Positions

Overview

  • Introduction:

    I am currently associate professor and associate scientist at the University of Alabama at Birmingham Comprehensive Cancer Center (UABCCC). I am board certified in Internal Medicine, Hematology and Oncology.

    Clinical Interests:

    My focus of interest is LYMPHOMA (Hodgkin lymphoma, Non Hodgkin lymphoma-T cell and B cell lymphomas). I specialize in treatments all types of lymphoma in my clinic.

    Research:

    I am also involved in lymphoma related research, which includes genomic and proteomic (gene and protein related) studies in various kinds of lymphomas. As a clinical investigator I am also part of many clinical trials as principal investigator or sub investigator particularly in lymphomas. Many new promising targeted and immunologic treatments for lymphomas are being developed at UABCCC, which patients of lymphoma can benefit. My passion is to develop targeted and immunologic therapies in lymphomas with less toxicities and more effectiveness.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Patterns of Utilization and Outcomes of Autologous Stem Cell Transplantation and Chimeric Antigen Receptor T-Cell Therapy in Relapsed or Refractory Diffuse Large B-cell Lymphomas with MYC and BCL2 and/or BCL6 RearrangementsClinical Lymphoma, Myeloma and Leukemia.  22:825-834. 2022
    2022 High-dose methotrexate and rituximab induction regimen in immunocompetent patients with primary CNS lymphoma: a retrospective single-center study of survival predictorsJournal of Neuro-Oncology.  158:33-40. 2022
    2022 Transcriptional determinants of cancer immunotherapy response and resistanceTrends in Cancer.  8:404-415. 2022
    2021 Healthcare utilization and spending among older patients diagnosed with Non-Hodgkin lymphomaJournal of Geriatric Oncology.  12:1225-1232. 2021
    2021 Obinutuzumab-atezolizumab-lenalidomide for the treatment of patients with relapsed/refractory follicular lymphoma: final analysis of a Phase Ib/II trialBlood Cancer Journal.  11. 2021
    2021 Co-Occurrence of Familial Hemophagocytic Lymphohistiocytosis Type 2 and Chronic Active Epstein-Barr Virus in AdulthoodAmerican Journal of the Medical Sciences.  361:388-393. 2021
    2021 Cerebral invasive aspergillosis in a case of chronic lymphocytic leukemia with bruton tyrosine kinase inhibitor 2021
    2021 Phase 2 study of parsaclisib (INCB050465), a highly selective, next-generation PI3Kδ inhibitor, in relapsed or refractory diffuse large B-cell lymphoma (CITADEL-202) 2021
    2020 A phase 1b study of AFM13 in combination with pembrolizumab in patients with relapsed or refractory Hodgkin lymphomaBlood.  136:2401-2409. 2020
    2020 Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study 2020
    2020 Primary cutaneous lymphomas, version 2.2020. Featured updates to the NCCN guidelinesJournal of the National Comprehensive Cancer Network : JNCCN.  18:522-536. 2020
    2020 Development of 2 bromodomain and extraterminal inhibitors with distinct pharmacokinetic and pharmacodynamic profiles for the treatment of advanced malignancies a CClinical Cancer Research.  26:1247-1257. 2020
    2020 Outcomes of patients with limited-stage aggressive large B-cell lymphoma with high-risk cytogeneticsBlood Advances.  4:253-262. 2020
    2020 Safety and activity of ibrutinib in combination with durvalumab in patients with relapsed or refractory follicular lymphoma or diffuse large B-cell lymphomaAmerican Journal of Hematology.  95:18-27. 2020
    2019 A review of chimeric antigen receptor T-cells in lymphomaExpert Review of Hematology.  12:551-561. 2019
    2019 Polatuzumab vedotin in combination with immunochemotherapy in patients with previously untreated diffuse large B-cell lymphoma: an open-label, non-randomised, phase 1b–2 study 2019
    2019 The impact of structural factors on diagnostic delay in diffuse large B-cell lymphomaCancer Medicine.  8:1416-1422. 2019
    2019 AIDS-related Kaposi sarcoma, version 2.2019Journal of the National Comprehensive Cancer Network : JNCCN.  17:171-189. 2019
    2019 B-cell lymphomas, version 3.2019: Featured updates to the NCCN GuidelinesJournal of the National Comprehensive Cancer Network : JNCCN.  17:650-661. 2019
    2019 Survival outcomes of younger patients with mantle cell lymphoma treated in the rituximab eraJournal of Clinical Oncology.  37:471-480. 2019
    2018 Primary Bone Marrow Diffuse Large B-cell Lymphoma Presenting as Transverse MyelitisAmerican Journal of the Medical Sciences.  356:561-566. 2018
    2018 Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical modelsNature Communications.  9. 2018
    2018 Congestive heart failure in older adults diagnosed with follicular lymphoma: A population-based studyCancer.  124:4221-4230. 2018
    2018 Gene Expression Profiling of Advanced Penile Squamous Cell Carcinoma Receiving Cisplatin-based Chemotherapy Improves Prognostication and Identifies Potential Therapeutic TargetsEuropean urology focus.  4:733-736. 2018
    2018 Cancer in people living with HIV, version 1.2018: Clinical practice guidelines in oncologyJournal of the National Comprehensive Cancer Network : JNCCN.  16:986-1017. 2018
    2018 Imitating the great imitator: The intersection of sarcoidosis and hodgkin’s lymphoma a report of two cases 2018
    2018 Improving shared decision-making in chronic lymphocytic leukemia through multidisciplinary educationTranslational Behavioral Medicine.  8:175-182. 2018
    2018 T-Cell Lymphomas, Version 2.2018 Featured Updates to the NCCN GuidelinesJournal of the National Comprehensive Cancer Network : JNCCN.  16:123-135. 2018
    2017 C-MYC–positive relapsed and refractory, diffuse large B-cell lymphoma: Impact of additional “hits” and outcomes with subsequent therapyCancer.  123:4411-4418. 2017
    2017 PD-1 blockade for relapsed lymphoma post-allogeneic hematopoietic cell transplant: High response rate but frequent GVHDBlood.  130:221-228. 2017
    2017 Treatment approaches of hard-to-treat non-Hodgkin lymphomasExpert Review of Hematology.  10:259-273. 2017
    2017 Diffuse large B-cell lymphoma with primary treatment failure: Ultra-high risk features and benchmarking for experimental therapiesAmerican Journal of Hematology.  92:161-170. 2017
    2017 Diagnostic, prognostic and therapeutic role of CD30 in lymphomaExpert Review of Hematology.  10:29-37. 2017
    2017 Kinase analysis of penile squamous cell carcinoma on multiple platforms to identify potential therapeutic targetsOncotarget.  8:21710-21718. 2017
    2017 Kinomic profiling identifies focal adhesion kinase 1 as a therapeutic target in advanced clear cell renal cell carcinomaOncotarget.  8:29220-29232. 2017
    2016 Amitkumar Mehta on the Immunomodulating Effects of Targeted Therapy for Multiple MyelomaOncology (Williston Park, N.Y.).  30. 2016
    2016 Amitkumar Mehta on the immunomodulating effects of targeted therapy for multiple myelomaOncology (Williston Park, N.Y.).  30. 2016
    2016 Diffuse Large B-cell lymphoma: Prognostic markers and their impact on therapyExpert Review of Hematology.  9:471-477. 2016
    2016 Treatment of CD30-positive systemic mastocytosis with brentuximab vedotinLeukemia Research.  44:25-31. 2016
    2015 Development and Integration of Antibody–Drug Conjugate in Non-Hodgkin LymphomaCurrent Oncology Reports.  17. 2015
    2015 High throughput kinomic profiling of human clear cell renal cell carcinoma identifies kinase activity dependent molecular subtypesPLoS One.  10. 2015
    2015 Novel agents for the treatment of Hodgkin lymphomaExpert Review of Hematology.  8:659-667. 2015
    2015 Current trends in the treatment of mantle cell lymphoma 2015
    2015 Advanced prostate cancer presenting as bilateral testicular hydroceleIndian Journal of Cancer.  52:264-265. 2015
    2015 Tivozanib: Status of DevelopmentCurrent Oncology Reports.  17:1-7. 2015
    2014 The development and deployment of integrated electronic care records in a regional adult and paediatric cystic fibrosis unitJournal of Cystic Fibrosis.  13:681-686. 2014
    2014 Tivozanib for the treatment of renal cell carcinoma: Results and implications of the TIVO-1 trialFuture Oncology.  10:1819-1826. 2014
    2014 A nomogram including baseline prognostic factors to estimate the activity of second-line therapy for advanced urothelial carcinomaBJU International.  113. 2014
    2014 Disseminated fusariosis during acute myelogenous leukemia induction treatmentBlood.  123:3379. 2014
    2014 How do i recommend extended adjuvant hormonal therapy?Current Treatment Options in Oncology.  15:55-62. 2014
    2014 Prognostic risk stratification derived from individual patient level data for men with advanced penile squamous cell carcinoma receiving first-line systemic therapyUrologic Oncology: seminars and original investigations.  32:501-508. 2014
    2014 Six-month progression-free survival as the primary endpoint to evaluate the activity of new agents as second-line therapy for advanced urothelial carcinomaClinical Genitourinary Cancer.  12:130-137. 2014
    2014 Update in systemic therapy of urologic malignanciesPostgraduate medicine.  126:44-54. 2014
    2013 Heparin induced thrombocytopenia: ReviewExpert Review of Hematology.  6:419-428. 2013
    2013 A cautionary tale for probiotic use in hematopoietic SCT patients-Lactobacillus acidophilus sepsis in a patient with mantle cell lymphoma undergoing hematopoietic SCTBone Marrow Transplantation.  48:461-462. 2013
    2013 Current advances in understanding and managing secondary brain metastasisCNS Oncology.  2:75-85. 2013
    2011 Massive pulmonary embolism and cardio-pulmonary resuscitation leading to disseminated intravascular coagulationAsian Journal of Transfusion Science.  5:188-189. 2011
    2011 An unusual case of squamous cell carcinoma of lung with metastases to the heartIndian Journal of Cancer.  48:266-267. 2011

    Chapter

    Year Title Altmetric
    2015 Mantle cell lymphoma: Current treatment strategies in the era of targeted agents.  35-62. 2015

    Research Overview

  • Clinical:
    My research area involves:

    -Development of newer agents and combination of newer biologic agents in various kinds of lymphomas. I am principal investigator and sub investigator in many Phase I, II or III clinical trials. My passion is to develop biologic therapies with less toxicities and more effectiveness.

    -Survivorship research which involves well being of all lymphoma patients who have been exposed to chemotherapy, radiation therapy or had bone marrow transplant in past.

    -Development of blood test to diagnose and monitor lymphoma during and after treatment. This highly sensitive blood test identifies tumor related genes to monitor lymphoma. This test is still in developmental phase but may eliminate need for biopsies in future.

    Translational:
    -Lymphomas are biologically diverse tumors. Learning about their genetic make up and protein expression help us understand about their biology and develop new targeted and biological treatments. I collaborate with basic scientists and analyze lymphoma biopsies to understand biologic diversity and develop newer therapies.

    UAB Lymphoma program:
    UABCCC lymphoma program is comprehensive program involving specialists (medical oncology, surgical oncology, radiation oncology, Bone marrow transplant, survivorship and integrative medicine) and great nurses.

    Apart from lymphomas, I also see patients with blood cancers (malignant hematology) and blood related disorders (benign hematology).

    You can call my clinic (205-934-5077) or office (205-996-8400) for initial consultation, second opinions or clinical trials.

    Special Interests:

    Lymphoma
    Diffuse large B-cell
    Follicular lymphoma
    Hodgkin Lymphoma
    Mantle Cell Lymphoma
    T-Cell Lymphoma
    Other B-Cell Lymphomas
    Agressive Lymphomas
    Any kind of skin lymphomas (Cutaneous T cell/B cell lymphomas)
    Targeted Therapy
    Clinical Trials
    Disparity Research
  • Principal Investigator On

  • Comprehensive Cancer Center Core Support Grant - Create Access to Targeted Cancer Therapy for Underserved Populations (CATCH-UP)  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Support Grant - CCSG Supplement - Mehta - CATCH UP site Transition to EDDOP  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Support Grant - Clinical Protocol and Data Management  awarded by National Cancer Institute/NIH/DHHS
  • Outcomes of Limited Stage Diffuse Large B-Cell Lymphoma with MYC Rearrangement  awarded by Roswell Park Cancer Institute
  • Private Grant  awarded by MedImmune
  • Private Grant  awarded by F.Hoffmann-La Roche Ltd.
  • Private Grant  awarded by MERCK SHARP & DOHME CORP
  • Private Grant  awarded by PHARMACYCLICS, INC.
  • Private Grant  awarded by BRISTOL MYERS SQUIBB PHARMACEUTICAL COMPANY
  • Private Grant  awarded by Genentech
  • Private Grant  awarded by F.Hoffmann-La Roche Ltd.
  • Private Grant  awarded by Pfizer Inc., U.S. Pharmaceuticals Group
  • Private Grant  awarded by EPIZYME INC.
  • Private Grant  awarded by INCYTE CORPORATION
  • Private Grant  awarded by SEATTLE GENETICS, INC.
  • Private Grant  awarded by CAREVIVE SYSTEMS, INC.
  • Private Grant  awarded by SEATTLE GENETICS, INC.
  • Private Grant  awarded by INCYTE CORPORATION
  • Private Grant  awarded by INCYTE CORPORATION
  • Private Grant  awarded by Genentech
  • Private Grant  awarded by PHARMACYCLICS, INC.
  • Private Grant  awarded by MILLENNIUM PHARMACEUTICALS, INC.
  • Private Grant  awarded by IMMUNOGEN, INC.
  • Private Grant  awarded by RHIZEN PHARMACEUTICALS SA
  • Private Grant  awarded by RHIZEN PHARMACEUTICALS SA
  • Private Grant  awarded by Genentech
  • Private Grant  awarded by Genentech
  • Private Grant  awarded by CAREVIVE SYSTEMS, INC.
  • Private Grant  awarded by FORTY SEVEN, INC.
  • Private Grant  awarded by JUNO THERAPEUTICS
  • Private Grant  awarded by ASTEX PHARMACEUTICALS
  • Private Grant  awarded by MILLENNIUM PHARMACEUTICALS, INC.
  • Private Grant  awarded by INCYTE CORPORATION
  • Private Grant  awarded by Gilead Sciences ^
  • Private Grant  awarded by SEATTLE GENETICS, INC.
  • Private Grant  awarded by SEATTLE GENETICS, INC.
  • Private Grant  awarded by MIRAGEN THERAPEUTICS INC.
  • Private Grant  awarded by F.Hoffmann-La Roche Ltd.
  • Private Grant  awarded by ADC THERAPEUTICS SA
  • Private Grant  awarded by INCYTE CORPORATION
  • Private Grant  awarded by MILLENNIUM PHARMACEUTICALS, INC.
  • Private Grant  awarded by Genentech
  • Private Grant  awarded by KITE PHARMA
  • Private Grant  awarded by CELGENE CORPORATION
  • Private Grant  awarded by INCYTE CORPORATION
  • Private Grant  awarded by TG THERAPEUTICS
  • Private Grant  awarded by JUNO THERAPEUTICS
  • Private Grant  awarded by INNATE PHARMA
  • Private Grant  awarded by ONCOTARTIS, INC.
  • Private Grant  awarded by AFFIMED GMBH
  • Private Grant  awarded by CAREVIVE SYSTEMS, INC.
  • Private Grant  awarded by MILLENNIUM PHARMACEUTICALS, INC.
  • Private Grant  awarded by JUNO THERAPEUTICS
  • Private Grant  awarded by SEATTLE GENETICS, INC.
  • Private Grant  awarded by INCYTE CORPORATION
  • Private Grant  awarded by JANSSEN RESEARCH & DEVELOPMENT, LLC
  • Private Grant  awarded by FATE THERAPEUTICS, INC.
  • Private Grant  awarded by ARTIVA BIOTHERAPEUTICS INC
  • Private Grant  awarded by JUNO THERAPEUTICS
  • Private Grant  awarded by TG THERAPEUTICS
  • Private Grant  awarded by INCYTE CORPORATION
  • Private Grant  awarded by TAKEDA DEVELOPMENT CENTER AMERICAS, INC.
  • Private Grant  awarded by CELGENE CORPORATION
  • Private Grant  awarded by ONO PHARMACEUTICAL COMPANY LTD
  • Private Grant  awarded by BRISTOL-MYERS SQUIBB COMPANY
  • Private Grant  awarded by CELGENE CORPORATION
  • Private Grant  awarded by I-MAB BIOPHARMA US LIMITED
  • Private Grant  awarded by MERCK & COMPANY, INC. ^
  • SWOG NCORP Research Base  awarded by Oregon Health & Science University
  • SWOG Purchase Services Agreement  awarded by Oregon Health & Science University
  • UAB 1923: A Phase 2 Front-Line PET/CT-2 Response-Adapted Brentuximab Vedotin and Nivolumab Incorporated and Radiation-Free Management of Early Stage Classical Hodgkin Lymphoma (cHL) study  awarded by City of Hope
  • Investigator On

  • A Multicenter Retrospective Analysis of Treatment Patterns and Outcomes in Patients with Rare T-Cell Lymphoma Subtypes  awarded by Memorial Sloan-Kettering Cancer Center
  • A Multicenter Retrospective Analysis of Treatment Patterns and Outcomes in Patients with Rare T-Cell Lymphoma Subtypes  awarded by NHS GREATER GLASGOW AND CLYDE
  • AHOD1822 -- AnOpen-label, Uncontrolled, Multicenter Phase II Trial of MK-3475 (Pembrolizumab) in Children and Young Adults with Newly Diagnosed Classical Hodgkin Lymphoma with Inadequate (Slow Early) Response to Frontline Chemotherapy (KEYNOTE 667)  awarded by CHILDREN'S HOSPITAL (PHILADELPHIA)
  • Alliance for Clinical Trials in Oncology Payment Agreement  awarded by MAYO CLINIC
  • Alliance for Clinical Trials in Oncology Payment Agreement  awarded by MAYO CLINIC
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Support Grant - CCSG Supplement - Mehta - CATCH UP site Transition to EDDOP  awarded by National Cancer Institute/NIH/DHHS
  • Determinants of Efficacy and Toxicities among Patients with Lymphoid and Histiocytic Disorders  awarded by Memorial Sloan-Kettering Cancer Center
  • ECOG-ACRIN Purchase Service Agreement  awarded by Eastern Cooperative Oncology Group
  • ECOG-ACRIN Purchase Service Agreement  awarded by Eastern Cooperative Oncology Group
  • NCTN Deep South Research Consortium  awarded by National Cancer Institute/NIH/DHHS
  • NCTN Deep South Research Consortium  awarded by National Cancer Institute/NIH/DHHS
  • Private Grant  awarded by MedImmune
  • Private Grant  awarded by SEATTLE GENETICS, INC.
  • Private Grant  awarded by MedImmune
  • Private Grant  awarded by SEATTLE GENETICS, INC.
  • Private Grant  awarded by SEATTLE GENETICS, INC.
  • Private Grant  awarded by SEATTLE GENETICS, INC.
  • Private Grant  awarded by SEATTLE GENETICS, INC.
  • Private Grant  awarded by SEATTLE GENETICS, INC.
  • Private Grant  awarded by INCYTE CORPORATION
  • Private Grant  awarded by GlaxoSmithKline
  • Private Grant  awarded by Gilead Sciences ^
  • Private Grant  awarded by MILLENNIUM PHARMACEUTICALS, INC.
  • Private Grant  awarded by SEATTLE GENETICS, INC.
  • Private Grant  awarded by AILERON THERAPEUTICS
  • Private Grant  awarded by Genentech
  • Private Grant  awarded by INCYTE CORPORATION
  • Private Grant  awarded by BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. ^
  • Private Grant  awarded by INCYTE CORPORATION
  • Private Grant  awarded by Pfizer Inc., U.S. Pharmaceuticals Group
  • Private Grant  awarded by SEATTLE GENETICS, INC.
  • Private Grant  awarded by AILERON THERAPEUTICS
  • Private Grant  awarded by KARYOPHARM THERAPEUTICS, INC.
  • Private Grant  awarded by SEATTLE GENETICS, INC.
  • Private Grant  awarded by INCYTE CORPORATION
  • Private Grant  awarded by TESARO, INC.
  • Private Grant  awarded by BRISTOL MYERS SQUIBB PHARMACEUTICAL COMPANY
  • Private Grant  awarded by JUNO THERAPEUTICS
  • Private Grant  awarded by ELI LILLY AND COMPANY
  • Private Grant  awarded by AFFIMED GMBH
  • Private Grant  awarded by BRISTOL MYERS SQUIBB PHARMACEUTICAL COMPANY
  • Private Grant  awarded by Pfizer Inc., U.S. Pharmaceuticals Group
  • Private Grant  awarded by FORTY SEVEN, INC.
  • Private Grant  awarded by SEATTLE GENETICS, INC.
  • Private Grant  awarded by BRISTOL MYERS SQUIBB PHARMACEUTICAL COMPANY
  • Private Grant  awarded by ASTEX PHARMACEUTICALS
  • Private Grant  awarded by INCYTE CORPORATION
  • Private Grant  awarded by INCYTE CORPORATION
  • Private Grant  awarded by ROCHE TCRC, INC.
  • Private Grant  awarded by CELGENE INTERNATIONAL II SÀRL
  • Private Grant  awarded by JUNO THERAPEUTICS
  • Private Grant  awarded by IOVANCE BIOTHERAPEUTICS INC.
  • Private Grant  awarded by AMGEN, INC.^
  • Private Grant  awarded by Pfizer Inc., U.S. Pharmaceuticals Group
  • Private Grant  awarded by MERCK & COMPANY, INC. ^
  • Private Grant  awarded by INCYTE CORPORATION
  • Private Grant  awarded by CELGENE CORPORATION
  • Private Grant  awarded by CELGENE CORPORATION
  • Private Grant  awarded by CELGENE CORPORATION
  • Private Grant  awarded by MERCK SHARP & DOHME CORP
  • Private Grant  awarded by I-MAB BIOPHARMA US LIMITED
  • Private Grant  awarded by SEATTLE GENETICS, INC.
  • Private Grant  awarded by JUNO THERAPEUTICS
  • Private Grant  awarded by TG THERAPEUTICS
  • Private Grant  awarded by SUTRO BIOPHARM
  • Private Grant  awarded by TAKEDA PHARMACEUTICALS COMPANY LTD
  • Private Grant  awarded by IONIS PHARMACEUTICALS, INC.
  • Private Grant  awarded by GENMAB
  • Private Grant  awarded by GENMAB
  • Private Grant  awarded by Genentech
  • Private Grant  awarded by Genentech
  • Private Grant  awarded by SEATTLE GENETICS, INC.
  • Private Grant  awarded by Gilead Sciences ^
  • Private Grant  awarded by INCYTE CORPORATION
  • Private Grant  awarded by INNATE PHARMA
  • Private Grant  awarded by CELGENE CORPORATION
  • Private Grant  awarded by VIRACTA INC
  • Private Grant  awarded by ROCHE PHARMACEUTICAL
  • Private Grant  awarded by EUSA PHARMA
  • Private Grant  awarded by Genentech
  • Private Grant  awarded by SEATTLE GENETICS, INC.
  • Private Grant  awarded by BEIGENE
  • Southwest Oncology Group Purchase Service Agreement  awarded by Oregon Health & Science University
  • UAB 1764:The Targeted Agent and Profiling Utilization Registry (TAPUR) Study  awarded by American Society of Clinical Oncology
  • Whole Exome and Comprehensive Kinomics Analysis of Penile Squamous Cell Carcinoma  awarded by Conquer Cancer Foundation of ASCO
  • Education And Training

  • George Washington University Hospital, Residency
  • UAB Hospital, Postdoctoral Fellowship
  • Bachelor of Medicine & Surgery (MBBS), The Maharaja Sayajirao University of Baroda 2002
  • Full Name

  • Amitkumar Mehta