Positions

Overview

  • Dr. Elmets major research interests focus on environmental influences on the skin and on the immune system. His research has investigated how ultraviolet light and other environmental agents interact with immunological function of the skin. Initial studies in mice showed that in vivo exposure of murine skin produced a local deficiency in the antigen presenting function of skin, thereby resulting in the preferential generation of antigen specific regulatory T-cells. Studies examining the mechanism by which ultraviolet radiation impaired the function of antigen presenting cells in in vitro systems showed that ultraviolet radiation inhibited expression of the adhesion molecule CD54 (ICAM-1), which was at least in part, responsible for deficient activation of T-cells. More recent studies have assessed the cutaneous and immunological effects of photodynamic therapy. Those studies were the first to show that photodynamic therapy has immunosuppressive effects which may reduce the overall efficacy of this form of cancer therapy.

    Another major research interest is the immunogenicity of topically applied chemical carcinogens. Using polyaromatic hydrocarbons as prototypic carcinogenic chemicals, he has shown that topical application of these compounds results in the development of allergic contact hypersensitivity. Metabolism of the compounds is required for the development of this response which only occurs in mice with certain MHC haplotypes and in Ah receptor positive strains of mice. Bases on these results, he has developed the hypothesis that the presence of allergic contact hypersensitivity to polyaromatic hydrocarbons serves to protect mice from the carcinogenic effects of these agents. In support of this hypothesis, he has shown the MHC congenic strains of mice that do not develop polyaromatic hyrdrocarbon contact hypersensitivity are at increased risk for development of skin cancers by those agents.

    A third area of research interest is in chemoprevention of skin cancer. In both animals and humans green tea polyphenols have a protective effect on UV-induced damage to the skin. He has shown in animals that this agent protects against UV induced immunosuppression and in humans it prevents the clinical and histological features of sunburn reaction and DNA damage. He is also investigating whether celecoxib exerts a chemopreventive effect against actinic keratoses in humans and whether topical application of DNA repair enzymes will prevent the development of non-melanoma skin cancers in renal transplant patients.
  • Research Overview

  • Keywords - psoriasis, contact dermatitis, photosensitivity diseases, phototherapy
  • Principal Investigator On

  • A Phase IIB Randomized, Placebo-Controlled Trial of Pioglitazone for Oral Pre-Malignant Lesions: An Inter-Consortium Collaborative Study  awarded by University of Wisconsin-Madison
  • A Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Trial of Lovastatin for Various Endpoints of Melanoma Pathobiology  awarded by University of California, Irvine
  • Cancer Prevention Agent Development Program: Early Phase Clinical Research  awarded by University of Wisconsin-Madison
  • Comprehensive Cancer Center Core Support Grant - Cancer Chemoprevention Program  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant - Cancer Chemoprevention Program  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant - Cancer Chemoprevention Program  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant - Cancer Chemoprevention Program  awarded by National Cancer Institute/NIH/DHHS
  • Dietary Prevention of Photodamage in Skin with Grapes: A Human Clinical Study  awarded by California Table Grape Commission
  • Private Grant  awarded by BIOGEN, INC.
  • Private Grant  awarded by Genentech
  • Private Grant  awarded by ABBVIE INC
  • Private Grant  awarded by ABBOTT LABORATORIES
  • Private Grant  awarded by BASILEA PHARMACEUTICA LTD
  • Private Grant  awarded by ALLERGAN, INC.
  • Private Grant  awarded by AMGEN, INC.^
  • Private Grant  awarded by AMGEN, INC.^
  • Private Grant  awarded by KYOWA PHARMACEUTICAL, INC.
  • Private Grant  awarded by SOLIGENIX, INC
  • Private Grant  awarded by IDERA PHARMACEUTICALS, INC.
  • Private Grant  awarded by ELORAC, INC.
  • Private Grant  awarded by F.Hoffmann-La Roche Ltd.
  • RXR Rexinoids for Cancer Chemoprevention  awarded by National Cancer Institute/NIH/DHHS
  • RXR Rexinoids for Cancer Chemoprevention - Core 1: Administrative Core  awarded by National Cancer Institute/NIH/DHHS
  • RXR Rexinoids for Cancer Chemoprevention - Program Integration and Management  awarded by National Cancer Institute/NIH/DHHS
  • RXR Rexinoids for Cancer Chemoprevention - Project 1: Evaluation if UAB30 on Skin Cancer Biomarkers in Human Renal Transplant Recipients  awarded by National Cancer Institute/NIH/DHHS
  • The Effect of Polypodium Leucotomos on UV-Induced Photodamage in Skin  awarded by HENRY FORD HOSPITAL
  • Topical Chemoprevention of Skin Cancer Biomarkers  awarded by National Cancer Institute/NIH/DHHS
  • Training in Investigative Dermatology  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • UAB Skin Disease Research Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • UAB Skin Disease Research Center - Administrative Core - Core A  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Investigator On

  • Active - Major Program Leader - Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Bid Regulation of Cutaneous Photodamage Responses  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Blocking Arsenicals-Induced Cutaneous Injury  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Chemoprevention of Environmental UVB-Induced Skin Cancer in Immunosuppressed Mice  awarded by National Institute of Environmental Health Sciences/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Inhibiting Multiple Molecular Targets for Preventing Non-Melanoma Skin Cancer  awarded by National Cancer Institute/NIH/DHHS
  • Mechanism of Action and Function of Novel Secosteroid 20(OH)D3 in the Skin  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Mechanism of Ultraviolet Radiation Induced Immune Tolerance  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Mechanisms of Ultraviolet Radiation Induced Immune Suppression  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Optimization of Novel Molecular Target-based Drugs for Arsenical Skin Injury  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Pharmacological Management of Ultraviolet Radiation Induced Skin Cancer  awarded by DOD - Department of Defense
  • Private Grant  awarded by BRISTOL MYERS SQUIBB PHARMACEUTICAL COMPANY
  • Private Grant  awarded by Solvay Pharmaceuticals, Inc.
  • Private Grant  awarded by ABBVIE INC
  • Private Grant  awarded by JANSSEN RESEARCH & DEVELOPMENT, LLC
  • Private Grant  awarded by MIRAGEN THERAPEUTICS INC.
  • RXR Rexinoids for Cancer Chemoprevention  awarded by National Cancer Institute/NIH/DHHS
  • Role of Trem1 in Ultraviolet Radiation-Induced Immune Suppression  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Significance of Metabolic Activation of Lumisterol in the Skin  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • UAB Research Center of Excellence in Arsenicals  awarded by National Institute of Environmental Health Sciences/NIH/DHHS
  • Teaching Activities

  • 96-504 - DERMATOLOGY MS3 ELECTIVE (Spring Term 2018) 2018
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2017) 2017
  • 96-504 - DERMATOLOGY MS3 ELECTIVE (Fall Term 2017) 2017
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2017) 2017
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2017) 2017
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2017) 2017
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2017) 2017
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2017) 2017
  • 96-504 - DERMATOLOGY MS3 ELECTIVE (Spring Term 2017) 2017
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Spring Term 2017) 2017
  • 16-506 - UAB DERMATOLOGY EXPERIENCE (Spring Term 2017) 2017
  • 16-506 - UAB DERMATOLOGY EXPERIENCE (Spring Term 2017) 2017
  • 16-506 - UAB DERMATOLOGY EXPERIENCE (Spring Term 2017) 2017
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Spring Term 2017) 2017
  • 96-504 - DERMATOLOGY MS3 ELECTIVE (Spring Term 2017) 2017
  • 16-506 - UAB DERMATOLOGY EXPERIENCE (Spring Term 2017) 2017
  • 16-502 - DERMATOLOGY RESEARCH (Spring Term 2017) 2017
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2016) 2016
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2016) 2016
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2016) 2016
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2016) 2016
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2016) 2016
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2016) 2016
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Fall Term 2016) 2016
  • 16-501 - DERMATOLOGY ACTING INTERNSHIP (Spring Term 2016) 2016
  • 96-504 - DERMATOLOGY MS3 ELECTIVE (Spring Term 2016) 2016
  • 96-504 - DERMATOLOGY MS3 ELECTIVE (Fall Term 2015) 2015
  • 16-509 - VISITING ELECTIVE IN CANCER DERMATOLOGY (Spring Term 2012) 2012
  • 10-999D - SCHOLARS' WEEK EXPERIENCE IN DERMATOLOGY (Fall Term 2009) 2009
  • Education And Training

  • University of Kansas Medical Center, Internship
  • University of Iowa Hospitals and Clinics, Residency
  • University of Kansas Medical Center, Residency
  • University of Texas Southwestern Medical Center, Postdoctoral Fellowship
  • Doctor of Medicine, University of Iowa 1975
  • Bachelor of Science or Mathematics in Natural Sciences, University of Iowa 1971
  • Full Name

  • Craig Elmets