Positions

Overview

  • We are a team of kidney scientists of diverse backgrounds that love all things science. Currently the lab is interested in determining the functional significance of the post-translational modification of lysine acetylation. Much like serine, threonine, or tyrosine phosphorylation, lysine acetylation is a dynamic modification that may be critically important for regulation protein functions in our cells. Our focus is on understanding the physiological consequences of lysine acetylation in the kidney and how regulation of these processes may become dysfunctional in kidney disease.

    See our labwebsite for up to date information on the lab https://sites.uab.edu/hyndmanlab/

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Endothelin system expression in the kidney following cisplatin-induced acute kidney injury in male and female mice.  Canadian Journal of Physiology and Pharmacology.  100:868-879. 2022
    2022 Endothelin-1 via ETA receptor activation promotes renal iron deposition in murine models of iron overload 2022
    2022 Epigenetic regulation of genes involved in fluid-electrolyte balance in the kidney 2022
    2022 Introduction: The 2022 Acute Kidney Injury: Bench to Bedside Conference.  Seminars in Nephrology.  42. 2022
    2022 Novel Regulation of Nitric Oxide Synthase 3 (NOS3) Isoform by Acetylation at Lysine 610 2022
    2022 Lipopolysaccharide Pretreatment Prevents Medullary Vascular Congestion following Renal Ischemia by Limiting Early Reperfusion of the Medullary Circulation.  Journal of the American Society of Nephrology.  33:769-785. 2022
    2022 Acclimation to a High-Salt Diet Is Sex Dependent.  Journal of the American Heart Association.  11. 2022
    2022 Kidney cell type-specific changes in the chromatin and transcriptome landscapes following epithelial Hdac1 and Hdac2 knockdown.  Physiological Genomics.  54:45-57. 2022
    2022 The Seventeenth International Conference on Endothelin (ET-17).  Canadian Journal of Physiology and Pharmacology.  100:1028-1032. 2022
    2021 Role of collecting duct principal cell NOS1β in sodium and potassium homeostasis.  Physiological Reports.  9. 2021
    2021 Sex-dependent effects of nephron ift88 disruption on bp, renal function, and cystogenesis.  Journal of the American Society of Nephrology.  32:2210-2222. 2021
    2021 Could NAD1 precursor supplements induce a legacy of protection against diabetic nephropathy?.  Journal of the American Society of Nephrology.  32:1270-1273. 2021
    2021 Early life stress induces dysregulation of the heme pathway in adult mice.  Physiological Reports.  9. 2021
    2021 High salt intake induces collecting duct HDAC1-dependent NO signaling 2021
    2020 Fluid-electrolyte homeostasis requires histone deacetylase function.  JCI Insight.  5. 2020
    2020 Aquaporin-3 in the epidermis: More than skin deep 2020
    2020 Diurnal Control of Blood Pressure Is Uncoupled from Sodium Excretion.  Hypertension.  75:1624-1634. 2020
    2020 Histone Deacetylases in Kidney Physiology and Acute Kidney Injury.  Seminars in Nephrology.  40:138-147. 2020
    2020 Loss of endothelin type B receptor function improves insulin sensitivity in rats.  Canadian Journal of Physiology and Pharmacology.  98:604-610. 2020
    2019 The contribution of collecting duct NOS1 to the concentrating mechanisms in male and female mice 2019
    2019 Dynamic changes in histone deacetylases following kidney ischemia-reperfusion injury are critical for promoting proximal tubule proliferation 2019
    2019 Hyperfiltration predicts long-term renal outcomes in humanized sickle cell mice.  Blood Advances.  3:1460-1475. 2019
    2018 Proteomic determination of the lysine acetylome and phosphoproteome in the rat native inner medullary collecting duct.  Physiological Genomics.  50:669-679. 2018
    2018 Diurnal pattern in skin Na+and water content is associated with salt-sensitive hypertension in ETBreceptor-deficient rats 2018
    2018 Acute pressor response to psychosocial stress is dependent on endothelium-derived endothelin-1.  Journal of the American Heart Association.  7. 2018
    2018 High dietary sodium causes dyssynchrony of the renal molecular clock in rats 2018
    2018 Natriuretic response to renal medullary endothelin B receptor activation is impaired in Dahl-salt sensitive rats on a high-fat diet.  Physiological Research.  67:S149-S154. 2018
    2017 Collecting duct nitric oxide synthase 1ß activation maintains sodium homeostasis during high sodium intake through suppression of aldosterone and renal angiotensin II pathways.  Journal of the American Heart Association.  6. 2017
    2017 Dynamic regulation of lysine acetylation: The balance between acetyltransferase and deacetylase activities 2017
    2016 High salt induces autocrine actions of ET-1 on inner medullary collecting duct NO production via upregulated ETB receptor expression 2016
    2016 In vivo organ specific drug delivery with implantable peristaltic pumps.  Scientific Reports.  6. 2016
    2016 Early life stress in male mice induces superoxide production and endothelial dysfunction in adulthood 2016
    2016 Dynamin-2 is a novel NOS1β interacting protein and negative regulator in the collecting duct 2016
    2016 Endothelin.  Pharmacological Reviews.  68:357-418. 2016
    2015 Endothelin-1 as a master regulator of whole-body Na+ homeostasis 2015
    2015 Estradiol regulates AQP2 expression in the collecting duct: A novel inhibitory role for estrogen receptor α 2015
    2015 NOS1-dependent negative feedback regulation of the epithelial sodium channel in the collecting duct 2015
    2014 Histone deacetylase 1 reduces NO production in endothelial cells via lysine deacetylation of NO synthase 3 2014
    2013 Sex differences in ET-1 receptor expression and Ca2+ signaling in the IMCD 2013
    2013 Renal collecting duct nos1 maintains fluid-electrolyte homeostasis and blood pressure.  Hypertension.  62:91-98. 2013
    2013 Distinct regulation of inner medullary collecting duct nitric oxide production from mice and rats.  Clinical and Experimental Pharmacology and Physiology.  40:233-239. 2013
    2013 Nitric oxide and the A and B of endothelin of sodium homeostasis.  Current Opinion in Nephrology and Hypertension.  22:26-31. 2013
    2012 The effect of environmental salinity on H + efflux in the euryhaline barramundi (Lates calcarifer).  Annual review of fish diseases.  338-341:190-196. 2012
    2011 Urotensin II and its receptor in the killifish gill: Regulators of NaCl extrusion 2011
    2011 Relationship between oxidizable fatty acid content and level of antioxidant glutathione peroxidases in marine fish 2011
    2011 Investigation of acute nanoparticulate aluminum toxicity in zebrafish.  Environmental toxicology and water quality.  26:541-551. 2011
    2011 Dynamin activates NO production in rat renal inner medullary collecting ducts via protein-protein interaction with NOS1 2011
    2010 Functional morphology of the gills of the shortfin mako, Isurus oxyrinchus, a lamnid shark.  Journal of Morphology.  271:937-948. 2010
    2010 Renal NOS activity, expression, and localization in male and female spontaneously hypertensive rats 2010
    2009 Morphology and histochemistry of juvenile American alligator (Alligator mississippiensis) nephrons 2009
    2009 Phylogeny, taxonomy, and evolution of the endothelin receptor gene family.  Molecular Phylogenetics and Evolution.  52:677-687. 2009
    2009 Comparison of molecular and histological changes in zebrafish gills exposed to metallic nanoparticles.  Toxicological Sciences.  107:404-415. 2009
    2009 Effects of environmental salinity on gill endothelin receptor expression in the killifish, Fundulus heteroclitus 2009
    2009 Immunolocalization of Na+/K+-ATPase and Na+/K+/2Cl- cotransporter in the tubular epithelia of sea snake salt glands 2009
    2009 Short-term low-salinity tolerance by the longhorn sculpin, Myoxocephalus octodecimspinosus.  Journal of Experimental Zoology. Part a, Ecological and Integrative Physiology.  311:45-56. 2009
    2007 Endothelin and endothelin converting enzyme-1 in the fish gill: Evolutionary and physiological perspectives 2007
    2007 Exposure to copper nanoparticles causes gill injury and acute lethality in zebrafish (Danio rerio) 2007
    2006 COX2 in a euryhaline teleost, Fundulus heteroclitus: Primary sequence, distribution, localization, and potential function in gills during salinity acclimation 2006
    2006 Neuronal nitric oxide synthase in the gill of the killifish, Fundulus heteroclitus 2006

    Research Overview

  • epigenetics
    kidney health
    physiology
    fluid-electrolyte balance
    Acute Kidney Injury
    Chronic Kidney Disease
    Aquaporins

    • Principal Investigator On

    Investigator On

    Education And Training

  • Doctor of Philosophy in Zoology / Animal Biology, University of Florida 2008

    • Full Name

  • Kelly Hyndman