• Our eyes are composed of living tissues, which are constantly remodeling in response to mechanical, chemical, and visual stimuli. In particular, the loadbearing collagenous structures of the eye can undergo substantial growth and remodeling during physiological and pathophysiological conditions. I seek to elucidate the biomechanical mechanisms that underlie growth and remodeling in ocular diseases. My laboratory focuses on establishing experimental methods and predictive computational simulation tools for elucidating growth and remodeling mechanisms in glaucoma, keratoconus and myopia. My laboratory‚Äôs goal is to provide predictive computational simulation tools that support the development of new diagnostics and therapeutics in ocular diseases and conditions.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Special Issue: Imaging-based methods in computational medicine 2022
    2022 Scleral crosslinking using genipin can compromise retinal structure and function in tree shrewsExperimental Eye Research.  219. 2022
    2022 Nonlinear distortion correction for posterior eye segment optical coherence tomography with application to tree shrewsBiomedical Optics Express.  13:1070-1086. 2022
    2021 Modeling the biomechanics of the lamina cribrosa microstructure in the human eyeActa Biomaterialia.  134:357-378. 2021
    2021 Effect of different preconditioning protocols on the viscoelastic inflation response of the posterior scleraActa Biomaterialia.  128:332-345. 2021
    2021 Histologic validation of optical coherence tomography-based three-dimensional morphometric measurements of the human optic nerve head: Methodology and preliminary resultsExperimental Eye Research.  205. 2021
    2021 A novel tree shrew model of pulmonary fibrosisLaboratory Investigation.  101:116-124. 2021
    2021 Analysis of the effects of finite element type within a 3D biomechanical model of a human optic nerve head and posterior poleComputer Methods and Programs in Biomedicine.  198. 2021
    2021 Effect of scleral crosslinking using multiple doses of genipin on experimental progressive myopia in tree shrews 2021
    2021 How chromatic cues can guide human eye growth to achieve good focusJournal of Vision.  21. 2021
    2020 Technical advance: The use of tree shrews as a model of pulmonary fibrosisPLoS One.  15. 2020
    2020 Connective tissue remodeling in myopia and its potential role in increasing risk of glaucoma 2020
    2020 A mesh-free approach to incorporate complex anisotropic and heterogeneous material properties into eye-specific finite element modelsComputer Methods in Applied Mechanics and Engineering.  358. 2020
    2020 Scleral structure and biomechanicsProgress in Retinal and Eye Research.  74. 2020
    2019 Matching the LenStar optical biometer to A-Scan ultrasonography for use in small animal eyes with application to tree shrewsExperimental Eye Research.  180:250-259. 2019
    2018 Experimental myopia increases and scleral crosslinking using genipin inhibits cyclic softening in the tree shrew scleraOphthalmic and Physiological Optics.  38:246-256. 2018
    2017 Multi-scale Modeling of Vision-Guided Remodeling and Age-Dependent Growth of the Tree Shrew Sclera During Eye Development and Lens-Induced MyopiaJournal of Elasticity.  129:171-195. 2017
    2016 A novel organ culture model to quantify collagen remodeling in tree shrew scleraPLoS One.  11. 2016
    2015 Changing material properties of the tree shrew sclera during minus lens compensation and recovery 2015
    2014 Human scleral structural stiffness increases more rapidly with age in donors of African descent compared to donors of European descent 2014
    2014 Age-and race-related differences in human scleral material properties 2014
    2014 Age-related changes in human peripapillary scleral strainBiomechanics and Modeling in Mechanobiology.  13:551-563. 2014
    2014 Material properties of the posterior human scleraJournal of The Mechanical Behavior of Biomedical Materials.  29:602-617. 2014
    2013 A forward incremental prestressing method with application to inverse parameter estimations and eye-specific simulations of posterior scleral shellsComputer Methods in Biomechanics and Biomedical Engineering.  16:768-780. 2013
    2012 Regional variations in mechanical strain in the posterior human sclera 2012
    2012 Lamina cribrosa thickening in early glaucoma predicted by a microstructure motivated growth and remodeling approachMechanics of Materials.  44:99-109. 2012
    2012 Perspectives on biomechanical growth and remodeling mechanisms in glaucomaMechanics Research Communications.  42:92-106. 2012
    2011 The collagen fibril architecture in the lamina cribrosa and peripapillary sclera predicted by a computational remodeling approachBiomechanics and Modeling in Mechanobiology.  10:371-382. 2011
    2010 A computational remodeling approach to predict the physiological architecture of the collagen fibril network in corneo-scleral shellsBiomechanics and Modeling in Mechanobiology.  9:225-235. 2010
    2009 Constitutive modeling of crimped collagen fibrils in soft tissuesJournal of The Mechanical Behavior of Biomedical Materials.  2:522-533. 2009
    2008 Consistent micro-macro transitions at large objective strains in curvilinear convective coordinatesInternational Journal for Numerical Methods in Engineering.  73:805-824. 2008
    2004 Incompressibility at large strains and finite-element implementationActa Mechanica.  168:75-101. 2004


    Year Title Altmetric
    2018 Scleral Remodeling in Myopia 2018
    2018 Scleral Remodeling in Myopia 2018
    2016 Glaucoma and structure-based mechanics of the lamina cribrosa at multiple scales.  93-122. 2016
    2015 Mechanical Strain and Restructuring of the Optic Nerve Head.  67-87. 2015

    Education And Training

  • Devers Eye Institute Ocular Biomechanics Laboratory, Postdoctoral Fellowship
  • Doctor of Philosophy in Civil Engineering, 2009
  • Full Name

  • Rafael Grytz
  • Fax

  • 205-934-3425