Molecular and Genetic Epidemiology of Immune-Mediated Clinical Phenotypes - The research conducted in Dr. Brown’s laboratory is mainly targeted to advance the understanding of aberrant immune function common to inflammatory-mediated chronic diseases, such as select autoimmune diseases as well as multiple myeloma and related precursor states, each with underlying B cell pathology. Within this purview, she uses a multidisciplinary functional genomics approach to explore pathways involved in chronic immune perturbation, inflammation as modifiers of disease, and B cell homeostasis. The objective of this research is to identify and validate molecular biomarkers, which may be used to target high-risk populations to improve disease surveillance and modify therapeutic intervention leading to significant reductions in morbidity and mortality associated with advanced stage disease.
Keywords - multiple myeloma, autoimmune, lupus, genetics, genomics, epidemiology
