• The research in the Ren Laboratory seeks to determine critical molecular signaling pathways in the transdifferentiation of vascular endothelial cells, angiogenesis (the formation of new blood vessels from preexisting blood vessels), and arteriogenesis (de novo formation of small arteries), and to develop molecular strategies for stimulating or inhibiting the growth of these vessels. The current research focuses on how extracellular signaling couples epigenetic and transcriptional regulation of functional angiogenesis to control the development of peripheral and cerebral vessels in heart and vascular disease, cancer, obesity, neurological disorders and the cardiovascular complications of diabetes. Elucidating the cellular and molecular mechanisms of endothelial cell differentiation and functional angiogenesis will aid in our understanding of the pathobiology of these conditions and in the discovery of innovative and effective therapeutic strategies to promote public health.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 Development of an arteriolar niche and self-renewal of breast cancer stem cells by lysophosphatidic acid/protein kinase D signalingCommunications Biology.  4. 2021
    2021 Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolismAlcohol.  92:41-52. 2021
    2021 Gamma Secretase Inhibitors in Cancer: A Current Perspective on Clinical Performance 2021
    2021 Notch Signaling in Vascular Endothelial Cells, Angiogenesis, and Tumor Progression: An Update and ProspectiveFrontiers in Cell and Developmental Biology.  9. 2021
    2021 RRY Inhibits Amyloid-β1-42 Peptide Aggregation and Neurotoxicity 2021
    2020 cis-4-[18F]fluoro-L-proline Molecular Imaging Experimental Liver FibrosisFrontiers in Molecular Biosciences.  7. 2020
    2019 Heterogeneity of vascular endothelial cells, de novo arteriogenesis and therapeutic implications in pancreatic neuroendocrine tumorsJournal of Clinical Medicine.  8. 2019
    2019 Translating Ribosome Affinity Purification (TRAP) for RNA Isolation from Endothelial Cells In VivoJournal of Visualized Experiments.  2019. 2019
    2019 Liver Fibrosis Conventional and Molecular Imaging Diagnosis Update.Journal of liver.  8. 2019
    2019 Regulation of ezrin tension by s-nitrosylation mediates non-small cell lung cancer invasion and metastasisTheranostics.  9:2555-2571. 2019
    2018 VEGF/PKD-1 signaling mediates arteriogenic gene expression and angiogenic responses in reversible human microvascular endothelial cells with extended lifespan 2018
    2018 FoxO1 transcriptional activities in VEGF expression and beyond: a key regulator in functional angiogenesis? 2018
    2018 Decreased Taurine and Creatine in the Thalamus May Relate to Behavioral Impairments in Ethanol-Fed Mice: A Pilot Study of Proton Magnetic Resonance Spectroscopy.Molecular Imaging.  17:1536012117749051. 2018
    2018 Quantification of Hepatic Lipid Using 7.0T Proton Magnetic Resonance Spectroscopy and Computed Tomography in Mild Alcoholic Steatotic Mice.Journal of liver.  7. 2018

    Research Overview

  • 1. Molecular signaling in epigenetic and transcriptional regulation of endothelial cell differentiation and angiogenesis (growth of new functional blood vessels).
    2. Arteriolar differentiation and arteriogenesis in ischemic heart and vascular diseases and stemness of cancer stem cells.
  • Full Name

  • Bin Ren