Positions

Selected Publications

Academic Article

Year Title Altmetric
2022 Kidney implications of SARS-CoV2 infection in childrenPediatric Nephrology.  37:1453-1467. 2022
2021 Effect of Serum Urate Lowering With Allopurinol on Blood Pressure in Young Adults: A Randomized, Controlled, Crossover TrialArthritis and Rheumatology.  73:1514-1522. 2021
2021 Hyperuricemia and abnormal nocturnal dipping impact glomerular filtration rate in patients with sickle cell anemiaAmerican Journal of Hematology.  96:E143-E146. 2021
2021 Trends in Blood Pressure and Hypertension among US Children and Adolescents, 1999-2018JAMA Network Open.  4. 2021
2020 The editorialist repliesNew England Journal of Medicine.  383:1692. 2020
2020 Longitudinal Changes in Health-Related Quality of Life in Primary Glomerular Disease: Results From the CureGN StudyKidney International Reports.  5:1679-1689. 2020
2020 Reply to ‘The case for evidence-based medicine for the association between hyperuricaemia and CKD’Nature Reviews Nephrology.  16:422-423. 2020
2020 Uric acid and hypertension: An update with recommendationsAmerican Journal of Hypertension.  33:583-594. 2020
2020 Urate-lowering therapy and chronic kidney disease progressionNew England Journal of Medicine.  382:2567-2568. 2020
2020 Persistent Disease Activity in Patients With Long-Standing Glomerular DiseaseKidney International Reports.  5:860-871. 2020
2020 Hyperuricemia is associated with a lower glomerular filtration rate in pediatric sickle cell disease patientsPediatric Nephrology.  35:883-889. 2020
2019 The case for uric acid-lowering treatment in patients with hyperuricaemia and CKDNature Reviews Nephrology.  15:767-775. 2019
2019 Cytomegalovirus and Epstein-Barr virus infections among pediatric kidney transplant recipients at a center using universal Valganciclovir ProphylaxisPediatric Transplantation.  23. 2019
2019 Health-related quality of life in glomerular diseaseKidney International.  95:1209-1224. 2019
2019 Hyperfiltration during early childhood precedes albuminuria in pediatric sickle cell nephropathyAmerican Journal of Hematology.  94:417-423. 2019
2019 Phase I study of single-dose pharmacokinetics and pharmacodynamics of belatacept in adolescent kidney transplant recipientsAmerican Journal of Transplantation.  19:1218-1223. 2019
2019 CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular DiseaseAmerican Journal of Kidney Diseases.  73:218-229. 2019
2019 CYP3A5 genotype affects time to therapeutic tacrolimus level in pediatric kidney transplant recipientsPediatric Transplantation.  23. 2019
2018 Rituximab treatment for chronic steroid-dependent Henoch-Schonlein purpura: 8 cases and a review of the literaturePediatric Rheumatology Online Journal.  16. 2018
2018 Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN StudyKidney International Reports.  3:1373-1384. 2018
2018 Subclinical inflammation phenotypes and long-term outcomes after pediatric kidney transplantationAmerican Journal of Transplantation.  18:2189-2199. 2018
2017 Effect of Febuxostat on ambulatory blood pressure in subjects with hyperuricemia and hypertension: A Phase 2 randomized placebo-controlled studyJournal of the American Heart Association.  6. 2017
2017 Evaluating risk factors for chronic kidney disease in pediatric patients with sickle cell anemiaPediatric Nephrology.  32:1565-1573. 2017
2017 Added sugars and cardiovascular disease risk in children: A scientific statement from the American Heart AssociationCirculation.  135:e1017-e1034. 2017
2017 Severe anemia early in life as a risk factor for sickle-cell kidney diseaseBlood.  129:385-387. 2017
2017 Uric Acid Excretion Predicts Increased Blood Pressure Among American Adolescents of African DescentAmerican Journal of the Medical Sciences.  353:336-341. 2017
2016 The effects of urate lowering therapy on inflammation, endothelial function, and blood pressure (SURPHER) study design and rationaleContemporary Clinical Trials.  50:238-244. 2016
2016 Prevalence of acute kidney injury during pediatric admissions for acute chest syndromePediatric Nephrology.  31:1363-1368. 2016
2016 Smaller circuits for smaller patients: improving renal support therapy with Aquadex™Pediatric Nephrology.  31:853-860. 2016
2016 Obstructive sleep apnea and periodic limb movement disorder in a population of children with hypertension and/or nocturnal nondipping blood pressuresJournal of the American Society of Hypertension.  10:101-107. 2016
2015 Serum uric acid and risk of CKD in type 2 diabetesClinical Journal of the American Society of Nephrology.  10:1921-1929. 2015
2015 Pharmacokinetics, pharmacodynamics, and safety of lisinopril in pediatric kidney transplant patients: Implications for starting dose selectionClinical Pharmacology and Therapeutics.  98:25-33. 2015
2014 Serum uric acid and the risk of hypertension and chronic kidney diseaseCurrent Opinion in Rheumatology.  26:176-185. 2014
2013 Serum urate: A biomarker or treatment target in pediatric hypertension?Current Opinion in Cardiology.  28:433-438. 2013
2013 The utility of cortical-sparing adrenalectomy in pheochromocytomas associated with genetic syndromesJournal of Pediatric Surgery.  48:1422-1425. 2013
2013 Uric acid and the origins of hypertensionJournal of Pediatrics.  162:896-902. 2013
2013 What are the key arguments against uric acid as a true risk factor for hypertension?Hypertension.  61:948-951. 2013
2012 Hyperuricemia and Hypertension 2012
2012 Uric acid reduction rectifies prehypertension in obese adolescentsHypertension.  60:1148-1156. 2012
2012 The Role of Uric Acid in the Pathogenesis of Hypertension in the YoungJournal of Clinical Hypertension.  14:346-352. 2012
2012 Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduriaAmerican Journal of Human Genetics.  90:836-846. 2012
2012 Association between left ventricular mass index and cardiac function in pediatric dialysis patientsPediatric Nephrology.  27:835-841. 2012
2011 Uric acid: A clinically useful marker to distinguish preeclampsia from gestational hypertensionHypertension.  58:548-549. 2011
2011 Uric Acid and HypertensionSeminars in Nephrology.  31:441-446. 2011
2011 Serum uric acid is associated with high blood pressure in pediatric hemodialysis patientsPediatric Nephrology.  26:1123-1128. 2011
2011 Safety and efficacy of intravenous labetalol for hypertensive crisis in infants and small childrenPediatric Critical Care Medicine.  12:28-32. 2011
2010 Sugar-sweetened beverages and hypertensionFuture Cardiology.  6:773-776. 2010
2010 Uric acid and hypertension: Cause or effect?Current Rheumatology Reports.  12:108-117. 2010
2010 Pediatrics: Uncontrolled hypertension in children on hemodialysisNature Reviews Nephrology.  6:7-8. 2010
2009 Uric acid: A novel mediator and marker of risk in chronic kidney disease?Current Opinion in Nephrology and Hypertension.  18:526-530. 2009
2009 A sensitive and specific liquid chromatography-tandem mass spectrometry method for the determination of intracellular and extracellular uric acidJournal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences.  877:2032-2038. 2009
2009 Sour Notes on Sweet DrinksJournal of Pediatrics.  154:783-784. 2009
2009 Prenatal programming: Maybe not so hopeless after all?American Journal of Hypertension.  22:348. 2009
2009 Minimal change disease with IgM+ immunofluorescence: A subtype of nephrotic syndromePediatric Nephrology.  24:1187-1192. 2009
2009 Hypothesis: Could excessive fructose intake and uric acid cause type 2 diabetes?Endocrine Reviews.  30:96-116. 2009
2009 Letter to the editorsNew England Journal of Medicine.  360:540-541. 2009
2009 Allopurinol and the role of uric acid in hypertension: ReplyJAMA: Journal of the American Medical Association.  301:270-271. 2009
2008 Cost-effectiveness of ambulatory blood pressure monitoring in the initial evaluation of hypertension in childrenPediatrics.  122:1177-1181. 2008
2008 Medical progress: Uric acid and cardiovascular riskNew England Journal of Medicine.  359:1811-1821. 2008
2008 Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: A randomized trialJAMA: Journal of the American Medical Association.  300:924-932. 2008
2008 Frequent hemodialysis with NxStage™ system in pediatric patients receiving maintenance hemodialysisPediatric Nephrology.  23:129-135. 2008
2008 Pathogenesis of essential hypertension: Historical paradigms and modern insightsJournal of Hypertension.  26:381-391. 2008
2007 Recent advances in the diagnosis and treatment of pheochromocytoma in childrenThe American Journal of Surgery.  194:792-797. 2007
2007 Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease1-3American Journal of Clinical Nutrition.  86:899-906. 2007
2007 Coincident activation of Th2 T cells with onset of the disease and differential expression of GRO-gamma in peripheral blood leukocytes in minimal change diseaseAmerican Journal of Nephrology.  27:253-261. 2007
2007 Inaccuracy in pediatric outpatient blood pressure measurementPediatrics (Spanish Edition).  119. 2007
2007 The Role of Uric Acid in Pediatric HypertensionJournal of Renal Nutrition.  17:79-83. 2007
2006 Nephron number, uric acid, and renal microvascular disease in the pathogenesis of essential hypertensionHypertension.  48:25-26. 2006
2006 Unearthing uric acid: An ancient factor with recently found significance in renal and cardiovascular diseaseKidney International.  69:1722-1725. 2006
2006 Uric acid and hypertensionCurrent Hypertension Reports.  8:111-115. 2006
2006 Childhood hypertension is not a silent diseasePediatric Nephrology.  21:527-532. 2006
2006 Serum uric acid: A risk factor and a target for treatment?Journal of the American Society of Nephrology.  17. 2006
2006 3-5 year longitudinal follow-up of pediatric patients after acute renal failureKidney International.  69:184-189. 2006
2006 A causal role for uric acid in fructose-induced metabolic syndromeAmerican Journal of Physiology: Renal Physiology.  290. 2006
2006 Hormonal and cytokine effects of uric acidCurrent Opinion in Nephrology and Hypertension.  15:30-33. 2006
2005 Subtle renal injury is likely a common mechanism for salt-sensitive essential hypertensionHypertension.  45:326-330. 2005
2005 A unifying pathway for essential hypertensionAmerican Journal of Hypertension.  18:431-440. 2005
2005 Resurrection of uric acid as a causal risk factor in essential hypertensionHypertension.  45:18-20. 2005
2005 Uric acid and hypertension in adolescentsSeminars in Nephrology.  25:32-38. 2005
2004 Does asymptomatic hyperuricaemia contribute to the development of renal and cardiovascular disease? An old controversy renewedNephrology.  9:394-399. 2004
2004 Calcium oxalate deposition in renal allografts: Morphologic spectrum and clinical implicationsAmerican Journal of Transplantation.  4:1338-1344. 2004
2004 Diuretic-induced hyperuricemia does not decrease cardiovascular risk.Journal of Hypertension.  22:1415-1417. 2004
2004 Management of a Severe Carbamazepine Overdose Using Albumin-Enhanced Continuous Venovenous HemodialysisPediatrics.  113:406-409. 2004
2004 Diuretic-induced hyperuricemia does not decrease cardiovascular risk [2] (multiple letters)Journal of Hypertension.  22:1415-1419. 2004
2004 Hypothesis: Uric acid, nephron number, and the pathogenesis of essential hypertensionKidney International.  66:281-287. 2004
2003 Hyperuricemia in childhood primary hypertensionHypertension.  42:247-252. 2003
2003 Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?Hypertension.  41:1183-1190. 2003
1994 Reverse chemical mutagenesis: Identification of the mutagenic lesions resulting from reactive oxygen species-mediated damage to DNAProceedings of the National Academy of Sciences of USA.  91:6609-6613. 1994
1994 Reactive oxygen species in tumorigenesis.Cancer Research.  54:1890s-1894s. 1994
1994 Oxygen radical induced mutagenesis is DNA polymerase specificJournal of Molecular Biology.  235:33-41. 1994
1994 Mutagenesis by metal-induced oxygen radicalsEnvironmental Health Perspectives.  102:57-61. 1994
1993 Mechanisms of Mutation by Oxidative DNA Damage: Reduced Fidelity of Mammalian DNA Polymerase βBiochemistry.  32:4466-4473. 1993
1988 The C proteins of heterogeneous nuclear ribonucleoprotein complexes interact with RNA sequences downstream of polyadenylation cleavage sitesMolecular and Cellular Biology.  8:4477-4483. 1988

Chapter

Year Title Altmetric
2018 Uric acid in the pathogenesis of hypertension.  73-90. 2018
2013 Uric acid in the pathogenesis of hypertension.  67-82. 2013
2012 Renal Urate Metabolism inthe Fetus and Newborn.  75-83. 2012
2012 Renal Urate Metabolism inthe Fetus and Newborn.  75-83. 2012
2012 Hypertension.  123-157. 2012

Research Overview

  • Childhood hypertension
    Sickle cell nephropathy
    FSGS
    Renal transplantation
  • Principal Investigator On

  • (Protocol Development Team) for Safety and Pharmacokinetics of Lisinopril in Pediatric Kidney Transplant Patients  awarded by Duke University
  • CUREGN 2.0 - Midwest Pediatric Nephrology Consortium - PCC  awarded by NATIONWIDE CHILDREN'S
  • Cure Glomerulonephropathy (CureGN): Integrative Proteomics & Metabolomics for Pediatric Glomerula Disease Biomarkers  awarded by NATIONWIDE CHILDREN'S HOSPITAL
  • Cure Glomerulonephropathy (CureGN): Integrative Proteomics & Metabolomics for Pediatric Glomerula Disease Biomarkers  awarded by NATIONWIDE CHILDREN'S HOSPITAL
  • ESTaBLISH: Impact of Early Life STressors on the BLood Pressure and Vascular Function In AdoleScents and cHildren  awarded by KAUL PEDIATRIC RESEARCH INSTITUTE
  • Novel Therapies for Chronic Allograft Dysfunction in Children  awarded by CHILDREN'S HOSPITAL (BOSTON)
  • Pharmacogenomics of Tacrolimus in Pediatric Kidney Transplant Recipients  awarded by American Kidney Fund
  • Private Grant  awarded by BRISTOL MYERS SQUIBB PHARMACEUTICAL COMPANY
  • Private Grant  awarded by NOVARTIS PHARMACEUTICALS CORPORATION
  • Private Grant  awarded by NOVARTIS PHARMACEUTICALS CORPORATION
  • Private Grant  awarded by NOVARTIS PHARMACEUTICALS CORPORATION
  • Private Grant  awarded by RETROPHIN, INC.
  • Private Grant  awarded by BRISTOL MYERS SQUIBB PHARMACEUTICAL COMPANY
  • Private Grant  awarded by APELLIS PHARMACEUTICALS INC
  • Reaching Equity for Adults and CHildren in Transplant (REACH-TRANSPLANT  awarded by THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
  • Safety and Pharmacokinetics of Multiple Dose Lisinopril in Pediatric Kidney Transplant Recipients  awarded by Duke University
  • Steering Committee for Safety and Pharmacokinetics of Lisinopril in Pediatric Kidney Transplant Patients  awarded by Duke University
  • Viral Triggers of Alioimmunity and Autoimmunity in Pediatric Lung Transplantation  awarded by Washington University
  • Investigator On

  • Center for Clinical and Translational Science (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS
  • Centers of Research Translation (CoRT)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Centers of Research Translation (CoRT) - Project 2  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Chronic Kidney Disease in Children  awarded by CHILDREN'S MERCY HOSPITAL
  • Chronic Kidney Disease in Children (CKiD III)  awarded by CHILDREN'S MERCY HOSPITAL
  • Chronic Kidney Disease in Children CKID IV  awarded by CHILDREN'S MERCY HOSPITAL
  • Chronobiology and Chronopharmacology to Prevent Sickle Cell Nephropathy  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • INvestigations In Gout, Hyperuricemia, and ComorbidiTies (INSIGHT) Center of Research Translation (CORT)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • INvestigations In Gout, Hyperuricemia, and ComorbidiTies (INSIGHT) Center of Research Translation (CORT) - Project 4: Protecting Renal Function with Urate-Lowering Drugs  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Interdisciplinary Training In Kidney-Related Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Interdisciplinary Training in Kidney-Related Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • International Pediatric Peritoneal Biopsy Study in Children  awarded by UNIVERSITY OF HEIDELBERG
  • Kidney Undergraduate Research Experience (KURE)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • NGAL Usage In Determining AKI Risk in Critically Ill Children (GUIDANCE)  awarded by CHILDREN'S HOSPITAL MEDICAL CENTER (CINCINNATI)
  • PRO00106090/Genomics of Nephrotic Syndrome  awarded by Duke University
  • PRedOctoral Phd and MD Research Training In TEams (PROmoTE)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • PRedoctoral Interdisciplinary Training in Renal Physiology and MEdIcIne (PRIME)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Peer Support for Lowering Blood Pressure among Adolescents: A Pilot, Randomized Controlled Trial  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Phase 2 Study of Selective Cytopheretic Device for the Treatment of Pediatric Patients with Acute Kidney Injury  awarded by CINCINNATI CHILDREN'S HOSPITAL
  • Preemptive Rituximab to Prevent Recurrent Focal Segmental Glomerulosclerosis Post -Transplant  awarded by University of Minnesota
  • Private Grant  awarded by AMGEN, INC.^
  • Private Grant  awarded by ABBVIE INC
  • Private Grant  awarded by ALEXION PHARMACEUTICALS, INC.
  • Private Grant  awarded by ROCKWELL MEDICAL, INC.
  • Private Grant  awarded by OCTAPHARMA - NEW
  • Private Grant  awarded by VIFOR
  • Private Grant  awarded by OTSUKA PHARMACEUTICAL DEVELOPMENT & COMMERCIALIZATION, INC
  • Private Grant  awarded by ALEXION PHARMACEUTICALS, INC.
  • Private Grant  awarded by Sanofi US Services Inc
  • Private Grant  awarded by Genentech
  • Private Grant  awarded by ASTRAZENECA PHARMACEUTICALS LP
  • Private Grant  awarded by TRANSPLANT GENOMICS, INC.
  • Randomized Intervention for Children with Vesicoureteral Reflux  awarded by Wayne State University
  • Reaching Equity for Adults and Chldren in Transplant (REACH-TRANSPLANT)  awarded by CHILDREN'S MERCY HOSPITAL
  • The Child-Centered Outcomes in Practice and Research (COPR) Center of Excellence: Strengthing the Clinical Validity Evidence Base for PROMIS Measures in Chronically Ill Children  awarded by CHILDREN'S HOSPITAL (PHILADELPHIA)
  • The Genetic Contribution to Drug Induced Renal lnjury:The Drug Induced Renal Injury Consortium (DIRECT)  awarded by INTERNATIONAL SAE CONSORTIOUM, LTD
  • UAB Center for Clinical and Translational Science (CCTS) (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS
  • Education And Training

  • University of Washington Medical Center, Internship
  • University of Washington Medical Center, Residency
  • Children's Hospital Boston, Postdoctoral Fellowship
  • Master of Science in Public Health, Baylor College of Medicine 2014
  • Doctor of Medicine, University of Washington 1995
  • Doctor of Philosophy in Biochemistry, University of Washington 1993
  • Bachelor of Science or Mathematics in Molecular Biology, Princeton University 1987
  • Full Name

  • Daniel Feig