Positions

Overview

  • Dr. Orihuela obtained his Bachelor of Science Degree from Baylor University in 1996. He subsequently earned his PhD in Microbiology and Immunology from the University of Texas Medical Branch at Galveston where he was a Kempner Scholar. From 2001 to 2005, Dr. Orihuela completed his postdoctoral research training in the Department of Infectious Diseases at St. Jude Children's Research Hospital in Memphis TN. He returned to Texas in 2005, as an Assistant Professor in the Department of Microbiology and Immunology at The University of Texas Health Science Center at San Antonio. While at San Antonio, Dr. Orihuela was promoted with tenure to Associate Professor and recipient of the Presidential Junior Research Scholar Award, Distinguished Hispanic Faculty Award from the Graduate School, and Glenn Award for Research in Biological Mechanisms of Aging. In Fall of 2015 Dr. Orihuela joined the Department of Microbiology at UAB where he is now Vice-Chair of Faculty Development. Dr. Orihuela currently is a member of the Host Interactions with Bacterial Pathogens Study Section for the NIH, Associate Editor for the journals PLoS Pathogens and Infection and Immunity, and editor of a recent book on the molecular mechanisms of Streptococcus pneumoniae pathogenesis.
  • Research Overview

  • Dr. Orihuela's research focus has been the host-pathogen interactions that underlie development of invasive pneumococcal disease. Most recently this includes examining the role of necroptosis (i.e. a pro-inflammatory cell death program) on pulmonary injury during bacterial infection, exploring the molecular basis of cardiac invasion during severe Streptococcus pneumoniae infection, and dissecting how the toxin pneumolysin kills lung cell and cardiomyocytes. His laboratory routinely uses knockout mice, isogenic deletion and complemented mutants of S. pneumoniae, “omic” technologies (e.g. genomic, transcriptomic, proteomic), therapeutic drug treatments, CRISPR/Cas9 gene edited cell lines, and fluorescent and electron microscopy.
  • Principal Investigator On

  • Capsule Protects Intracellular Pneumococci during Vascular Endothelial Cell Translocation  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Cardiac Microlesion Formation During Invasive Pneumococcal Disease  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Cardiac Microlesion Formation during Invasive Pneumococcal Disease  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Caspase-Associated Necroptosis of Cardiomyocytes  awarded by American Heart Association
  • Cellular Senescence Due to Invasive Pneumococcal Disease Leads to Cardiac Interstitial Fibrosis  awarded by UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER (HOUSTON)
  • Dual RNA-seq for Characterization of the Streptococcus Pneumoniae and Host Transciptomes during Bacteremia/ Invasive Disease  awarded by University of Maryland
  • Host-bacterial Determinants of Cardiac Damage and Invasive Pneumococcal Disease  awarded by Burroughs Wellcome Fund
  • Influenza Secondary Pneumococcal Models of Infection  awarded by University of Maryland
  • Inhibition of Necroptosis During Inflamm-Aging and Pneumonia  awarded by National Institute on Aging/NIH/DHHS
  • Pneumococcal Biofilm Formation is SpxB Dependent  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • PspA Binds Necroptotic Cells to Cause Disease and Transmit  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Resident Cardiac Macrophage Dysfunction and Pneumonia-Associated Adverse Cardiac Events  awarded by American Heart Association
  • Education And Training

  • St. Jude Children's Research Hospital Infectious Diseases, Postdoctoral Fellowship
  • Doctor of Philosophy in Microbiological Sciences and Immunology, University of Texas System : Medical Branch 2001
  • Bachelor of Science or Mathematics in Biology, Baylor University 1996
  • Full Name

  • Carlos Orihuela