Positions

Overview

  • Dr. Bansal's research interest focuses on adaptive T-cell responses in HIV-1 transmission and pathogenesis. She's especially interested in understanding the role of HIV-1 specific CD8 and CD4 T-cells and their interplay with the host genetics in influencing the course of HIV-1 disease. This basic information is imperative for HIV-1 vaccine design as the correlates of immune protection are yet unknown. She is also interested in studying the role of T cell in HIV associated cancers.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 HLA-II-Associated HIV-1 Adaptation Decreases CD4+ T-Cell Responses in HIV-1 Vaccine Recipients.  Journal of Virology.  96. 2022
    2021 A 12-year retrospective evaluation of anal pre-cancerous lesions and cancer in people living with HIV-1 infection in the Southeastern U.S.  Infectious Agents and Cancer.  16. 2021
    2021 Cross-Reactivity to Mutated Viral Immune Targets Can Influence CD8+ T Cell Functionality: An Alternative Viral Adaptation Strategy.  Frontiers in Immunology.  12. 2021
    2021 HLA-E–restricted HIV-1–specific CD8+ T cell responses in natural infection.  Journal of Clinical Investigation.  131. 2021
    2021 Duration of post-COVID-19 symptoms is associated with sustained SARS-CoV-2-specific immune responses.  JCI Insight.  6. 2021
    2021 Elevated HIV infection of CD4 T cells in MRKAd5 vaccine recipients due to CD8 T cells targeting adapted epitopes.  Journal of Virology.  95. 2021
    2021 SARS-CoV-2-specific circulating T follicular helper cells correlate with neutralizing antibodies and increase during early convalescence.  PLoS Pathogens.  17. 2021
    2021 Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection.  Journal of Clinical Investigation.  131. 2021
    2021 HIV-1 Nef counteracts autophagy restriction by enhancing the association between BECN1 and its inhibitor BCL2 in a PRKN-dependent manner.  Autophagy.  17:553-577. 2021
    2020 Rates and Correlates of Incident Type 2 Diabetes Mellitus Among Persons Living With HIV-1 Infection.  Frontiers in Endocrinology.  11. 2020
    2020 SARS-CoV-2-specific peripheral T follicular helper cells correlate with neutralizing antibodies and increase during convalescence. 2020
    2020 Peripheral CD4 T follicular cells induced by a conjugated pneumococcal vaccine correlate with enhanced opsonophagocytic antibody responses in younger individuals.  Vaccine.  38:1778-1786. 2020
    2020 Cross-reactive CD8 T-cell responses elicited by adenovirus type 5-based HIV-1 vaccines contributed to early viral evolution in vaccine recipients who became infected.  Journal of Virology.  94. 2020
    2019 HLA-I Associated Adaptation Dampens CD8 T-Cell Responses in HIV Ad5-Vectored Vaccine Recipients.  Journal of Infectious Diseases.  220:1620-1628. 2019
    2019 CD8 T cells targeting adapted epitopes in chronic HIV infection promote dendritic cell maturation and CD4 T cell trans-infection.  PLoS Pathogens.  15. 2019
    2018 Antisense-derived HIV-1 cryptic epitopes are not major drivers of viral evolution during the acute phase of infection.  Journal of Virology.  92. 2018
    2018 Tetraspanin blockage reduces exosome-mediated HIV-1 entry.  Archives of Virology.  163:1683-1689. 2018
    2018 Herpes Zoster in Persons Living with HIV-1 Infection: Viremia and Immunological Defects Are Strong Risk Factors in the Era of Combination Antiretroviral Therapy.  Frontiers in Public Health.  6. 2018
    2017 Role of TIM-4 in exosome-dependent entry of HIV-1 into human immune cells.  International Journal of Nanomedicine.  12:4823-4833. 2017
    2016 Balance between transmitted HLA preadapted and nonassociated polymorphisms is a major determinant of HIV-1 disease progression.  Journal of Experimental Medicine.  213:2049-2063. 2016
    2016 Impact of pre-Adapted HIV transmission.  Nature Medicine.  22:606-613. 2016
    2016 HIV-1-specific CD8 T cells exhibit limited cross-reactivity during acute infection.  Journal of Immunology.  196:3276-3286. 2016
    2016 HIV-1 latency and virus production from unintegrated genomes following direct infection of resting CD4 T cells.  Retrovirology.  13. 2016
    2015 Normal T-cell activation in elite controllers with preserved CD4 + T-cell counts.  AIDS.  29:2245-2254. 2015
    2015 Enhanced recognition of HIV-1 cryptic epitopes restricted by HLA Class I alleles associated with a favorable clinical outcome 2015
    2015 HLA Class-II Associated HIV Polymorphisms Predict Escape from CD4+ T Cell Responses.  PLoS Pathogens.  11. 2015
    2015 The HIV-1 Antisense Protein (ASP) induces CD8 T cell responses during chronic infection.  Retrovirology.  12. 2015
    2014 Human Immunodeficiency Virus Vaccines.  Infectious Disease Clinics of North America.  28:615-631. 2014
    2014 Characterization of programmed death-1 homologue-1 (PD-1H) expression and function in normal and HIV infected individuals.  PLoS One.  9. 2014
    2014 Characterization of T-Cell responses to cryptic epitopes in recipients of a noncodon-optimized HIV-1 Vaccine 2014
    2014 Effects of atorvastatin and pravastatin on immune activation and T-cell function in antiretroviral therapy-suppressed HIV-1-infected patients.  AIDS.  28:2627-2631. 2014
    2014 Immune activation is associated with CD8 T cell interleukin-21 production in HIV-1-infected individuals.  Journal of Virology.  88:10259-10263. 2014
    2013 HIV-specific CD8+ T cells from elite controllers are primed for survival.  Journal of Virology.  87:5170-5181. 2013
    2012 Protocol for analyzing human leukocyte antigen variants and sexually transmitted infections: From genotyping to immunoassays.  Methods in Molecular Biology.  903:359-380. 2012
    2011 Interleukin-2 production by polyfunctional HIV-1-specific CD8 T cells is associated with enhanced viral suppression 2011
    2011 CD8 T-cell proliferative capacity is compromised in primary HIV-1 infection 2011
    2011 Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllers.  Journal of Virology.  85:2316-2324. 2011
    2010 Enhanced induction of HIV-specific cytotoxic t lymphocytes by dendritic cell-targeted delivery of SOCS-1 siRNA.  Molecular Therapy.  18:2028-2037. 2010
    2010 CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcription.  Journal of Experimental Medicine.  207:51-59. 2010
    2009 P16-04. Cryptic CTL epitopes derived from antisense transcription are frequently recognized in HIV-1 infection.  Retrovirology.  6. 2009
    2008 Multifunctional T-cell characteristics induced by a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 vaccine regimen given to healthy adults are dependent on the route and dose of administration.  Journal of Virology.  82:6458-6469. 2008
    2008 Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients.  Journal of Experimental Medicine.  205:1009-1017. 2008
    2008 Treatment response in acute/early infection versus advanced AIDS: Equivalent first and second phases of HIV RNA decline.  AIDS.  22:957-962. 2008
    2007 Immunological control of chronic HIV-1 infection: HLA-mediated immune function and viral evolution in adolescents.  AIDS.  21:2387-2397. 2007
    2007 Functionally competent antigen-specific Cd127hi memory CD8 + T cells are preserved only in HIV-infected individuals receiving early treatment.  Journal of Infectious Diseases.  195:108-117. 2007
    2006 Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV), and cytomegalovirus (CMV) specific CD8+ T cell proliferation in HIV infection.  Journal of Medical Virology.  78:1147-1157. 2006
    2006 Group M-based HIV-1 Gag peptides are frequently targeted by T cells in chronically infected US and Zambian patients.  AIDS.  20:353-360. 2006
    2005 Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection 2005
    2005 CD8 T-cell responses in early HIV-1 infection are skewed towards high entropy peptides.  AIDS.  19:241-250. 2005
    2003 T Cell Responses in HIV Type 1-Infected Adolescent Minorities Share Similar Epitope Specificities with Whites Despite Significant Differences in HLA Class I Alleles.  AIDS Research and Human Retroviruses.  19:1017-1026. 2003
    2003 Cross-reactive CD8+ T cell epitopes identified in US adolescent minorities 2003
    2002 Magnitude of functional CD8+ T-cell responses to the Gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasma.  Journal of Virology.  76:2298-2305. 2002
    2000 Characterization of the R572T point mutant of a putative cleavage site in human foamy virus env.  Journal of Virology.  74:2949-2954. 2000
    2000 A significant number of human immunodeficiency virus epitope-specific cytotoxic T lymphocytes detected by tetramer binding do not produce gamma interferon.  Journal of Virology.  74:10249-10255. 2000
    1999 An endoplasmic reticulum retrieval signal partitions human foamy virus maturation to intracytoplasmic membranes.  Journal of Virology.  73:7210-7217. 1999
    1998 Membrane organization of bluetongue virus nonstructural glycoprotein NS3.  Journal of Virology.  72:3362-3369. 1998
    1997 Characterization of the polyhedrin gene of Spodoptera litura nuclear polyhedrosis virus.  Virus Genes.  14:175-180. 1997
    1997 Expression of lacZ reporter gene under the control of the polyhedrin promoter of Spodoptera litura nuclear polyhedrosis virus.  Gene.  190:145-150. 1997
    1997 Hemagglutinin specificity and neuraminidase coding capacity of neuraminidase-deficient influenza viruses.  Virology.  229:155-165. 1997
    1996 Rapid and gentle method for the isolation of DNA from nuclear polyhedrosis viruses. 1996
    1995 Molecular Basis for the Resistance of Influenza Viruses to 4-Guanidino-Neu5Ac2en.  Virology.  214:642-646. 1995

    Research Overview

  • HIV-1, Vaccines, Infectious Diseases, T cell immunology, AIDS associated malignancies

    • Principal Investigator On

    Investigator On

  • A Rational Approach for HIV Vaccine T Cell Epitope Selection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Analysis of Variant Epitope Specific CD8 T-Cells to Optimize HIV Vaccine Design  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • CTL and HIV Polymorphisms in Heterosexual Transmission  awarded by Emory University
  • CTL and HIV Polymorphisms in Heterosexual Transmission  awarded by Emory University
  • Comprehensive Cancer Center Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Defining the Biological Relevance of HIV Specific HLA-E Restricted CD8 T cell Responses  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Defining the Biological Relevance of HIV-1 Adaptation to CD4 T Cell Responses  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • HIV-1 Cryptic Epitopes: Implications for Vaccine Design  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Immunologic Health in Aging PLWH  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Mapping Novel Subdominant B*5701 Epitopes in Conserved Regions of the HIV Proteome  awarded by UNIVERSITY OF TEXAS
  • Multidisciplinary Evaluation of Accelerated Aging in HIV-1 Infection  awarded by National Institute on Aging/NIH/DHHS
  • Oxidative Stress and T Cell Balance: Effect on Pulmonary Tuberculosis During HIV  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Private Grant  awarded by Pfizer Inc., U.S. Pharmaceuticals Group
  • Private Grant  awarded by Pfizer Inc., U.S. Pharmaceuticals Group
  • The Impact of HIV Adaptation to CD8 T Cells on Infection and Viral Control  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • UAB Center for AIDS Research  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • UAB Center for AIDS Research  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Vaccine and Treatment Evaluation Units  awarded by VANDERBILT UNIVERSITY MEDICAL CENTER ^

    • Teaching Overview

  • I have taught HIV-1 virology and immunology to undergraduate and graduate students working in an Infectious Diseases Laboratory.

    • Education And Training

  • University of Alabama University of Alabama, Postdoctoral Fellowship
  • Doctor of Philosophy in Virology, 1996

    • Full Name

  • Anju Bansal