Positions

Research Overview

  • B cell and repertoire development. Although at first glance the power of the mechanisms used to diversify the B- and T-cell antigen receptors appear to generate repertoires of random diversity, closer examination reveals striking constraints that are preserved across evolution. The implication is that violation of these constraint programs could lead to immune dysfunction, and thus to disease. My group has used Cre-loxP gene targeting to generate mice wherein the DH locus has been altered for force expression of polyclonal antibody repertoires that lie outside normal constraints. In these mice, B cell numbers are reduced, responses to T-independent antigens decline in a co-dominant manner, and responses to T-dependent antigens and autoantigens are affected in a dominant manner. The mechanisms that underlie these alterations and the contribution of a failure to properly regulate the repertoire are a major focus of the laboratory.

    Genetics of primary immune deficiency diseases. A second focus in the laboratory is the use of classic reverse genetics techniques to study human immune deficiency disorders.
  • Principal Investigator On

  • Common Variable Immune Deficiency (CVID) Project  awarded by National Cancer Institute/NIH/DHHS
  • HLA *B Associated Genes and Memory B Cells in Patients with CVD  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • HLA Region and KIR Genomics in Common Variable Immune Deficiency  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Immunoglobulin CDR-H3 and Neutralizing Antibodies to HIV  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Immunologic Diseases and Basic Immunology  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Immunologic Diseases and Basic Immunology  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Immunologic Diseases and Basic Immunology  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Private Grant  awarded by BIOTEST PHARMACEUTICALS CORPORATION
  • Private Grant  awarded by GREEN CROSS CORPORATION
  • Private Grant  awarded by BIOTEST PHARMACEUTICALS CORPORATION
  • Private Grant  awarded by CSL BEHRING, LLC
  • Role of IG CDR-H3 in Responses to HIV Vaccines  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Role of Immunoglobulin CDR-H3 in Heterosubtypic Immunity to Influenza Virus  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Role of VpreB in Immunoglobulin Antigen Binding Site Selection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • The Pre-BCR CDR-H3 Sensing Site and H Chain Selection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • The Role of Immunoglobulin CDRH3 in Autoimmune Disease  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Teaching Activities

  • GBSC723 - Career Dev Courses (Spring Term 2021) 2021
  • GBSC723 - Career Dev Courses (Fall Term 2020) 2020
  • GBSC723 - Career Dev Courses (Spring Term 2020) 2020
  • GBSC723 - Career Dev Courses (Fall Term 2019) 2019
  • GBSC723 - Career Dev Courses (Spring Term 2019) 2019
  • GBSC723 - Career Dev Courses (Fall Term 2018) 2018
  • GBSC723 - Career Dev Courses (Spring Term 2018) 2018
  • GBSC723 - Career Dev Courses (Fall Term 2017) 2017
  • GBSC723 - Career Dev Courses (Spring Term 2017) 2017
  • MIC741 - Topics in Professional Develop (Fall Term 2016) 2016
  • MIC741 - Topics in Professional Develop (Spring Term 2016) 2016
  • MIC741 - Topics in Professional Develop (Fall Term 2015) 2015
  • GBS741 - Lymphocyte Biology (Spring Term 2015) 2015
  • MIC741 - Topics in Professional Develop (Spring Term 2015) 2015
  • MIC741 - Topics in Professional Develop (Fall Term 2014) 2014
  • GBS741 - Lymphocyte Biology (Spring Term 2014) 2014
  • MIC741 - Topics in Professional Develop (Spring Term 2014) 2014
  • MIC741 - Topics in Professional Develop (Fall Term 2013) 2013
  • GBS741 - Lymphocyte Biology (Spring Term 2013) 2013
  • MIC741 - Topics in Professional Develop (Fall Term 2012) 2012
  • MIC741 - Topics in Professional Develop (Spring Term 2012) 2012
  • MIC741 - Topics in Professional Develop (Fall Term 2011) 2011
  • MIC741 - Topics in Professional Develop (Spring Term 2011) 2011
  • MIC778 - Primary Immune Deficiencies (Spring Term 2011) 2011
  • MIC741 - Topics in Professional Develop (Fall Term 2010) 2010
  • MIC709 - Topics in Profession Dev (Spring Term 2010) 2010
  • MIC741 - Topics in Professional Develop (Spring Term 2010) 2010
  • MIC741 - Topics in Professional Develop (Fall Term 2009) 2009
  • MIC778 - Primary Immune Deficiencies (Fall Term 2008) 2008
  • Education And Training

  • Howard Hughes Medical Institute Medicine, Postdoctoral Research
  • University of Kentucky/Chandler Hospital Medicine, Internship
  • University of Kentucky/Chandler Hospital Medicine, Residency
  • University of Washington Medical Center Medicine, Postdoctoral Fellowship
  • Doctor of Medicine, Baylor University 1981
  • Doctor of Philosophy, Baylor University 1979
  • Full Name

  • Harry Schroeder