David Bedwell, Professor and Chairman of the Department of Biochemistry and Molecular Genetics, completed his undergraduate studies in Microbiology at Purdue University (B.S. with Honors, 1979). His graduate work in Molecular Biology was done with Dr. Masayasu Nomura at the University of Wisconsin-Madison, (Ph.D., 1985). He then carried out a postdoctoral fellowship in Dr. Scott Emr's laboratory at Caltech. Dr. Bedwell joined the faculty at UAB in 1988. At the national level, he is in a second 5...
I am generally interested in discovering and characterizing mechanisms by which cells control gene expression. Much of my career has focused on the regulation of ribosomal RNA synthesis, using an array of biochemical, genetic, and genomic approaches. As an independent academic investigator, I am privileged to be involved in the act of discovery every day. In addition, I take my roles as mentor and educator equally serious. Our goal is to create an environment where we can aggressively ask and an...
David Bedwell, Professor and Chairman of the Department of Biochemistry and Molecular Genetics, completed his undergraduate studies in Microbiology at Purdue University (B.S. with Honors, 1979). His graduate work in Molecular Biology was done with Dr. Masayasu Nomura at the University of Wisconsin-Madison, (Ph.D., 1985). He then carried out a postdoctoral fellowship in Dr. Scott Emr's laboratory at Caltech. Dr. Bedwell joined the faculty at UAB in 1988. At the national level, he is in a second 5...
I am generally interested in discovering and characterizing mechanisms by which cells control gene expression. Much of my career has focused on the regulation of ribosomal RNA synthesis, using an array of biochemical, genetic, and genomic approaches. As an independent academic investigator, I am privileged to be involved in the act of discovery every day. In addition, I take my roles as mentor and educator equally serious. Our goal is to create an environment where we can aggressively ask and an...
I was raised in a small town in northeast Ohio. My parents were either first or second generation Italian-Americans. We had an extended family where my aunts and uncles were like parents, and my cousins were my sisters and brothers. Our motto was family, food, and fun. My parents were never formally educated but they valued it greatly. They instilled a sense of hard work that only a middleclass immigrant family can, while we played and watched sports. My brothers and I worked hard and when we we...
Our goal is using cryo-EM to understand and design large assemblies.
Large protein assemblies in nature are universal and essential. They represent a unique gold mine to identify functional modules that display seemingly simple molecular architectures analogous to each LEGO piece; when assembled, they form remarkably complex structures. Our research program aims to discover and understand the biochemical principle behind those nature’s LEGO, especially microbial appendages involved in p...
Dr. Kejin Hu received his PhD degree in molecular biology in 2003 from the University of Hong Kong. Before that, he conducted his master research program in fungal biochemistry at the Hong Kong Polytechnic University. He then conducted his first postdoctoral research in muscle development in C elegant at Cornell University. His second postdoctoral research is Tor signaling in budding yeast at the University of Pittsburgh. He received extensive training in human embryonic stem cell biology and p...
Dr. Rama Krishna is a Professor Emeritus in the Department of Biochemistry and Molecular Genetics. He received his Ph.D. from the Indian Institute of Technology-Kanpur in India. He served as the Director of the NMR Core Facility of the UAB Cancer Center for 32 years (1984 - 2016) and as the first Director of the Central Alabama High-Field NMR Facility at UAB that he established with a state-of-the-art 850 MHz Bruker Biospin NMR system as its center piece. He held joint appointments in the Compre...
Cancer is complex disease, which involve alternation of multiple genetic and epigenetic factors and pathways in normal cells for them to become cancerous. Because of its complex nature and the ability of cancer cells to evolve rapidly undertreatment, cancer treatment with durable outcome is a challenging problem. Therefore, in-depth molecular understanding of cancer initiation and progression is necessary for developing effective therapies. In-order to identify and characterize critical cancer v...
Rui Zhao is an Associate Professor of Biochemistry and Molecular Genetics. Dr. Zhao received his B.S. degree from Peking University in China (1998) and Ph.D. degree from the University of Iowa (2004). He received his postdoctoral training at Children’s Hospital Boston and Harvard Medical School, and joined the UAB faculty in 2012.
My research goal is to better understand the biochemical mechanisms that facilitate chemoresistance and employ NMR spectroscopy and synthetic peptides to identify novel therapeutic targets to suppress chemoresistance. To this end, my research focuses on two primary avenues: 1) Characterization of rBH3 motif mediated regulation of anti-apoptotic Bcl-2 family members; 2) Development of targeted inhibitors of the SUMOylation E2 enzyme, Ubc9. We also employ our expertise in peptide synthesis and ass...
Dr Edwards holds a PhD and an MS in Bioinformatics from Birkbeck College, University of London, United Kingdom and a BS in Biochemistry and Pharmacology from Kings College, University of London, United Kingdom.
Dr Edwards has over 20 years of leadership experience in Bioinformatics research and development environments in world class organizations such as the National Institutes of Health, National Cancer Institute, Bethesda, Maryland. Dr Edwards has expertise in the application of next...
Dr. Anupam Agarwal is Senior Vice President for Medicine and Dean, Heersink School of Medicine at the University of Alabama at Birmingham (UAB). He served as Executive Vice Dean for the Heeersink School of Medicine (2014-2022) and served as the Director for the Division of Nephrology from Jan 1, 2008 to Sept 30, 2021. He also serves as the Program Director of the NIH/NIDDK funded O’Brien Center for Acute Kidney Injury Research. He has graduate faculty status in the Departments of Biochemistry an...
Over the last 25 years at UAB, I have dedicated a significant effort toward project leadership and mentoring. I have served as the Ph.D. thesis mentor for 14 graduate students in my own laboratory and have served on 71 other graduate student Ph.D. thesis committees. I have been the K-award mentor of two fellows and have trained other hematology/oncology fellows (2) and postdocs (7), the vast majority of whom continue to work in science-related careers. I have also served as the Co-Director of th...
Dr. Debasish Chattopadhyay received his BS in Chemistry and MS in Biochemistry from Calcutta University, India. He obtained Ph.D. degree in Chemistry from Jadavpur University, India in 1989. He conducted his postdoctoral research at the Upjohn Company in Michigan. This work was part of an NIH funded collaborative effort involving several academic institutions and pharmaceutical industries for the discovery of potent antiretroviral drugs. Dr. Chattopadhyay's work focussed on the structure-functio...
Introduction:
A graduate of Boston University in Boston, Massachusetts, Dr. Davis completed medical school at the University of Alabama School of Medicine (UASOM), where he also served his internship, residency, and the ABIM academic subspecialty research fellowship clinical investigator pathway in Hematology/Oncology. He is Professor of Medicine, Microbiology, and Biochemistry and Molecular Genetics in the division of Hematology/Oncology. He is board certified in Hematology.
R...
Scott M Wilson PhD
Associated Professor
Department of Neurobiology
Dr. Chen is a neuroscientist whose research is focused on neurodegenerative diseases including prion disease, Alzheimer's disease, Lewy body dementia, and Parkinson's disease. He received his Ph.D. in biochemical pharmacology from the State University of New York at Buffalo in 1993. Before coming to UAB in 2021, he was a Professor of Pathology at the Case Western Reserve University School of Medicine.
Dr. Chen's laboratory investigates pathogenic mechanisms underlying neurodegenerative ...
Dr. Barnes was trained in Chemistry and Biochemistry in the UK. He joined UAB in 1977 and pursued research on bile acids and latterly polyphenols, particularly soy isoflavones. He was promoted to Associate Professor (with tenure) in 1985 and Full Professor in 1994. He has received NIH support from several areas to pursue the conjugation of bile acids, the chemistry, biochemistry and physiology of polyphenols, the underlying chemistry of lens cataracts and the use of omics approaches in biomedica...
