Positions

Overview

  • Dr. Gaggar obtained his medical degree from the University of Michigan in 2000 as a member of the prestigious Inteflex program. He then moved to Birmingham, AL where he completed his internship and residency in internal medicine at the University of Alabama at Birmingham (UAB) in 2003. Following residency training, he began fellowship training at UAB in pulmonary and critical care medicine. During the research phase of his fellowship training, he worked in the laboratories of Dr. JP Clancy (Chief, Pediatric Pulmonology) and Dr. J. Edwin Blalock (Professor, Department of Medicine). He completed his fellowship in 2006, with special emphasis in cystic fibrosis and lung transplantation.

    The following year, Dr. Gaggar completed a PhD in Molecular and Cellular Physiology at UAB. Dr. Gaggar was invited to joined the UAB Division of Pulmonary, Allergy & Critical Care Medicine in 2006 as instructor in medicine. He currently serves as a director of the Pulmonary Biospecimen Repository and the Cystic Fibrosis Inflammation Group at UAB. He continues to see patients as both an inpatient physician and in the clinic setting. In addition, his laboratory program continues to investigate the roles of proteases in lung disease.

    Dr. Gaggar currently sees patients after lung transplantation and individuals with cystic fibrosis at University Hospital. He also holds a staff position at the Birmingham VA Medical Center (BVAMC) where he sees individuals with chronic obstructive lung disease (COPD). In addition, he serves as an attending physician at both the UAB and the BVAMC intensive care units.
  • Selected Publications

    Research Overview

  • Dr. Gaggar's laboratory interests focus on the roles proteases play in modulation of lung disease. Dr. Gaggar utilizes a combination of cell-based systems, unique murine models, and clinical specimens, leading to research which is truly "translational" in nature. The Gaggar lab's interests focus on 3 major arenas: proteases and neutrophilic airway inflammation, proteases and ion transportation, and the Regulation of Surfactant Protein D by Airway Proteases.

    Recently, Dr. Gaggar's laboratory and Dr. J. Edwin Blalock's laboratory have worked together to describe the proteolytic pathways involved in the generation of a novel neutrophil chemoattractant, proline-glycine-proline (PGP). Dr. Gaggar's group has shown that this chemoattractant is generated by the cleavage of collagen by matrix metalloprotease (MMP)-8 and MMP-9, in conjunction with a novel serine protease, prolyl endopeptidase (PE). Dr. Gaggar's group has also highlighted the relative contribution of PGP in development of BOS, demonstrating for the first time the impact this peptide might play in clinical lung disease. Ongoing efforts are now being focused in further delineation of the biological roles PGP may induce in the airway beyond neutrophil recruitment.
  • Investigator On

  • A Novel Exosomal Inflammatory Pathway  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Cellular Lipids and Leukocyte Function  awarded by National Institute of General Medical Sciences/NIH/DHHS
  • Environmental Cadmium and COPD  awarded by National Institute of Environmental Health Sciences/NIH/DHHS
  • Genetics of Smoke-Altered LTA4H in COPD  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Influenza Regulation of Epithelial Pneumococcal Host Defense  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Integrating Genomic Risk Assessment for Chronic Disease Management in a Diverse Population  awarded by National Human Genome Research Institute/NIH/DHHS
  • Matrix Metalloproteinase Driven Lung Inflammation in RSV Disease  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Mechanisms Driving Endothelial Angiopoietin-2 Expression and Vascular Dysfunction during Pediatric Sepsis  awarded by National Institute of General Medical Sciences/NIH/DHHS
  • Mechanisms and Correlates of Immune Protection against Genital Chlamydia in Humans  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Mechanisms of Pulmonary Microbiota-Induced Inflammation and Vascular Dysfunction in Neonatal Lung Injury  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Molecular Pathogenesis and Phenotype of Acquired CFTR Dysfunction in COPD  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Pediatric Critical Care Scientist Development Program: "RSV-Induced Respiratory Failure: Role of MMP-9 in Lung Injury Through Generation of PGP"  awarded by University of Utah
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC.
  • Private Grant  awarded by INSMED PHARMACEUTICALS, INC.
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC.
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC.
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC.
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC.
  • Private Grant  awarded by NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC.
  • Private Grant  awarded by PROQR THERAPEUTICS
  • Private Grant  awarded by CELTAXSYS, INC.
  • Private Grant  awarded by NIVALIS THERAPEUTICS, INC. - NEW
  • Private Grant  awarded by CARTESIAN THERAPEUTIC INC
  • Private Grant  awarded by EDESA BIOTECH INC
  • Private Grant  awarded by Gilead Sciences ^
  • Proof of Principal Evaluation of IV Gallium Nitrate (Ganite) in Patients with Cystic Fibrosis  awarded by SEATTLE CHILDREN'S HOSPITAL
  • Role of Heme and PGP Matrikines in Lung Inflammation  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Standardized Treatment of Pulmonary Exacerbations II  awarded by SEATTLE CHILDREN'S HOSPITAL
  • Targeted Cell Therapy for Acute Lung Injury  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • UAB CF Research and Translation Core Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB CF Research and Translation Core Center - Admin Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB CF Research and Translation Core Center - Core C  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Cystic Fibrosis Center for Care, Teaching, and Research (Adult)  awarded by Cystic Fibrosis Foundation ^
  • UAB Research and Development Program  awarded by Cystic Fibrosis Foundation ^
  • Education And Training

  • UAB Hospital, Internship
  • UAB Hospital, Residency
  • UAB Hospital, Postdoctoral Fellowship
  • Doctor of Philosophy in Molecular Physiology, University of Alabama at Birmingham 2007
  • Doctor of Medicine, University of Michigan System : Ann Arbor 2000
  • Full Name

  • Amit Gaggar