Carmel McNicholas-Bevensee

Carmel McNicholas-Bevensee
Associate Professor

Scholar (C), Interprof Sim for Innov Clinical Practice , Office of the Provost
Associate Scientist (C), Cystic Fibrosis Research Center , School of Medicine
Associate Professor (S), Dept of Medical Education , School of Medicine
Scholar (C), Center for Clinical and Translational Science (CCTS) , General Clinical Research Center
Associate Professor (S), Biomedical & Health Sciences MS Program , Cytotechnology Program
Associate Professor (P), Cell, Developmental and Integrative Biology (CDIB) , Academic Joint Departments

Selected Publications

Academic Article

Year	Title	Altmetric
2021	Admissions Is Not Enough: The Racial Achievement Gap in Medical Education. Academic Medicine. 96:176-181. 2021
2019	Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung. Cell. 176:113-126.e15. 2019
2019	Proline-glycine-proline peptides are critical in the development of smoke-induced emphysema. American Journal of Respiratory Cell and Molecular Biology. 61:560-566. 2019
2017	Beyond cystic fibrosis transmembrane conductance regulator (CFTR) single channel kinetics: implications for therapeutic intervention 2017
2017	The cystic fibrosis transmembrane conductance regulator potentiator ivacaftor augments mucociliary clearance abrogating cystic fibrosis transmembrane conductance regulator inhibition by cigarette smoke. American Journal of Respiratory Cell and Molecular Biology. 56:99-108. 2017
2016	Analysis of cystic fibrosis–associated P67L CFTR illustrates barriers to personalized therapeutics for orphan diseases. JCI Insight. 1. 2016
2016	Expression and purification of the alpha subunit of the epithelial sodium channel, ENaC. Protein Expression and Purification. 117:67-75. 2016
2015	Physical and functional interactions between a glioma cation channel and Integrin-β1 require α-actinin 2015
2014	Sinupret activates CFTR and TMEM16A-dependent transepithelial chloride transport and improves indicators of mucociliary clearance. PLoS One. 9. 2014
2014	An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine. 190:51-61. 2014
2014	Erratum: Resveratrol Enhances Airway Surface Liquid Depth in Sinonasal Epithelium by Increasing Cystic Fibrosis Transmembrane Conductance Regulator Open Probability (PLoS ONE (2014) 9:1 (DOI:10.1371/annotation/d852ff1d-2824- 4f4d-80f2-9be7a42a5f25)). PLoS One. 9. 2014
2014	Cystic fibrosis transmembrane conductance regulator activation by roflumilast contributes to therapeutic benefit in chronic bronchitis. American Journal of Respiratory Cell and Molecular Biology. 50:549-558. 2014
2013	Cigarette smoke induces systemic defects in cystic fibrosis transmembrane conductance regulator function. American Journal of Respiratory and Critical Care Medicine. 188:1321-1330. 2013
2013	Resveratrol enhances airway surface liquid depth in sinonasal epithelium by increasing cystic fibrosis transmembrane conductance regulator open probability. PLoS One. 8. 2013
2013	IL-8 inhibits cAMP-stimulated alveolar epithelial fluid transport via a GRK2/PI3K-dependent mechanism 2013
2012	Glioma-specific cation conductance regulates migration and cell cycle progression. Journal of Biological Chemistry. 287:4053-4065. 2012
2011	Interaction of ASIC1 and ENaC subunits in human glioma cells and rat astrocytes 2011
2009	Mammalian target of rapamycin: Mastor mediator of cellular changes in pathological states?. Hypertension. 54:1221-1222. 2009
2009	Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulates the electrogenic Na/HCO3 cotransporter NBCe1-A expressed in Xenopusoocytes 2009
2006	Activation of gadolinium-sensitive ion channels in cardiomyocytes in early adaptive stages of volume overload-induced heart failure. Cardioscience. 72:262-270. 2006
2006	Electrogenic Na/HCO³ cotransporter (NBCe1) variants expressed in Xenopus oocytes: Functional comparison and roles of the amino and carboxy termini. Journal of General Physiology. 127:639-658. 2006
2006	Reactive species mediate inhibition of alveolar type II sodium transport during mycoplasma infection. American Journal of Respiratory and Critical Care Medicine. 173:334-344. 2006
2004	Regulation of amiloride-sensitive Na⁺ transport by basal nitric oxide. American Journal of Respiratory Cell and Molecular Biology. 30:720-728. 2004
2002	Ablation of internalization signals in the carboxyl-terminal tail of the cystic fibrosis transmembrane conductance regulator enhances cell surface expression. Journal of Biological Chemistry. 277:49952-49957. 2002
1998	pH-dependent modulation of the cloned renal K+ channel, ROMK.. American Journal of Physiology. 275:F972-F981. 1998
1998	Partially active channels produced by PKA site mutation of the cloned renal K⁺ channel, ROMK2 (kir1.2). American Journal of Physiology. 275. 1998
1998	pH-dependent modulation of the cloned renal K⁺ channel, ROMK 1998
1997	Diversity of channels generated by different combination of epithelial sodium channel subunits. Journal of General Physiology. 109:681-692. 1997
1997	A functional CFTR-NBF1 is required for ROMK2-CFTR interaction. American Journal of Physiology. 273. 1997
1996	Sensitivity of a renal K⁺ channel (ROMK2) to the inhibitory sulfonylurea compound glibenclamide is enhanced by coexpression with the ATP-binding cassette transporter cystic fibrosis transmembrane regulator 1996
1996	Molecular site for nucleotide binding on an ATP-sensitive renal K+ channel (ROMK2). American Journal of Physiology. 271. 1996
1995	Primary structure and functional expression of a cGMP-gated potassium channel 1995
1995	Role of Ca2+/CaMK II in Ca(2+)-induced K+ channel inhibition in rat CCD principal cell.. American Journal of Physiology. 268:F211-F219. 1995
1995	Regulation of ATP-sensitive K⁺ channel by membrane-bound protein phosphatases in rat principal tubule cell. American Journal of Physiology. 269. 1995
1995	Role of Ca²⁺/CaMK II in Ca²⁺-induced K⁺ channel inhibition in rat CCD principal cell 1995
1994	Na-K-Cl cotransport in villus and crypt cells from rat duodenum 1994
1994	Na-K-Cl cotransport in villus and crypt cells from rat duodenum.. American Journal of Physiology. 267:G1004-G1011. 1994
1994	Regulation of ROMK1 K⁺ channel activity involves phosphorylation processes 1994
1994	Properties and regulation of basolateral K+ channels in rat duodenal crypts. 1994
1994	A novel approach allows identification of K channels in the lateral membrane of rat CCD.. American Journal of Physiology. 266:F813-F822. 1994
1994	A novel approach allows identification of K channels in the lateral membrane of rat CCD. American Journal of Physiology. 266. 1994
1994	A novel approach allows identification of K channels in the lateral membrane of rat CCD 1994
1994	Aldosterone-induced apical Na+ and K+ conductances are located predominantly in surface cells in rat distal colon. American Journal of Physiology. 266. 1994
1994	Aldosterone-induced apical Na⁺ and K⁺ conductances are located predominantly in surface cells in rat distal colon. American Journal of Physiology. 266. 1994
1994	Na-K-Cl cotransport in villus and crypt cells from rat duodenum 1994
1994	Potassium channels in colonic crypts 1994
1992	A Cl‐ conductance sensitive to external pH in the apical membrane of rat duodenal enterocytes. 1992
1990	Lithium clearance in healthy humans: effects of sodium intake and diuretics. Kidney international. Supplement. 28:s36-s38. 1990

Research Overview

My research primarily focuses on the biology of human sweat gland cells with an emphasis on development of methods of cell culture, electrophysiological characterization of cultured cells, and the regulation and pharmacological modulation of CFTR expressed in these cells. Another area of interest is the impact of inflammation and tissue remodeling on ion channel function in airway cells. Studies include examining the effect on cellular electrophysiological changes following release of inflammatory mediators. Recent studies examine the potential role of extracellular vesicles in transferring CFTR protein and mRNA to epithelial cells.