• Introduction:

    Dr. Datta earned his Bachelor of Science (BS), Honors in Chemistry; Physics and Mathematics, and his Master of Science (MS), Organic Chemistry from The University of Burdwan, India.  He erned his Ph.D. in Organic Chemistry, from the Bose Institute, Calcutta, India.  His thesis title was Studies on Natural Carbocyclic Compounds. He worked as a research associate with Dr. Srilata Bagchi at the University of Illinois in Chicago and with Dr. Harold L. Moses at The Vanderbilt-Ingram Cancer Center in Nashville. He began work as assistant professor in Surgical Oncology Cancer Biology at Vanderbilt University in 2000. Dr. Datta also served as a research scientist at the Veterans Affairs Medical Center in Nasvhille.


    In 2012, Dr. Datta joined the faculty at UAB, where he is Professor and Director of Research in the Division of Hematology/Oncology. He is also leader of the Colon and Lung Cancer Basic Research Program. He is senior scientist in the Cancer Cell Biology Program at the UAB Comprehensive Cancer Center. In addition, Dr. Datta also serves as Research Scientist at the Veterans Affairs Medical Center in Birmingham.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 Serine-threonine kinase receptor-associated protein (Strap) knockout decreases the malignant phenotype in neuroblastoma cell linesCancers2021
    2020 TRIP13 promotes metastasis of colorectal cancer regardless of p53 and microsatellite instability status 2020
    2020 PTPRε Acts as a Metastatic Promoter in Hepatocellular Carcinoma by Facilitating Recruitment of SMAD3 to TGF-β Receptor 1Hepatology.  72:997-1012. 2020
    2018 Serine Threonine Kinase Receptor-Associated Protein Deficiency Impairs Mouse Embryonic Stem Cells Lineage Commitment Through CYP26A1-Mediated Retinoic Acid HomeostasisSTEM CELLS.  36. 2018
    2017 Regulation of EMT in colorectal cancer: A culprit in metastasisCancers.  9. 2017
    2017 STRAP promotes stemness of human colorectal cancer via epigenetic regulation of the NOTCH pathwayaCancer Research.  77:5464-5478. 2017
    2016 Novel role of STRAP in progression and metastasis of colorectal cancer through Wnt/β-catenin signalingOncotarget.  7:16023-16037. 2016
    2014 Reduced expression of transcriptional intermediary factor 1 gamma promotes metastasis and indicates poor prognosis of hepatocellular carcinomaHepatology.  60:1620-1636. 2014
    2014 Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathwayBritish Journal of Cancer.  110:946. 2014
    2013 Targeting the ERK pathway reduces liver metastasis of Smad4-inactivated colorectal cancerCancer Biology and Therapy.  14:1059-1067. 2013
    2013 Transforming growth factor β induces expression of connective tissue growth factor in hepatic progenitor cells through Smad independent signalingCellular Signalling.  1981-1992. 2013
    2012 Clinical profile of periodic paralysis. 2012
    2011 Role of STRAP in regulating GSK3β function and Notch3 stabilizationCell Cycle.  10:1639-1654. 2011
    2011 STRAP regulates c-Jun ubiquitin-mediated proteolysis and cellular proliferation 2011
    2010 Antimetastatic Role of Smad4 Signaling in Colorectal CancerGastroenterology.  138. 2010
    2010 Serine Threonine Receptor-Associated Protein (STRAP) plays a role in the maintenance of mesenchymal morphologyCellular Signalling.  22:138-149. 2010
    2010 Targeting the transforming growth factor-β signaling pathway in human cancer 2010
    2007 Smad4 regulates claudin-1 expression in a transforming growth factor-β-independent manner in colon cancer cellsCancer Research.  67:1571-1579. 2007
    2006 Oncogenic serine-threonine kinase receptor-associated protein modulates the function of ewing sarcoma protein through a novel mechanismCancer Research.  66:10824. 2006
    2006 Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-βJournal of Biological Chemistry.  281:33971-33981. 2006
    2005 Restoration of TGF-β signalling reduces tumorigenicity in human lung cancer cellsBritish Journal of Cancer.  93:1157-1167. 2005
    2005 Smad7 induces tumorigenicity by blocking TGF-β-induced growth inhibition and apoptosisExperimental Cell Research.  307:231-246. 2005
    2001 Oncogenic Ras Represses Transforming Growth Factor-β/Smad Signaling by Degrading Tumor Suppressor Smad4Journal of Biological Chemistry.  276:29531-29537. 2001
    2000 Regulation of plasminogen activator inhibitor-1 expression by transforming growth factor-β-induced physical and functional interactions between Smads and Sp1Journal of Biological Chemistry.  275:40014-40019. 2000
    2000 STRAP and Smad7 synergize in the inhibition of transforming growth factor β signalingMolecular and Cellular Biology.  20:3157-3167. 2000
    1998 Identification of STRAP, a novel WD domain protein in transforming growth factor-β signalingJournal of Biological Chemistry.  273:34671-34674. 1998
    1998 RhoB is stabilized by transforming growth factor β and antagonizes transcriptional activationJournal of Biological Chemistry.  273:9921-9926. 1998
    1998 Signal transduction by transforming growth factor-β: A cooperative paradigm with extensive negative regulationJournal of Cellular Biochemistry.  111-122. 1998
    1995 Association of p107 with Sp1: Genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcriptionMolecular and Cellular Biology.  15:5444-5452. 1995
    1994 Repression of transforming growth factor β1 promoter by the adenovirus oncogene E1A. Identification of a unique GC-rich sequence as a target for E1A repressionJournal of Biological Chemistry.  269:25392-25399. 1994
    Effect of cigarette smoking on Epithelial to Mesenchymal Transition (EMT) in lung cancerJournal of Clinical Medicine.  5.


    Year Title Altmetric
    2011 Osteopetrosis..  715-718. 2011

    Education And Training

  • Doctor of Philosophy in Organic Chemistry, Jadavpur University 1987
  • Master of Sciences or Mathematics in Organic Chemistry, University of Burdwan 1982
  • Bachelor of Science or Mathematics in Chemistry, University of Burdwan 1979
  • Full Name

  • Pran Datta