Positions

Overview

  • Dr. He is a physician-scientist investigating innate immunity in chronic lung diseases. He is a graduate of UAB American Board of Internal Medicine Research Pathway. He finished his internal medicine residency and pulmonary and critical care medicine fellowship in 2019. He is an awardee of the Parker B. Francis Foundation Fellowship program which supports his research of new treatment of pulmonary fibrosis.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Plasticity towards Rigidity: A Macrophage Conundrum in Pulmonary Fibrosis.  International Journal of Molecular Sciences.  23. 2022
    2022 CRTH2 in Pulmonary Fibrosis: Friend or Foe?.  American Journal of Respiratory Cell and Molecular Biology.  67:145-146. 2022
    2022 Extracellular Matrix Stiffness in Lung Health and Disease.  Comprehensive Physiology.  12:3523-3558. 2022
    2022 Targeting Asporin in Lung Fibrosis: A New Approach to an Old Concept.  American Journal of Respiratory Cell and Molecular Biology.  66:115-116. 2022
    2022 Targeting Cpt1a-Bcl-2 interaction modulates apoptosis resistance and fibrotic remodeling.  Cell Death and Differentiation.  29:118-132. 2022
    2021 Post-translational regulation of PGC-1α modulates fibrotic repair 2021
    2020 Technical advance: The use of tree shrews as a model of pulmonary fibrosis.  PLoS One.  15. 2020
    2020 Mitochondrial quality control in pulmonary fibrosis.  Redox Biology.  33. 2020
    2020 C(C)Learing the role of chemokines in pulmonary fibrosis.  American Journal of Respiratory Cell and Molecular Biology.  62:546-547. 2020
    2019 Effect of a fluid bolus on cardiovascular collapse among critically ill adults undergoing tracheal intubation (PrePARE): a randomised controlled trial 2019
    2019 Increased flux through the mevalonate pathway mediates fibrotic repair without injury.  Journal of Clinical Investigation.  129:4962-4978. 2019
    2019 NOX4 modulates macrophage phenotype and mitochondrial biogenesis in asbestosis.  JCI Insight.  4. 2019
    2016 Cu,Zn-superoxide dismutase-mediated redox regulation of Jumonji domain containing 3 modulates macrophage polarization and pulmonary fibrosis.  American Journal of Respiratory Cell and Molecular Biology.  55:58-71. 2016
    2015 Alternative activation of macrophages and pulmonary fibrosis are modulated by scavenger receptor, macrophage receptor with collagenous structure 2015
    2014 3 Asbestos-induced disruption of calcium homeostasis induces endoplasmic reticulum stress in macrophages.  Journal of Biological Chemistry.  289:33391-33403. 2014
    2013 Accelerated development of pulmonary fibrosis via Cu,Zn-superoxide dismutase-induced alternative activation of macrophages.  Journal of Biological Chemistry.  288:20745-20757. 2013
    2012 Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis.  Journal of Biological Chemistry.  287:3301-3312. 2012
    2011 Mitochondrial Cu,Zn-superoxide dismutase mediates pulmonary fibrosis by augmenting H2O2 generation.  Journal of Biological Chemistry.  286:15597-15607. 2011
    2010 Rac1-mediated mitochondrial H2O2 generation regulates MMP-9 gene expression in macrophages via inhibition of SP-1 and AP-1.  Journal of Biological Chemistry.  285:25062-25073. 2010

    Research Overview

  • Dr. He’s research is focused on defining the role of alveolar macrophages in lung fibrosis. He has previously shown that macrophages undergo different polarization process during fibrosis development and the process is regulated by redox signaling. His current work investigates NOX4 and its role in mediating lung macrophage polarization.

    Preliminary data from this work showed NOX4 promotes lung macrophages polarized into a pro-fibrotic phenotype via modulating mitochondrial biogenesis. He is working on generating a macrophage/monocyte specific NOX4 knock-out mice model to evaluate the role of lung macrophages in different pulmonary diseases.

    • Principal Investigator On

    Investigator On

    Education And Training

  • Doctor of Philosophy Level Degree in Radiation Biology / Radiobiology, University of Iowa 2014
  • Doctor of Medicine, 2009

    • Full Name

  • Chao He