Yu Holly Chen

Faculty Member

Selected Publications

Academic Article

Year Title Altmetric
2022 Nicotinamide Promotes Formation of Retinal Organoids From Human Pluripotent Stem Cells via Enhanced Neural Cell Fate CommitmentFrontiers in Cellular Neuroscience.  16. 2022
2021 Genetics and therapy for pediatric eye diseasesEBioMedicine.  67. 2021
2021 Primary cilia biogenesis and associated retinal ciliopathiesSeminars in Cell and Developmental Biology.  110:70-88. 2021
2020 Accelerated Development of Rod Photoreceptors in Retinal Organoids Derived from Human Pluripotent Stem Cells by Supplementation with 9-cis Retinal 2020
2020 HIPRO: A High-Efficiency, Hypoxia-Induced Protocol for Generation of Photoreceptors in Retinal Organoids from Mouse Pluripotent Stem Cells 2020
2020 A simple and efficient method for generating human retinal organoidsMolecular Vision.  26:97-105. 2020
2019 Improved Retinal Organoid Differentiation by Modulating Signaling Pathways Revealed by Comparative Transcriptome Analyses with Development In VivoStem Cell Reports.  13:891-905. 2019
2019 Retinal disease in ciliopathies: Recent advances with a focus on stem cell-based therapies. 2019
2019 The peripheral eye: A neurogenic area with potential to treat retinal pathologies?Progress in Retinal and Eye Research.  68:110-123. 2019
2019 Transcriptome-based molecular staging of human stem cell-derived retinal organoids uncovers accelerated photoreceptor differentiation by 9-cis retinalMolecular Vision.  25:663-678. 2019
2018 A CEP290 C-Terminal Domain Complements the Mutant CEP290 of Rd16 Mice In Trans and Rescues Retinal DegenerationCell Reports.  25:611-623.e6. 2018
2018 Accelerated and Improved Differentiation of Retinal Organoids from Pluripotent Stem Cells in Rotating-Wall Vessel BioreactorsStem Cell Reports.  10:300-313. 2018
2016 The mechanism of transactivation regulation due to polymorphic short tandem repeats (STRs) using IGF1 promoter as a modelScientific Reports.  6. 2016
2016 Three-dimensional retinal organoids from mouse pluripotent stem cells mimic in vivo development with enhanced stratification and rod photoreceptor differentiationMolecular Vision.  22:1077-1094. 2016
2013 Functional Interaction Between SNPs and Microsatellite in the Transcriptional Regulation of Insulin-Like Growth Factor 1Human Mutation.  34:1289-1297. 2013
2011 Haplotype effect in the IGF1 promoter accounts for the association between microsatellite and serum IGF1 concentrationClinical Endocrinology.  74:520-527. 2011

Research Overview

  • Ciliopathies affect very specific tissues while most of the disease-causing genes are ubiquitously expressed in almost every cell types. My research focuses on the molecular mechanisms of this pleiotropic effect in ciliopathies using complementary modeling systems of pluripotent stem cell-derived organoid culture systems and.mouse models. I am also interested in utilizing biochemical and bioengineering approaches to improve the organoid culture systems to generate a more comprehensive in vitro model.
  • Education And Training

  • National Institutes of Health National Eye Institute, Postdoctoral Fellowship
  • Doctor of Philosophy in Pathology Residency Program, The Chinese University of Hong Kong 2012