Positions

Overview

  • As an Instructor of the Division of Clinical Immunology and Rheumatology, Dr. Aaron Silva-Sanchez focuses his research on understanding the origin and function of neonatal regulatory dendritic cells (mregDCs) and their role in controlling CD8 T cell responses.

    Dr. Silva-Sanchez graduated with a Ph.D. in Immunology from the National School of Biomedical Sciences in Mexico City. He joined UAB as a postdoctoral fellow in 2011 to work with Dr. Harry Schroeder on the study of mice with altered B cell receptor repertoire and the production of anti-DNA antibodies.

    In 2013, Dr. Silva-Sanchez joined the laboratory of Troy Randall where he researched the development and immunological impact of the inducible Bronchus-Associated Lymphoid Tissue (iBALT), a type of tertiary lymphoid structures in the lung. During this period, Dr. Silva-Sanchez also studied the pulmonary immune system of neonate mice in order to understand the immunological mechanisms responsible for increased susceptibility to viral infections during early life.

    During the Covid-19 pandemic, Dr. Silva-Sanchez formed part of the task force in charge of developing the preclinical trials for an intranasal vaccine against SARS-CoV-2 in collaboration with Dr. Frances Lund, Southeastern Biosafety Laboratory Alabama Birmingham (SEBLAB), and Altimmune, Inc.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Circulating Tregs Accumulate in Omental Tumors and Acquire Adipose-Resident Features.  Cancer Immunology Research.  10:641-655. 2022
    2022 A single intranasal administration of AdCOVID protects against SARS-CoV-2 infection in the upper and lower respiratory tracts.  Human Vaccines and Immunotherapeutics.  18. 2022
    2021 Distinct innate immune responses between sublethal and lethal models of disseminated candidiasis in newborn BALB/c mice.  Microbial Pathogenesis.  158. 2021
    2021 Intestinal cDC1 drive cross-tolerance to epithelial-derived antigen via induction of FoxP3+CD8+ Tregs.  Science Immunology.  6. 2021
    2021 Specialized immune responses in the peritoneal cavity and omentum.  Journal of Leukocyte Biology.  109:717-729. 2021
    2020 Inducible Bronchus–Associated Lymphoid Tissue (iBALT) Attenuates Pulmonary Pathology in a Mouse Model of Allergic Airway Disease.  Frontiers in Immunology.  11. 2020
    2020 Role of iBALT in Respiratory Immunity.  Current Topics in Microbiology and Immunology.  426:21-43. 2020
    2019 Defining Genetic Variation in Widely Used Congenic and Backcrossed Mouse Models Reveals Varied Regulation of Genes Important for Immune Responses.  Immunity.  51:155-168.e5. 2019
    2018 Tertiary Lymphoid Structures Among the World of Noncanonical Ectopic Lymphoid Organizations.  Methods in Molecular Biology.  1845:1-15. 2018
    2017 Immunization of newborn mice accelerates the architectural maturation of lymph nodes, but AID-dependent IgG responses are still delayed compared to the adult.  Frontiers in Immunology.  8. 2017
    2017 Fugue G Minor: Getting the Lymph Node Ensemble Together with Circadian Rhythm.  Immunity.  46:6-8. 2017
    2016 Inducible bronchus-associated lymphoid tissue: Taming inflammation in the lung.  Frontiers in Immunology.  7. 2016
    2016 HIV-1 gp140 epitope recognition is influenced by immunoglobulin DH gene segment sequence.  Immunogenetics.  68:145-155. 2016
    2015 Violation of an evolutionarily conserved immunoglobulin diversity gene sequence preference promotes production of dsDNA-specific IgG antibodies.  PLoS One.  10. 2015
    2015 ESAT-6 Targeting to DEC205+ Antigen Presenting Cells Induces Specific-T Cell Responses against ESAT-6 and Reduces Pulmonary Infection with Virulent Mycobacterium tuberculosis..  PLoS One.  10:e0124828. 2015
    2012 Reduced in vivo cytotoxicity and increased Mycobacterial burden are associated with virulent Mycobacterium tuberculosis strains during lung infection. 2012
    2010 T-cell responses and in vivo cytotoxicity in the target organ and the regional lymphoid tissue during airborne infection with the virulent Mycobacterium tuberculosis MT103 and its lipid mutant fadD26..  Scandinavian Journal of Immunology.  71:20-28. 2010
    2009 Epidermal Langerhans cells in Actinic Prurigo: a comparison between lesional and non-lesional skin..  Journal of the European Academy of Dermatology and Venereology.  23:438-440. 2009
    2008 Characterization of langerhans cells in epidermal sheets along the body of Armadillo (Dasypus novemcinctus)..  Veterinary Immunology and Immunopathology.  124:220-229. 2008
    2008 Probiotics and autoimmunity: an evolutionary perspective..  Medical Hypotheses.  70:657-660. 2008

    Chapter

    Year Title Altmetric
    2019 Anatomical uniqueness of the mucosal immune system (GALT, NALT, iBALT) for the induction and regulation of mucosal immunity and tolerance.  21-54. 2019
    2012 Human cutaneous tuberculosis and skin dendritic cells.  89-104. 2012

    Research Overview

  • Lung Immunology
    Dendritic cells
    Neonatal Immune system
    Infectious diseases

    • Investigator On

    Education And Training

  • Doctorate Level Degree in Immunology, National Polytechnic Institute 2010
  • Master of Science in Immunology, National Polytechnic Institute 2006

    • Full Name

  • Aaron Silva Sanchez