Positions

Overview

  • Dr Dana Rizk is Professor of Medicine in the Division of Nephrology at the University of Alabama at Birmingham (UAB).
    Her clinical and research interests revolve around glomerular diseases and, in particular IgA Nephropathy. She has served as the site principal investigator on many clinical trials and is part of several multi-disciplinary translational research projects focused on the role of biomarkers in IgAN. Her research efforts resulted in more than 45 peer-reviewed publications in prestigious medical journals including the New England Journal of Medicine.
    Dr Rizk has been the Director of Clinical Trials Research in the Division of Nephrology since 2015 and also serves as the Medical Director for the Clinical Trials Administrative Office at UAB since October 2019.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2023 Pregnancy History and Kidney Disease Progression Among Women Enrolled in Cure Glomerulonephropathy.  Kidney International Reports.  2023
    2023 Targeting the Alternative Complement Pathway With Iptacopan to Treat IgA Nephropathy: Design and Rationale of the APPLAUSE-IgAN Study.  Kidney International Reports.  2023
    2022 Lactated Ringer's solution and risk of hyperkalemia in patients with reduced kidney function: Safety of Lactated Ringer's in kidney disease.  American Journal of the Medical Sciences.  364:433-443. 2022
    2022 Phosphatase control of cytokine-mediated overproduction of galactose-deficient IgA1, the main autoantigen in IgA nephropathy.  Journal of Autoimmunity.  132. 2022
    2022 Cytokines and Production of Aberrantly O-Glycosylated IgA1, the Main Autoantigen in IgA Nephropathy.  Journal of Interferon and Cytokine Research.  42:301-315. 2022
    2022 The Forgotten Cost of Nephrotic Syndrome to Patients and Caregivers in the United States. 2022
    2022 New Treatment Strategies for IgA Nephropathy: Targeting Plasma Cells as the Main Source of Pathogenic Antibodies.  Journal of Clinical Medicine.  11. 2022
    2022 IgA vasculitis with nephritis: update of pathogenesis with clinical implications.  Pediatric Nephrology.  37:719-733. 2022
    2022 Prognostic value of silent myocardial infarction in patients with chronic kidney disease after kidney transplantation.  American Journal of Transplantation.  22:1115-1122. 2022
    2021 An update on the current state of management and clinical trials for iga nephropathy.  Journal of Clinical Medicine.  10. 2021
    2021 IgA Nephropathy: An Interesting Autoimmune Kidney Disease: IgA Nephropathy.  American Journal of the Medical Sciences.  361:176-194. 2021
    2021 The mystery of cherry red ultrafiltrate in continuous renal replacement therapy.  Kidney International.  99:270. 2021
    2020 Persistent Disease Activity in Patients With Long-Standing Glomerular Disease.  Kidney International Reports.  5:860-871. 2020
    2019 Second-Chance Placement of Hemodialysis Patients After Involuntary Discharge for Disruptive Behavior.  American Journal of Kidney Diseases.  74:544-548. 2019
    2019 Description of 5 Novel SLC34A3/NPT2c Mutations Causing Hereditary Hypophosphatemic Rickets With Hypercalciuria.  Kidney International Reports.  4:1179-1186. 2019
    2019 Effects of Bardoxolone Methyl on Magnesium in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease.  CardioRenal Medicine.  9:316-325. 2019
    2019 Rituximab or cyclosporine in the treatment of membranous nephropathy.  New England Journal of Medicine.  381:36-46. 2019
    2019 Health-related quality of life in glomerular disease.  Kidney International.  95:1209-1224. 2019
    2019 A novel fluorescent clinical method to rapidly quantify plasma volume.  CardioRenal Medicine.  9:168-179. 2019
    2019 CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular Disease.  American Journal of Kidney Diseases.  73:218-229. 2019
    2019 Confidence in women’s health: A cross border survey of adult nephrologists.  Journal of Clinical Medicine.  8. 2019
    2019 Glomerular immunodeposits of patients with IgA nephropathy are enriched for IgG autoantibodies specific for galactose-deficient IgA1.  Journal of the American Society of Nephrology.  30:2017-2026. 2019
    2019 Renal Complications in Pregnancy Preceding Glomerulonephropathy Diagnosis.  Kidney International Reports.  4:159-162. 2019
    2019 The emerging role of complement proteins as a target for therapy of IgA nephropathy.  Frontiers in Immunology.  10. 2019
    2018 Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN Study.  Kidney International Reports.  3:1373-1384. 2018
    2018 Prognostic value of myocardial perfusion imaging performed pre-renal transplantation: post-transplantation follow-up and outcomes.  European Journal of Nuclear Medicine and Molecular Imaging.  45:1998-2008. 2018
    2018 Secondary IgA nephropathy.  Kidney International.  94:674-681. 2018
    2018 Assay for galactose-deficient IgA1 enables mechanistic studies with primary cells from IgA nephropathy patients 2018
    2018 A novel method for rapid bedside measurement of GFR.  Journal of the American Society of Nephrology.  29:1609-1613. 2018
    2018 Serum galactose-deficient-IgA1 and IgG autoantibodies correlate in patients with IgA nephropathy.  PLoS One.  13. 2018
    2017 Prognostic value of silent myocardial infarction in patients with chronic kidney disease being evaluated for kidney transplantation.  International Journal of Cardiology.  249:377-382. 2017
    2016 The origin and activities of IgA1-containing immune complexes in IGA nephropathy.  Frontiers in Immunology.  7. 2016
    2015 Migrated intra-jejunal peritoneal dialysis catheter.  Kidney International.  88:1457. 2015
    2015 Oral anticoagulants and risk of nephropathy.  Drug Safety.  38:527-533. 2015
    2015 New Insights into the Pathogenesis of IgA Nephropathy..  Kidney Diseases.  1:8-18. 2015
    2015 Screening for Coronary Artery Disease in Kidney Transplant Candidates.  Journal of Nuclear Cardiology.  22:297-300. 2015
    2015 A Multicenter Randomized Controlled Trial of Rituximab versus Cyclosporine in the Treatment of Idiopathic Membranous Nephropathy (MENTOR) 2015
    2015 Cinacalcet, fibroblast growth factor-23, and cardiovascular disease in hemodialysis: The evaluation of cinacalcet HCl therapy to lower cardiovascular events (EVOLVE) trial.  Circulation.  132:27-39. 2015
    2015 The effects of cinacalcet in older and younger patients on hemodialysis: The evaluation of cinacalcet HCL therapy to lower cardiovascular events (EVOLVE) trial.  Clinical Journal of the American Society of Nephrology.  10:791-799. 2015
    2014 Dietary patterns and risk of death and progression to ESRD in individuals with CKD: A cohort study.  American Journal of Kidney Diseases.  64:204-213. 2014
    2014 The interdisciplinary team: The whole is larger than the parts.  Advances in Chronic Kidney Disease.  21:333-337. 2014
    2013 Renovascular hypertension associated with pseudoaneurysm following blunt trauma.  American Journal of Kidney Diseases.  62:839-843. 2013
    2013 Bullous Lesions After Use of a Commercial Therapeutic Hypothermia Temperature Management System: A Possible Burn Injury?.  Therapeutic Hypothermia and Temperature Management.  3:147-150. 2013
    2013 Association between urinary albumin excretion and coronary heart disease in black vs white adults.  Journal of the American Medical Association.  310:706-713. 2013
    2013 Cardiovascular risk factors in CKD associate with both ESRD and mortality.  Journal of the American Society of Nephrology.  24:1159-1165. 2013
    2013 Cardioprotective medication use and risk factor control among US adults with unrecognized myocardial infarction: The REasons for geographic and racial differences in stroke (REGARDS) study.  Vascular Health and Risk Management.  9:47-55. 2013
    2013 Association of duration of residence in the southeastern United States with chronic kidney disease may differ by race: The REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort study.  International Journal of Health Geographics.  12. 2013
    2013 Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease.  New England Journal of Medicine.  369:2492-2503. 2013
    2012 Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis.  New England Journal of Medicine.  367:2482-2494. 2012
    2012 Racial differences in albuminuria, kidney function, and risk of stroke.  Neurology.  79:1686-1692. 2012
    2012 Prevalence and prognosis of unrecognized myocardial infarctions in chronic kidney disease.  Nephrology Dialysis Transplantation.  27:3482-3488. 2012
    2012 Kidney disease education one year after the medicare improvement of patients and providers act: A survey of US nephrology practices.  American Journal of Kidney Diseases.  59:892-894. 2012
    2011 Age-specific association of reduced estimated glomerular filtration rate and albuminuria with all-cause mortality.  Clinical Journal of the American Society of Nephrology.  6:2200-2207. 2011
    2011 Warfarin-related nephropathy: Another newly recognized complication of an old drug.  Kidney International.  80:131-133. 2011
    2009 Quality of life in autosomal dominant polycystic kidney disease patients not yet on dialysis.  Clinical Journal of the American Society of Nephrology.  4:560-566. 2009
    2008 Gadolinium nephrotoxicity: case report of a rare entity and review of the literature..  Clinical Nephrology.  70:518-522. 2008
    2008 Treatment of autosomal dominant polycystic kidney disease (ADPKD): The new horizon for children with ADPKD.  Pediatric Nephrology.  23:1029-1036. 2008
    2008 Gadolinium nephrotoxicity: Case report of a rare entity and review of the literature.  Clinical Nephrology.  70:518-522. 2008
    2004 Medullary cystic kidney disease type 2 [1] (multiple letters).  American Journal of Kidney Diseases.  43:1142-1143. 2004
    2003 Cystic and Inherited Kidney Diseases.  American Journal of Kidney Diseases.  42:1305-1317. 2003

    Chapter

    Year Title Altmetric
    2022 Cystic Diseases of the Kidney.  39-94. 2022
    2017 Inherited Cystic Kidney Diseases 2017
    2013 Polycystic and other cystic kidney diseases.  362-370. 2013

    Research Overview

  • IgA nephropathy
    Glomerular diseases

    • Principal Investigator On

  • A Randomized Controlled Trial of Rituximub versus Cyclosporine in the Treatment of Idiopathic Membranous Nephropathy (IMN)  awarded by MAYO CLINIC
  • Cure GN 2.0 - UNC-PCC  awarded by University of North Carolina
  • CureGN-2: UNCPCC (Cost Reimbursement)  awarded by University of North Carolina at Chapel Hill
  • Efficacy of Belimumab and Rituximab Compared to Rituximab Alone for the Treatment of Primary Membranous Nephropathy  awarded by BENAROYA RESEARCH INSTITUTE (BRI)
  • Private Grant  awarded by REATA PHARMACEUTICALS
  • Private Grant  awarded by AMGEN, INC.^
  • Private Grant  awarded by REATA PHARMACEUTICALS
  • Private Grant  awarded by REATA PHARMACEUTICALS
  • Private Grant  awarded by BRISTOL MYERS SQUIBB PHARMACEUTICAL COMPANY
  • Private Grant  awarded by FAST BIOMEDICAL
  • Private Grant  awarded by NEPHROGENEX, INC.
  • Private Grant  awarded by ABBVIE INC
  • Private Grant  awarded by REATA PHARMACEUTICALS
  • Private Grant  awarded by FAST BIOMEDICAL
  • Private Grant  awarded by REATA PHARMACEUTICALS
  • Private Grant  awarded by ACHILLION PHARMACEUTICALS INC
  • Private Grant  awarded by CALLIDITAS THERAPEUTICS AB
  • Private Grant  awarded by RETROPHIN, INC.
  • Private Grant  awarded by Pfizer Inc., U.S. Pharmaceuticals Group
  • Private Grant  awarded by REATA PHARMACEUTICALS
  • Private Grant  awarded by REATA PHARMACEUTICALS
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC.
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC.
  • Private Grant  awarded by VISTERRA, INC
  • Private Grant  awarded by MORPHOSYS AG
  • Private Grant  awarded by ALEXION PHARMACEUTICALS, INC.
  • Private Grant  awarded by VALENZA BIO INC
  • Private Grant  awarded by CHINOOK THERAPEUTICS, INC
  • Private Grant  awarded by VERA THERAPEUTICS INC.
  • Private Grant  awarded by OTSUKA PHARMACEUTICAL DEVELOPMENT & COMMERCIALIZATION, INC
  • Private Grant  awarded by OTSUKA PHARMACEUTICAL DEVELOPMENT & COMMERCIALIZATION, INC
  • The Impact of Diabetes on Patients with Glomerular Disease: CureGN-Diabetes (CR)  awarded by University of North Carolina at Chapel Hill

    • Investigator On

  • Abnormal STAT3 Signaling and Aberrant O-Glycosylation of IgA1 in IgA Nephropathy  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • COMPLETED - UAB-UCSD O'Brien Center for Acute Kidney Injury Research - Core A  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Cellular Bioenergetics as a Predictor of Diabetic Nephropathy  awarded by GEORGIA REGENTS UNIVERSITY (AUGUSTA)
  • Center for Clinical and Translational Science (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS
  • Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) IV: Prognosis for End-Stage Renal Disease and Biomarker Validation  awarded by UNIVERSITY OF KANSAS (MEDICAL CENTER)
  • Cure GN 2.0 - UNC-PCC  awarded by University of North Carolina at Chapel Hill
  • Distinct Glycophenotypes and Abnormal Signaling Define a Subpopulation of B cells Responsible for Production of Autoantigen in IgA Nephropathy  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Elucidating lgA Nephropathy through Genetic Studies of lgA 1 Glycosylation  awarded by Columbia University
  • GDCN Clinical Center - Advancing Clinical Research in Primary Glomerular Diseases  awarded by University of North Carolina at Chapel Hill
  • Improving Scientific Rigor of Renal Clinical Endpoints for Sickle Cell Anemia  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Interdisciplinary Training In Kidney-Related Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Interdisciplinary Training in Kidney-Related Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Kidney Undergraduate Research Experience (KURE)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Molecular Basis of Pathogenicity of IgA1-Containing Immune Complexes  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • PRedOctoral Phd and MD Research Training In TEams (PROmoTE)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • PRedoctoral Interdisciplinary Training in Renal Physiology and MEdIcIne (PRIME)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Pathogenic Autoantibodies with Specificity for Aberrant Glycoproteins: Assessment of a Therapeutic Target in an Autoimmune Disease  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Private Grant  awarded by AMICUS THERAPEUTICS, INC
  • Private Grant  awarded by QUESTCOR PHARMACEUTICALS, INC.
  • Private Grant  awarded by Genzyme Corporation
  • Private Grant  awarded by Bayer HealthCare
  • Private Grant  awarded by OTSUKA PHARMACEUTICAL DEVELOPMENT & COMMERCIALIZATION, INC
  • Private Grant  awarded by IDORSIA PHARMACEUTICALS LTD
  • Private Grant  awarded by IDORSIA PHARMACEUTICALS LTD
  • UAB-UCSD O'Brien Center For Acute Kidney Injury Research - Core A  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB-UCSD O'Brien Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS

    • Education And Training

  • American University of Beirut Medical Center, Internship
  • St. Louis University Hospitals, Internship
  • Emory University Hospital Systems, Residency
  • St. Louis University Hospitals, Residency
  • Emory University Hospital Systems, Postdoctoral Fellowship
  • Doctor of Medicine, American University of Beirut 1997

    • Full Name

  • Dana Rizk