Selected Publications

Academic Article

Year Title Altmetric
2023 Ponatinib Drives Cardiotoxicity by S100A8/A9-NLRP3-IL-1β Mediated InflammationCirculation Research.  132:267-289. 2023
2022 Metabolic labeling of cardiomyocyte-derived small extracellular-vesicle (sEV) miRNAs identifies miR-208a in cardiac regulation of lung gene expressionJournal of Extracellular Vesicles.  11. 2022
2022 Fibroblast GSK-3α Promotes Fibrosis via RAF-MEK-ERK Pathway in the Injured HeartCirculation Research.  131:620-636. 2022
2022 Cardiac natriuretic peptide deficiency sensitizes the heart to stress-induced ventricular arrhythmias via impaired CREB signallingCardioscience.  118:2124-2138. 2022
2022 Isoform-Specific Role of GSK-3 in High Fat Diet Induced Obesity and Glucose IntoleranceCells.  11. 2022
2021 Novel Mechanisms of Exosome-Mediated Phagocytosis of Dead Cells in Injured HeartCirculation Research.  129:1006-1020. 2021
2021 Mechanisms of fibroblast activation and myocardial fibrosis: Lessons learned from FB-specific conditional mouse modelsCells.  10. 2021
2021 Repurposing Nintedanib for pathological cardiac remodeling and dysfunctionPharmacological Research.  169. 2021
2021 Targeting 5-HT2B Receptor Signaling Prevents Border Zone Expansion and Improves Microstructural Remodeling after Myocardial InfarctionCirculation.  143:1317-1330. 2021
2021 Tom Force (1951–2020): Our Dearest Friend, Our Mentor, and a Brilliant Cardiovascular ScientistJACC. CardioOncology.  3:167-169. 2021
2020 The BDNF rs6265 polymorphism is a modifier of cardiomyocyte contractility and dilated cardiomyopathyInternational Journal of Molecular Sciences.  21:1-16. 2020
2020 Cardiotoxicity of the BCR-ABL1 tyrosine kinase inhibitors: Emphasis on ponatinibInternational Journal of Cardiology.  316:214-221. 2020
2020 Mouse Models of Heart Failure with Preserved or Reduced Ejection FractionAmerican Journal of Pathology.  190:1596-1608. 2020
2020 A pharmacovigilance study of hydroxychloroquine cardiac safety profile: Potential implication in COVID‐19 mitigationJournal of Clinical Medicine.  9:1-13. 2020
2020 Deletion of Cardiomyocyte Glycogen Synthase Kinase-3 Beta (GSK-3β) Improves Systemic Glucose Tolerance with Maintained Heart Function in Established ObesityCells.  9. 2020
2020 Neutrophil-derived S100A8/A9 amplify granulopoiesis after myocardial infarctionCirculation.  1080-1094. 2020
2019 Cardiomyocyte Homeodomain-Interacting Protein Kinase 2 Maintains Basal Cardiac Function via Extracellular Signal-Regulated Kinase SignalingCirculation.  140:1820-1833. 2019
2019 Cadherin-11 blockade reduces inflammation-driven fibrotic remodeling and improves outcomes after myocardial infarctionJCI Insight.  4. 2019
2019 Cardiomyocyte-GSK-3α promotes mPTP opening and heart failure in mice with chronic pressure overloadJournal of Molecular and Cellular Cardiology.  130:65-75. 2019
2019 Ponatinib-induced cardiotoxicity: Delineating the signalling mechanisms and potential rescue strategiesCardioscience.  115:966-977. 2019
2019 Cardiomyocyte SMAD4-Dependent TGF-β Signaling is Essential to Maintain Adult Heart HomeostasisJACC: Basic to Translational Science.  4:41-53. 2019
2019 Generation of Nppa-tagBFP reporter knock-in mouse line for studying cardiac chamber specification 2019
2019 IL-10–producing B cells are enriched in murine pericardial adipose tissues and ameliorate the outcome of acute myocardial infarction 2019
2019 Inhibition of GSK-3 to induce cardiomyocyte proliferation: a recipe for in situ cardiac regenerationCardioscience.  115:20-30. 2019
2018 Cardiomyocyte-specific deletion of GSK-3β leads to cardiac dysfunction in a diet induced obesity modelInternational Journal of Cardiology.  259:145-152. 2018
2017 Chronic Neuregulin-1β Treatment Mitigates the Progression of Postmyocardial Infarction Heart Failure in the Setting of Type 1 Diabetes Mellitus by Suppressing Myocardial Apoptosis, Fibrosis, and Key Oxidant-Producing EnzymesJournal of Cardiac Failure.  23:887-899. 2017
2017 Entanglement of GSK-3β, β-catenin and TGF-β1 signaling network to regulate myocardial fibrosisJournal of Molecular and Cellular Cardiology.  110:109-120. 2017
2017 Mechanistic Insights of Empagliflozin-Mediated Cardiac Benefits: Nearing the Starting Line: Editorial to: “Empagliflozin Improves Left Ventricular Diastolic Dysfunction in a Genetic Model of Type 2 Diabetes” by N. Hammoudi et al.Cardiovascular Drugs and Therapy.  31:229-232. 2017
2017 Activation of the amino acid response pathway blunts the effects of cardiac stressJournal of the American Heart Association.  6. 2017
2016 Response by Zhou et al to Letter Regarding Article, Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated CardiomyopathyCirculation Research.  119:e29-e30. 2016
2016 Loss of adult cardiac myocyte GSK-3 leads to mitotic catastrophe resulting in fatal dilated cardiomyopathyCirculation Research.  118:1208-1222. 2016
2015 The GSK-3 family as therapeutic target for myocardial diseasesCirculation Research.  116:138-149. 2015
2014 Cardiomyocyte-specific deletion of Gsk3α mitigates post-myocardial infarction remodeling, contractile dysfunction, and heart failureJournal of the American College of Cardiology.  64:696-706. 2014
2014 Cardiac fibroblast glycogen synthase kinase-3β regulates ventricular remodeling and dysfunction in ischemic heartCirculation.  130:419-430. 2014
2014 Sorafenib cardiotoxicity increases mortality after myocardial infarctionCirculation Research.  114:1700-1712. 2014
2014 Prevention of liver cancer cachexia-induced cardiac wasting and heart failureEuropean Heart Journal.  35:932-941. 2014
2014 Troponin I-interacting protein kinase - A novel cardiac-specific kinase, emerging as a molecular target for the treatment of cardiac disease 2014
2013 Anthrax lethal toxin induces acute diastolic dysfunction in rats through disruption of the phospholamban signaling networkInternational Journal of Cardiology.  168:3884-3895. 2013
2013 Caveolin and β1-integrin coordinate angiotensinogen expression in cardiac myocytesInternational Journal of Cardiology.  168:436-445. 2013
2013 GSK-3α is a central regulator of age-related pathologies in miceJournal of Clinical Investigation.  123:1821-1832. 2013
2013 Cancer genetics and the cardiotoxicity of the therapeuticsJournal of the American College of Cardiology.  61:267-274. 2013
2012 Glycogen synthase kinase-3α limits ischemic injury, cardiac rupture, post-myocardial infarction remodeling and deathCirculation.  125:65-75. 2012
2011 Rac1 and RhoA differentially regulate angiotensinogen gene expression in stretched cardiac fibroblastsCardioscience.  90:88-96. 2011
2011 A novel cardioprotective p38-MAPK/mTOR pathwayExperimental Cell Research.  317:2938-2949. 2011
2010 GSK-3α directly regulates β-adrenergic signaling and the response of the heart to hemodynamic stress in miceJournal of Clinical Investigation.  120:2280-2291. 2010
2010 Glycogen synthase kinase-3β regulates post-myocardial infarction remodeling and stress-induced cardiomyocyte proliferation in vivoCirculation Research.  106:1635-1645. 2010
2009 Anthrax toxin: Pathologic effects on the cardiovascular systemFrontiers in Bioscience-Landmark.  14:2335-2357. 2009
2009 Integrins and proximal signaling mechanisms in cardiovascular diseaseFrontiers in Bioscience-Landmark.  14:2307-2334. 2009
2008 Stretch-induced regulation of angiotensinogen gene expression in cardiac myocytes and fibroblasts: Opposing roles of JNK1/2 and p38α MAP kinasesJournal of Molecular and Cellular Cardiology.  45:770-778. 2008
2007 Stretch-induced MAP kinase activation in cardiac myocytes: Differential regulation through β1-integrin and focal adhesion kinaseJournal of Molecular and Cellular Cardiology.  43:137-147. 2007
2007 Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunctionFrontiers in Bioscience-Landmark.  12:4670-4675. 2007
2007 Integrins: Novel therapeutic targets for cardiovascular diseasesCardiovascular and Hematological Agents in Medicinal Chemistry.  5:109-132. 2007
2000 Stress induced phosphate solubilization in bacteria isolated from alkaline soilsFEMS Microbiology Letters.  182:291-296. 2000


Year Title Altmetric
2009 Molecular Signaling Mechanisms of Myocardial Stretch: Implications for Heart Disease 2009

Education And Training

  • Doctor of Philosophy in Microbiology, 2006
  • Full Name

  • Hind Lal