal of Physiology.  264. 1993
    1993 Alterations in circulating blood volume during polymicrobial sepsis.  Journal of inflammation.  40:92-98. 1993
    1993 Chemically induced hypotension increases PGE2 release and depresses macrophage antigen presentation.  American Journal of Physiology.  264. 1993
    1993 Chloroquine inhibits macrophage tumour necrosis factor-α mRNA transcription.  Immunology.  80:122-126. 1993
    1993 Diltiazem reduces whole blood viscosity following trauma-hemorrhagic shock and resuscitation.  Journal of inflammation.  39:231-236. 1993
    1993 Endothelial cell dysfunction occurs after hemorrhage in nonheparinized but not in preheparinized models.  Journal of Surgical Research.  54:499-506. 1993
    1993 Endothelial cell dysfunction occurs very early following trauma- hemorrhage and persists despite fluid resuscitation.  American Journal of Physiology.  265. 1993
    1993 Insights into the mechanism by which interferon-γ improves macrophage function following hemorrhage and resuscitation.  Journal of Surgical Research.  54:322-327. 1993
    1993 Mechanism of diltiazem's immunomodulatory effects after hemorrhage and resuscitation.  American Journal of Physiology.  265. 1993
    1993 Mechanism of increased susceptibility to infection following hemorrhage 1993
    1993 Modulation of Macrophage Membrane Phospholipids by n-3 Polyunsaturated Fatty Acids Increases Interleukin 1 Release and Prevents Suppression of Cellular Immunity Following Hemorrhagic Shock.  JAMA Surgery.  128:15-21. 1993
    1993 Prevention of secondary cardiovascular instability after intestinal ischemia and reperfusion improves survival.  American Journal of Physiology.  264. 1993
    1993 Restoration of gut absorptive capacity following trauma-hemorrhagic shock by the adjuvant use of heparan sulfate.  Journal of Trauma and Acute Care Surgery.  34:645-652. 1993
    1993 Role of Interleukin 6 and Transforming Growth Factor–β in the Induction of Depressed Splenocyte Responses Following Sepsis.  JAMA Surgery.  128:89-95. 1993
    1993 The release of transforming growth factor-β following haemorrhage: Its role as a mediator of host immunosuppression.  Immunology.  79:479-484. 1993
    1993 Trauma-hemorrhage and resuscitation in the mouse: Effects on cardiac output and organ blood flow.  American Journal of Physiology.  264. 1993
    1993 Tumor necrosis factor depresses gut absorptive function.  Journal of inflammation.  39:279-284. 1993
    1993 Tumor necrosis factor-α produces hepatocellular dysfunction despite normal cardiac output and hepatic microcirculation.  American Journal of Physiology.  265. 1993
    1992 Direct comparison between Czerny-Lembert and circular-stapled anastomotic techniques in colorectal anastomosis: A similar pattern of healing for both.  Diseases of the Colon and Rectum.  35:862-869. 1992
    1992 Differential alterations in microvascular perfusion in various organs during early and late sepsis..  American Journal of Physiology.  263:G38-G43. 1992
    1992 Omeprazole-induced hypergastrinemia does not influence growth of colon carcinoma.  Digestive Diseases and Sciences.  37:485-489. 1992
    1992 Does a proximal colostomy affect colorectal anastomotic healing?.  Diseases of the Colon and Rectum.  35:182-188. 1992
    1992 ATP-MgCl2 restores renal microcirculation following trauma and severe hemorrhage.  Canadian Journal of Physiology and Pharmacology.  70:349-357. 1992
    1992 ATP-MgCl2 restores the depressed cardiac output following trauma and severe hemorrhage even in the absence of blood resuscitation.  Journal of inflammation.  36:277-283. 1992
    1992 Chloroquine Attenuates Hemorrhagic Shock—Induced Immunosuppression and Decreases Susceptibility to Sepsis.  JAMA Surgery.  127:70-76. 1992
    1992 Crystalloid is as effective as blood in the resuscitation of hemorrhagic shock.  Annals of Surgery.  215:377-382. 1992
    1992 Differential alterations in microvascular perfusion in various organs during early and late sepsis.  American Journal of Physiology.  263. 1992
    1992 Differential effects of ATP-MgCl2 on portal and hepatic arterial blood flow after hemorrhage and resuscitation.  American Journal of Physiology.  263. 1992
    1992 Differential effects of hemorrhage on kupffer cells: decreased antigen presentation despite increased inflammatory cytokine (IL-1, IL-6 and TNF) release.  Cytokine.  4:66-75. 1992
    1992 Diltiazem restores cardiac output and improves renal function after hemorrhagic shock and crystalloid resuscitation.  American Journal of Physiology.  262. 1992
    1992 Does Endotoxin Tolerance Prevent the Release of Inflammatory Monokines (Interleukin 1, Interleukin 6, or Tumor Necrosis Factor) During Sepsis?.  JAMA Surgery.  127:191-197. 1992
    1992 Hepatocellular dysfunction persists during early sepsis despite increased volume of crystalloid resuscitation.  Journal of Trauma and Acute Care Surgery.  32:389-397. 1992
    1992 Ibuprofen restores cellular immunity and decreases susceptibility to sepsis following hemorrhage.  Journal of Surgical Research.  53:55-61. 1992
    1992 Measurement of hepatic blood flow after severe hemorrhage: Lack of restoration despite adequate resuscitation.  American Journal of Physiology.  262. 1992
    1992 Mechanism of the beneficial effects of ATP-MgCl2 following trauma-hemorrhage and resuscitation: Downregulation of inflammatory cytokine (TNF, IL-6) release.  Journal of Surgical Research.  52:364-371. 1992
    1992 Pharmacologic agents in the treatment of ischemia, hemorrhagic shock, and sepsis.  Journal of Critical Care.  7:189-216. 1992
    1992 Polymicrobial sepsis selectively activates peritoneal but not alveolar macrophages to release inflammatory mediators (interleukins-1 and -6 and tumor necrosis factor).  Journal of inflammation.  36:191-199. 1992
    1992 Preoperative radiation therapy produces an early and persistent reduction in colorectal anastomotic blood flow.  Journal of Surgical Research.  53:464-469. 1992
    1992 Protective effects of preheparinization on the microvasculature during and after hemorrhagic shock.  Journal of Trauma and Acute Care Surgery.  32:420-426. 1992
    1992 Sepsis induces an early increased spontaneous release of hepatocellular stimulatory factor (interleukin-6) by Kupffer cells in both endotoxin tolerant and intolerant mice.  Journal of Surgical Research.  52:635-641. 1992
    1992 Sepsis produces early depression of gut absorptive capacity: Restoration with diltiazem treatment.  American Journal of Physiology.  263. 1992
    1991 Hemorrhage induces enhanced Kupffer cell cytotoxicity while decreasing peritoneal or splenic macrophage capacity: Involvement of cell-associated tumor necrosis factor and reactive nitrogen.  Journal of Immunology.  147:4147-4154. 1991
    1991 ATP-MgCl2 restores the depressed hepatocellular function and hepatic blood flow following hemorrhage and resuscitation.  Journal of Surgical Research.  50:368-374. 1991
    1991 Adequate crystalloid resuscitation restores but fails to maintain the active hepatocellular function following hemorrhagic shock.  Journal of Trauma and Acute Care Surgery.  31:601-608. 1991
    1991 Anti-TNF monoclonal antibodies prevent haemorrhage-induced suppression of Kupffer cell antigen presentation and MHC class II antigen expression.  Immunology.  74:290-297. 1991
    1991 Association between decreased splenic ATP levels and immunodepression: Amelioration with ATP-MgCl2.  American Journal of Physiology.  261. 1991
    1991 Blockade of prostaglandin production increases cachectin synthesis and prevents depression of macrophage functions after hemorrhagic shock.  Annals of Surgery.  213:265-271. 1991
    1991 Chloroquine attenuates hemorrhagic shock-induced suppression of Kupffer cell antigen presentation and major histocompatibility complex class II antigen expression through blockade of tumor necrosis factor and prostaglandin release.  Blood.  78:1781-1788. 1991
    1991 Crystalloid resuscitation restores but does not maintain cardiac output following severe hemorrhage.  Journal of Surgical Research.  50:163-169. 1991
    1991 Depressed gut absorptive capacity early after trauma-hemorrhagic shock: Restoration with diltiazem treatment.  Annals of Surgery.  214:712-718. 1991
    1991 Differential alterations in plasma IL-6 and TNF levels after trauma and hemorrhage.  American Journal of Physiology.  260. 1991
    1991 Diltiazem restores IL-2, IL-3, IL-6, and IFN-γ synthesis and decreases host susceptibility to sepsis following hemorrhage.  Journal of Surgical Research.  51:158-164. 1991
    1991 Eicosanoids regulate tumor necrosis factor synthesis after hemorrhage in vitro and in vivo.  Journal of Trauma and Acute Care Surgery.  31:609-616. 1991
    1991 Hepatic Extraction of Indocyanine Green Is Depressed Early in Sepsis Despite Increased Hepatic Blood Flow and Cardiac Output.  JAMA Surgery.  126:219-224. 1991
    1991 Improved methodology for the evaluation of the velocity of clearance of indocyanine green in the rat.  Journal of inflammation.  33:26-32. 1991
    1991 Increase in hepatic blood flow during early sepsis is due to increased portal blood flow.  American Journal of Physiology.  261. 1991
    1991 Measurement of D-xylose gut absorptive capacity in conscious rats.  American Journal of Physiology.  261. 1991
    1991 The complex pattern of cytokines in sepsis: Association between prostaglandins, cachectin, and interleukins.  Annals of Surgery.  214:141-148. 1991
    1990 Hemorrhage produces depression in microvascular blood flow which persists despite fluid resuscitation.  Journal of inflammation.  32:307-318. 1990
    1990 Intramural pH: A quantitative measurement for predicting colorectal anastomotic healing.  Diseases of the Colon and Rectum.  33:175-179. 1990
    1990 Cellular dysfunction in sepsis.  Journal of Critical Care.  5:62-69. 1990
    1990 Decreased Fc receptor expression on macrophages following simple hemorrhage as observed by scanning immunoelectron microscopy.  Journal of Leukocyte Biology.  48:512-518. 1990
    1990 Defective macrophage antigen presentation following haemorrhage is associated with the loss of MHC class II (Ia) antigens.  Immunology.  70:33-39. 1990
    1990 Enhanced Susceptibility to Sepsis After Simple Hemorrhage: Depression of Fc and C3b Receptor-Mediated Phagocytosis.  JAMA Surgery.  125:70-75. 1990
    1990 Hemorrhage and resuscitation: Immunological aspects.  American Journal of Physiology.  259. 1990
    1990 Hemorrhage induces an increase in serum TNF which is not associated with elevated levels of endotoxin.  Cytokine.  2:170-174. 1990
    1990 Hepatocellular dysfunction occurs early after hemorrhage and persists despite fluid resuscitation.  Journal of Surgical Research.  48:464-470. 1990
    1990 Preheparinization improves organ function after hemorrhage and resuscitation.  American Journal of Physiology.  259. 1990
    1990 Use of ATP following Shock and Ischemia.  Annals of the New York Academy of Sciences.  603:130-140. 1990
    1989 Measurement of hepatocellular function, cardiac output, effective blood volume, and oxygen saturation in rats.  American Journal of Physiology.  257. 1989
    1989 Mechanism of immunosuppression following hemorrhage: Defective antigen presentation by macrophages.  Journal of Surgical Research.  46:553-556. 1989
    1988 Effect of Blood Transfusion on Antigen Presentation Function and on Interleukin 2 Generation.  JAMA Surgery.  123:235-240. 1988
    1988 Mechanism of calcium and magnesium translocation in acute pancreatitis: A temporal correlation between hypocalcemia and membrane-mediated excessive intracellular calcium accumulation in soft tissues.  Magnesium.  7:91-102. 1988
    1988 Metabolic Interaction Between Skeletal Muscle and Liver During Bacteremia.  JAMA Surgery.  123:1415-1419. 1988
    1988 Prostaglandin E2 depresses antigen-presenting cell function of peritoneal macrophages.  Journal of Surgical Research.  44:733-739. 1988
    1988 Use of magnesium-ATP following liver ischemia.  Magnesium.  7:68-77. 1988
    1987 Alleviation of cyclosporine nephrotoxicity with verapamil and ATP-MgCl2: Mitochondrial respiratory and calcium studies.  Annals of Surgery.  206:655-660. 1987
    1987 Aterations in hepatic membrane potentials in vivo during early and late sepsis.  Journal of inflammation.  22:1-9. 1987
    1987 Comparison effects of ATP-MgCl2 and adenosine-MgCl2 on renal function following ischemia.  American Journal of Physiology.  252. 1987
    1987 Hemorrhage Without Tissue Trauma Produces Immunosuppression and Enhances Susceptibility to Sepsis.  JAMA Surgery.  122:62-68. 1987
    1987 Reperfusion with ATP-MgCl2 following prolonged ischemia improves myocardial performance.  Journal of Surgical Research.  43:114-117. 1987
    1986 Effects of ATP-MgCl2 and adenosine-MgCl2 administration on intracellular ATP levels in the kidney 1986
    1986 Depression of Cellular Immunity After Major Injury: Its Association With Posttraumatic Complications and Its Reversal With Immunomodulation.  JAMA Surgery.  121:1000-1005. 1986
    1986 Hepatic ischemia models for determining the effects of ATP-MgCl2 treatment.  Journal of Surgical Research.  40:167-175. 1986
    1986 Reoxygenation injury in isolated hepatocytes: Effect of extracellular ATP on cation homeostasis.  American Journal of Physiology.  250. 1986
    1986 Salutary effects of ATP-MgCl2 are not dependent on the presence of vanadium or the source of ATP..  Journal of inflammation.  18:259-261. 1986
    1986 The role of ATP-magnesium in ischemia and shock..  Magnesium.  5:211-220. 1986
    1985 Hepatic microcirculatory failure after ischemia and reperfusion: improvement with ATP-MgCl2 treatment..  American Journal of Physiology.  248. 1985
    1985 Adenine nucleotides and reversal of post-ischemic mitochondrial dysfunction 1985
    1985 Adenosine Triphosphate—Magnesium Chloride Ameliorates Reperfusion Injury Following Ischemia as Determined by Phosphorus Nuclear Magnetic Resonance.  JAMA Surgery.  120:233-240. 1985
    1985 Cellular alterations in shock and ischemia and their correction.  Physiologist.  28:109-118. 1985
    1985 Effect of pyridoxalated stabilized stroma-free hemoglobin solution on the clearance of intravascular lipid by the reticuloendothelial system.  Journal of inflammation.  16:165-172. 1985
    1985 Effects of heart rate and extracellular calcium on the inotropic effects of ATP and adenosine in isolated rat heart 1985
    1985 Hepatic microcirculatory failure after ischemia and reperfusion: Improvement with ATP-MgCl2 treatment.  American Journal of Physiology.  17. 1985
    1985 Phospholipid and adenine nucleotide metabolism in muscle after burn injury.  American Journal of Physiology.  18. 1985
    1985 Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. 1. Effects on the cis-Diamminedichloroplatinum-treated isolated perfused kidneys.  Journal of Surgical Research.  38:429-437. 1985
    1985 Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. II. Effects on gentamicin-treated isolated perfused kidneys.  Journal of Surgical Research.  38:438-445. 1985
    1985 Renal handling of exogenous ATP-MgCl2 (ATP) 1985
    1985 Restoration of post-ischemic tissue ATP+ADP and tissue and mitochondrial (Mt) magnesium (Mg) by ATP-MgCl2 1985
    1984 Accelerated functional recovery of isolated rat kidney with ATP-MgCl2 after warm ischemia 1984
    1984 ATP-MgCl2 produces sustained improvement in hepatic mitochondrial function and blood flow after hepatic ischemia.  Journal of Surgical Research.  37:226-234. 1984
    1984 Accelerated functional recovery of isolated rat kidney with ATP-MgCl2 after warm ischemia.  American Journal of Physiology.  16. 1984
    1984 Alterations in Hepatic Water and Electrolyte Balance in Sepsis.  JAMA Surgery.  119:44-48. 1984
    1984 Cellular energetics and ATP-MgCl2 therapy in sepsis.  American Journal of Emergency Medicine.  2:38-44. 1984
    1984 Dissociation between the early and late effects of ATP- and adenosine-MgCl2 on hepatocellular function following ischemia 1984
    1984 Effect of exogenous ATP-MgCl2 on contractility in the isolated rat heart 1984
    1984 Hydroxyethylstarch administration does not depress reticuloendothelial function or increase mortality from sepsis.  Journal of inflammation.  13:21-26. 1984
    1984 Hypothyroidism abolishes the hyperdynamic phase and increases susceptibility to sepsis.  Journal of Surgical Research.  36:265-273. 1984
    1984 Improved Myocardial Recovery From Ischemia: Treatment With Low-Dose Adenosine Triphosphate-Magnesium Chloride.  JAMA Surgery.  119:1379-1384. 1984
    1984 Improved mitochondrial function following ischemia and reflow by ATP-MgCl2.  American Journal of Physiology.  15. 1984
    1984 Improved mitochondrial function following ischemia and reflow by ATP-MgCl2 1984
    1984 Insulin resistance and depressed gluconeogenic capability during early hyperglycemic sepsis.  Journal of Trauma and Acute Care Surgery.  24:701-708. 1984
    1983 Beneficial effects of implanted muscle tissue on pulmonary particulate retention and survival following splenectomy.  Journal of Trauma and Acute Care Surgery.  23:584-590. 1983
    1983 Cellular mechanisms in shock and ischemia and their correction 1983
    1983 Cellular mechanisms in shock and ischemia and their correction.  American Journal of Physiology.  14. 1983
    1983 Regulation of glucose production from lactate in experimental sepsis.  American Journal of Physiology.  13. 1983
    1983 Regulation of glucose production from lactate in experimental sepsis 1983
    1983 Studies on the mechanism of beneficial effects of ATP-MgCl2 following hepatic ischemia 1983
    1983 Studies on the mechanism of beneficial effects of ATP-MgCl2 following hepatic ischemia.  American Journal of Physiology.  13. 1983
    1982 Impairment of reticuloendothelial function following thermal injury and its restoration with ATP-MgCl2 administration.  Journal of inflammation.  9:297-305. 1982
    1982 Accelerated recovery of single nephron function by the postischemic infusion of ATP-MgCl2.  Kidney International.  22:13-20. 1982
    1982 Altered Hepatocellular Active Transport: An Early Change in Peritonitis.  JAMA Surgery.  117:151-157. 1982
    1982 Comparison of the neuromuscular and central effects of 4-amino- and 3,4-diaminopyridine 1982
    1982 Editorial Commentary: 'The effect of ATP on survival in intestinal ischemia shock, hemorrhagic shock, and endotoxin shock in rats'.  Journal of inflammation.  9:629-631. 1982
    1982 Hemodynamic effects of ATP-MgCl2 infusion in conscious normovolemic (NV) and hypovolemic (HV) dogs 1982
    1982 Hemodynamic effects of ATP-MgCl2 infusion in conscious normovolemic and hypovolemic primates.  Circulatory shock.  9. 1982
    1982 Hepatic gluconeogenic capability in sepsis is depressed before changes in oxidative capability.  Journal of Trauma and Acute Care Surgery.  22:723-729. 1982
    1982 Lysine restores gluconeogenic capability but not α-adrenergic sensitivity in livers from late septic rats 1982
    1982 Preparation of ATP-MgCl2 and precautions for its use in the study and treatment of shock and ischemia 1982
    1982 Preparation of ATP-MgCl2 and precautions for its use in the study and treatment of shock and ischemia.  American Journal of Physiology.  11. 1982
    1982 Restoration of hepatic mitochondrial function following global ischemia by ATP-MgCl2 1982
    1982 Restoration of hepatocellular function and blood flow following hepatic ischemia with ATP-MgCl2..  Advances in shock research.  8:177-186. 1982
    1981 Hepatocellular dysfunction in early sepsis despite increased hepatic blood flow..  Advances in shock research.  6:65-74. 1981
    1981 Oxidative capability of hepatic tissue in late sepsis..  Advances in shock research.  6:55-64. 1981
    1981 Alterations in Cell Function With Ischemia and Shock and Their Correction.  JAMA Surgery.  116:1309-1317. 1981
    1981 Effect of hemorrhagic shock on hepatic transmembrane potentials and intracellular electrolytes, in vivo.  American Journal of Physiology.  9. 1981
    1981 Effect of prolonged starvation on reticuloendothelial function and survival following trauma.  Journal of Trauma and Acute Care Surgery.  21:604-611. 1981
    1981 Effects of ATP-MgCl2 on hepatic metabolism and oxygen consumption.  Physiologist.  24. 1981
    1981 Local effect of thermal injury on skeletal muscle blood flow and nucleotide levels.  Journal of inflammation.  8:31-40. 1981
    1981 Red blood cell sodium, potassium, and ATP levels during hemorrhagic shock.  Journal of Surgical Research.  31:225-231. 1981
    1980 Some clinical adventures and misadventures..  Advances in shock research.  3:67-75. 1980
    1980 The use of substrates and energy in the treatment of shock..  Advances in shock research.  3:27-46. 1980
    1980 Amelioration of toxic acute renal failure by infusion of ATP-MgCl2.  Pediatric Research.  14. 1980
    1980 Effect of adenosine tri phosphate-glucose administration following sepsis.  Journal of Surgical Research.  29:348-356. 1980
    1980 Effect of splenectomy on reticuloendothelial function and survival following sepsis.  Journal of Trauma and Acute Care Surgery.  20:649-656. 1980
    1980 Enhanced recovery from acute renal failure by the postischemic infusion of adenine nucleotides and magnesium chloride in rats.  Kidney International.  17:338-349. 1980
    1980 Further evidence for ATP uptake by rat tissues 1980
    1980 Inhalation anesthetic-relaxant interactions in vitro.  Anesthesiology.  53. 1980
    1980 Is there a positive muscarinic feedback mechanism for acetylcholine release at the neuromuscular junction?.  Pharmacologist -Washington-.  22. 1980
    1980 Sepsis and septic shock—A review of laboratory models and a proposal.  Journal of Surgical Research.  29:189-201. 1980
    1979 Impairment of reticuloendothelial system function with sepsis and its improvement with ATP-MgCl2 plus glucose administration..  Advances in shock research.  2:153-162. 1979
    1979 Dose response and cardiovascular effects of ATP-MgCl2 administration in intact dogs 1979
    1979 Prostaglandin metabolism, synthesis, and blockade in hemorrhage and sepsis.  Journal of the American College of Surgeons.  Vol. 30:476-477. 1979
    1979 Studies of Peripheral Glucose Uptake During Sepsis.  JAMA Surgery.  114:740-745. 1979
    1978 Beneficial effect of ATP-MgCl2-glucose administration on survival following sepsis.  Journal of the American College of Surgeons.  Vol 29:11-14. 1978
    1978 Effect of insulin on glucose uptake in muscle during sepsis 1978
    1978 Enhanced recovery from severe ischemic renal injury with adenosine triphosphate-magnesium chloride: Administration after the insult.  Journal of the American College of Surgeons.  Vol 29:82-84. 1978
    1978 Glucocorticoid effects on gluconeogenesis during hemorrhagic shock.  Journal of Surgical Research.  24:26-34. 1978
    1978 Impairment of reticuloendothelial system (RES) function with sepsis and its improvement with ATP-MgCl2 and glucose administration.  Advances in shock research.  5. 1978
    1978 Interaction of muscle relaxants and local anesthetics at the neuromuscular junction.  Anesthesia and Analgesia.  57:580-587. 1978
    1977 Depletion and replenishment of cellular cyclic adenosine monophosphate in hemorrhagic shock.  Journal of the American College of Surgeons.  145:877-881. 1977
    1977 Accelerated recovery of acute renal failure by infusion of adenine nucleotides - MgCl2.  Kidney International.  12:534. 1977
    1977 Amelioration of acute renal failure with ATP MgCl2 infusion.  Pediatric Research.  11:1117. 1977
    1977 Evidence for enhanced uptake of ATP by liver and kidney in hemorrhagic shock 1977
    1977 Evidence for enhanced uptake of ATP by liver and kidney in hemorrhagic shock.  American Journal of Physiology.  2:83-88. 1977
    1977 Postischemic Renal Failure: Accelerated Recovery With Adenosine Triphosphate-Magnesium Chloride Infusion.  JAMA Surgery.  112:729-731. 1977
    1977 Restoration of cellular adenosine 3'-5'-monophosphate levels by ATP-MgCl2 in hemorrhagic shock 1977
    1976 Alterations in adenosine 3',5' monophosphate levels in hemorrhagic shock.  Journal of the American College of Surgeons.  Vol.27:51-53. 1976
    1976 Differences in the altered energy metabolism of hemorrhagic shock and hypoxemia.  Canadian Journal of Physiology and Pharmacology.  54:750-756. 1976
    1976 Effect of glucocorticoids on gluconeogenesis during hemorhagic shock 1976
    1976 Failure of nicotinamide in the treatment of hemorrhagic shock.  Journal of Surgical Research.  21:27-32. 1976
    1976 Insulin resistance and its reversal by in vivo infusion of ATP in hemorrhagic shock.  Canadian Journal of Physiology and Pharmacology.  54:736-741. 1976
    1976 The effects of atherosclerosis on the hypertrophied rabbit heart.  Experimental and Molecular Pathology.  25:293-300. 1976
    1976 Uptake of ATP by liver and kidney in vitro.  Canadian Journal of Physiology and Pharmacology.  54:742-749. 1976
    1975 Effect of hydrocortisone and dexamethasone on xylose uptake by isolated rat soleus muscle 1975
    1975 Characteristics of sodium and potassium transport in the lung.  American Journal of Physiology.  229:1073-1079. 1975
    1975 Enhanced uptake of 14C ATP by liver and kidney of animals in shock 1975
    1975 Relationship between nicotinamide adenine dinucleotide and survival in hemorrhagic shock.  Physiologist.  18:165. 1975
    1975 Reversal of insulin resistance by ATP in hemorrhagic shock.  Canadian Journal of Physiology and Pharmacology.  53:859-865. 1975
    1975 Reversal of insulin resistance by in vivo infusion of ATP in experimental shock.  Journal of the American College of Surgeons.  Vol. 26:44-46. 1975
    1975 The effect of EDTA, cations, and various buffers on the morphology of erythrocyte membranes: an electron microscopic study.  Blood.  45:709-724. 1975
    1975 The effect of insulin on glucose uptake in soleus muscle during hemorrhagic shock.  Canadian Journal of Physiology and Pharmacology.  53:67-73. 1975
    1974 Active sodium potassium transport and ATP levels in lung and liver during shock.  Journal of the American College of Surgeons.  VOL. 25:5-7. 1974
    1974 Cation transport in the liver in hemorrhagic shock 1974
    1974 Cellular alterations with shock and ischemia.  Angiology.  25:31-42. 1974
    1974 Depletion and Restoration of Tissue ATP in Hemorrhagic Shock.  JAMA Surgery.  108:208-211. 1974
    1974 Distribution of High-Energy Phosphates in the Heart.  Experimental Biology and Medicine.  145:1382-1385. 1974
    1974 Effect of hemorrhagic shock on tissue adenine nucleotides in conscious rats.  Canadian Journal of Physiology and Pharmacology.  52:131-137. 1974
    1974 Insulin Resistance in Experimental Shock.  JAMA Surgery.  109:412-415. 1974
    1974 Protein synthesis by rat liver slices in hemorrhagic shock 1974
    1973 ATP depletion and replenishment in hemorrhagic shock..  Journal of the American College of Surgeons.  24:77-79. 1973
    1973 Impairment of cell membrane transport during shock and after treatment.  Annals of Surgery.  178:412-422. 1973
    1973 The Effect of Low ATP on Glucose Uptake in Soleus Muscle During Hemorrhagic Shock.  Experimental Biology and Medicine.  144:321-325. 1973
    1973 The effect of insulin and low ATP on glucose uptake in muscle during shock 1973
    1972 Alterations in adenosine nucleotides in hemorrhagic shock.  Journal of the American College of Surgeons.  Vol. 23:1-3. 1972
    1972 Insulin: an allosteric modifier of the sugar carrier mechanism 1972
    1970 The action of insulin on glucose uptake by isolated rat soleus muscle I. Effects of cations 1970
    1970 The action of insulin on glucose uptake by isolated rat soleus muscle II. Dissociation of a priming effect of insulin from its stimulatory effect 1970
    1970 Effect of externally added ATP on glucose uptake by isolated rat soleus muscle 1970
    1970 Evidence for the uptake of ATP by rat soleus muscle in vitro 1970
    1969 Kinetics of glucose uptake in isolated soleus muscle 1969

    Chapter

    Year Title Altmetric
    2017 The Use of Estrogen for the Treatment of Traumatic Brain Injury.  161-177. 2017
    2015 Sex differences in sepsis following trauma and injury.  255-271. 2015
    2012 Metabolic and inflammatory responses to trauma and infection 2012
    2009 Experimental Models of Sepsis and Non-Infectious SIRS.  373-389. 2009
    2007 Insight into the mechanism of gender-specific response to trauma-hemorrhage.  869-879. 2007
    2007 Trauma-hemorrhage and its effects on the endothelium.  1513-1522. 2007
    2006 Gender dimorphism and the use of sex steroid/receptor antagonist after trauma.  101-121. 2006
    2004 Ischemia and Reperfusion Injury.  73-84. 2004
    2003 The immune/inflammatory system.  377-390. 2003

    Research Overview

  • trauma, hemorrhage, sepsis, gender dimorphism, immune functions, cardiovascular functions

    • Principal Investigator On

    Education And Training

  • Doctor of Philosophy Level Degree in Biochemistry, Monash University 1969

    • Full Name

  • Irshad Chaudry