Positions

Overview

  • Victor Darley-Usmar received his Ph.D. at the University of Essex in England and then moved to the University of Oregon as a Post-Doctoral Fellow to pursue his interests in the structure and function of mitochondrial proteins in human disease. After a period as a lecturer in Japan and ten years as a Research Scientist in Burroughs Wellcome in London he joined UAB to establish his own research group in the Department of Pathology in 1995. He has received multiple awards for training and mentoring and served as the Associate Dean for Post-Doctoral Education and the Pathology Graduate Program Director. He co-established the UAB Center for Free Radical Biology from 2006-2015 as an international center for research in redox biology. In his current role of Senior Associate Dean for Research Compliance and Administration he brings his experience in the commercial sector and career development programs to the strategic management of the School of Medicine Research. In his own research program he has been instrumental in defining how redox biology modifies mitochondrial function in pathology and in recognition of these achievements was awarded a Lifetime Achievement Award by the Society for Free Radical Biology and Medicine in 2012. He has been continuously funded by NIH for 25 years and has published over 300 articles with an H factor of over 100. At UAB his contribution to research in mitochondrial pathology was recognized by his appointment as the Foundation Faculty for the “Endowed Professorship in Mitochondrial Medicine and Pathology”. He is now developing a program to apply measures of bioenergetic health to personalized medicine. He was a recent recipient of the prestigious “Creativity is a Decision” and “Blue Sky” awards from UAB for the Bioenergetic Health Index concept. He was recently recognized as the 2017 UAB Distinguished Faculty Lecturer, which is is the highest honor bestowed by the Academic Medical Center on a faculty member who has advanced the frontiers of science and made outstanding contributions to education, research and public service.
  • Research Overview

  • Dr. Darley-Usmar's major research interests are in translating basic research in redox biology and bioenergetics to a clinical setting. His research is focused on the contribution of mitochondrial dysfunction to the pathophysiology of human disease. He recently developed the methods for the assessment of bioenergetic function in cells isolated from human blood which opens up the potential for using mitochondrial function in translational medicine. Deteriorating mitochondrial quality control is an important mechanism for understanding how bioenergetics changes in response to metabolic stress and the interface with autophagy was explore in the context of diabetes and heme toxicity. Recently he has shown how novel metabolic therapeutics can have utility in cancer.
  • Principal Investigator On

  • Accelerating Translational Bioenergetics at UAB  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION
  • Cellular Bioenergetics as a Predictor of Diabetic Nephropathy  awarded by GEORGIA REGENTS UNIVERSITY (AUGUSTA)
  • Comparative Energetics and Aging - Comparative Molecular Energetics Analysis Core D  awarded by National Institute on Aging/NIH/DHHS
  • Development of Mitochondrially Targeted Antioxidants for Diabetic Therapy  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Diverse Roles of Reactive Oxygen Species and Inflammation in Vascular Disease  awarded by Emory University
  • Ethanol Hepatotoxicity and NO-Dependent Mitochondrial Dysfunction  awarded by National Institute on Alcohol Abuse and Alcoholism/NIH/DHHS
  • Induction of Antioxidant Defenses by Oxidized Lipids  awarded by National Institute of Environmental Health Sciences/NIH/DHHS
  • Private Grant  awarded by SEAHORSE BIOSCIENCE
  • Private Grant  awarded by SEAHORSE BIOSCIENCE
  • Private Grant  awarded by LEIDOS BIOMEDICAL RESEARCH, INC.
  • Private Grant  awarded by LIFE TECHNOLOGIES, INC.^
  • SCCOR in Cardiac Dysfunction and Disease - Core B  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Task 3.2 Oxygen Consumption Rate (OCR) and Extracellular Acidification  awarded by SOUTHERN RESEARCH INSTITUTE
  • The Role of the Mitochondrial DNA in Oxidative Stress and Bioenergetic Function of Monocytes and Macrophages  awarded by American Heart Association
  • Training Program in Cardiovascular Pathophysiology  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Training Program in Cardiovascular Pathophysiology  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Translational Bioenergetics in Patients with Alcoholic Liver Disease  awarded by National Institute on Alcohol Abuse and Alcoholism/NIH/DHHS
  • Investigator On

  • A Novel Optogenetic Tool for Precise Mitochondrial Control  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • A Targeted Mitochondrial Luminoptogenetic Gene Therapy to Treat Triple Negative Breast Cancer  awarded by DOD - Department of Defense
  • AMPK Activation and Acute Lung Injury  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • AMPK in the Development and Resolution of Lung Fibrosis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Aberrant Circadian Regulation Of Autophagy In The Heart During Diabetes  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Alcoholic Liver Dysfunction Potentiation by Hyperlipidemia and Cigarette Smoke  awarded by National Institute on Alcohol Abuse and Alcoholism/NIH/DHHS
  • Biosynthetic Metabolic Pathway Regulation of Glioma Growth  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Comparative Bioenergetics of Aging  awarded by National Institute on Aging/NIH/DHHS
  • Comparative Bioenergetics of Aging - Core D - Comparative Mitochondrial Health Assessment Core  awarded by National Institute on Aging/NIH/DHHS
  • Comparative Energetics and Aging  awarded by National Institute on Aging/NIH/DHHS
  • Cytochrome C Oxidase in Malignant Gliomas  awarded by National Cancer Institute/NIH/DHHS
  • Defining the Impact of Frataxin Point Mutations on Friedreich's Ataxia pathogenesis  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Enhancing Autophagy and Mitochondrial Biogenesis to Mitigate Cardiac Reperfusion Injury  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Functional Significance of Ferritin Light Chain in Sepsis-associated Kidney Injury  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Glucose-Mediated Remodeling of Cardiac DNA Methylation  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Glycolate Metabolism and Kidney Oxalate  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • HDL and Cellular Repair Mechanisms  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Interdisciplinary Training In Kidney-Related Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Interdisciplinary Training in Kidney-Related Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Kidney Undergraduate Research Experience (KURE)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Mechanisms in Hypertension and Cardiovascular Diseases  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Mitochondria-SR Redox Signaling and Ca2+ Handling in Healthy and Failing Hearts  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Mitochondrial Bioenergetic Dysfunction and Chlorine Toxicity  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Mitochondrial Haplotype Influences LV Dysfunction in Heart Failure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Mitochondrial Metabolism in Primary Hyperoxaluria  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Mitochondrial Nuclear Interactions and CVD Susceptibility  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Mitochondrial UCP2 in Age-Related Lung Fibrosis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Mitochondrial-Based Determinants of Sex Differences in Acute Kidney Injury  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Monocyte Mitochondrial Dysfunction and Kidney Stone Disease  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Myofibroblast Senescence in Pulmonary Fibrosis  awarded by National Institute on Aging/NIH/DHHS
  • Nitrite Dependent Protection Against Cl2 Gas Toxicity Role of Chlorinated Lipids  awarded by National Institute of Environmental Health Sciences/NIH/DHHS
  • PAI-1 and Aging-Related Susceptibility to Lung Fibrosos  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • PRedoctoral Interdisciplinary Training in Renal Physiology and MEdIcIne (PRIME)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Regulation of Skeletal Muscle Mitochondrial Quality Control Parameters and Systemic Metabolism  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • SCCOR in Cardiac Dysfunction and Disease  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • STIM1 and its Role in Regulating Cardiac Metabolism  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • STIMulating Stress: A Novel Role of the ER Ca2+Sensor STIM1 in the Adult Heart  awarded by American Heart Association (Southeast Affiliate)
  • Saturated Fatty Acid-Induced Autophagy in Vascular Endothelium  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • The Role of Wheat-Gluten in Polycystic Kidney Disease  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Therapeutic Recovery of Immune and Lung Tissue Bioenergetic Homeostasis in Sepsis-Induced Immunosuppression  awarded by DOD - Department of Defense
  • UAB -UCSD O'Brien Core Center for Acute Kidney Injury Research - Core C  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Center for AIDS Research  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • UAB Center for AIDS Research  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • UAB Center for AIDS Research - The Detrimental Nexus of HCV and HIV Infection on Bioenergetics and Immune Function  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • UAB Center for AIDS Research - The Role of HIV-Infection and Antiretroviral Therapy Related Mitochondrial Toxicity in Accelerated Aging  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • UAB Center for Clinical and Translational Science (CCTS) (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS
  • UAB-UCSD O'Brien Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB-UCSD O'Brien Center for Acute Kidney Injury Research - Core C  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB-UCSD O'Brien Core Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB-UCSD O'Brien Core Center for Acute Kidney Injury Research - Administrative Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB/UCSD O'Brien Core Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB/UCSD O'Brien Core Center for Acute Kidney Injury Research - Core C  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Xanthine Oxidase and Bioenergetic Function in Volume Overload  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Teaching Overview

  • Since joining UAB in 1995, Dr. Darley-Usmar has actively engaged in graduate training and post-doctoral training. During his time at UAB he has mentored 16 graduate students, has served on over 25 student thesis committees and over this period mentored the transition to independence of 9 Post Docs to faculty (3, are Assistant Professors, 2 are now Associate Professors and 2 Full Professors). He has played an active role in developing educational programs at UAB at both the administrative and faculty level. He served as graduate program director for the Pathology Graduate Program (50-60 students) from 2003-2005 and as Associate Dean for Post-Doctoral Education from 2003-2007 (290-320 Post Doctoral Trainees). In 2009 he received the Deans award for Mentorship and most valued faculty member award from the Pathology graduate students on four occasions. He has served as a charter member of the Atherosclerosis and Inflammation study section in addition to reviewing program projects, training grants and the K99 training program. As a member of the Center for Free Radical Biology and member of the Clinical Nutrition Center Center, Comprehensive Diabetes and Cardiovascular Centers and Nephrology Research Training Center, Co-Director of a Core in the O’Brien AKI injury center, Dr. Darley-Usmar has contributed to the career development of the trainees in the program by offering mentoring guidance and expertise in metabolism and bioenergetics.
  • Education And Training

  • Doctor of Philosophy in Biochemistry, Biophysics and Molecular Biology, University of Essex 1980
  • Full Name

  • Victor Darley-Usmar