• Dr. Siegal was born in New York where he attended college. He received his medical degree from the University of Louisville and his PhD from the University of Minnesota. He was a Resident and Research Fellow at the Mayo Graduate School of Medicine and completed both a post-doctoral fellowship at the National Cancer Institute, NIH and a surgical pathology fellowship at the University of Minnesota. Prior to coming to UAB in 1990, he was a tenured faculty member at the University of North Carolina at Chapel Hill. Dr. Siegal has been married for over 40 years and has 2 adult daughters and 4 grandchildren.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2023 Gratitude and a Warning.Laboratory Investigation.  103:100065. 2023
    2023 Periosteal Fasciitis With Unusual Radiologic Features Harboring a Novel STAG1::USP6 Fusion GeneInternational Journal of Surgical Pathology2023
    2022 Characterizing Clinicopathologic Features of Estrogen Receptor-Positive/Progesterone Receptor-Negative Breast CancersClinical Breast Cancer.  22:e788-e797. 2022
    2022 The diagnostic utility of RNA-based fusion panel testing ordered by pathologists in challenging casesAnnals of Diagnostic Pathology.  60. 2022
    2022 Intramuscular Tenosynovial Giant Cell Tumor Harboring a Novel CSF1-CD96 Fusion TranscriptInternational Journal of Surgical Pathology.  30:335-338. 2022
    2022 Discordance Between Immunohistochemistry and In Situ Hybridization to Detect HER2 Overexpression/Gene Amplification in Breast Cancer in the Modern Age: A Single Institution Experience and Pooled Literature Review Study: Discordance between HER2 overexpression and gene amplification in breast cancerClinical Breast Cancer.  22:e123-e133. 2022
    2022 Small Round Cell Tumors of Soft Tissue and BoneArchives of Pathology and Laboratory Medicine.  146:47-59. 2022
    2022 Some Reactive Lesions of Bone Are Probably Neoplasms A ReviewArchives of Pathology and Laboratory Medicine.  146:60-69. 2022
    2022 Validation of PRKCB Immunohistochemistry as a Biomarker for the Diagnosis of Ewing SarcomaFetal and Pediatric Pathology2022
    2021 A simplified breast cancer prognostic score: comparison with the AJCC clinical prognostic staging systemModern Pathology.  34:2141-2147. 2021
    2021 Fine-tuned repression of Drp1 driven mitochondrial fission primes a ‘stem/progenitor-like state’ to support neoplastic transformationeLife.  10. 2021
    2021 Round cell tumor with a myxoid matrix harboring a PHF1-TFE3 fusion: Myoepithelial neoplasm or ossifying fibromyxoid tumor? 2021
    2021 Characterization of estrogen receptor-low-positive breast cancerBreast Cancer Research and Treatment.  188:225-235. 2021
    2021 Osteosarcoma with Telangiectatic Features Metastatic to the Small BowelHuman Pathology: Case Reports.  24. 2021
    2021 Validation of the revised 8th AJCC breast cancer clinical prognostic staging system: analysis of 5321 cases from a single institutionModern Pathology.  34:291-299. 2021
    2020 Receptor conversion in metastatic breast cancer: analysis of 390 cases from a single institutionModern Pathology.  33:2499-2506. 2020
    2020 Mandibular undifferentiated pleomorphic sarcoma: Molecular analysis of a primary cell populationClinical and Experimental Dental Research.  6:495-505. 2020
    2020 RANKLed by the Complexity of Signaling in Breast Cancer Metastasis to the BrainClinical Breast Cancer.  20:e569-e575. 2020
    2020 A Rare Cause of Left Atrial Mass.Case :: Cardiovascular Imaging Case Reports.  4:260-262. 2020
    2020 Return of Individual Research Results: A Guide for Biomedical Researchers Utilizing Human BiospecimensAmerican Journal of Pathology.  190:918-933. 2020
    2019 Synchronous and metachronous bilateral breast cancer: clinicopathologic characteristics and prognostic outcomesHuman Pathology.  92:1-9. 2019
    2019 Erratum: Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis (Cell Reports (2018) 25(7) (1938–1952.e5), (S2211124718316772), (10.1016/j.celrep.2018.10.073))Cell Reports.  28:3286. 2019
    2019 Bone Pathology for HematopathologistsSurgical Pathology Clinics.  12:831-847. 2019
    2019 Inflammatory myofibroblastic tumor of bone harboring an ALK gene amplification 2019
    2019 Let’s go swimmingLaboratory Investigation.  99:450-451. 2019
    2019 PAX8 Expression in Solitary Fibrous Tumor: A Potential Diagnostic PitfallApplied Immunohistochemistry and Molecular Morphology.  27:195-202. 2019
    2019 Extraskeletal Myxoid Chondrosarcoma of the Midfoot Presenting as Charcot Arthropathy: A Case ReportJBJS Case Connector.  9. 2019
    2018 Comparison of AJCC Anatomic and Clinical Prognostic Stage Groups in Breast Cancer: Analysis of 3322 Cases From a Single InstitutionClinical Breast Cancer.  18:e1347-e1352. 2018
    2018 Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human TuberculosisCell Reports.  25:1938-1952.e5. 2018
    2018 Clinicopathologic Features and Clinical Outcome Differences in De Novo Versus Secondary Histiocytic Sarcomas: A Multi-institutional Experience and Review of the LiteratureClinical Lymphoma, Myeloma and Leukemia.  18:e427-e435. 2018
    2018 Chondroblastoma-like tumor of the skull in a patient with cardio-facio-cutaneous syndrome 2018
    2018 Malignant Ewing-Like Neoplasm With an EWSR1-KLF15 Fusion: At the Crossroads of a Myoepithelial Carcinoma and a Ewing-Like Sarcoma. A Case Report With Treatment OptionsInternational Journal of Surgical Pathology.  26:440-447. 2018
    2018 Detection of BRAF V600E mutations with next-generation sequencing in infarcted thyroid carcinomas after fine-needle aspirationAmerican Journal of Clinical Pathology.  150:177-185. 2018
    2018 Surviving at a distant site: The organotropism of metastatic breast cancerSeminars in Diagnostic Pathology.  35:108-111. 2018
    2017 Prognostic outcomes in advanced breast cancer: the metastasis-free interval is importantHuman Pathology.  70:70-76. 2017
    2017 Clinical and pathological factors related to brain relapse-free survival in breast cancer patients—replyHuman Pathology.  69:142. 2017
    2017 Corrigendum to “Diagnostic utility of IDH1/2 mutations to distinguish dedifferentiated chondrosarcoma from undifferentiated pleomorphic sarcoma of bone” (Human Pathology (2017) 65 (239–246) (S0046817717301727) (10.1016/j.humpath.2017.05.015))Human Pathology.  69:143. 2017
    2017 Extraskeletal aneurysmal bone cyst: Report of a case and review of the literature 2017
    2017 The CD4/CD8 ratio of tumor-infiltrating lymphocytes at the tumor-host interface has prognostic value in triple-negative breast cancerHuman Pathology.  69:110-117. 2017
    2017 Implementation and utilization of the molecular tumor board to guide precision medicine.Oncotarget.  8:57845-57854. 2017
    2017 Diagnostic utility of IDH1/2 mutations to distinguish dedifferentiated chondrosarcoma from undifferentiated pleomorphic sarcoma of boneHuman Pathology.  65:239-246. 2017
    2017 Clinicopathological factors associated with survival in patients with breast cancer brain metastasisHuman Pathology.  64:53-60. 2017
    2017 Reacquisition of E-cadherin expression in metastatic deposits of signet-ring cell carcinoma of the upper gastrointestinal system: A potential anchor for metastatic deposition 2017
    2017 Location of tumor affects local and distant immune cell type and number:Immunity, Inflammation and Disease.  5:85-94. 2017
    2017 Mammary analog secretory carcinoma, low-grade salivary duct carcinoma, and mimickers: a comparative study.Modern Pathology.  30:312. 2017
    2017 Implementation and utilization of the molecular tumor board to guide precision medicineOncotarget.  8:57845-57854. 2017
    2017 Metastatic organotropism: An intrinsic property of breast cancer molecular subtypesAdvances in Anatomic Pathology.  24:78-81. 2017
    2017 Reduced E-Cadherin and Aberrant β-Catenin Expression are Associated with Advanced Disease in Signet-Ring Cell CarcinomasApplied Immunohistochemistry and Molecular Morphology.  25:432-438. 2017
    2016 Clinicopathologic factors associated with de novo metastatic breast cancer 2016
    2016 Primary intraosseous smooth muscle tumor of uncertain malignant potential: Original report and molecular characterizationRare Tumors.  8:155-158. 2016
    2016 In Memorium: Nathan Kaufman.Laboratory Investigation.  96:1142-1143. 2016
    2016 Laboratory Investigation web focus on ChinaLaboratory Investigation.  96:1144-1146. 2016
    2016 A microscopic landscape of the invasive breast cancer genomeScientific Reports.  6. 2016
    2016 ERBB2 mutation is associated with a worse prognosis in patients with CDH1 altered invasive lobular cancer of the breastOncotarget.  7:80655-80663. 2016
    2016 Prognostic factors in advanced breast cancer: Race and receptor status are significant after development of metastasis 2016
    2016 Prognostic value of E-cadherin and β-catenin in triple-negative breast cancerAmerican Journal of Clinical Pathology.  146:603-610. 2016
    2016 The rank pathway in advanced breast cancer: Does Src play a role?Applied Immunohistochemistry and Molecular Morphology.  24:42-50. 2016
    2015 Characterization of estrogen receptor-negative/progesterone receptor-positive breast cancerHuman Pathology.  46:1776-1784. 2015
    2015 GATA3 expression in advanced breast cancer: Prognostic value and organ-specific relapseAmerican Journal of Clinical Pathology.  144:756-763. 2015
    2015 Nucleic acid amplification from individual cells: Laser microdissectionCurrent protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.].  2015. 2015
    2015 Solitary, adult-onset, intraosseous myofibroma of the finger: report of a case and review of literatureHand.  10:550-554. 2015
    2015 Genetic and informatic analyses implicate Kif12 as a candidate gene within the Mpkd2 locus that modulates renal cystic disease severity in the Cys1cpk mousePLoS One.  10. 2015
    2015 Mammary analog secretory carcinoma, low-grade salivary duct carcinoma, and mimickers: A comparative studyModern Pathology.  28:1084-1100. 2015
    2015 Hyperglycemia in the absence of cilia accelerates cystogenesis and induces renal damage 2015
    2015 Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGSPLoS Genetics.  11. 2015
    2015 Flexor tendon repair with a knotless, bidirectional barbed suture: An in vivo biomechanical analysisJournal of Hand Surgery (American Volume).  40:963-968. 2015
    2015 Breast cancer subtypes predispose the site of distant metastasesAmerican Journal of Clinical Pathology.  143:471-478. 2015
    2015 Targeting the effector domain of the myristoylated alanine rich C-kinase substrate enhances lung cancer radiation sensitivityInternational Journal of Oncology.  46:1079-1088. 2015
    2015 Subsets of airway myeloid-derived regulatory cells distinguish mild asthma from chronic obstructive pulmonary diseaseJournal of Allergy and Clinical Immunology.  135:413-424.e15. 2015
    2015 Autosomal dominant familial angiolipomatosis: A case report and review of the literature.Cutis.  95:E26-E29. 2015
    2015 Autosomal-dominant familial angiolipomatosisCutis.  95:E26-E29. 2015
    2015 Florid reactive periostitis ossificans of the humerus: Case report and differential diagnosis of periosteal lesions of long bonesWorld Journal of Orthopedics.  6:559-563. 2015
    2015 The utility of phosphohistone H3 in breast cancer gradingApplied Immunohistochemistry and Molecular Morphology.  23:689-695. 2015
    2014 GSK3β-Dependent inhibition of AMPK potentiates activation of neutrophils and macrophages and enhances severity of acute lung injury 2014
    2014 Therapeutic targeting of Src kinase in myofibroblast differentiation and pulmonary fibrosisJournal of Pharmacology and Experimental Therapeutics.  351:87-95. 2014
    2014 Dietary stearic acid leads to a reduction of visceral adipose tissue in athymic nude micePLoS One.  9. 2014
    2014 Anterior gradient protein-2 is a regulator of cellular adhesion in prostate cancerPLoS One.  9. 2014
    2014 Changing prognostic factors in osteosarcoma: Analysis of 381 cases from two institutionsHuman Pathology.  45:1688-1696. 2014
    2014 Detection of Merkel cell polyomavirus in formalin-fixed, paraffin-embedded tissue of merkel cell carcinoma and correlation with prognosisRomanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie.  55:1057-1062. 2014
    2014 Diet modulation is an effective complementary agent in preventing and treating breast cancer lung metastasisClinical and Experimental Metastasis.  31:625-638. 2014
    2014 Extensive urinary malakoplakia with lymph node involvement: A Case Report. 2014
    2014 Mining genome sequencing data to identify the genomic features linked to breast cancer histopathology.Journal of Pathology Informatics.  5:3. 2014
    2014 Optimal handling of bone tumor specimensMethods in Molecular Biology.  1180:353-368. 2014
    2014 Prognostic factors in patients with metastatic breast cancer at the time of diagnosis 2014
    2014 Reduction of visceral fat by dietary stearate is mediated by apoptosis of preadipocytes. 2014
    2014 Round cell tumors of bone: An update on recent molecular genetic advancesAdvances in Anatomic Pathology.  21:359-372. 2014
    2013 A decade in banking Ewing sarcoma: A report from the Children's Oncology GroupFrontiers in Oncology.  3 MAR. 2013
    2013 LRRK2 secretion in exosomes is regulated by 14-3-3Human Molecular Genetics.  22:4988-5000. 2013
    2013 Enhancement of antitumor immunity in lung cancer by targeting myeloid-derived suppressor cell pathwaysCancer Research.  73:6609-6620. 2013
    2013 Syndecan-1 overexpression is associated with nonluminal subtypes and poor prognosis in advanced breast cancerAmerican Journal of Clinical Pathology.  140:468-474. 2013
    2013 A phase i clinical trial of Ad5/3-Δ24, a novel serotype-chimeric, infectivity-enhanced, conditionally-replicative adenovirus (CRAd), in patients with recurrent ovarian cancerGynecologic Oncology.  130:518-524. 2013
    2013 Erratum: Elevated levels of NO are localized to distal airways in asthma (Free Radical Biology and Medicine (2011) 50 (1679-1688))Free Radical Biology and Medicine.  58:45. 2013
    2013 Alpha-CaMKII plays a critical role in determining the aggressive behavior of human osteosarcomaMolecular Cancer Research.  11:349-359. 2013
    2013 Expression of osteoprotegerin from a replicating adenovirus inhibits the progression of prostate cancer bone metastases in a murine modelLaboratory Investigation.  93:268-278. 2013
    2013 Glycoengineering in cancer therapeutics: A review with fucose-depleted trastuzumab as the model 2013
    2013 Epiphyseal Chondromyxoid Fibroma with Prominent Adipose Tissue: Report of a Case wit Unusual Radiological and Histological PresentationThe American journal of orthopedics.  42:121-124. 2013
    2013 Epiphyseal chondromyxoid fibroma with prominent adipose tissue: an unusual radiologic and histologic presentation.American journal of orthopedics (Belle Mead, N.J.).  42:175-178. 2013
    2013 Finding a new generation of spies and manuscript reviewersLaboratory Investigation.  93:1262-1264. 2013
    2012 Bilateral mesenchymal hamartoma of the chest wall in an infant boyFetal and Pediatric Pathology.  31:415-422. 2012
    2012 Depletion of plasmacytoid dendritic cells inhibits tumor growth and prevents bone metastasis of breast cancer cellsJournal of Immunology.  189:4258-4265. 2012
    2012 Gene transfer of active Akt1 by an infectivity-enhanced adenovirus impacts β-cell survival and proliferation differentially in vitro and in vivoIslets.  4:366-378. 2012
    2012 Metastatic inflammatory myofibroblastic tumor identified by EUS-FNA in mediastinal lymph nodes with ancillary FISH studies for ALK rearrangementDiagnostic Cytopathology.  40. 2012
    2012 Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: A report from the children's oncology groupJournal of Clinical Oncology.  30:2545-2551. 2012
    2012 A phase I clinical trial of Ad5.SSTR/TK.RGD, a novel infectivity-enhanced bicistronic adenovirus, in patients with recurrent gynecologic cancerClinical Cancer Research.  18:3440-3451. 2012
    2012 A novel t(6;13)(q15;q34) translocation in a giant cell reparative granuloma (solid aneurysmal bone cyst)Human Pathology.  43:952-957. 2012
    2012 Foxp3 expression patterns in microscopic colitides: A clinicopathologic study of 69 patientsAmerican Journal of Clinical Pathology.  137:931-936. 2012
    2012 Regeneration of pancreatic non-β endocrine cells in adult mice following a single diabetes-inducing dose of streptozotocinPLoS One.  7. 2012
    2012 CD138 (syndecan-1) expression in bone-forming tumorsAmerican Journal of Clinical Pathology.  137:423-428. 2012
    2012 Complex analysis of a recurrent pleomorphic hyalinizing angiectatic tumor of soft partsHuman Pathology.  43:121-126. 2012
    2012 Gene Transer of Constitutively Active AKL by an Infectivity-Enhanced Adenoviral Vector Improves Beta Cell Survival and Proliferation.Islets.  4:366-378. 2012
    2012 Intracranial meningeal hemangiopericytoma metastatic to the scapulaOrthopedics.  35. 2012
    2012 Nicotine exposure and the progression of chronic kidney disease: Role of the α7-nicotinic acetylcholine receptor 2012
    2012 Striking Pathology Gold: A Singular Experience with Daily Reverberations: Sinonasal Hemangiopericytoma (Glomangiopericytoma) and Oncogenic OsteomalaciaHead and Neck Pathology.  6:64-74. 2012
    2012 The dark side of publishing: Promoting ethics in AJP 2003 to 2008American Journal of Pathology.  181:730-732. 2012
    2011 A 23-year-old woman with a right femoral neck fractureJournal of the American Medical Association.  306:2385-2386. 2011
    2011 Interleukin-4 inhibits RANKL-induced NFATc1 expression via STAT6: A novel mechanism mediating its blockade of osteoclastogenesisJournal of Cellular Biochemistry.  112:3385-3392. 2011
    2011 Conditionally replicating adenovirus expressing TIMP2 increases survival in a mouse model of disseminated ovarian cancerPLoS One.  6. 2011
    2011 The emerging importance of α-L-fucose in human breast cancer: A reviewAmerican Journal of Translational Research.  3:292-322. 2011
    2011 Prevention of carcinogenesis and inhibition of breast cancer tumor burden by dietary stearateCarcinogenesis.  32:1251-1258. 2011
    2011 A new generation of serotype chimeric infectivity-enhanced conditionally replicative adenovirals: The safety profile of Ad5/3-Δ24 in advance of a phase i clinical trial in ovarian cancer patientsHuman gene therapy. Clinical development.  22:821-828. 2011
    2011 Characterization of CXCR4 expression in chondrosarcoma of boneArchives of Pathology and Laboratory Medicine.  135:753-758. 2011
    2011 Elevated levels of NO are localized to distal airways in asthmaFree Radical Biology and Medicine.  50:1679-1688. 2011
    2011 Evaluation of lymph node numbers for adequate staging of Stage II and III colon cancerJournal of Hematology and Oncology.  4. 2011
    2011 LL-37 as a therapeutic target for late stage prostate cancer 2011
    2011 Laboratory Investigation editorial internship programLaboratory Investigation.  91:646. 2011
    2011 Loss of primary cilia upregulates renal hypertrophic signaling and promotes cystogenesisJournal of the American Society of Nephrology.  22:839-848. 2011
    2011 Breast carcinomas with isolated bone metastases have different hormone receptor expression profiles than those with metastases to other sites or multiple organsAnnals of Diagnostic Pathology.  15:79-83. 2011
    2011 Conditionally replicating adenovirus expressing TIMP2 for ovarian cancer therapyClinical Cancer Research.  17:538-549. 2011
    2010 Arming a replicating adenovirus with osteoprotegerin reduces the tumor burden in a murine model of osteolytic bone metastases of breast cancerCancer Gene Therapy.  17:893-905. 2010
    2010 Erratum: Arming a replicating adenovirus with osteoprotegerin reduces the tumor burden in a murine model of osteolytic bone metastases of breast cancer (Cancer Gene Therapy (2010) 17 (893-905))Cancer Gene Therapy.  17:906. 2010
    2010 A phase I study of a tropism-modified conditionally replicative adenovirus for recurrent malignant gynecologic diseasesClinical Cancer Research.  16:5277-5287. 2010
    2010 Juxtatumoral stromal reactions in uterine endometrioid adenocarcinoma and their prognostic significance 2010
    2010 Merkel cell carcinoma: Correlation of KIT expression with survival and evaluation of KIT gene mutational statusHuman Pathology.  41:1405-1412. 2010
    2010 Aggressive osteoblastoma: A case report involving a unique chromosomal aberrationInternational Journal of Surgical Pathology.  18:219-224. 2010
    2010 Ex vivo transfer of the Hoxc-8-interacting domain of smad1 by a tropism-modified adenoviral vector results in efficient bone formation in a rabbit model of spinal fusionClinical Spine Surgery.  23:63-73. 2010
    2010 Bizarre Parosteal Osteochondromatous Prolifeation (Nora’s Lesion): A report of the first case originating in soft tissue. 2010
    2010 Small cell tumors of boneAdvances in Anatomic Pathology.  17:1-11. 2010
    2010 What editors want in an abstractLaboratory Investigation.  90:4-5. 2010
    2009 E-cadherin/β-catenin and CD10: A limited immunohistochemical panel to distinguish pancreatic endocrine neoplasm from solid pseudopapillary neoplasm of the pancreas on endoscopic ultrasound-guided fine-needle aspirates of the pancreasAmerican Journal of Clinical Pathology.  132:831-839. 2009
    2009 Therapeutic potential of adult bone marrow-derived mesenchymal stem cells in prostate cancer bone metastasisClinical Cancer Research.  15:7175-7185. 2009
    2009 Novel infectivity-enhanced oncolytic adenovirus With a capsid-incorporated dual-imaging moiety for monitoring virotherapy in ovarian cancerMolecular Imaging.  8:264-277. 2009
    2009 Stearate preferentially induces apoptosis in human breast cancer cells 2009
    2009 Identifying the safety profile of Ad5.SSTR/TK.RGD, a novel infectivity-enhanced bicistronic adenovirus, in anticipation of a phase I clinical trial in patients with recurrent ovarian cancerClinical Cancer Research.  15:4131-4137. 2009
    2009 Dietary stearate reduces human breast cancer metastasis burden in athymic nude miceClinical and Experimental Metastasis.  26:415-424. 2009
    2009 Promotion of incisional wound repair by human mesenchymal stem cell transplantationExperimental Dermatology.  18:362-369. 2009
    2009 Adenovirus infection activates akt1 and induces cell proliferation in pancreatic islets1Transplantation.  87:821-824. 2009
    2009 Navigating interpersonal conflict and peer reviewLaboratory Investigation.  89:256-258. 2009
    2009 Unplanned surgical excision of extremity soft tissue sarcomas: patient profile and referral patterns.Journal of surgical orthopaedic advances.  18:93-98. 2009
    2009 Who's on first?Laboratory Investigation.  89:4-5. 2009
    2008 Immunohistochemistry in the evaluation of neovascularization in tumor xenografts 2008
    2008 Role of oxygen availability in CFTR expression and functionAmerican Journal of Respiratory Cell and Molecular Biology.  39:514-521. 2008
    2008 Thy-1 promoter hypermethylation: A novel epigenetic pathogenic mechanism in pulmonary fibrosisAmerican Journal of Respiratory Cell and Molecular Biology.  39:610-618. 2008
    2008 Mechanisms modulating inflammatory osteolysis: A review with insights into therapeutic targets 2008
    2008 Reporting guidelines for clinical laboratory reports in surgical pathologyArchives of Pathology and Laboratory Medicine.  132:1608-1616. 2008
    2008 Large, clear cytoplasmic vacuolation : An under-recognized cytologic clue to distinguish solid pseudopapillary neoplasms of the pancreas from pancreatic endocrine neoplasms on fine-needle aspirationCancer.  114:249-254. 2008
    2008 Silencing of transforming growth factor-β1 in situ by RNA interference for breast cancer: Implications for proliferation and migration in vitro and metastasis in vivoClinical Cancer Research.  14:4961. 2008
    2008 Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injuryAmerican Journal of Respiratory and Critical Care Medicine.  178:168-179. 2008
    2008 A fiber-modified mesothelin promoter-based conditionally replicating adenovirus fortreatment of ovarian cancerClinical Cancer Research.  14:3582-3588. 2008
    2008 Cell surface associated alpha-L-fucose moieties modulate human breast cancer neoplastic progressionPathology and Oncology Research.  14:145-156. 2008
    2008 Development of an optimized conditionally replicative adenoviral agent for ovarian cancerInternational Journal of Oncology.  32:1179-1188. 2008
    2008 Juvenile juxtacortical chondromyxoid fibroma of bone: a case reportHuman Pathology.  39:960-965. 2008
    2008 Characterization of infectivity of knob-modified adenoviral vectors in glioma.Cancer Biology and Therapy.  7:786-793. 2008
    2008 Alterations in human breast cancer adhesion-motility in response to changes in cell surface glycoproteins displaying α-L-fucose moietiesInternational Journal of Oncology.  32:797-807. 2008
    2008 Intracranial metastasis from synovial sarcoma.Orthopedics.  31:405. 2008
    2008 Cancer-specific targeting of a conditionally replicative adenovirus using mRNA translational controlBreast Cancer Research and Treatment.  108:43-55. 2008
    2008 p53 nuclear accumulation and Bcl-2 expression in contiguous adenomatous components of colorectal adenocarcinomas predict aggressive tumor behavior 2008
    2008 Osteosarcoma: The addition of muramyl tripeptide to chemotherapy improves overall survival - A report from the children's oncology groupJournal of Clinical Oncology.  26:633-638. 2008
    2008 Targeting p38 MAPK for the treatment of inflammatory arthritisInternational Journal of Clinical Rheumatology.  3:37-42. 2008
    2008 Characterization of infectivity of knob-modified adenoviral vectors in gliomaCancer Biology and Therapy.  7:788-795. 2008
    2008 In the blink of an eye...American Journal of Pathology.  172:1443-1444. 2008
    2008 Intracranial metastasis from synovial sarcomaOrthopedics.  31. 2008
    2008 Solid pseudopapillary tumor of the pancreas: A review of salient clinical and pathologic featuresAdvances in Anatomic Pathology.  15:39-45. 2008
    2008 Systemic osteoprotegerin gene therapy restores tumor-induced bone loss in a therapeutic model of beast cancer bone metastasisMolecular Therapy.  16:871-878. 2008
    2007 Genetic incorporation of the protein transduction domain of Tat into Ad5 fiber enhances gene transfer efficacyVirology Journal.  4. 2007
    2007 Involvement of vitronectin in lipopolysaccaride-induced acute lung injuryJournal of Immunology.  179:7079-7086. 2007
    2007 Juxtacortical chondromyxoid fibroma of bone: A unique variant - A case study of 20 patientsAmerican Journal of Surgical Pathology.  31:1662-1668. 2007
    2007 Targeting of a conditionally replicative adenovirus agent to human squamous cell carcinomas of the head and neckInternational Journal of Oncology.  31:1213-1222. 2007
    2007 Mesenchymal stem cells as a vehicle for targeted delivery of CRAds to lung metastases of breast carcinomaBreast Cancer Research and Treatment.  105:157-167. 2007
    2007 Breast cancer metastasis to bone: Evaluation of bioluminescent imaging and microSPECT/CT for detecting bone metastasis in immunodeficient miceClinical and Experimental Metastasis.  24:389-401. 2007
    2007 α-CaMKII controls the growth of human osteosarcoma by regulating cell cycle progressionLaboratory Investigation.  87:938-950. 2007
    2007 Fine-needle aspiration: A powerful modality in the preoperative diagnosis of solid pseudopapillary neoplasm of the pancreasPathology Case Reviews.  12:170-176. 2007
    2007 A mosaic fiber adenovirus serotype 5 vector containing reovirus σ1 and adenovirus serotype 3 knob fibers increases transduction in an ovarian cancer ex vivo system via a coxsackie and adenovirus receptor-independent pathwayClinical Cancer Research.  13:2777-2783. 2007
    2007 Effect of adenoviral mediated overexpression of fibromodulin on human dermal fibroblasts and scar formation in full-thickness incisional woundsJournal of Molecular Medicine.  85:481-496. 2007
    2007 A three-dimensional assay for measurement of viral-induced oncolysisCancer Gene Therapy.  14:421-430. 2007
    2007 Evolving gene therapy approaches for osteosarcoma using viral vectors: ReviewBone.  40:797-812. 2007
    2007 Stromal cell-derived factor 1 promotes angiogenesis via a heme oxygenase 1-dependent mechanismJournal of Experimental Medicine.  204:605-618. 2007
    2007 Combining high selectivity of replication via CXCR4 promoter with fiber chimerism for effective adenoviral oncolysis in breast cancerInternational Journal of Cancer.  120:935-941. 2007
    2007 Targeting lung cancer using an infectivity enhanced CXCR4-CRAdLung Cancer.  55:145-156. 2007
    2007 An 18 year old man with knee pain [osteoblastoma +ABC (medial lesion) & nonossifying fibroma (lateral lesion)Clinical Orthopaedics and Related Research.  242-247. 2007
    2007 An 18-year-old man with knee painClinical Orthopaedics and Related Research.  462:242-247. 2007
    2007 Fine Needle Aspiration: A powerful modality in the preoperative diagnosis of solid pseudopappillary neoplasm of the pancreas.Pathology Case Reviews.  1-7. 2007
    2007 Reliability of histopathologic and radiologic grading of cartilaginous neoplasms in long bones 2007
    2007 Wandering chordoma - A mid-line crisis? 2007
    2007 p38 MAPK as a potential therapeutic target for inflammatory osteolysisAdvances in Anatomic Pathology.  14:42-45. 2007
    2006 Administration of a conditionally replicative oncolytic canine adenovirus in normal dogsCancer Biotherapy and Radiopharmaceuticals.  21:601-606. 2006
    2006 Molecular pathology of chondroid neoplasms: Part 2, malignant lesions 2006
    2006 Solid-pseudopapillary neoplasm of the pancreas: Three cases with a literature reviewApplied Immunohistochemistry and Molecular Morphology.  14:445-453. 2006
    2006 Molecular pathology of chondroid neoplasms: Part 1, benign lesions 2006
    2006 227 RNA interference against Hec1 targets malignant mesothelioma (MM)Lung Cancer.  54:s55. 2006
    2006 Signal transduction cross-talk during colorectal tumorigenesisAdvances in Anatomic Pathology.  13:270-274. 2006
    2006 Adenovirus-mediated p53 tumor suppressor gene therapy of osteosarcomaLaboratory Investigation.  86:748-766. 2006
    2006 Employment of liver tissue slice analysis to assay hepatotoxicity linked to replicative and nonreplicative adenoviral agentsCancer Gene Therapy.  13:606-618. 2006
    2006 The human survivin promoter: A novel transcriptional targeting strategy for treatment of gliomaJournal of Neurosurgery.  104:583-592. 2006
    2006 Infectivity enhancement for adenoviral transduction of canine osteosarcoma cells 2006
    2006 Desmoplastic fibroma of the jaw: A case report and review of literatureOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.  101:82-94. 2006
    2006 Introducing biological perspectivesAmerican Journal of Pathology.  169:337. 2006
    2006 Osteosarcoma: Anatomic and histologic variantsAmerican Journal of Clinical Pathology.  125:555-581. 2006
    2006 Survivin promoter-based conditionally replicative adenoviruses target cholangiocarcinomaInternational Journal of Oncology.  29:1319-1329. 2006
    2006 Targeting mesothelioma using an infectivity enhanced survivin-conditionally replicative adenovirusesJournal of Thoracic Oncology.  1:701-711. 2006
    2005 A human adenoviral vector with a chimeric fiber from canine adenovirus type 1 results in novel expanded tropism for cancer gene therapy 2005
    2005 Fluorescently tagged canine adenovirus via modification with protein IX-enhanced green fluorescent proteinJournal of General Virology.  86:3201-3208. 2005
    2005 Osteosarcoma: A randomized, prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin, doxorubicin, and high-dose methotrexateJournal of Clinical Oncology.  23:2004-2011. 2005
    2005 Cytologic grade independently predicts survival of patients with pancreatic adenocarcinomaAmerican Journal of Clinical Pathology.  124:697-707. 2005
    2005 A fiber-modified, secretory leukoprotease inhibitor promoter-based conditionally replicating adenovirus for treatment of ovarian cancerClinical Cancer Research.  11:1327-1335. 2005
    2005 Adenoviruses with an RGD-4C modification of the fiber knob elicit a neutralizing antibody response but continue to allow enhanced gene deliveryGynecologic Oncology.  96:341-348. 2005
    2005 Optimal molecular profiling of tissue and tissue components: Defining the best processing and microdissection methods for biomedical applicationsMolecular Biotechnology.  29:119-152. 2005
    2005 Antiangiogenic cancer gene therapy by adeno-associated virus 2-mediated stable expression of the soluble FMS-like tyrosine kinase-1 receptorCancer Gene Therapy.  12:26-34. 2005
    2005 Gene transfer to carcinoma of the breast with fiber-modified adenoviral vectors in a tissue slice model systemCancer Biology and Therapy.  4:1203-1210. 2005
    2005 Incorporating the survivin promoter in an infectivity enhanced CRAd-analysis of oncolysis and anti-tumor effects in vitro and in vivoInternational Journal of Oncology.  27:237-246. 2005
    2005 Loss of fibroblast Thy-1 expression correlates with lung fibrogenesisAmerican Journal of Pathology.  167:365-379. 2005
    2005 Optimal molecular profiling of tissue and tissue components: defining the best processing and microdissection methods for biomedical applications.Methods in Molecular Medicine.  103:15-66. 2005
    2005 Preclinical evaluation of transcriptional targeting strategies for carcinoma of the breast in a tissue slice model systemBreast Cancer Research.  7:R1141-R1152. 2005
    2005 Productive replication of human adenovirus type 5 in canine cellsJournal of Virology.  79:1308-1311. 2005
    2005 The natural history of a novel, systemic, disseminated model of syngeneic mouse B-cell lymphoma 2005
    2004 Inter-patient variation in efficacy of five oncolytic adenovirus candidates for ovarian cancer therapyJournal of Gene Medicine.  6:1333-1342. 2004
    2004 Evaluation of tissue-specific promoters in carcinomas of the cervix uteriJournal of Gene Medicine.  6:1281-1289. 2004
    2004 Transport across a polarized monolayer of Caco-2 cells by transferrin receptor-mediated adenovirus transcytosisVirology.  325:116-128. 2004
    2004 An adenovirus vector with a chimeric fiber derived from canine adenovirus type 2 displays novel tropismVirology.  324:103-116. 2004
    2004 A cyclooxygenase-2 promoter-based conditionally replicating adenovirus with enhanced infectivity for treatment of ovarian adenocarcinoma 2004
    2004 A 32-year-old man with knee painClinical Orthopaedics and Related Research.  427:272-277. 2004
    2004 A 36-Year-Old Woman with a Toe MassClinical Orthopaedics and Related Research.  421:314-321. 2004
    2004 Evolutionary change and The American Journal of PathologyAmerican Journal of Pathology.  165:1055-1056. 2004
    2004 Recommendations for the reporting of bone tumorsHuman Pathology.  35:1173-1178. 2004
    2004 Ulnar mass in a 51-year-old womanClinical Orthopaedics and Related Research.  424:272-279. 2004
    2003 MUC1 and MUC2 Expression in Pancreatic Ductal Carcinoma Obtained by Fine-Needle AspirationCancer.  99:365-371. 2003
    2003 Infectivity enhanced, cyclooxygenase-2 promoter-based conditionally replicative adenovirus for pancreatic cancerGastroenterology.  125:1203-1218. 2003
    2003 Painful sclerotic medial clavicle in a 46-year-old womanClinical Orthopaedics and Related Research.  414:342-346. 2003
    2003 Intravenous delivery of adenovirus-mediated soluble FLT-1 results in liver toxicityClinical Cancer Research.  9:2701-2710. 2003
    2003 Replication of an integrin targeted conditionally replicating adenovirus on primary ovarian cancer spheroidsCancer Gene Therapy.  10:377-387. 2003
    2003 Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expressionCancer Research.  63:847-853. 2003
    2003 A canine conditionally replicating adenovirus for evaluating oncolytic virotherapy in a syngeneic animal modelMolecular Therapy.  7:163-173. 2003
    2003 Infiltration of Helicobacter pylori in the gastric mucosaAmerican Journal of Clinical Pathology.  119:101-107. 2003
    2003 Osteosarcoma in a patient with McCune-Albright syndrome and Mazabraud's syndrome: A case report emphasizing the cytological and cytogenetic findingsHuman Pathology.  34:1354-1357. 2003
    2003 Prosthetic implant associated sarcomas: A case report emphasizing surface evaluation and spectroscopic trace metal analysisAnnals of Diagnostic Pathology.  7:35-46. 2003
    2002 Comparison of five antibodies as markers in the diagnosis of melanoma in cytologic preparationsAmerican Journal of Clinical Pathology.  118:930-936. 2002
    2002 MDA-7: a novel prognostic marker?Advances in Anatomic Pathology.  9:323. 2002
    2002 Effective single chain antibody (scFv) concentrations in vivo via adenoviral vector mediated expression of secretory scFv 2002
    2002 Chondromyxoid fibroma of the cervical spine: Case reportNeurosurgery.  50:409-411. 2002
    2002 Phase II/III trial of etoposide and high-dose ifosfamide in newly diagnosed metastatic osteosarcoma: A pediatric oncology group trialJournal of Clinical Oncology.  20:426-433. 2002
    2002 Cytogenetics and molecular biology of osteosarcomaLaboratory Investigation.  82:365-373. 2002
    2002 Effective single chain antibody (scFv) concentrations in vivo via adenoviral vector mediated expression of secretory scFv 2002
    2002 Gene transfer to ovarian cancer versus normal tissues with fiber-modified adenovirusesMolecular Therapy.  5:695-704. 2002
    2002 Microdissection of histologic sections: Past, present, and futureAdvances in Anatomic Pathology.  9:316-322. 2002
    2001 Cell surface fucose ablation as a therapeutic strategy for malignant neoplasmsAdvances in Anatomic Pathology.  8:330-337. 2001
    2001 Use of the internet in pathology resident training and educationAdvances in Anatomic Pathology.  8:290-297. 2001
    2001 Adeno-associated virus for cancer gene therapyCancer Research.  61:6313-6321. 2001
    2001 Laser capture microdissection.Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.].  Chapter 25:Unit-25A.1. 2001
    2001 Pathologic quiz case: An asymptomatic patient with a large renal massArchives of Pathology and Laboratory Medicine.  125:828-830. 2001
    2001 Osteochondromyxoma of bone: A lot more than fodder for the spelling-challengedAmerican Journal of Surgical Pathology.  25:268. 2001
    2001 Adenovirus-mediated soluble FLT-1 gene therapy for ovarian carcinomaClinical Cancer Research.  7:2057-2066. 2001
    2001 Aggressive osteoblastoma of the mandible closely simulating calcifying epithelial odontogenic tumor. Report of two cases with unusual histopathologic findings 2001
    2001 An adenovirus with enhanced infectivity mediates molecular chemotherapy of ovarian cancer cells and allows imaging of gene expressionMolecular Therapy.  4:223-231. 2001
    2001 An immunomagnetic-based method for the purification of ovarian cancer cells from patient-derived ascitesGynecologic Oncology.  82:57-63. 2001
    2001 Enlarging toe mass in a 13-year-old girlClinical Orthopaedics and Related Research.  390. 2001
    2001 Eradication of c-erbB-2-Positive Ovarian Cancer Cells Mediated by Intracellular Expression of Anti-c-erbB-2 Antibody.Methods in Molecular Medicine.  39:757-768. 2001
    2001 Laser capture microdissection.Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.].  Chapter 25. 2001
    2001 Paraspinal mass in a 14-year-old girlClinical Orthopaedics and Related Research.  382. 2001
    2001 Presurgical window of carboplatin and surgery and multidrug chemotherapy for the treatment of newly diagnosed metastatic or unresectable osteosarcoma: Pediatric oncology group trialJournal of Pediatric Hematology/Oncology.  23:340-348. 2001
    2001 Strategies to accomplish targeted expression of transgenes in ovarian cancer for molecular therapeutic applicationsClinical Cancer Research.  7:2496-2504. 2001
    2001 Transcriptional targeting for ovarian cancer gene therapyGynecologic Oncology.  82:229-237. 2001
    2000 A cancer gene therapy approach utilizing an anti-erbB-2 single-chain antibody-encoding adenovirus (AD21): A phase I trialClinical Cancer Research.  6:3081-3087. 2000
    2000 A prospective trial of telepathology for intraoperative consultation (frozen sections)Human Pathology.  31:781-785. 2000
    2000 Adenoviral-mediated suicide gene therapy for ovarian cancerMolecular Therapy.  2:524-530. 2000
    2000 An adenovirus encoding proapoptotic Bax induces apoptosis and enhances the radiation effect in human ovarian cancerMolecular Therapy.  1:545-554. 2000
    2000 Antineoplastic effect of anti-erbB-2 intrabody is not correlated with scFv affinity for its targetCancer Gene Therapy.  7:1250-1256. 2000
    2000 Genetically modified CD34+ cells exert a cytotoxic bystander effect on human endothelial and cancer cellsClinical Cancer Research.  6:4442-4448. 2000
    2000 Osteoblastoma: A mimic of osteosarcomaFetal and Pediatric Pathology.  19:305-322. 2000
    2000 Pro-apoptotic treatment with an adenovirus encoding Bax enhances the effect of chemotherapy in ovarian cancerJournal of Gene Medicine.  2:97-106. 2000
    1999 Osteosarcoma in a patient with McCune-Albright syndrome and Mazabraud's syndrome 1999
    1999 An inducible recombinant adenoviral vector encoding Bax selectively induces apoptosis in ovarian cancer cellsTumor Targeting.  4:84-91. 1999
    1999 Interleukin-6 modulated conditionally replicative adenovirus as an antitumor/cytotoxic agent for cancer therapyClinical Cancer Research.  5:43-50. 1999
    1999 An advanced generation of adenoviral vectors selectively enhances gene transfer for ovarian cancer gene therapy approachesGynecologic Oncology.  74:227-234. 1999
    1999 Apoptosis and tumorigenesis in human cholangiocarcinoma cells: Involvement of Fas/APO-1 (CD95) and calmodulinAmerican Journal of Pathology.  155:193-203. 1999
    1999 Detection of coxsackie-adenovirus receptor (CAR) immunoreactivity in ovarian tumors of epithelial derivationApplied Immunohistochemistry and Molecular Morphology.  7:266-270. 1999
    1999 Epithelioid variant of malignant peripheral nerve sheath tumor (malignant schwannoma) of the urinary bladder.Annals of Diagnostic Pathology.  3:304-308. 1999
    1999 Examination of tumor and tumor-like conditions of boneAnnals of Diagnostic Pathology.  3:364-369. 1999
    1999 From the Gross Bench: Examination of tumor and tumor-like conditions of boneAnnals of Diagnostic Pathology.  364-369. 1999
    1999 Pathologic femoral fracture in a 76-year-old womanClinical Orthopaedics and Related Research.  364:276-280. 1999
    1999 Targeted adenovirus vector for cancer gene therapy. 1999
    1998 Modulation of drug-induced apoptosis by an anti-Bcl-2 single-chain antibody in ovarian cancer cellsTumor Targeting.  3:147-155. 1998
    1998 Transcomplementation of a replication-incompetent adenovirus expressing herpes simplex virus thymidine kinase in ovarian carcinoma cells produces progeny virus capable of killing after treatment with ganciclovirTumor Targeting.  3:169-177. 1998
    1998 Use of a tissue-specific promoter for targeted expression of the herpes simplex virus thymidine kinase gene in cervical carcinoma cellsCancer Gene Therapy.  5:331-336. 1998
    1998 Alpha-L-fucose: a potentially critical molecule in pathologic processes including neoplasia.American Journal of Clinical Pathology.  110:425-440. 1998
    1998 Basic fibroblast growth factor enhancement of adenovirus-mediated delivery of the herpes simplex virus thymidine kinase gene results in augmented therapeutic benefit in a murine model of ovarian cancerClinical Cancer Research.  4:2455-2461. 1998
    1998 Intracellular expression of the anti-erbB-2 sFv N29 fails to accomplish efficient target modulationBiochemical and Biophysical Research Communications.  250:699-703. 1998
    1998 Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate 1998
    1998 Gene therapy for ovarian carcinomaSeminars in Oncology.  25:397-406. 1998
    1998 The level of erbB2 expression predicts sensitivity to the cytotoxic effects of an intracellular anti-erbB2 sFvJournal of Molecular Medicine.  76:451-458. 1998
    1998 Intracellular expression of a single-chain antibody directed against human papillomavirus type 16 E7 oncoprotein achieves targeted antineoplastic effectsCancer Research.  58:1893-1900. 1998
    1998 Endothelial cell vehicles for delivery of cytotoxic genes as a gene therapy approach for carcinoma of the ovaryClinical Cancer Research.  4:265-270. 1998
    1998 A potentially critical molecule in pathologic processes including neoplasiaAmerican Journal of Clinical Pathology.  110:425-440. 1998
    1998 An initial trial of a prototype telepathology system featuring static imaging with discrete control of the remote microscopeAmerican Journal of Clinical Pathology.  110:43-49. 1998
    1998 Gene therapy: Ovarian carcinoma as the paradigmAmerican Journal of Clinical Pathology.  109:444-467. 1998
    1998 High-efficacy thymidine kinase gene transfer to ovarian cancer cell lines mediated by herpes simplex virus type I vectorGynecologic Oncology.  71:278-287. 1998
    1998 Orthopaedic · Radiology · Pathology conference: Shoulder mass in a 38- year-old womanClinical Orthopaedics and Related Research.  323-327+330. 1998
    1998 Orthopaedic · Radiology · Pathology conference: Shoulder mass in a 38- year-old womanClinical Orthopaedics and Related Research.  355. 1998
    1998 Shoulder mass in a 38-year-old woman.Clinical Orthopaedics and Related Research.  355. 1998
    1997 1α,25-Dihydroxyvitamin D (calcitriol) inhibits the invasiveness of human prostate cancer cellsCancer Epidemiology, Biomarkers and Prevention.  6:727-732. 1997
    1997 1 alpha,25-Dihydroxyvitamin D (calcitriol) inhibits the invasiveness of human prostate cancer cells.Cancer Epidemiology, Biomarkers and Prevention.  6:727-732. 1997
    1997 Epidermal growth factor induces CD44 gene expression through a novel regulatory element in mouse fibroblastsJournal of Biological Chemistry.  272:14139-14146. 1997
    1997 Targeted gene delivery to Kaposi's sarcoma cells via the fibroblast growth factor receptorCancer Research.  57:1447-1451. 1997
    1997 An intracellular anti-erbB-2 single-chain antibody is specifically cytotoxic to human breast carcinoma cells overexpressing erbB-2 1997
    1997 Gene therapy and ovarian cancer: A reviewObstetrics and Gynecology.  89:145-155. 1997
    1997 Stable in vivo gene transduction via a novel adenoviral/retroviral chimeric vectorNature Biotechnology.  15:866-870. 1997
    1997 Transductional efficacy and safety of an intraperitoneally delivered adenovirus encoding an anti-erbB-2 intracellular single-chain antibody for ovarian cancer gene therapyGynecologic Oncology.  64:378-385. 1997
    1996 Intracellular antibody against erbB-2 mediates targeted tumor cell eradication by apoptosisCancer Gene Therapy.  3:89-98. 1996
    1996 Epidermal growth factor modulates cell attachment to hyaluronic acid by the cell surface glycoprotein CD44Clinical and Experimental Metastasis.  14:268-276. 1996
    1996 Novel gene therapy strategy to accomplish growth factor modulation induces enhanced tumor cell chemosensitivityClinical Cancer Research.  2:1089-1095. 1996
    1996 Adenoviral-mediated deliver of herpes simplex virus thymidine kinase results in tumor rduction and prolonged survival in a SCID mouse model of human ovarian carcinomaJournal of Molecular Medicine.  74:455-462. 1996
    1996 In vitro AL-amyloid formation by rat and human mesangial cellsLaboratory Investigation.  74:290-302. 1996
    1996 Tumor cell invasion of basement membrane in vitro is regulated by amino acidsCancer Investigation.  14:6-18. 1996
    1995 Cationic lipids for reporter gene and CFTR transfer to rat pulmonary epithelium 1995
    1995 Stearate inhibits human tumor cell invasionInvasion & metastasis.  15:144-155. 1995
    1995 In vitro invasiveness of DU-145 human prostate carcinoma cells is modulated by EGF receptor-mediated signalsClinical and Experimental Metastasis.  13:407-419. 1995
    1995 Adenoviral-Mediated Delivery of the Herpes Simplex Virus Thymidine Kinase Gene Selectively Sensitizes Human Ovarian Carcinoma Cells to GanciclovirClinical Cancer Research.  1:1571-1580. 1995
    1995 Small cell osteosarcoma of the soft tissue 1995
    1995 Amino acid transport systems modulate human tumor cell growth and invasion: A working hypothesisMedical Hypotheses.  44:195-201. 1995
    1995 Cationic lipids for reporter gene and CFTR transfer to rat pulmonary epithelium. 1995
    1995 Endocrine and metabolic characteristics of polyoma large T transgenic mice that develop ACTH-producing pituitary tumorsJournal of Neurosurgery.  82:879-885. 1995
    1995 Extraskeletal osteosarcoma: An unusual presentation as tarsal tunnel syndromeFoot and Ankle International.  16:796-799. 1995
    1995 Recombinant adenovirus-mediated gene transfer to genitourinary epithelium in vitro and in vivo.Cancer Gene Therapy.  2:97-104. 1995
    1995 Targeted eradication of ovarian cancer mediated by intracellular expression of anti-erbb-2 single-chain antibodyGynecologic Oncology.  59:8-14. 1995
    1995 Targeted tumor killing via an intracellular antibody against erbB-2Journal of Clinical Investigation.  96:2980-2989. 1995
    1994 Intracellular single-chain antibody directed against erbB2 down-regulates cell surface erbB2 and exhibits a selective anti-proliferative effect in erbB2 overexpressing cancer cell lines 1994
    1994 Development of a metastatic model for human endometrial carcinoma using orthotopic implantation in nude miceInternational Journal of Oncology.  4:1163-1171. 1994
    1994 Developmental analysis of bone tumors in polyomavirus transgenic miceLaboratory Investigation.  70:86-94. 1994
    1994 In vivo modulation of human tumor cell growth by normal human extracellular matrix 1994
    1993 Development of a novel human extracellular matrix for quantitation of the invasiveness of human cellsCancer Letters.  69:123-132. 1993
    1993 Ewing sarcoma of bone in infants and toddlers. A clinicopathologic report from the Intergroup Ewing's Study.Cancer.  71:2109-2118. 1993
    1993 Ewing sarcoma of bone in infants and toddlers. A clnicopathologic report from the intergroup Ewing's studyCancer.  71:2109-2118. 1993
    1993 Localization of tenascin in uterine sarcomas and partially transformed endometrial stromal cells 1993
    1993 Mutation of the Ki-ras Protooncogene in Human Endometrial Hyperplasia and CarcinomaCancer Research.  53:1906-1910. 1993
    1992 Fibronectin as a component of pseudophakic acellular membranesJournal of Cataract and Refractive Surgery.  18:180-183. 1992
    1992 Transgenic mice that develop pituitary tumors: A model for Cushing's diseaseAmerican Journal of Pathology.  140:1071-1080. 1992
    1991 Altered tenascin expression during spontaneous endometrial carcinogenesis in the bdii/han ratVirchows Archiv B Cell Pathology Zell-Pathologie.  60:83-89. 1991
    1991 Altered tenascin expression during spontaneous endometrial carcinogenesis in the BDII/Han rat.Virchows Archiv B Cell Pathology Zell-Pathologie.  60:83-89. 1991
    1990 PathologyJournal of the American Medical Association.  263:2671-2672. 1990
    1990 Adenomatoid tumors: Adrenal cysts and being firstArchives of Pathology and Laboratory Medicine.  114:641-642. 1990
    1990 Bronchial Carcinoids with S-100 Positive Sustentacular Cells: A Comparative Study with Gastrointestinal Carcinoids, Pheochromocytomas and Paragangliomas 1990
    1990 Immunoreactivity in malignant mesotheliomas with antibodies to basement membrane components and their receptors.Modern Pathology.  3:11-18. 1990
    1990 Malignant transformation of human endometrial stromal cells by transfection of c-myc: Effects of pRSVneo cotransfection and treatment with MNNG 1990
    1990 Massive florid reactive periostitis 1990
    1990 Metastasizing Pleomorphic Adenoma with Myoepithelial Cell Predominance 1990
    1990 Tenascin expression in the human endometrium and in endometrial adenocarcinomasLaboratory Investigation.  62:725-730. 1990
    1990 Ultrastructural characterization of two new human endometrial carcinoma cell lines and normal human endometrial epithelial cells cultured on extracellular matrixIn vitro cellular & developmental biology : journal of the Tissue Culture Association.  26:701-708. 1990
    1989 Central odontogenic fibroma, granular cell variant A case report with S-100 immunohistochemistry and a review of the literatureOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.  67:725-730. 1989
    1989 Establishment and characterization of a human cell line from a serous papillary endometrial carcinomaGynecologic Oncology.  33:301-312. 1989
    1989 Using melanoma-associated monoclonal antibodies as a paradigm in the search for tumor-specific antigens. 1989
    1988 Falsification of Credentials by Applicants for Medical StaffsNew England Journal of Medicine.  319:376-377. 1988
    1988 A novel method for selection of invasive tumor cells: Derivation and characterization of highly metastatic K1735 melanoma cell lines based on in vitro and in vivo invasive capacityClinical and Experimental Metastasis.  6:301-318. 1988
    1988 Flow cytometric analysis of DNA ploidy in lymphomas of the thyroid 1988
    1987 Primary Ewing's sarcoma involving the bones of the head and neck.Cancer.  60:2829-2840. 1987
    1987 Adenosquamous carcinoma of the fallopian tube. A clinicopathologic case report with verification of the diagnosis by immunohistochemical and ultrastructural studies.American Journal of Obstetrics and Gynecology.  157:903-905. 1987
    1987 Flow Cytometric Analysis of Human Uterine Sarcomas and Cell LinesCancer Research.  47:2814-2820. 1987
    1987 Adenosquamous carcinoma of the fallopian tube: A clinicopathologic case report with verification of the diagnosis by immunohistochemical and ultrastructural studiesAmerican Journal of Obstetrics and Gynecology.  157:903-905. 1987
    1987 Analysis of changes in rat prostate carcinoma following hormone deprivationAmerican Journal of Pathology.  128:566-572. 1987
    1987 Dedifferentiated chondrosarcoma of bone - An immunohistochemical and lectin-histochemical studyVirchows Archiv. A, Pathological anatomy and histopathology.  411:23-32. 1987
    1987 Gastroesophageal reflux and esophagitis in infants and children. 1987
    1987 Primary Ewing's sarcoma involving the bones of the head and neckCancer.  60:2829-2840. 1987
    1987 Stromal proliferations of the breast: An ultrastructural and immunohistochemical evaluation of cystosarcoma phyllodes, juvenile fibroadenoma, and fibroadenomaHuman Pathology.  18:45-49. 1987
    1987 The epithelial origin of a stromal cell population in adenocarcinoma of the rat prostateAmerican Journal of Pathology.  128:555-565. 1987
    1986 In vitro inhibition of human sarcoma cells invasive ability by bis(5-amidino-2-benzimidazolyl)methane: A novel esteroprotease inhibitorAmerican Journal of Pathology.  123:46-56. 1986
    1986 Degradation of glycoprotein and collagenous components of the basement membrane: studies with urokinase-type plasminogen activator, alpha-thrombin, and plasmin.Seminars in vascular medicine.  12:335-336. 1986
    1986 Immunohistochemical evidence for the vascular origin of primary adrenal pseudocystsArchives of Pathology and Laboratory Medicine.  110:121-123. 1986
    1986 Case report 362 1986
    1986 Collagen and laminin immunoreactivity in ewing's sarcoma: Support for an uncommitted mesenchymal cell derivationFetal and Pediatric Pathology.  5:485-487. 1986
    1986 Degradation of glycoprotein and collagenous components of the basement membrane: Studies with urokinase-type plasminogen activator, α-thrombin, and plasminSeminars in Thrombosis and Hemostasis.  12:335-336. 1986
    1986 Endometrial stromal cells in culture: An attempt to understand the genesis and biologic activity of uterine sarcomasGynecologic Oncology.  24:247-257. 1986
    1986 Laminin promotes rabbit neutrophil motility and attachmentJournal of Clinical Investigation.  77:1180-1186. 1986
    1986 Osteogenic sarcoma and soft tissue myxoma in a patient with fibrous dysplasia and hemoglobins J(Baltimore) and SClinical Orthopaedics and Related Research.  204:245-252. 1986
    1985 Cellular immunolocalization of S100 protein within fixed tissue sections by monoclonal antibodiesArchives of Pathology and Laboratory Medicine.  109:117-122. 1985
    1985 Analysis of isoenzymes in normal and carcinogen-treated human endometrial stromal cells in cultureCarcinogenesis.  6:181-188. 1985
    1985 Chronic lymphocytic leukemia presenting as an anal massJournal of Clinical Gastroenterology.  7:83-87. 1985
    1985 Effect of a novel esteroprotease inhibitor on tumor cell invasion in vitro 1985
    1985 Esophagitis: A frequent consequence of gastroesophageal reflux in infancyJournal of Pediatrics.  107:881-884. 1985
    1985 Ewing's sarcoma in bones of the hands and feet: A clinicopathologic study and review of the literatureJournal of Clinical Oncology.  3:686-697. 1985
    1985 Histiocytosis X (Langerhans' cell granulomatosis) of the thymus. A clinicopathologic study of four childhood casesAmerican Journal of Surgical Pathology.  9:117-124. 1985
    1985 Juxtadrenal schwannoma: Verification of the diagnosis by immunohistochemical and ultrastructural studies 1985
    1985 Neuron-specific enolase immunoreactivity in small-cell carcinoma of the uterine cervix.Archives of Pathology and Laboratory Medicine.  109:5-6. 1985
    1985 Primary transitional cell carcinoma of the female urethra with features of clear cell adenocarcinomaActa Urologica Italica.  40:294-297. 1985
    1985 Radiographic appearance of Ewing sarcoma of the hands and feet: Report from the Intergroup Ewing Sarcoma StudyAmerican Journal of Roentgenology.  144:331-336. 1985
    1984 The heterogeneity of LDH isoenzyme patterns of human uterine sarcomas and cultured sarcoma cell linesAmerican Journal of Pathology.  116:85-93. 1984
    1984 Roentgenographic-pathologic correlation of diffuse sclerosis in Ewing Sarcoma of bone 1984
    1983 Characterization of a pure heterologous sarcoma of the uterus: Rhabdomyosarcoma of the corpus 1983
    1983 Loss of basement membrane components by invasive tumors but not by their benign counterpartsLaboratory Investigation.  49:140-147. 1983
    1983 Role of laminin in the adherence and chemotaxis of neutrophils. 1983
    1983 Use of anti-basement membrane antibodies to distinguish blood vessel capillaries from lymphatic capillariesAmerican Journal of Surgical Pathology.  7:667-677. 1983
    1982 Interferon enhancement of the invasive capacity of Ewing sarcoma cells in vitro 1982
    1982 Enhancement of human cancer cell invasiveness by human interferons 1982
    1982 Interactions of tumor cells with whole basement membrane in the presence or absence of endothelium.Progress in clinical and biological research.  89:353-371. 1982
    1981 Stages of neoplastic transformation of human breast tissue as monitored by dissolution of basement membrane components. An immunoperoxidase studyInvasion & metastasis.  1:54-70. 1981
    1981 Effect of Plasminogen Activator (Urokinase), Piasmin, and Thrombin on Glycoprotein and Collagenous Components of Basement MembraneCancer Research.  41:4629-4636. 1981
    1981 Antibodies to collagenase-resistant terminal regions of pro-type IV collagen recognize whole basement membrane and 7 S collagenFEBS Letters.  127:263-266. 1981
    1981 Death by drowning. An overview.Minnesota Medicine.  64:295. 1981
    1981 Spontaneous rupture of the kidney following renal artery revascularization.Minnesota Medicine.  64:153-154. 1981
    1981 Antibodies to collagenase-resistant terminal regions of pro-type IV collagen recognize whole basement membrane and 7 S collagenFEBS Letters.  127:257-262. 1981
    1981 Preparation of Interferon Messenger RNAs with the Use of Ribonucleoside-Vanadyl ComplexesMethods in Enzymology.  79:59-68. 1981
    1981 Preparation of interferon messenger RNAs with the use of ribonucleoside--vanadyl complexes.Methods in Enzymology.  79:59-68. 1981
    1981 Sarcomas of bone complicating osteitis deformans (Paget's disease). Fifty years' experienceAmerican Journal of Surgical Pathology.  5:47-59. 1981
    1980 Primary mediastinal embryonal carcinomaMinnesota Medicine.  63:723-726. 1980
    1980 Non-Hodgkin's lymphoma with features of "Sternberg's sarcoma" manifesting as a pelvic mass.Minnesota Medicine.  63:94-96. 1980
    1980 Polyadenylate‐deficient analogues of poly(A)‐containing mRNA sequences in cultured AKR mouse embryo cellsJournal of Cellular Physiology.  103:417-428. 1980
    1979 Testicular surprises in two apparently healthy young men.Minnesota Medicine.  62:671-672. 1979
    1979 Frequency differences between nuclear and polysomal sequences of poly(A)‐containing RNA from cultured akr mouse embryo cellsJournal of Cellular Physiology.  98:283-297. 1979
    1978 Idiopathic pulmonary hemosiderosis. Two cases in a familyMayo Clinic Proceedings.  53:113-118. 1978
    1977 Gene expression in chemically transformed mouse embryo cells: Selective enhancement of the expression of C type RNA tumor virus genesCell.  11:909-921. 1977
    1976 Solitary leiomyomas arising from the tunica dartos scrotiInvestigative urology.  116:69-71. 1976
    1975 Osteoblastic osteogenic sarcoma in a 35 month old girl. Report of a caseAmerican Journal of Clinical Pathology.  63:886-890. 1975


    Year Title Altmetric
    2017 Quality Assurance in Anatomic Pathology: Strategies for Assessment, Improvement and Management 2017
    2015 Practical Orthopedic Pathology: A Diagnostic Approach E-Book: A Volume in the Pattern Recognition Series 2015
    2014 Pathobiology of human disease: a dynamic encyclopedia of disease mechanisms 2014
    2013 Atlas of bone pathology 2013
    2011 Atlas of Nontumor Pathology Vol. 9:\lnotNon-Neoplastic Diseases of Bones and Joints 2011
    2011 Frozen Section Library: Bone 2011
    2011 Laboratory Administration for Pathologists 2011
    2007 Updates in Diagnostic Pathology 2007
    2005 Foreword - Another brief history in time.  Ed. 563.  2005
    1988 Monoclonal antibodies in diagnostic immunohistochemistry 1988
    1979 The Frequency and Distribution of Nuclear and Polysomal Messenger RNA Sequences of Cultured AKR Mouse Embryo Cells 1979


    Year Title Altmetric
    2021 Molecular pathology of osteosarcoma.  579-590. 2021
    2020 Fibrous Dysplasia 2020
    2020 McCune-Albright Syndrome.  514-516. 2020
    2017 Ceramic Coatings in Load-Bearing Articulating Joint Implants.  315-347. 2017
    2017 Communication, Handouts and Transitions.  29-42. 2017
    2016 Ceramic Coatings in Load-Bearing Articulating Joint Implants 2016
    2016 Gene therapy in the treatment of human cancer.  811-841. 2016
    2015 Molecular pathology of osteosarcoma.  213-222. 2015
    2015 Specimen Precessing for laser microdissection. 2015
    2015 Virotherapy 2015
    2014 Optimal Handling of Bone Tumor Specimens.  353-368. 2014
    2013 Fibrous Dysplasia.  352-353. 2013
    2013 McCune-Albright Syndrome.  382-383. 2013
    2011 Therapeutic options using recombinant adeno-associated virus for orthopedic oncology..  281-289. 2011
    2011 Virotherapy - Using Conditionally Replicative Adenoviruses (CRAds) to Target Tumor Cells 2011
    2010 Molecular pathology of osteosarcoma.  193-199. 2010
    2006 In Vitro Matrices for Studying Tumor Cell Invasion. 2006
    2005 Forward: Another Brief History in Time..  v-vi. 2005
    2005 Tumor-like Lesions and Neoplasms of Joints and Related Structures..  2117-2131. 2005
    2004 Bone Pathology: Chondroid Tumours.  99-108. 2004
    2004 Molecular Aspects of Chondroid Tumors: A Brief Review.  99-108. 2004
    2004 Optimal Molecular Profiling of Tissue and Tissue Components: Defining the Best Processing and Microdissection Methods for Biomedical Applications..  15-66. 2004
    2003 Bone Tumors (excluding Ewing’s sarcoma).  237-245. 2003
    2002 Fibrous Dysplasia 2002
    2002 McCune-Albright Syndrome.  357-359. 2002
    2002 Telangiectatic Osteosarcoma. In: eMedicine: Orthopedic Surgery 2002
    2001 Laser capture microdissection. 2001
    2000 Eradication of c-erB-2 positive ovarian cancer cells mediated by intracellular expression of anti-erbB-2 sFv. 2000
    1998 In vivo efficacy of an anti-erbB-2 intracellular single chain antibody in combination with cisplatin in a murine model 1998
    1998 Primary tumors of muscle..  183-212. 1998
    1991 The effect of selected amino acids and polyamines on tumor invasion..  42-45. 1991
    1989 Organ Culture: Use in experimental oncology for comparisons among species. 1989
    1988 Antibodies which recognize basement membrane components - their use in tumor pathology and related conditions..  593-621. 1988
    1988 Monoclonal Antibodies in Diagnostic Immunohistology - A brief prospective and look to the future..  631-637. 1988
    1988 S-100 Protein..  455-503. 1988
    1987 Gastroesophageal reflux and esophagitis in infants and children..  124-151. 1987
    1982 Applications of immunoperoxidase staining to studies of human breast disease..  511-529. 1982
    1982 Basement membrane attachment and degradation by metastatic tumor cells..  277-286. 1982
    1982 Interactions of tumor cells with whole basement membrane in the presence or absence of endothelium..  351-371. 1982
    1981 Preparation of interferon messenger RNAs with the use of ribonucleoside-vanadyl complexes..  59-59. 1981

    Research Overview

  • Dr. Siegal is an extramurally funded experimental and diagnostic pathologist whose research interest for more than 3 decades has been focused in Cancer Biology. Specifically, he has been interested in studying tumor-matrix interactions during angiogenesis, tumor invasion and metastasis in breast cancer. Previous efforts by his group have been directed towards developing new reliable in vitro model systems for studying the effect of nutritional and other factors on prostate and breast cancer progression in humans. He has participated in multiple gene therapy studies utilizing a variety of distinct strategies including mutation compensation, genetic immunopotentiation, and molecular chemotherapy to treat solid human neoplasms, principally ovarian carcinoma. Dr. Siegal also directs the UAB AP Core. Dr. Siegal's clinical research interests have focused on studies of bone tumors and related conditions. He is the Editor-in-Chief of Laboratory Investigation and serves on the editorial board of multiple additional journals.
  • Education And Training

  • Mayo Graduate School of Medicine, Internship
  • Mayo Graduate School of Medicine, Residency
  • Mayo Graduate School of Medicine, Residency
  • Mayo Graduate School of Medicine, Residency
  • Mayo Graduate School of Medicine, Postdoctoral Fellowship
  • Warren G. Magnuson Clinical Center, Postdoctoral Fellowship
  • Doctor of Philosophy in Pathology Residency Program, University of Minnesota System : Twin Cities 1979
  • Doctor of Medicine, University of Louisville 1974
  • Awards And Honors

  • Inaugural Fellow of Sigma Xi, 2020
  • 3rd Jishuitan Pathology Forum Lecturer – Bone & Soft Tissue Tumours, 2018
  • C.A.P. Lifetime Achievement Award, 2017
  • Albert Nelson Marquis Lifetime Achievement Award, 2017
  • Vernie A. Stembridge Lecturer – 95th Ann. Meeting, Texas Soc. Of Pathologists, 2016
  • A.S.I.P. Robbins Distinguished Educator Award, 2015
  • Miembro Honorario, Asociacion Venezolana para el Estudio de Tumors Musculo-Esqueleticos (AVETME), 2013
  • Emma Sadler Moss Lecturer - Louisiana State University (LSU), 2012
  • The Griffin Society [UAB Scientific Society], 2009
  • Arthur Purdy Stout Lecturer - A.S.C.P. Annual Meeting, 2009
  • Citation Classic (Ref #18) Barsky S. et al. Lab Invest 49:140, 1983, 2003
  • Milton S. Hales Lecturer - West Virginia University, 2003
  • 1st Carter/Makley Lecturer -Case Western Reserve Univ., Institute of Pathology, 2003
  • 3rd Walter R. Benson Lecturer -University of North Carolina, 2003
  • Farrell Prize, International Skeletal Society [Shared with M.J. Pitt], 2001
  • Alpha Omega Alpha, the Medical Honor Society, 1996
  • International Skeletal Society, 1994
  • Phi Beta Delta, Honor Society for International Scholars, 1993
  • Fellow of the Royal Society of Medicine, London, 1992
  • Order of the Grail - Valkyries (UNC Honorary), 1990
  • Order of the Grail - Valkyries (UNC Honorary), 1990
  • Jefferson-Pilot Fellow in Academic Medicine, 1986
  • International Business Machines Corporation Junior Faculty Development Awardee, 1985
  • Junior Faculty Fellow of the American Cancer Society, 1983
  • Clinical Fellow of the American Cancer Society, 1981
  • Sigma Xi, The Scientific Research Society of North America, 1976
  • Omicron Delta Kappa, the National Leadership Honor Society, 1974
  • Who's Who Among Students in American Colleges & Universities, 1969
  • Beta Beta Beta, The National Biology Honor Society, 1968
  • Alpha Epsilon Delta, the International Premedical Honor Society, 1966
  • Full Name

  • Gene Siegal