Positions

Overview

  • Dr. C. Vivek Lal is an Assistant Professor of Pediatrics at University of Alabama at Birmingham where he serves as the Director of Golden Week Small Baby Program. His lab studies various ‘omic’ mechanisms as they relate to the prediction, pathogenesis and treatment of chronic lung disease of prematurity. Dr. Lal’s particular interest lies in studying the mechanisms by which pulmonary microbiome dysbiosis and exosomes affects the inflammation in premature lungs, for which his lab is funded by National Institute of Health (NIH) and American Heart Association (AHA). His scientific contributions have been published in leading journals (JCI, Cell, Pediatric Research, etc) and he has been recognized by the American Academy of Pediatrics and Society of Pediatric Research with young investigator research awards.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 Toll-like receptors: Shapers of the pulmonary microbiome? 2021
    2021 Prolyl endopeptidase contributes to early neutrophilic inflammation in acute myocardial transplant rejection.  JCI insight.  6. 2021
    2021 Neutrophilic inflammation during lung development disrupts elastin assembly and predisposes adult mice to COPD.  Journal of Clinical Investigation.  131. 2021
    2021 Bronchopulmonary dysplasia is associated with reduced oral nitrate reductase activity in extremely preterm infants.  Redox Biology.  38. 2021
    2020 The closed eye harbours a unique microbiome in dry eye disease.  Scientific Reports.  10. 2020
    2020 Airway nitrite is increased in extremely preterm infants with bronchopulmonary dysplasia.  Respiratory Research.  21. 2020
    2020 Reply to de Steenhuijsen Piters and Bogaert.  American Journal of Respiratory and Critical Care Medicine.  201:1311-1312. 2020
    2020 Human Fetal Lungs Harbor a Microbiome Signature.  American Journal of Respiratory and Critical Care Medicine.  201:1002-1006. 2020
    2020 Predicting BPD: Lessons Learned From the Airway Microbiome of Preterm Infants.  Frontiers in Pediatrics.  7. 2020
    2020 Effects of hyperoxia on alveolar and pulmonary vascular development in germ-free mice 2020
    2020 Maternal antibiotics augment hyperoxia-induced lung injury in neonatal mice 2020
    2020 The closed eye harbors a unique microbiome in dry eye disease 2020
    2019 Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung.  Cell.  176:113-126.e15. 2019
    2019 Airway Microbiome and Development of Bronchopulmonary Dysplasia in Preterm Infants: A Systematic Review.  Journal of Pediatrics.  204:126-133.e2. 2019
    2019 Integrating multiomics longitudinal data to reconstruct networks underlying lung development 2019
    2018 Supraphysiological Levels of Oxygen Exposure During the Neonatal Period Impairs Signaling Pathways Required for Learning and Memory.  Scientific Reports.  8. 2018
    2018 Early airway microbial metagenomic and metabolomic signatures are associated with development of severe bronchopulmonary dysplasia 2018
    2018 Genomics, microbiomics, proteomics, and metabolomics in bronchopulmonary dysplasia.  Seminars in Perinatology.  42:425-431. 2018
    2018 Mechanisms of ventilator-induced lung injury: Is the elafin in the room?.  American Journal of Respiratory Cell and Molecular Biology.  59:531-532. 2018
    2018 The neutrophil chemoattractant peptide proline-glycine-proline is associated with acute respiratory distress syndrome 2018
    2018 The neutrophil chemoattractant peptide proline-glycine-proline is associated with acute respiratory distress syndrome. 2018
    2018 Iloprost attenuates hyperoxia-mediated impairment of lung development in newborn mice 2018
    2018 Transfusion-associated necrotizing enterocolitis in preterm infants: An updated meta-analysis of observational data 2018
    2018 Exosomal microRNA predicts and protects against severe bronchopulmonary dysplasia in extremely premature infants.  JCI insight.  3. 2018
    2018 Early progressive feeding in extremely preterm infants: A randomized trial.  American Journal of Clinical Nutrition.  107:365-370. 2018
    2018 MicroRNA-145 antagonism reverses TGF-b inhibition of F508del CFTR correction in airway Epithelia.  American Journal of Respiratory and Critical Care Medicine.  197:632-643. 2018
    2018 Early-Onset Neonatal Sepsis with Extended Spectrum Beta-Lactamase Producing Escherichia Coli in Infants Born to South and South East Asian Immigrants: A Case Series.  American Journal of Perinatology Reports.  8:e277-e279. 2018
    2017 Impact of the Neonatal Resuscitation Program–Recommended Low Oxygen Strategy on Outcomes of Infants Born Preterm.  Journal of Pediatrics.  191:35-41. 2017
    2017 Cellular and humoral biomarkers of Bronchopulmonary Dysplasia.  Early Human Development.  105:35-39. 2017
    2017 Ureaplasma infection-mediated release of matrix metalloproteinase-9 and PGP: A novel mechanism of preterm rupture of membranes and chorioamnionitis.  Pediatric Research.  81:75-79. 2017
    2016 Endothelial monocyte-activating polypeptide II mediates macrophage migration in the development of hyperoxia-induced lung disease of prematurity.  American Journal of Respiratory Cell and Molecular Biology.  55:602-612. 2016
    2016 The Airway Microbiome at Birth.  Scientific Reports.  6. 2016
    2016 Regulation of alveolar septation by microRNA-489 2016
    2015 Genetic predisposition to bronchopulmonary dysplasia.  Seminars in Perinatology.  39:584-591. 2015
    2015 Biomarkers, Early Diagnosis, and Clinical Predictors of Bronchopulmonary Dysplasia.  Clinics in Perinatology.  42:739-754. 2015
    2015 Necrotizing Enterocolitis (NEC): A Devastating Disease of Prematurity 2015
    2014 Hypomagnesemia secondary to cerebrospinal fluid losses in a patient with congenital hydrocephalus.  Journal of Perinatology.  34:640-641. 2014
    2014 Vascular mediators in chronic lung disease of infancy: Role of endothelial monocyte activating polypeptide II (EMAP II) 2014
    2013 Ephrin-B2 reverse signaling increases α5β1 integrin-mediated fibronectin deposition and reduces distal lung compliance.  American Journal of Respiratory Cell and Molecular Biology.  49:680-687. 2013
    2012 Cerebellar hemorrhage: A major morbidity in extremely preterm infants.  Journal of Perinatology.  32:699-704. 2012

    Chapter

    Year Title Altmetric
    2016 Pulmonary Hypertension in Bronchopulmonary Dysplasia.  259-279. 2016

    Education And Training

  • University of South Alabama, Internship
  • University of South Alabama, Residency
  • University of Texas Southwestern Medical Center, Postdoctoral Fellowship
  • Doctor of Medicine, 2007

    • Full Name

  • Charitharth Lal