Positions

Overview

  • Dr. Debasish Chattopadhyay received his BS in Chemistry and MS in Biochemistry from Calcutta University, India. He obtained Ph.D. degree in Chemistry from Jadavpur University, India in 1989. He conducted his postdoctoral research at the Upjohn Company in Michigan. This work was part of an NIH funded collaborative effort involving several academic institutions and pharmaceutical industries for the discovery of potent antiretroviral drugs. Dr. Chattopadhyay's work focussed on the structure-function analysis of target enzymes its application in drug development. Dr. Chattopadhyay joined the University of Alabama in 1994 and was recruited as an Assistant Professor in the School of Medicine in 1998. Dr. Chattopadhyay was promoted to the Associate Professor rank in 2007 and to the Professor rank in 2013.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 A simple and reliable method for determination of optimum pH in coupled enzyme assays 2020
    2019 Mosquito bite-induced controlled human malaria infection with Plasmodium vivax or P. Falciparum generates immune responses to homologous and heterologous preerythrocytic and erythrocytic antigens.  Infection and Immunity.  87. 2019
    2016 Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.  Biochemical Pharmacology.  109:14-26. 2016
    2015 Binding of undamaged double stranded DNA to vaccinia virus uracil-DNA Glycosylase.  BMC Structural Biology.  15. 2015
    2011 Identification of protein-protein interaction inhibitors targeting vaccinia virus processivity factor for development of antiviral agents.  Antimicrobial Agents and Chemotherapy.  55:5054-5062. 2011
    2011 Crystal structure of Plasmodium falciparum phosphoglycerate kinase: Evidence for anion binding in the basic patch.  Biochemical and Biophysical Research Communications.  412:203-206. 2011
    2011 Malaria immunoepidemiology in low transmission: Correlation of infecting genotype and immune response to domains of Plasmodium falciparum merozoite surface protein 3.  Infection and Immunity.  79:2070-2078. 2011
    2010 Synthesis and characterization of potent inhibitors of Trypanosoma cruzi dihydrofolate reductase.  Bioorganic and Medicinal Chemistry.  18:4056-4066. 2010
    2009 An unexpected phosphate binding site in Glyceraldehyde 3-Phosphate Dehydrogenase: Crystal structures of apo, holo and ternary complex of Cryptosporidium parvum enzyme.  BMC Structural Biology.  9. 2009
    2007 Crystal structure of vaccinia virus uracil-DNA glycosylase reveals dimeric assembly.  BMC Structural Biology.  7. 2007
    2007 Selective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase.  Antimicrobial Agents and Chemotherapy.  51:1795-1803. 2007
    2005 Lipophilic antifolate trimetrexate is a potent inhibitor of trypanosoma cruzi: Prospect for chemotherapy of chagas' disease.  Antimicrobial Agents and Chemotherapy.  49:3234-3238. 2005
    2005 Crystallization of three key glycolytic enzymes of the opportunistic pathogen Cryptosporidium parvum 2005
    2004 Biochemical characterization and crystallization of recombinant 3-phosphoglycerate kinase of Plasmodium falciparum 2004
    2004 Plasmodium falciparum ARFGAP: Expression and crystallization of the catalytic domain 2004
    2003 Docking and biological activity of pteridine analogs: Search for inhibitors of pteridine reductase enzymes from Trypanosoma cruzi 2003
    2003 The Plasmodium falciparum family of Rab GTPases.  Gene.  306:13-25. 2003
    2002 Crystal structure of human carbonic anhydrase II complexed with an anti-convulsant sugar sulphamate.  Biochemical Journal.  361:437-441. 2002
    1998 Large-scale preparation of the Δ10 form of staphylokinase by in vitro processing of recombinant staphylokinase with purified human plasminogen.  Applied Biochemistry and Biotechnology.  69:147-156. 1998

    Research Overview

  • Structure-Function Analysis of Proteins - The main objective of our research is to define the relationship between the structure and function of biological macromolecules. Our research focuses on macromolecules that regulate the key steps in the life of eukaryotic and prokaryotic pathogens including parasites, bacteria and viruses. Results of our investigations inform drug discovery and vaccine development. We use a variety of biophysical and biochemical techniques in our studies.

    Keywords - Structural biology, Protein structure function, Malaria, Chagas' disease, Parasitic disease, Small pox, Bacterial pneumonia,

    • Principal Investigator On

    Investigator On

    Education And Training

  • University of Miami and The Upjohn Company Physical & Analytical Chemistry, Postdoctoral Fellowship
  • Doctor of Philosophy Level Degree in Chemistry, 1989

    • Full Name

  • Debasish Chattopadhyay