Positions

Overview

  • My research interests have always been centered on glioblastoma (GBM) tumors, a particularly devastating brain tumor. My current research interests are centered around discovering new therapies for patients with GBM, which include pharmacological inhibition of the JAK/STAT pathway in patient-derived xenograft models, exploiting inflammatory (anti-tumor) macrophages to enhance standard of care in immunocompetent models, and understanding how the gut microbiome is altered by the diet as well as by certain drug therapies in mouse models of glioma.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Hedgehog blockade remodels the gut microbiota and the intestinal effector CD8+ T cells in a mouse model of mammary carcinoma.Laboratory Investigation.  102:1236-1244. 2022
    2022 Hedgehog blockade remodels the gut microbiota and the intestinal effector CD8+ T cells in a mouse model of mammary carcinomaLaboratory Investigation.  102:1236-1244. 2022
    2022 Glioma and the gut-brain axis: opportunities and future perspectivesNOA.  4. 2022
    2021 Changes in the gut microbiome community of nonhuman primates following radiation injuryBMC Microbiology.  21. 2021
    2021 IMMU-09. HUMAN MICROBIOTA INFLUENCE THE EFFICACY OF IMMUNOTHERAPY IN A MOUSE MODEL OF GLIOBLASTOMANeuro-Oncology.  23:vi93-vi94. 2021
    2021 Human gut microbial communities dictate efficacy of anti-PD-1 therapy in a humanized microbiome mouse model of gliomaNOA.  3. 2021
    2020 TMOD-19. INDIVIDUAL SPECIFIC HUMAN GUT MICROBE COMMUNITIES INFLUENCE RESPONSE TO IMMUNOTHERAPY IN A HUMANIZED MICROBIOME MOUSE MODEL OF GLIOMANeuro-Oncology.  22:ii232-ii232. 2020
    2020 An individualized mosaic of maternal microbial strains is transmitted to the infant gut microbial communityRoyal Society Open Science.  7. 2020
    2019 TMOD-19. ELUCIDATING THE RESISTANCE TO IMMUNOTHERAPY IN BRAIN TUMORS USING A HUMANIZED MICROBIOME MOUSE MODELNeuro-Oncology.  21:vi266-vi266. 2019
    2019 Reactive astrocytes foster brain metastases via STAT3 signaling.Annals of translational medicine.  7:S83. 2019
    2018 TMOD-27. HUMANIZED MICROBIOME MOUSE MODELS TO ENHANCE IMMUNOTHERAPY IN GLIOBLASTOMANeuro-Oncology.  20:vi274-vi274. 2018
    2017 EXTH-30. THERAPEUTIC BENEFIT OF A KETOGENIC DIET THROUGH ALTERED GUT MICROBIOTA IN A MOUSE MODEL OF GLIOMANeuro-Oncology.  19:vi78-vi78. 2017
    2017 Protein kinase CK2 is important for the function of glioblastoma brain tumor initiating cellsJournal of Neuro-Oncology.  132:219-229. 2017
    2016 Attenuation of PKR-like ER Kinase (PERK) signaling selectively controls endoplasmic reticulum stress-induced inflammation without compromising immunological responsesJournal of Biological Chemistry.  291:15830-15840. 2016
    2016 Abstract 3861: Ruxolitinib inhibits STAT-3 activation in glioblastomaCancer Research.  76:3861-3861. 2016
    2016 Loss of SOCS3 in myeloid cells prolongs survival in a syngeneic model of gliomaOncotarget.  7:20621-20635. 2016
    2015 TMIC-17LOSS OF SOCS3 IN MYELOID CELLS PROMOTES A DECREASED M2 MACROPHAGE PHENOTYPE AND AN INCREASED CYTOTOXIC T-CELL RESPONSE IN A SYNGENEIC MODEL OF GLIOMANeuro-Oncology.  17:v218-v218. 2015
    2015 SOCS3 deficiency in myeloid cells promotes tumor development: Involvement of STAT3 activation and myeloid-derived suppressor cellsCancer Immunology Research.  3:727-740. 2015
    2015 Loss of tumor suppressive microRNA-31 enhances TRADD/NF-κB signaling in glioblastomaOncotarget.  6:17805-17816. 2015
    2014 ME-13LOSS OF SOCS3 IN MYELOID CELLS DELAYS TUMOR GROWTH AND PROLONGS SURVIVAL IN A SYNGENEIC MODEL OF GLIOBLASTOMANeuro-Oncology.  16:v122-v122. 2014
    2014 NF-κB and STAT3 in glioblastoma: Therapeutic targets coming of age 2014
    2014 Involvement of the Janus kinase/signal transducer and activator of transcription signaling pathway in multiple sclerosis and the animal model of experimental autoimmune encephalomyelitisJournal of Interferon and Cytokine Research.  34:577-588. 2014
    2014 Therapeutic CK2 inhibition attenuates diverse prosurvival signaling cascades and decreases cell viability in human breas cancer cellsOncotarget.  5:6484-6496. 2014
    2014 Therapeutic efficacy of suppressing the JAK/STAT pathway in multiple models of experimental autoimmune encephalomyelitisJournal of Immunology.  192:59-72. 2014
    2013 Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastomaClinical Cancer Research.  19:6484-6494. 2013
    2013 NF-κB-induced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastomaPLoS One.  8. 2013
    2013 The role of Rac proteins in glioblastoma stem cells.Journal of Clinical Oncology.  31:e13011-e13011. 2013
    2013 Activation of the NF-κB pathway by the STAT3 inhibitor JSI-124 in human glioblastoma cellsMolecular Cancer Research.  11:494-505. 2013
    2011 Therapeutic potential of AZD1480 for the treatment of human glioblastomaMolecular Cancer Therapeutics.  10:2384-2393. 2011
    2011 CS10-4. Function of SOCS3 on Macrophage Polarization and InflammationCytokine.  56:58. 2011
    2009 Plasminogen kringle 5 induces apoptosis of brain microvessel endothelial cells: Sensitization by radiation and requirement for GRP78 and LRP1Cancer Research.  69:5537-5545. 2009
    2008 New molecular targets in angiogenic vessels of glioblastoma tumoursExpert Reviews in Molecular Medicine.  10. 2008
    2007 Erratum: HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cells (Oncogene (2006) 25, (1721-1732) DOI: 10.1038/sj.onc.1209199)Oncogene.  26:7282. 2007
    2006 New concepts regarding focal adhesion kinase promotion of cell migration and proliferationJournal of Cellular Biochemistry.  99:35-52. 2006
    2006 HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cellsOncogene.  25:1721-1732. 2006

    Chapter

    Year Title Altmetric
    2015 Protein kinase CK2 and dysregulated oncogenic inflammatory signaling pathways.  259-280. 2015

    Teaching Activities

  • CNBY210 - Colloquium in Cancer Biology (Fall Term 2021)
  • CNBY210 - Colloquium in Cancer Biology (Fall Term 2022)
  • CNBY210 - Colloquium in Cancer Biology (Spring Term 2021)
  • CNBY210 - Colloquium in Cancer Biology (Spring Term 2022)
  • CNBY210 - Colloquium in Cancer Biology (Spring Term 2023)
  • CNBY320 - Introduction to Cancer Biology (Spring Term 2021)
  • CNBY320 - Introduction to Cancer Biology (Spring Term 2022)
  • CNBY320 - Introduction to Cancer Biology (Spring Term 2023)
  • CNBY420 - Genetic Basis of Cancer (Fall Term 2021)
  • CNBY420 - Genetic Basis of Cancer (Fall Term 2022)
  • CNBY430 - Tumor Microenvironment (Fall Term 2021)
  • CNBY460 - Tumor Pathobiology&Immunology (Spring Term 2023)
  • CNBY480 - Journal Club in Cancer Biology (Fall Term 2021)
  • CNBY480 - Journal Club in Cancer Biology (Fall Term 2022)
  • CNBY480 - Journal Club in Cancer Biology (Spring Term 2022)
  • CNBY480 - Journal Club in Cancer Biology (Spring Term 2023)
  • CNBY495 - Undergraduate Research (Fall Term 2021)
  • CNBY495 - Undergraduate Research (Fall Term 2022)
  • CNBY495 - Undergraduate Research (Spring Term 2021)
  • CNBY495 - Undergraduate Research (Spring Term 2022)
  • CNBY495 - Undergraduate Research (Spring Term 2023)
  • CNBY495 - Undergraduate Research (Summer Term 2021)
  • CNBY495 - Undergraduate Research (Summer Term 2022)
  • CNBY499 - Senior Capstone Course (Fall Term 2022)
  • CNBY499 - Senior Capstone Course (Spring Term 2022)
  • CNBY499 - Senior Capstone Course (Spring Term 2023)
  • CNBY499 - Senior Capstone Course (Summer Term 2022)
  • CNBY620 - The Cancer Genome (Fall Term 2022)
  • CNBY660 - Cancer Immuno-histopath (Spring Term 2023)
  • Education And Training

  • University of Alabama at Birmingham Cell, Developmental and Integrative Biology, Postdoctoral Fellowship
  • Doctor of Philosophy in Neurobiology and Neurosciences, University of Alabama at Birmingham 2009
  • Bachelor of Science or Mathematics in Biomedical Sciences, University of South Alabama 2004
  • Full Name

  • Braden McFarland