Doug’s collaborative research interests support accumulating evidence that many chronic diseases involve mitochondrial dysfunction, retrograde redox mitochondrial signaling and free radical-mediated tissue injury. His research focus includes energy metabolism, mitochondrial physiology, redox biology, exercise and nutrition, psychosocial life stress and their contributions to health & wellness, health disparities, cardiometabolic disease, diabetes, obesity, cancer, and aging. Model systems include in vitro cell culture, yeast, Drosophila melanogaster, rodents, fish, and human translational research. One of the current projects involves investigating the adverse effects of life stress, including discrimination, and dietary choices that may contribute to increased levels of oxidative stress, cardiometabolic disease risk and obesity.