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Guangxiang Luo M.D.
Professor of Microbiology
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E-mail
gluo@uab.edu
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Guangxiang Luo M.D.
Professor of Microbiology
Positions
Senior Scientist (C)
,
O'Neal Comprehensive Cancer Center
,
School of Medicine
Senior Scientist (C)
,
Center for AIDS Research
,
School of Medicine
Senior Scientist
,
Inflammation, Immunology and Immunotherapeutics
,
O'Neal Comprehensive Cancer Center
Professor (P)
,
Microbiology
,
Academic Joint Departments
Publications
Research
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
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2021
Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor
2021
2019
Functional characterization of apolipoproteins in the HCV life cycle
.
Methods in Molecular Biology
. 1911:235-246.
2019
2018
Tet-inducible production of infectious zika virus from the full-length cdna clones of African-and Asian-lineage strains
.
Viruses
. 10.
2018
2018
Characterization of apolipoprotein C1 in hepatitis C virus infection and morphogenesis
.
Virology
. 524:1-9.
2018
2018
Robust human and murine hepatocyte culture models of hepatitis B virus infection and replication
.
Journal of Virology
. 92.
2018
2017
Attachment and postattachment receptors important for hepatitis C virus infection and cell-to-cell transmission
.
Journal of Virology
. 91.
2017
2017
Identification of cellular genes and pathways important for tumorigenicity of hepatocellular carcinoma cell lines by proteomic profiling
.
Oncotarget
. 8:96171-96183.
2017
2017
TIM-1 promotes hepatitis C virus cell attachment and infection
.
Journal of Virology
. 91.
2017
2016
Roles of human apolipoprotein E in the infectivity and replication of hepatitis C virus genotype 2a.
2016
2015
Oncogenic viruses and cancer
.
Virologica Sinica
. 30:83-84.
2015
2015
A Dual-Reporter System for Real-Time Monitoring and High-throughput CRISPR/Cas9 Library Screening of the Hepatitis C Virus
.
Scientific Reports
. 5.
2015
2015
Characterization of hepatitis C virus interaction with heparan sulfate proteoglycans
.
Journal of Virology
. 89:3846-3858.
2015
2015
The serum very-low-density lipoprotein serves as a restriction factor against hepatitis C virus infection
.
Journal of Virology
. 89:6782-6791.
2015
2013
Apolipoprotein E Mediates Attachment of Clinical Hepatitis C Virus to Hepatocytes by Binding to Cell Surface Heparan Sulfate Proteoglycan Receptors
.
PLoS ONE
. 8.
2013
2013
Syndecan-1 serves as the major receptor for attachment of hepatitis C virus to the surfaces of hepatocytes
.
Journal of Virology
. 87:6866-6875.
2013
2013
Ribosomal protein S25 dependency reveals a common mechanism for diverse internal ribosome entry sites and ribosome shunting
.
Molecular and Cellular Biology
. 33:1016-1026.
2013
2012
Cell culture-adaptive mutations promote viral protein-protein interactions and morphogenesis of infectious hepatitis C virus.
.
Journal of Virology
. 86:8987-8997.
2012
2012
Hepatitis C virus attachment mediated by apolipoprotein E binding to cell surface heparan sulfate.
.
Journal of Virology
. 86:7256-7267.
2012
2012
Hepatitis C virus infects the endothelial cells of the blood-brain barrier
.
Gastroenterology
. 142:634-643.e6.
2012
2010
The C-terminal alpha-helix domain of apolipoprotein E is required for interaction with nonstructural protein 5A and assembly of hepatitis C virus.
.
Journal of Virology
. 84:11532-11541.
2010
2009
Apolipoprotein E but not B is required for the formation of infectious hepatitis C virus particles.
.
Journal of Virology
. 83:12680-12691.
2009
2009
Proteomics study of the hepatitis C virus replication complex.
.
Methods in Molecular Biology
. 510:185-193.
2009
2007
Human apolipoprotein e is required for infectivity and production of hepatitis C virus in cell culture.
.
Journal of Virology
. 81:13783-13793.
2007
2007
Human serum amyloid A protein inhibits hepatitis C virus entry into cells.
.
Journal of Virology
. 81:6128-6133.
2007
2006
Replication of hepatitis C virus (HCV) RNA in mouse embryonic fibroblasts: protein kinase R (PKR)-dependent and PKR-independent mechanisms for controlling HCV RNA replication and mediating interferon activities.
.
Journal of Virology
. 80:7364-7374.
2006
2006
The polypyrimidine tract-binding protein (PTB) is required for efficient replication of hepatitis C virus (HCV) RNA.
.
Virus Research
. 115:1-8.
2006
2005
Robust production of infectious hepatitis C virus (HCV) from stably HCV cDNA-transfected human hepatoma cells.
.
Journal of Virology
. 79:13963-13973.
2005
2005
Heterologous RNA replication enhancer stimulates in vitro RNA synthesis and template-switching by the carmovirus, but not by the tombusvirus, RNA-dependent RNA polymerase: implication for modular evolution of RNA viruses.
.
Virology
. 341:107-121.
2005
2005
Mutagenesis analysis of the rGTP-specific binding site of hepatitis C virus RNA-dependent RNA polymerase.
.
Journal of Virology
. 79:11607-11617.
2005
2005
Stimulation of hepatitis C virus (HCV) nonstructural protein 3 (NS3) helicase activity by the NS3 protease domain and by HCV RNA-dependent RNA polymerase.
.
Journal of Virology
. 79:8687-8697.
2005
2004
Effects of mutations of the initiation nucleotides on hepatitis C virus RNA replication in the cell.
.
Journal of Virology
. 78:3633-3643.
2004
2004
Orally active fusion inhibitor of respiratory syncytial virus.
.
Antimicrobial Agents and Chemotherapy
. 48:413-422.
2004
2003
Heterocyclic aminopyrrolidine derivatives as melatoninergic agents.
.
Bioorganic and Medicinal Chemistry Letters
. 13:4381-4384.
2003
2003
Replication of hepatitis C virus RNA occurs in a membrane-bound replication complex containing nonstructural viral proteins and RNA.
.
Journal of General Virology
. 84:2761-2769.
2003
2003
Role of the 5'-proximal stem-loop structure of the 5' untranslated region in replication and translation of hepatitis C virus RNA.
.
Journal of Virology
. 77:3312-3318.
2003
2002
Structure-activity relationships for a series of thiobenzamide influenza fusion inhibitors derived from 1,3,3-trimethyl-5-hydroxy-cyclohexylmethylamine.
.
Bioorganic and Medicinal Chemistry Letters
. 12:3379-3382.
2002
2001
An approach to the identification of potent inhibitors of influenza virus fusion using parallel synthesis methodology.
.
Bioorganic and Medicinal Chemistry Letters
. 11:2393-2396.
2001
2000
Salicylamide inhibitors of influenza virus fusion.
.
Bioorganic and Medicinal Chemistry Letters
. 10:1649-1652.
2000
2000
De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virus.
.
Journal of Virology
. 74:851-863.
2000
1999
Novel quinolizidine salicylamide influenza fusion inhibitors.
.
Bioorganic and Medicinal Chemistry Letters
. 9:2177-2180.
1999
1999
Conquering influenza: recent advances in anti-influenza drug discovery.
1999
1999
Cellular proteins bind to the poly(U) tract of the 3' untranslated region of hepatitis C virus RNA genome.
.
Virology
. 256:105-118.
1999
1999
pH-dependent changes in photoaffinity labeling patterns of the H1 influenza virus hemagglutinin by using an inhibitor of viral fusion.
.
Journal of Virology
. 73:1785-1794.
1999
1997
Inhibition of influenza viral polymerases by minimal viral RNA decoys.
.
Journal of General Virology
. 78 ( Pt 9):2329-2333.
1997
1997
Molecular mechanism underlying the action of a novel fusion inhibitor of influenza A virus.
.
Journal of Virology
. 71:4062-4070.
1997
1996
Characterization of a hemagglutinin-specific inhibitor of influenza A virus.
.
Virology
. 226:66-76.
1996
Research
Principal Investigator On
Cell Surface Receptors Promoting Hepatitis B Virus Infection
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
Role of Human Apolipoprotein E in Hepatitis B Virus Infection and Morphogenesis
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
Underlying Mechanism of ApoE in HCV Infection and Assembly
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
Viral and Cellular Determinants of HCV Assembly
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
Investigator On
UAB Center for AIDS Research
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
UAB Center for AIDS Research - Administrative Core
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
Background
Education And Training
Master of Public Health,
Capital Medical University
1986
Doctorate in Medicine,
Central South University
1983
Contact
Full Name
Guangxiang
Luo