Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor 2021
2019 Functional characterization of apolipoproteins in the HCV life cycle.  Methods in Molecular Biology.  1911:235-246. 2019
2018 Tet-inducible production of infectious zika virus from the full-length cdna clones of African-and Asian-lineage strains.  Viruses.  10. 2018
2018 Characterization of apolipoprotein C1 in hepatitis C virus infection and morphogenesis.  Virology.  524:1-9. 2018
2018 Robust human and murine hepatocyte culture models of hepatitis B virus infection and replication.  Journal of Virology.  92. 2018
2017 Attachment and postattachment receptors important for hepatitis C virus infection and cell-to-cell transmission.  Journal of Virology.  91. 2017
2017 Identification of cellular genes and pathways important for tumorigenicity of hepatocellular carcinoma cell lines by proteomic profiling.  Oncotarget.  8:96171-96183. 2017
2017 TIM-1 promotes hepatitis C virus cell attachment and infection.  Journal of Virology.  91. 2017
2016 Roles of human apolipoprotein E in the infectivity and replication of hepatitis C virus genotype 2a. 2016
2015 Oncogenic viruses and cancer.  Virologica Sinica.  30:83-84. 2015
2015 A Dual-Reporter System for Real-Time Monitoring and High-throughput CRISPR/Cas9 Library Screening of the Hepatitis C Virus.  Scientific Reports.  5. 2015
2015 Characterization of hepatitis C virus interaction with heparan sulfate proteoglycans.  Journal of Virology.  89:3846-3858. 2015
2015 The serum very-low-density lipoprotein serves as a restriction factor against hepatitis C virus infection.  Journal of Virology.  89:6782-6791. 2015
2013 Apolipoprotein E Mediates Attachment of Clinical Hepatitis C Virus to Hepatocytes by Binding to Cell Surface Heparan Sulfate Proteoglycan Receptors.  PLoS ONE.  8. 2013
2013 Syndecan-1 serves as the major receptor for attachment of hepatitis C virus to the surfaces of hepatocytes.  Journal of Virology.  87:6866-6875. 2013
2013 Ribosomal protein S25 dependency reveals a common mechanism for diverse internal ribosome entry sites and ribosome shunting.  Molecular and Cellular Biology.  33:1016-1026. 2013
2012 Cell culture-adaptive mutations promote viral protein-protein interactions and morphogenesis of infectious hepatitis C virus..  Journal of Virology.  86:8987-8997. 2012
2012 Hepatitis C virus attachment mediated by apolipoprotein E binding to cell surface heparan sulfate..  Journal of Virology.  86:7256-7267. 2012
2012 Hepatitis C virus infects the endothelial cells of the blood-brain barrier.  Gastroenterology.  142:634-643.e6. 2012
2010 The C-terminal alpha-helix domain of apolipoprotein E is required for interaction with nonstructural protein 5A and assembly of hepatitis C virus..  Journal of Virology.  84:11532-11541. 2010
2009 Apolipoprotein E but not B is required for the formation of infectious hepatitis C virus particles..  Journal of Virology.  83:12680-12691. 2009
2009 Proteomics study of the hepatitis C virus replication complex..  Methods in Molecular Biology.  510:185-193. 2009
2007 Human apolipoprotein e is required for infectivity and production of hepatitis C virus in cell culture..  Journal of Virology.  81:13783-13793. 2007
2007 Human serum amyloid A protein inhibits hepatitis C virus entry into cells..  Journal of Virology.  81:6128-6133. 2007
2006 Replication of hepatitis C virus (HCV) RNA in mouse embryonic fibroblasts: protein kinase R (PKR)-dependent and PKR-independent mechanisms for controlling HCV RNA replication and mediating interferon activities..  Journal of Virology.  80:7364-7374. 2006
2006 The polypyrimidine tract-binding protein (PTB) is required for efficient replication of hepatitis C virus (HCV) RNA..  Virus Research.  115:1-8. 2006
2005 Robust production of infectious hepatitis C virus (HCV) from stably HCV cDNA-transfected human hepatoma cells..  Journal of Virology.  79:13963-13973. 2005
2005 Heterologous RNA replication enhancer stimulates in vitro RNA synthesis and template-switching by the carmovirus, but not by the tombusvirus, RNA-dependent RNA polymerase: implication for modular evolution of RNA viruses..  Virology.  341:107-121. 2005
2005 Mutagenesis analysis of the rGTP-specific binding site of hepatitis C virus RNA-dependent RNA polymerase..  Journal of Virology.  79:11607-11617. 2005
2005 Stimulation of hepatitis C virus (HCV) nonstructural protein 3 (NS3) helicase activity by the NS3 protease domain and by HCV RNA-dependent RNA polymerase..  Journal of Virology.  79:8687-8697. 2005
2004 Effects of mutations of the initiation nucleotides on hepatitis C virus RNA replication in the cell..  Journal of Virology.  78:3633-3643. 2004
2004 Orally active fusion inhibitor of respiratory syncytial virus..  Antimicrobial Agents and Chemotherapy.  48:413-422. 2004
2003 Heterocyclic aminopyrrolidine derivatives as melatoninergic agents..  Bioorganic and Medicinal Chemistry Letters.  13:4381-4384. 2003
2003 Replication of hepatitis C virus RNA occurs in a membrane-bound replication complex containing nonstructural viral proteins and RNA..  Journal of General Virology.  84:2761-2769. 2003
2003 Role of the 5'-proximal stem-loop structure of the 5' untranslated region in replication and translation of hepatitis C virus RNA..  Journal of Virology.  77:3312-3318. 2003
2002 Structure-activity relationships for a series of thiobenzamide influenza fusion inhibitors derived from 1,3,3-trimethyl-5-hydroxy-cyclohexylmethylamine..  Bioorganic and Medicinal Chemistry Letters.  12:3379-3382. 2002
2001 An approach to the identification of potent inhibitors of influenza virus fusion using parallel synthesis methodology..  Bioorganic and Medicinal Chemistry Letters.  11:2393-2396. 2001
2000 Salicylamide inhibitors of influenza virus fusion..  Bioorganic and Medicinal Chemistry Letters.  10:1649-1652. 2000
2000 De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virus..  Journal of Virology.  74:851-863. 2000
1999 Novel quinolizidine salicylamide influenza fusion inhibitors..  Bioorganic and Medicinal Chemistry Letters.  9:2177-2180. 1999
1999 Conquering influenza: recent advances in anti-influenza drug discovery. 1999
1999 Cellular proteins bind to the poly(U) tract of the 3' untranslated region of hepatitis C virus RNA genome..  Virology.  256:105-118. 1999
1999 pH-dependent changes in photoaffinity labeling patterns of the H1 influenza virus hemagglutinin by using an inhibitor of viral fusion..  Journal of Virology.  73:1785-1794. 1999
1997 Inhibition of influenza viral polymerases by minimal viral RNA decoys..  Journal of General Virology.  78 ( Pt 9):2329-2333. 1997
1997 Molecular mechanism underlying the action of a novel fusion inhibitor of influenza A virus..  Journal of Virology.  71:4062-4070. 1997
1996 Characterization of a hemagglutinin-specific inhibitor of influenza A virus..  Virology.  226:66-76. 1996

Education And Training

  • Master of Public Health, Capital Medical University 1986
  • Doctorate in Medicine, Central South University 1983

    • Full Name

  • Guangxiang Luo